Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)
(Synonym: Methotrexate sodium)		[2] Abatacept,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D03203 		[4] CD80,
CD86,
DHFR,
DHFR2 💬		[17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬[1] 46
2Abatacept + Methotrexate
(Synonym: Methotrexate sodium)		[2] Abatacept,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D03203 		[4] CD80,
CD86,
DHFR,
DHFR2 💬		[17] Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬[1] 46
3Adalimumab with methotrexate
(Synonym: Methotrexate sodium)		[2] Adalimumab,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02597 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
4AZATHIOPRINE or METHOTREXATE
(Synonym: Methotrexate sodium)		[2] Azathioprine,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[4] D00142 ,
D00238 ,
D02115 (Name: Methotrexate sodium),
D03033 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
5BMS-582949 and Methotrexate
(Synonym: Methotrexate sodium)		[2] BMS-582949,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
6Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF
(Synonym: Methotrexate sodium)		[6] Busulfan,
Filgrastim,
Fludarabine,
Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Phosphate ion,
Tacrolimus		[8] D00107 ,
D00142 ,
D00248 ,
D01907 ,
D02115 (Name: Methotrexate sodium),
D03235 ,
D07966 ,
D08556 		[9] CSF3R,
DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬		[47] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 60
7Certolizumab Pegol + Methotrexate (MTX)
(Synonym: Methotrexate sodium)		[2] Certolizumab pegol,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D03441 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
8Clobetasol propionate + Methotrexate
(Synonym: Methotrexate sodium)		[3] Clobetasol,
Clobetasol propionate,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[4] D00142 ,
D01272 ,
D02115 (Name: Methotrexate sodium),
D07715 		[3] DHFR,
DHFR2,
NR3C1 💬		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 162
9Combination Product: Exercise, and methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
10Combination Product: Laser, exercise, and methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
11Combination Product: Methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
12CP-690,550 + methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
13Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids
(Synonym: Methotrexate sodium)		[3] Azathioprine,
Cyclophosphamide,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[6] D00142 ,
D00238 ,
D00287 ,
D02115 (Name: Methotrexate sodium),
D03033 ,
D07760 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44
14Cyclosporin, Methotrexate (GVHD prophylaxis)
(Synonym: Methotrexate sodium)		[2] Cyclosporine,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D00184 ,
D02115 (Name: Methotrexate sodium)		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 326
15DMARDs (methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
16Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase
(Synonym: Methotrexate sodium)		[4] Asparaginase Escherichia coli,
Cyclophosphamide,
Doxorubicin,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[6] D00142 ,
D00287 ,
D02115 (Name: Methotrexate sodium),
D02997 ,
D03899 ,
D07760 		[4] DHFR,
DHFR2,
TOP2A,
TOP2B 💬		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Platinum drug resistance 💬[1] 65
17Early immunosuppressants (azathioprine, methotrexate)
(Synonym: Methotrexate sodium)		[2] Azathioprine,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[4] D00142 ,
D00238 ,
D02115 (Name: Methotrexate sodium),
D03033 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
18Etanercept + Methotrexate
(Synonym: Methotrexate sodium)		[2] Etanercept,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D00742 ,
D02115 (Name: Methotrexate sodium)		[4] DHFR,
DHFR2,
LTA,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
19Etanercept , Methotrexate
(Synonym: Methotrexate sodium)		[2] Etanercept,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D00742 ,
D02115 (Name: Methotrexate sodium)		[4] DHFR,
DHFR2,
LTA,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
20Etanercept, methotrexate and depomedrone
(Synonym: Methotrexate sodium)		[2] Etanercept,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D00742 ,
D02115 (Name: Methotrexate sodium)		[4] DHFR,
DHFR2,
LTA,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
21Etanercept, Methotrexate, Prednisolone
(Synonym: Methotrexate sodium)		[3] Etanercept,
Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Prednisolone		[11] D00142 ,
D00472 ,
D00742 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02115 (Name: Methotrexate sodium),
D02156 ,
D03301 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 56
22Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)
(Synonym: Methotrexate sodium)		[4] Azathioprine,
Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Mycophenolate mofetil,
Mycophenolic acid		[8] D00142 ,
D00238 ,
D00752 ,
D02115 (Name: Methotrexate sodium),
D03033 ,
D05094 ,
D05095 ,
D05096 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		[7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism 💬[1] 49
23Immunosuppressors (Thiopurines or Methotrexate)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
24Infliximab + methotrexate (MTX)
(Synonym: Methotrexate sodium)		[2] Infliximab,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
25Infliximab plus methotrexate
(Synonym: Methotrexate sodium)		[2] Infliximab,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 107
26Infliximab, methylprednisolone, methotrexate
(Synonym: Methotrexate sodium)		[3] Infliximab,
Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Methylprednisolone		[9] D00142 ,
D00407 ,
D00751 ,
D00979 ,
D02115 (Name: Methotrexate sodium),
D02598 ,
D05000 ,
D05001 ,
