Drug Description in Trials / DrugBank / KEGG DRUG /

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
111C-ACETATE[2] Acetate,
Acetic acid C-11		---[3] 13, 86, 88
2[18F]Fluoro-2-deoxy-2-D-glucose[1] D-glucose[1] D00009 --[2] 86, 88
3Acetate[1] Acetate---[43] 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
4ACT-064992----[5] 51, 85, 86, 88, 210
5ACT-293987----[3] 51, 86, 88
6Adempas[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[5] 51, 86, 88, 225, 299
7Adempas (active agent riociguat)[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 88
8Adempas (Riociguat, BAY63-2521)[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 88
9Adempas®[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 86, 88
10Ambrisentan[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 51, 84, 85, 86, 88, 210, 211
11Ambrisentan 5 mg[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 88
12Ammonia[1] Ammonia[1] D02916 --[3] 86, 88, 296
13Atorvastatin[1] Atorvastatin[3] D00258 ,
D00887 ,
D07474 		[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
14Ballon Pulmonary Angioplasty----[1] 88
15Balloon Pulmonary Angioplasty (BPA)----[1] 88
16BARNASCAN----[1] 88
17BAY 63-2521----[2] 86, 88
18BAY 63-2521 coated tablets 0.5 mg----[2] 86, 88
19BAY 63-2521 coated tablets 1 mg----[2] 86, 88
20BAY 63-2521 coated tablets 1.5 mg----[2] 86, 88
21BAY 63-2521 coated tablets 2 mg----[2] 86, 88
22BAY 63-2521 coated tablets 2.5 mg----[2] 86, 88
23BAY 63-2521 IR coated tablet 1.0 mg----[1] 88
24BAY 63-2521 IR coated tablet 1.5 mg----[1] 88
25BAY 63-2521 IR coated tablet 2.0 mg----[1] 88
26BAY 63-2521 IR coated tablet 2.5 mg----[1] 88
27BAY 63-2521 IR tablet 0.5 mg----[1] 88
28BAY 63-2521 IR tablet 1.0 mg----[1] 88
29BAY 63-2521 IR tablet 1.5 mg----[1] 88
30BAY 63-2521 IR tablet 2.0 mg----[1] 88
31BAY 63-2521 IR tablet 2.5 mg----[1] 88
32BAY 63-2521 tablets 0.5 mg----[2] 86, 88
33BAY 63-2521 tablets 1 mg----[2] 86, 88
34BAY 63-2521 tablets 1.5 mg----[2] 86, 88
35BAY 63-2521 tablets 2 mg----[2] 86, 88
36BAY 63-2521 tablets 2.5 mg----[2] 86, 88
37BAY1237592----[2] 86, 88
38Behavioral: respiratory and exercise therapy----[1] 88
39Behavioral: respiratory and exercise therapy with supplemental oxygen[1] Oxygen[1] D00003 --[1] 88
40Bosentan[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
41BOSENTAN MONOHYDRATE[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 51, 84, 86, 88
42BPA----[1] 88
43Catheter directed therapy----[1] 88
44Cysteine[1] Cysteine[2] D00026 ,
D02326 		--[11] 6, 13, 19, 34, 84, 85, 88, 90, 254, 296, 310
45D-glucose[1] D-glucose[1] D00009 --[3] 49, 86, 88
46Diagnostic Test: Endogenous thrombin potential[1] Thrombin[1] D00090 --[2] 86, 88
47Diagnostic Test: Light transmission aggregometry----[2] 86, 88
48Diagnostic Test: Platelet function analyzer-100----[2] 86, 88
49Diagnostic Test: Rotational thromboelastometry----[2] 86, 88
50Edoxaban[1] Edoxaban[1] D09710 [1] F10 💬[1] Complement and coagulation cascades 💬[2] 46, 88
51Fludeoxyglucose[1] Fludeoxyglucose (18F)---[4] 34, 84, 85, 88
52Glucose[1] Dextrose, unspecified form---[15] 2, 6, 13, 49, 50, 65, 75, 86, 88, 96, 160, 195, 254, 257, 299
53GSK1325760----[2] 86, 88
54Imatinib[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
55IMATINIB MESILATE[1] Imatinib[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[3] 13, 86, 88
56Iodine[1] Iodine[1] D00108 --[2] 46, 88
57JNJ-67896062 / ACT-064992----[2] 86, 88
58JNJ-67896062/ ACT-064992----[2] 86, 88
59Long term oxygen therapy[1] Oxygen[1] D00003 --[1] 88
60Macitentan[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210
61Macitentan 10 mg[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 86, 88
62Macitentan 10mg[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 51, 88
63MACITENTAN COMPRESSE[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 86, 88
64MACITENTAN TABLETS[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 86, 88
65Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine-3-yl]-5-pyrimidinyl(methyl)carb----[2] 86, 88
66Methyl [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]meth----[2] 86, 88
67MultiHance[1] Gadobenic acid[2] D04283 ,
D08018 		--[2] 86, 88
68N-acetyl Cysteine[1] Cysteine[2] D00026 ,
D02326 		--[7] 13, 19, 34, 85, 88, 296, 310
69NS-304----[3] 70, 86, 88
70NS-304 Placebo----[2] 70, 88
71Opsumit[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210
72Opsumit®[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210
73Oxygen[1] Oxygen[1] D00003 --[20] 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
74Oxygen, liquid[1] Oxygen[1] D00003 --[2] 86, 88
75Placebo----[27] 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
76Potassium[1] Potassium[1] D08403 --[12] 36, 46, 66, 67, 88, 94, 98, 115, 167, 179, 215, 235
77Pulmonary endarterectomy----[1] 88
78Pulmonary Endarteriectomy----[1] 88
79Radiation: Cardiac PET imaging using F-18-FDG, N-13 ammonia( NH3)[1] Ammonia[1] D02916 --[1] 88
80Radiation: Computed tomography lung subtraction iodine mapping[1] Iodine[1] D00108 --[1] 88
81Remodulin[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[2] 86, 88
82Remodulin (R)[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 88
83Remodulin 10mg/ml 20ml[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 88
84Remodulin 1mg/ml 20ml[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 88
85Remodulin 2.5mg/ml 20ml[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 88
86Remodulin 5mg/ml 20ml[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 88
87RIOCIGUAT[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[6] 51, 84, 86, 88, 225, 299
88Riociguat (Adempas, BAY63-2521)[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 51, 86, 88, 299
89Riociguat Oral Tablet[1] Riociguat[1] D09572 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 88
90Ro 47-0203----[4] 51, 85, 86, 88
91Sauerstoff----[2] 86, 88
92Selexipag[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 47, 51, 70, 84, 86, 88
93Supplemental oxygen via a mask[1] Oxygen[1] D00003 --[1] 88
94Systemic anticoagulation----[1] 88
95Thrombin[1] Thrombin[1] D00090 --[2] 86, 88
96Tracleer[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[8] 13, 51, 84, 85, 86, 88, 210, 211
97TRACLEER 125MG 56CPR RIV.[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 88
98TRACLEER*56CPR RIV 125MG[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 86, 88
99Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 51, 84, 85, 86, 88, 210
100TREPROSTINIL SODIUM[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[3] 51, 86, 88
101Uptravi[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[3] 84, 86, 88
102Volibris[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 51, 85, 86, 88
103Warfarin[1] Warfarin[3] D00564 ,
D01280 ,
D08682 		[2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
104Warfarin Potassium[2] Potassium,
Warfarin		[4] D00564 ,
D01280 ,
D08403 ,
D08682 		[2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[1] 88