Disease details

臨床試験数 : 3,342 / 薬物数 : 2,355 - (DrugBank : 406) / 標的遺伝子数 : 269 - 標的パスウェイ数 : 241

10 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04749667 (ClinicalTrials.gov)	August 9, 2021	20/1/2021	Study of Mesenchymal Autologous Stem Cells as Regenerative Treatment for Multiple Sclerosis	Study of Mesenchymal Autologous Stem Cells as Regenerative Treatment for Multiple Sclerosis	Multiple Sclerosis;Progressive Multiple Sclerosis	Other: MSCs;Drug: Saline	Haukeland University Hospital	University of Bergen;University Hospital Ulm;University Hospital, Akershus;St. Olavs Hospital;University Hospital of North Norway	Recruiting	18 Years	55 Years	All	18	Phase 1/Phase 2	Norway
2	NCT04979650 (ClinicalTrials.gov)	May 22, 2021	2/7/2021	Corticosteroid Effects on Asymptomatic Gadolinium-enhancing Lesions in Multiple Sclerosis	Corticosteroid Pulse Therapy Effects on MRI Asymptomatic Gadolinium-enhancing Lesions Conversion to a Non-enhancing Black Hole With or Without Treatment in MS Clinic of Booalisina Hospital Sari 2021-2023	Multiple Sclerosis, Relapsing-Remitting;Magnetic Resonance Imaging;Methylprednisolone	Drug: Methylprednisolone succinate;Drug: Normal saline	Mazandaran University of Medical Sciences	NULL	Enrolling by invitation	18 Years	55 Years	All	104	Phase 2	Iran, Islamic Republic of
3	NCT03355365 (ClinicalTrials.gov)	September 21, 2018	14/11/2017	Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis	Autologous, Bone Marrow-Derived Mesenchymal Stem Cell-Derived Neural Progenitor Cells (MSC-NP), Expanded Ex Vivo; Administered Intrathecally	Multiple Sclerosis	Biological: Intrathecal MSC-NP injection;Other: Intrathecal saline injection	Tisch Multiple Sclerosis Research Center of New York	NULL	Active, not recruiting	18 Years	65 Years	All	50	Phase 2	United States
4	NCT02228213 (ClinicalTrials.gov)	October 2014	21/8/2014	Safety and Efficacy Study of MIS416 to Treat Secondary Progressive Multiple Sclerosis	A Phase 2B Randomised, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of MIS416 in the Treatment of Subjects With Secondary Progressive Multiple Sclerosis	Secondary Progressive Multiple Sclerosis	Biological: MIS416;Drug: Saline	Innate Immunotherapeutics	INC Research	Completed	18 Years	70 Years	All	93	Phase 2	Australia;New Zealand
5	NCT01911377 (ClinicalTrials.gov)	October 2013	25/7/2013	Botulinum Toxin Type A for Treating Allodynic Pain in SCI and MS	The Efficacy of Botulinum Toxin Type A in the Treatment of Allodynic-Type Neuropathic Pain in People With Spinal Cord Injury or Multiple Sclerosis	Neuropathic Pain;Allodynia	Drug: Botulinum Toxin Type A;Drug: Normal Saline for Injection	University of Manitoba	Allergan	Terminated	18 Years	70 Years	Both	12	Phase 2	Canada
6	NCT01600716 (ClinicalTrials.gov)	June 13, 2012	15/5/2012	Safety and Efficacy Study of OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Neurogenic Detrusor Overactivity (NDO) in Non-Catheterizing Patients With Multiple Sclerosis (MS)		Urinary Incontinence;Multiple Sclerosis;Neurogenic Bladder	Biological: OnabotulinumtoxinA;Drug: Placebo (Normal Saline)	Allergan	NULL	Completed	18 Years	N/A	All	144	Phase 3	United States;Belgium;Canada;Czechia;France;Poland;Portugal;Russian Federation;Czech Republic
7	NCT01435993 (ClinicalTrials.gov)	September 8, 2011	25/8/2011	Multiple Doses of Anti-NOGO A in Relapsing Forms of Multiple Sclerosis	A Randomized, Single Blind, Placebo-controlled, Single Ascending Dose/Repeat Dose Cohort Study to Assess Safety, Tolerability, Pharmacokinetics and Immunogenicity of GSK1223249 in Patients With Relapsing Forms of Multiple Sclerosis.	Multiple Sclerosis, Relapsing-Remitting	Drug: GSK1223249;Other: Saline placebo	GlaxoSmithKline	NULL	Terminated	18 Years	60 Years	All	3	Phase 1	Italy;Norway;Germany
8	NCT01212094 (ClinicalTrials.gov)	September 2010	29/9/2010	Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)	Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)	Multiple Sclerosis	Drug: Rituximab;Other: normal saline	National Institute of Neurological Disorders and Stroke (NINDS)	NULL	Terminated	18 Years	65 Years	All	44	Phase 1/Phase 2	United States
9	NCT00986960 (ClinicalTrials.gov)	December 2009	29/9/2009	Effect of Adrenocorticotropin Injection With Weekly Interferon Beta in Patients With Relapsing Remitting Multiple Sclerosis (MS)	Effect of Pulsed ACTH add-on Therapy to Weekly Avonex on Remyelination and Neuroregeneration in Patients With Relapsing Remitting Multiple Sclerosis. A 1-year Placebo-controlled, Double-blinded, Randomized Follow-up Study	Multiple Sclerosis	Drug: repository corticotropin injection;Drug: Saline	University at Buffalo	NULL	Terminated	18 Years	65 Years	All	3	Phase 2	United States
10	NCT01091727 (ClinicalTrials.gov)	October 2006	22/3/2010	Intravesical Injection of Botulinum Toxin A Versus Saline for Neurogenic Detrusor Overactivity	Prospective Randomized Double-blind Trial of Intravesical Injection of Botulinum Toxin A Versus Saline for Neurogenic Detrusor Overactivity and Urinary Incontinence Related to Spinal Cord Injury or Multiple Sclerosis	Neurogenic Detrusor Overactivity	Drug: Botulinum toxin A	Sunnybrook Health Sciences Centre	ethica Clinical Research Inc.	Completed	18 Years	75 Years	Both	57	Phase 3	Canada

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