D05002 		[4] DHFR,
DHFR2,
NR3C1,
TNF 💬		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
27Intrathecal methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 13
28Methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
29Methotrexate 'Lederle' 2,5mg tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
30Methotrexate 'Lederle' 2.5mg Tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
31Methotrexate 'Lederle' Tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
32Methotrexate (Metoject® prefilled pen)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
33Methotrexate (MTX)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
34Methotrexate (stable dose)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
35Methotrexate (tapering dose)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
36Methotrexate + biologic administration
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
37Methotrexate + Infliximab
(Synonym: Methotrexate sodium)		[2] Infliximab,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
38Methotrexate + Methylprednisolone
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Methylprednisolone		[8] D00142 ,
D00407 ,
D00751 ,
D00979 ,
D02115 (Name: Methotrexate sodium),
D05000 ,
D05001 ,
D05002 		[3] DHFR,
DHFR2,
NR3C1 💬		[6] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬[1] 46
39Methotrexate + salazopyrine + hydroxychloroquine administration
(Synonym: Methotrexate sodium)		[2] Hydroxychloroquine,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D08050 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
40METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 96
41Methotrexate - Amneal
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
42Methotrexate - DAVA
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
43Methotrexate - Delay
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
44Methotrexate - etanercept - prednisolone arm
(Synonym: Methotrexate sodium)		[3] Etanercept,
Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Prednisolone		[11] D00142 ,
D00472 ,
D00742 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02115 (Name: Methotrexate sodium),
D02156 ,
D03301 		[5] DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬		[72] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[2] 46, 107
45Methotrexate - Immediate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
46Methotrexate 10 mg
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
47Methotrexate 10 mg tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
48Methotrexate 2.5 mg
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44
49METHOTREXATE 2.5 mg tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
50Methotrexate 2.5mg Tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
51Methotrexate 2.5mg Tablets BP
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
52Methotrexate 25 mg
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 44
53Methotrexate 50mg/ml solution for injection, pre-filled syringe
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
54Methotrexate ``Lederle`` 2.5mg tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
55Methotrexate alone
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 107
56Methotrexate and folic acid
(Synonym: Methotrexate sodium)		[2] Folic acid,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00070 ,
D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 49
57Methotrexate as methotrexate disodium
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
58Methotrexate bellon
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97
59Methotrexate bellon 25mg/ml
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 97
60Methotrexate capsules
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
61METHOTREXATE DISODIUM
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[5] 46, 96, 97, 107, 271
62Methotrexate Ebewe
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
63METHOTREXATE HOSPIRA 2,5 mg tablety
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
64METHOTREXATE HOSPIRA 2.5 mg tablety
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
65Methotrexate injection
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 96, 97
66Methotrexate Lachema 5inj. sol
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50
67Methotrexate Lederle 2.5 mg Tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
68Methotrexate Pfizer 2,5 mg tabletter
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
69Methotrexate Placebo
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
70Methotrexate plus ENBREL or ENBREL alone
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
71Methotrexate plus ERB-041 for 12 weeks
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
72Methotrexate plus sulfasalazine
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Sulfasalazine		[3] D00142 ,
D00448 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
73Methotrexate pre-filled pen
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
74Methotrexate prefilled pen
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 107
75Methotrexate prefilled syringe
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
76METHOTREXATE SODIUM[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 256
77Methotrexate Sodium 2.5mg Tablets[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
78Methotrexate Sodium Tablets 2.5 mg[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
79Methotrexate Sodium Tablets 2.5mg[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
80Methotrexate Tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 40
81Methotrexate tablets 2.5 mg
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
82Methotrexate treatment
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 41, 46
83Methotrexate Wyeth 2,5mg
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50
84Methotrexate Wyeth 2,5mg tbl.
