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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	指定難病告示番号
1	Apelin signaling pathway 💬	1件: AGTR1 💬	D00150 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
2	Apelin signaling pathway 💬	1件: AGTR1 💬	D02014 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
3	Apelin signaling pathway 💬	1件: AGTR1 💬	D00522 💬	Candesartan	2件: 58, 67 💬
4	Apelin signaling pathway 💬	1件: AGTR1 💬	D00522 💬	Candesartan cilexetil	1件: 67 💬
5	Apelin signaling pathway 💬	1件: AGTR1 💬	D00626 💬	Candesartan cilexetil	1件: 67 💬
6	Apelin signaling pathway 💬	1件: AGTR1 💬	D00523 💬	Irbesartan	4件: 66, 167, 168, 222 💬
7	Apelin signaling pathway 💬	1件: AGTR1 💬	D00357 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
8	Apelin signaling pathway 💬	1件: AGTR1 💬	D08146 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
9	Apelin signaling pathway 💬	1件: AGTR1 💬	D11776 💬	Sparsentan	3件: 66, 218, 222 💬
10	Apelin signaling pathway 💬	1件: AGTR1 💬	D00627 💬	Telmisartan	2件: 66, 67 💬
11	Apelin signaling pathway 💬	1件: AGTR1 💬	D00400 💬	Valsartan	7件: 57, 58, 66, 75, 218, 222, 224 💬
12	Apelin signaling pathway 💬	1件: CCN2 💬	D10969 💬	Pamrevlumab	2件: 85, 113 💬
13	Apelin signaling pathway 💬	2件: HDAC4, HDAC5 💬	D06320 💬	Vorinostat	3件: 19, 75, 96 💬
14	Apelin signaling pathway 💬	2件: MAP2K1, MAP2K2 💬	D10604 💬	Binimetinib	1件: 34 💬
15	Apelin signaling pathway 💬	2件: MAP2K1, MAP2K2 💬	D10405 💬	Cobimetinib	1件: 280 💬
16	Apelin signaling pathway 💬	2件: MAP2K1, MAP2K2 💬	D09666 💬	Selumetinib	1件: 34 💬
17	Apelin signaling pathway 💬	2件: MAP2K1, MAP2K2 💬	D10175 💬	Trametinib	4件: 2 , 34, 279, 280 💬
18	Apelin signaling pathway 💬	1件: MTOR 💬	D02714 💬	Everolimus	9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
19	Apelin signaling pathway 💬	1件: MTOR 💬	D00753 💬	Sirolimus	41件: 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
20	Apelin signaling pathway 💬	1件: MTOR 💬	D06068 💬	Temsirolimus	4件: 13, 34, 89, 331 💬
21	Apelin signaling pathway 💬	1件: PDE3B 💬	D00227 💬	Aminophylline	1件: 63 💬
22	Apelin signaling pathway 💬	1件: PDE3B 💬	D05429 💬	Aminophylline	1件: 63 💬
23	Apelin signaling pathway 💬	1件: PDE3B 💬	D07546 💬	Bucladesine	1件: 246 💬
24	Apelin signaling pathway 💬	1件: PDE3B 💬	D00528 💬	Caffeine	9件: 2 , 6 , 13, 21, 46, 78, 96, 97, 265 💬
25	Apelin signaling pathway 💬	1件: PDE3B 💬	D01453 💬	Caffeine	9件: 2 , 6 , 13, 21, 46, 78, 96, 97, 265 💬
26	Apelin signaling pathway 💬	1件: PDE3B 💬	D01896 💬	Cilostazol	3件: 51, 70, 124 💬
27	Apelin signaling pathway 💬	1件: PDE3B 💬	D00718 💬	Flavoxate	1件: 226 💬
28	Apelin signaling pathway 💬	1件: PDE3B 💬	D07961 💬	Flavoxate	1件: 226 💬
29	Apelin signaling pathway 💬	1件: PDE3B 💬	D01385 💬	Ibudilast	2件: 2 , 13 💬
30	Apelin signaling pathway 💬	1件: PDE3B 💬	D04720 💬	Levosimendan	1件: 2 💬
31	Apelin signaling pathway 💬	1件: PDE3B 💬	D00417 💬	Milrinone	1件: 294 💬
32	Apelin signaling pathway 💬	1件: PDE3B 💬	D02085 💬	Milrinone	1件: 294 💬
33	Apelin signaling pathway 💬	1件: PDE3B 💬	D00371 💬	Theophylline	2件: 236, 299 💬
34	Apelin signaling pathway 💬	1件: PDE3B 💬	D01712 💬	Theophylline	2件: 236, 299 💬
35	Apelin signaling pathway 💬	1件: PDE3B 💬	D02017 💬	Theophylline	2件: 236, 299 💬
36	Apelin signaling pathway 💬	1件: PDE3B 💬	D06103 💬	Theophylline	2件: 236, 299 💬
37	Apelin signaling pathway 💬	1件: PDE3B 💬	D06104 💬	Theophylline	2件: 236, 299 💬
38	Apelin signaling pathway 💬	2件: PRKAA1, PRKAA2 💬	D00944 💬	Metformin	24件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
39	Apelin signaling pathway 💬	2件: PRKAA1, PRKAA2 💬	D04966 💬	Metformin	24件: 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
40	Apelin signaling pathway 💬	1件: PRKCE 💬	D09671 💬	Sotrastaurin	1件: 97 💬
41	Apelin signaling pathway 💬	1件: RAF1 💬	D06272 💬	Sorafenib	2件: 34, 86 💬
42	Apelin signaling pathway 💬	1件: RAF1 💬	D08524 💬	Sorafenib	2件: 34, 86 💬