158. 結節性硬化症 Tuberous sclerosis Clinical trials / Disease details

臨床試験数 : 108 / 薬物数 : 67 - (DrugBank : 17) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 118

17 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2019-000752-34-SK (EUCTR)	15/11/2019	01/10/2019	Study to evaluate if the study medication, Rapamycin, topical cream, is effective and safe at treati ...	A Phase 2/3, multi-center, double-blind, placebo-controlled, randomized, parallel-group, dose-respon ...	Facial Angiofibromas Associated with Tuberous Sclerosis Complex MedDRA version: 20.0;Level: PT;Class ...	Product Name: Rapamycin cream, topical, 0.5%, 1.0% w/w Product Code: Not applicable INN or Proposed INN ...	DSLP	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	United States;Hungary;Slovakia;Spain;Australia;New Zealand;United Kingdom
2	EUCTR2019-000752-34-HU (EUCTR)	14/11/2019	18/11/2019	Study to evaluate if the study medication, Rapamycin, topical cream, is effective and safe at treati ...	A Phase 2/3, multi-center, double-blind, placebo-controlled, randomized, parallel-group, dose-respon ...	Facial Angiofibromas Associated with Tuberous Sclerosis Complex MedDRA version: 20.0;Level: PT;Class ...	Product Name: Rapamycin cream, topical, 0.5%, 1.0% w/w Product Code: Not applicable INN or Proposed INN ...	DSLP	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	120	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	United States;Hungary;Slovakia;Spain;Australia;New Zealand;United Kingdom
3	NCT03826628 (ClinicalTrials.gov)	July 28, 2019	29/1/2019	Dose-Ranging Efficacy and Safety Study of Topical RapamycinCream for Facial Angiofibroma Associated ...	A Phase 2/3, Multi-Center, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group, Dose-Respon ...	Facial Angiofibroma;Tuberous Sclerosis	Drug: rapamycin;Drug: placebo	Dermatology Specialties Limited Partnership	NULL	Recruiting	6 Years	65 Years	All	120	Phase 2/Phase 3	United States;Australia;Czechia;Hungary;New Zealand;Serbia;Slovakia;Spain;Taiwan;United Kingdom
4	JPRN-UMIN000015114	2014/09/11	10/09/2014	Clinical study of safety and efficacy of rapamycintopical medication for skin lesions due to tuberou ...		Tuberous sclerosis complex	Application of 0.2% rapamycin gel on skin lesions of the face and trunk twice a day for 12 weeks.	Department of Dermatology Graduate School of Medicine, Osaka University	NULL	Recruiting	Not applicable	70years-old	Male and Female	24	Phase 2,3	Japan
5	NCT03140449 (ClinicalTrials.gov)	September 5, 2013	26/4/2017	Topical Rapamycin and Calcitriol for Angiofibroma of Tuberous Sclerosis	Study of Combination Therapy With Topical Rapamycinand Calcitriol for Cutaneous Lesions of Tuberous ...	Facial Angiofibroma	Drug: Rapamycin;Drug: Calcitriol;Drug: Rapamycin -calcitriol combination	National Taiwan University Hospital	NULL	Completed	7 Years	65 Years	All	52	Phase 3	NULL
6	EUCTR2011-006308-12-ES (EUCTR)	16/07/2012	29/03/2012	Clinical trial in patients with tuberous sclerosis for the study of the effects of topical rapamycin ...	phase II clinical trial, to study the efficacy and safety of topical rapamycinin reducing facial ang ...	Facial tumors (angiofibromas) associated with tuberous sclerosis complex.;Therapeutic area: Diseases ...	Trade Name: Rapamune 1 mg/ml solución oral INN or Proposed INN: RAPAMUNE	Fundación Investigación Hospital Ramón y Cajal	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes		Phase 2	Spain
7	NCT01526356 (ClinicalTrials.gov)	May 2012	1/2/2012	Topical Rapamycin to Erase Angiofibromas in TSC	Phase II Study of Topical Rapamycinto Erase Angiofibromas in TSC-Multicenter Evaluation of a Novel T ...	Angiofibromas;Tuberous Sclerosis	Drug: Placebo;Drug: Rapamycin	The University of Texas Health Science Center, Houston	NULL	Completed	N/A	N/A	All	179	Phase 2	United States;Australia
8	JPRN-UMIN000006108	2011/08/01	03/08/2011	Clinical trial for development of topical rapamycintreatment for white macules due to tuberous scler ...		tuberous sclerosis complex, vitiligo vulgaris, white macules due to congenital diseases	Application of 0.2% rapamycingel (base is carboxyvinyl polymer) on white macules of the face twice a ...	Department of Dermatology Graduate School of Medicine, Osaka University	NULL	Recruiting	Not applicable	Not applicable	Male and Female	21	Phase 2,3	Japan
9	EUCTR2010-022655-29-NL (EUCTR)	30/05/2011	22/10/2010	Randomised open label cross-over study into the efficacy of RApamycinin children with Tuberous scler ...	Randomised open label cross-over study into the efficacy of RApamycinin children with Tuberous scler ...	Epilepsy in children with Tuberous Sclerosis Complex	Trade Name: Rapamune	Erasmus MC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Netherlands
10	NCT01031901 (ClinicalTrials.gov)	December 2009	10/12/2009	Topical RapamycinTherapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex (TSC) a ...	Topical RapamycinTherapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex and Neu ...	Tuberous Sclerosis;Neurofibromatoses;Angiofibroma;Neurofibroma	Drug: Skincerity;Drug: Skincerity plus sirolimus/rapamycin;Drug: Skinercity plus sirolimus/rapamycin	The University of Texas Health Science Center, Houston	Society for Pediatric Dermatology	Completed	13 Years	N/A	Both	52	Phase 1	United States

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