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 50
85Methotrexate ® 2.5mg Tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
86Methotrexate(MTX)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
87Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
88Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
89Methotrexate(necessary)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
90METHOTREXATE*100CPR 2,5MG
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
91METHOTREXATE*10MG/1,33ML 4S
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
92METHOTREXATE*15MG/2ML 4SIR
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
93METHOTREXATE*2,5MG 25CPR
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
94METHOTREXATE*20MG/2,66ML 4S
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
95METHOTREXATE*25CPR 2,5MG
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[2] 46, 107
96METHOTREXATE*7,5MG/ML 4SIR.
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
97Methotrexate, Leucovorin and BMS-986142
(Synonym: Methotrexate sodium)		[3] BMS-986142,
Leucovorin,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[5] D00142 ,
D01211 ,
D02115 (Name: Methotrexate sodium),
D07986 ,
D07987 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
98Methotrexate,Adalimumab
(Synonym: Methotrexate sodium)		[2] Adalimumab,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02597 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
99Methotrexate-Lachema
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
100Methotrexate-Sulfasalazine-Hydroxychloroquine
(Synonym: Methotrexate sodium)		[3] Hydroxychloroquine,
Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Sulfasalazine		[4] D00142 ,
D00448 ,
D02115 (Name: Methotrexate sodium),
D08050 		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
101Methotrexate® 2.5 mg tablets
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
102MP-435(dose1) + Methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
103Mycophenolate mofetil,methotrexate
(Synonym: Methotrexate sodium)		[3] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Mycophenolate mofetil,
Mycophenolic acid		[6] D00142 ,
D00752 ,
D02115 (Name: Methotrexate sodium),
D05094 ,
D05095 ,
D05096 		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		[7] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45
104Oral methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
105Other: Methotrexate therapy
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
106Phase 1: Methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
107Response to anakinra associated with methotrexate
(Synonym: Methotrexate sodium)		[2] Anakinra,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02934 		[4] DHFR,
DHFR2,
IL1R1,
IL1R2 💬		[20] Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[1] 46
108Response to infliximab associated with methotrexate
(Synonym: Methotrexate sodium)		[2] Infliximab,
Methotrexate (Synonym: Methotrexate Sodium Injection USP)		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02598 		[3] DHFR,
DHFR2,
TNF 💬		[71] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[1] 46
109Stable weekly dose of methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
110Tacrolimus with Methotrexate
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Tacrolimus		[4] D00107 ,
D00142 ,
D02115 (Name: Methotrexate sodium),
D08556 		[7] DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[38] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[1] 46
111TAK-715 and methotrexate
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
TAK-715		[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
112TAK-783 and methotrexate
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46
113Tasocitinib plus Methotrexate
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Tofacitinib		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D09970 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46
114Tocilizumab + methotrexate(MTX)
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Tocilizumab		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02596 		[3] DHFR,
DHFR2,
IL6R 💬		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46
115Tocilizumab plus methotrexate
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Tocilizumab		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02596 		[3] DHFR,
DHFR2,
IL6R 💬		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46
116Tocilizumab+Methotrexate(MTX)
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Tocilizumab		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D02596 		[3] DHFR,
DHFR2,
IL6R 💬		[17] Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[1] 46
117Tofacitinib with methotrexate
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Tofacitinib		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D09970 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46
118Tofacitinib without methotrexate
(Synonym: Methotrexate sodium)		[2] Methotrexate (Synonym: Methotrexate Sodium Injection USP),
Tofacitinib		[3] D00142 ,
D02115 (Name: Methotrexate sodium),
D09970 		[6] DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬		[42] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[1] 46
119Treatment with systemic therapy (methotrexate)
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 162
120Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
(Synonym: Methotrexate sodium)		[1] Methotrexate (Synonym: Methotrexate Sodium Injection USP)[2] D00142 ,
D02115 (Name: Methotrexate sodium)		[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[1] 46