Target Gene/Pathway Pathway / Gene
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No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related | KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
---|---|---|---|---|---|
1 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
CYP17A1 1件: CYP17A1 💬 |
D00351 D00351 💬 |
Ketoconazole | 008 3件: 8 , 13, 75 💬 |
2 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 1件: ESR1 💬 |
D00289 D00289 💬 |
Danazol | 060 5件: 60, 63, 64, 65, 285 💬 |
3 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 1件: ESR1 💬 |
D02367 D02367 💬 |
Desogestrel | 230 1件: 230 💬 |
4 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 1件: ESR1 💬 |
D00554 D00554 💬 |
Ethinylestradiol | 013 4件: 13, 46, 49, 299 💬 |
5 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00962 D00962 💬 |
Clomifene | 074 1件: 74 💬 |
6 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D07726 D07726 💬 |
Clomifene | 074 1件: 74 💬 |
7 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D11513 D11513 💬 |
Estetrol | 053 1件: 53 💬 |
8 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D11514 D11514 💬 |
Estetrol | 053 1件: 53 💬 |
9 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00105 D00105 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
10 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01413 D01413 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
11 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01617 D01617 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
12 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01953 D01953 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
13 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D04061 D04061 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
14 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D04063 D04063 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
15 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D04064 D04064 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
16 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D04065 D04065 💬 |
Estradiol | 013 7件: 13, 46, 49, 65, 76, 226, 299 💬 |
17 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01413 D01413 💬 |
Estradiol valerate | 065 1件: 65 💬 |
18 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00185 D00185 💬 |
Estriol | 013 2件: 13, 227 💬 |
19 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01986 D01986 💬 |
Estriol | 013 2件: 13, 227 💬 |
20 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D01161 D01161 💬 |
Fulvestrant | 049 2件: 49, 86 💬 |
21 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00575 D00575 💬 |
Mestranol | 046 2件: 46, 49 💬 |
22 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D08409 D08409 💬 |
Prasterone | 049 6件: 49, 53, 83, 86, 96, 113 💬 |
23 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D02217 D02217 💬 |
Raloxifene | 046 1件: 46 💬 |
24 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D08465 D08465 💬 |
Raloxifene | 046 1件: 46 💬 |
25 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D00966 D00966 💬 |
Tamoxifen | 002 4件: 2 , 86, 113, 227 💬 |
26 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
ESR1 2件: ESR1, ESR2 💬 |
D08559 D08559 💬 |
Tamoxifen | 002 4件: 2 , 86, 113, 227 💬 |
27 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
JAK2 1件: JAK2 💬 |
D10308 D10308 💬 |
Baricitinib | 041 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬 |
28 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
JAK2 1件: JAK2 💬 |
D10653 D10653 💬 |
Peficitinib | 046 1件: 46 💬 |
29 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
JAK2 1件: JAK2 💬 |
D09959 D09959 💬 |
Ruxolitinib | 228 1件: 228 💬 |
30 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
JAK2 1件: JAK2 💬 |
D09970 D09970 💬 |
Tofacitinib | 011 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬 |
31 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10604 D10604 💬 |
Binimetinib | 034 1件: 34 💬 |
32 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10405 D10405 💬 |
Cobimetinib | 280 1件: 280 💬 |
33 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D09666 D09666 💬 |
Selumetinib | 034 1件: 34 💬 |
34 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
MAP2K1 2件: MAP2K1, MAP2K2 💬 |
D10175 D10175 💬 |
Trametinib | 002 4件: 2 , 34, 279, 280 💬 |
35 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
MAPK11 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 |
D09639 D09639 💬 |
Losmapimod | 113 2件: 113, 222 💬 |
36 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
MAPK11 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 |
D10959 D10959 💬 |
Neflamapimod | 008 1件: 8 💬 |
37 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
NFKB1 1件: NFKB1 💬 |
D01146 D01146 💬 |
Iguratimod | 046 4件: 46, 51, 53, 271 💬 |
38 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
PIK3CA 3件: PIK3CA, PIK3CB, PIK3CD 💬 |
D11158 D11158 💬 |
Leniolisib | 053 2件: 53, 65 💬 |
39 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
PIK3CD 1件: PIK3CD 💬 |
D11437 D11437 💬 |
Parsaclisib | 035 3件: 35, 53, 61 💬 |
40 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
PRL 1件: PRL 💬 |
D00780 D00780 💬 |
Bromocriptine | 006 2件: 6 , 74 💬 |
41 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
PRL 1件: PRL 💬 |
D03165 D03165 💬 |
Bromocriptine | 006 2件: 6 , 74 💬 |
42 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
PRL 1件: PRL 💬 |
D00987 D00987 💬 |
Cabergoline | 006 3件: 6 , 74, 75 💬 |
43 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
PRL 1件: PRL 💬 |
D01348 D01348 💬 |
Terguride | 051 2件: 51, 86 💬 |
44 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
RAF1 1件: RAF1 💬 |
D06272 D06272 💬 |
Sorafenib | 034 2件: 34, 86 💬 |
45 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
RAF1 1件: RAF1 💬 |
D08524 D08524 💬 |
Sorafenib | 034 2件: 34, 86 💬 |
46 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
RELA 1件: RELA 💬 |
D12181 D12181 💬 |
Edasalonexent | 113 1件: 113 💬 |
47 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
SRC 1件: SRC 💬 |
D03252 D03252 💬 |
Bosutinib | 002 2件: 2 , 67 💬 |
48 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
SRC 1件: SRC 💬 |
D03658 D03658 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
49 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
SRC 1件: SRC 💬 |
D06414 D06414 💬 |
Dasatinib | 051 2件: 51, 85 💬 |
50 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
SRC 1件: SRC 💬 |
D09664 D09664 💬 |
Saracatinib | 006 3件: 6 , 89, 272 💬 |
51 | Prolactin signaling pathway 💬 Related to 19 target genes, 36 drugs (DrugBank) and 53 diseases in DDrare |
TNFSF11 1件: TNFSF11 💬 |
D03684 D03684 💬 |
Denosumab | 046 7件: 46, 50, 93, 95, 96, 274, 299 💬 |