Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	指定難病告示番号
1	Antifolate resistance 💬	2件: DHFR, DHFR2 💬	D00142 💬	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
2	Antifolate resistance 💬	2件: DHFR, DHFR2 💬	D02115 💬	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
3	Antifolate resistance 💬	1件: IL1B 💬	D09315 💬	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
4	Antifolate resistance 💬	1件: IL1B 💬	D09911 💬	Gevokizumab	4件: 41, 50, 56, 269 💬
5	Antifolate resistance 💬	1件: IL1B 💬	D06635 💬	Rilonacept	4件: 51, 106, 107, 266 💬
6	Antifolate resistance 💬	3件: IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
7	Antifolate resistance 💬	1件: IL6 💬	D09669 💬	Siltuximab	2件: 28, 331 💬
8	Antifolate resistance 💬	1件: IL6 💬	D10080 💬	Sirukumab	2件: 41, 46 💬
9	Antifolate resistance 💬	2件: IL6, TNF 💬	D08976 💬	Pomalidomide	6件: 28, 34, 51, 85, 227, 331 💬
10	Antifolate resistance 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	4件: 46, 51, 53, 271 💬
11	Antifolate resistance 💬	1件: RELA 💬	D12181 💬	Edasalonexent	1件: 113 💬
12	Antifolate resistance 💬	1件: TNF 💬	D02597 💬	Adalimumab	18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
13	Antifolate resistance 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
14	Antifolate resistance 💬	1件: TNF 💬	D00742 💬	Etanercept	17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
15	Antifolate resistance 💬	1件: TNF 💬	D04358 💬	Golimumab	8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
16	Antifolate resistance 💬	1件: TNF 💬	D02598 💬	Infliximab	27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
17	Antifolate resistance 💬	1件: TNF 💬	D04687 💬	Lenalidomide	8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
18	Antifolate resistance 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
19	Antifolate resistance 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
20	Antifolate resistance 💬	1件: TNF 💬	D00754 💬	Thalidomide	20件: 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
21	Antifolate resistance 💬	1件: TYMS 💬	D01223 💬	Capecitabine	1件: 94 💬
22	Antifolate resistance 💬	1件: TYMS 💬	D01244 💬	Tegafur	1件: 46 💬