Target Gene/Pathway Pathway / Gene
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| No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
|---|---|---|---|---|---|
| 1 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C1R 3件: C1R, C1S, KLKB1 💬 |
D10845 D10845 💬 |
Conestat alfa | 061 1件: 61 💬 |
| 2 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C1S 1件: C1S 💬 |
D11530 D11530 💬 |
Sutimlimab | 061 1件: 61 💬 |
| 3 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C3 1件: C3 💬 |
D11613 D11613 💬 |
Pegcetacoplan | 002 3件: 2 , 62, 222 💬 |
| 4 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C5 1件: C5 💬 |
D11696 D11696 💬 |
Crovalimab | 062 2件: 62, 109 💬 |
| 5 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C5 1件: C5 💬 |
D03940 D03940 💬 |
Eculizumab | 011 7件: 11, 13, 14, 61, 62, 109, 222 💬 |
| 6 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C5 1件: C5 💬 |
D11473 D11473 💬 |
Nomacopan | 062 3件: 62, 109, 162 💬 |
| 7 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C5 1件: C5 💬 |
D11477 D11477 💬 |
Pozelimab | 011 2件: 11, 62 💬 |
| 8 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C5 1件: C5 💬 |
D11054 D11054 💬 |
Ravulizumab | 002 7件: 2 , 11, 13, 50, 62, 66, 109 💬 |
| 9 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C5 1件: C5 💬 |
D11838 D11838 💬 |
Vilobelimab | 043 3件: 43, 44, 269 💬 |
| 10 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
C5AR1 1件: C5AR1 💬 |
D11093 D11093 💬 |
Avacopan | 043 3件: 43, 44, 222 💬 |
| 11 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
CFB 1件: CFB 💬 |
D12251 D12251 💬 |
Iptacopan | 061 5件: 61, 62, 66, 109, 222 💬 |
| 12 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
CFD 1件: CFD 💬 |
D11641 D11641 💬 |
Danicopan | 062 2件: 62, 222 💬 |
| 13 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F10 1件: F10 💬 |
D03213 D03213 💬 |
Apixaban | 096 3件: 96, 97, 222 💬 |
| 14 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F10 1件: F10 💬 |
D09710 D09710 💬 |
Edoxaban | 046 2件: 46, 88 💬 |
| 15 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F10 1件: F10 💬 |
D07086 D07086 💬 |
Rivaroxaban | 046 5件: 46, 49, 75, 91, 210 💬 |
| 16 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F10 2件: F10, F9 💬 |
D10821 D10821 💬 |
Emicizumab | 288 1件: 288 💬 |
| 17 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F2 1件: F2 💬 |
D09707 D09707 💬 |
Dabigatran | 051 4件: 51, 85, 91, 124 💬 |
| 18 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F2 1件: F2 💬 |
D07144 D07144 💬 |
Dabigatran etexilate | 051 1件: 51 💬 |
| 19 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F2 1件: F2 💬 |
D06410 D06410 💬 |
Thrombomodulin Alfa | 085 1件: 85 💬 |
| 20 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F8 1件: F8 💬 |
D00291 D00291 💬 |
Desmopressin | 006 6件: 6 , 64, 72, 75, 225, 288 💬 |
| 21 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
F8 1件: F8 💬 |
D02235 D02235 💬 |
Desmopressin | 006 6件: 6 , 64, 72, 75, 225, 288 💬 |
| 22 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
MASP2 1件: MASP2 💬 |
D11531 D11531 💬 |
Narsoplimab | 064 4件: 64, 66, 109, 222 💬 |
| 23 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
PLG 1件: PLG 💬 |
D00160 D00160 💬 |
Aminocaproic acid | 070 1件: 70 💬 |
| 24 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
PLG 1件: PLG 💬 |
D01136 D01136 💬 |
Tranexamic acid | 046 6件: 46, 70, 215, 227, 288, 299 💬 |
| 25 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
SERPINC1 1件: SERPINC1 💬 |
D03674 D03674 💬 |
Enoxaparin | 046 1件: 46 💬 |
| 26 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
SERPINC1 1件: SERPINC1 💬 |
D07510 D07510 💬 |
Enoxaparin | 046 1件: 46 💬 |
| 27 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
SERPINC1 1件: SERPINC1 💬 |
D07510 D07510 💬 |
Heparin | 047 12件: 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 💬 |
| 28 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
SERPINC1 1件: SERPINC1 💬 |
D07510 D07510 💬 |
Parnaparin | 097 1件: 97 💬 |
| 29 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
SERPINC1 2件: SERPINC1, SERPIND1 💬 |
D08547 D08547 💬 |
Sulodexide | 013 4件: 13, 51, 271, 288 💬 |
| 30 | Complement and coagulation cascades 💬 Related to 17 target genes, 28 drugs (DrugBank) and 45 diseases in DDrare |
VWF 1件: VWF 💬 |
D11160 D11160 💬 |
Caplacizumab | 064 1件: 64 💬 |