160. 先天性魚鱗癬 Congenital ichthyosis Clinical trials / Disease details

臨床試験数 : 36 / 薬物数 : 72 - (DrugBank : 21) / 標的遺伝子数 : 18 - 標的パスウェイ数 : 111

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2021-003210-39-AT (EUCTR)	01/02/2022	08/09/2021	A phase I/II, multicenter, randomized, double-blind, placebo within-patient controlled study to eval ...	A phase I/II, multicenter, randomized, double-blind, placebo within-patient controlled, first-time-i ...	Netherton syndrome MedDRA version: 20.0;Level: PT;Classification code 10062909;Term: Netherton's syn ...	Product Code: SXR1096	Sixera Pharma	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 1;Phase 2	Finland;Austria
2	EUCTR2021-003210-39-FI (EUCTR)	23/11/2021	20/08/2021	A phase I/II, multicenter, randomized, double-blind, placebo within-patient controlled study to eval ...	A phase I/II, multicenter, randomized, double-blind, placebo within-patient controlled, first-time-i ...	Netherton-syndrome MedDRA version: 20.0;Level: PT;Classification code 10062909;Term: Netherton's syn ...	Product Code: SXR1096	Sixera Pharma	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 1;Phase 2	Finland
3	NCT04996485 (ClinicalTrials.gov)	March 1, 2021	21/7/2021	Scientific Substantiation and Assessment of the Effectiveness of Pathogenetic Methods of Therapy for ...	Scientific Substantiation and Assessment of the Effectiveness of Pathogenetic Methods of Therapy for ...	Congenital Ichthyosis	Drug: Secukinumab Injection;Drug: Ustekinumab Injection;Drug: Dupilumab Injection;Other: Symptomatic th ...	National Medical Research Center for Children's Health, Russian Federation	NULL	Recruiting	6 Months	18 Years	All	50	Phase 4	Russian Federation
4	ChiCTR2000037278	2020-09-01	2020-08-27	Effects and Safety of Simvastatin Ointment in the Treatment of Congenital Ichthyosis	Effects and Safety of Simvastatin Ointment in the Treatment of Congenital Ichthyosis	inherited ichthyosis	ARCI group:Concentration of simvastatin cream;XLI group:Concentration of simvastatin cream;	Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine	NULL	Recruiting			Both	ARCI group:45;XLI group:10;		China
5	NCT04244006 (ClinicalTrials.gov)	July 23, 2020	13/1/2020	A Pilot Study of the Efficacy and Safety of Dupilumab Versus Placebo in Patients With Netherton Synd ...	A Randomized Double-blinded Pilot Study of the Efficacy and Safety of Dupilumab Versus Placebo in Pa ...	Netherton Syndrome	Drug: Dupilumab Prefilled Syringe;Other: Placebo Prefilled Syringe	University Hospital, Toulouse	MedSharing	Recruiting	18 Years	N/A	All	24	Phase 2/Phase 3	France
6	NCT04154293 (ClinicalTrials.gov)	December 3, 2019	1/11/2019	A Vehicle Controlled Study to Evaluate Safety and Efficacy of Topical TMB-001 for Treatment of Conge ...	A Randomized, Parallel, Double-Blind, Vehicle Controlled Study to Evaluate the Safety and Efficacy o ...	Congenital Ichthyosis	Drug: Isotretinoin;Other: Vehicle	Timber Pharmceuticals LLC	NULL	Completed	9 Years	N/A	All	34	Phase 2	United States;Australia
7	EUCTR2019-001220-35-FR (EUCTR)	08/10/2019	23/04/2019	A pilot study of the efficacy and safety of dupilumab versus placebo in patients with Netherton synd ...	A randomized double-blinded pilot study of the efficacy and safety of dupilumab versus placebo in pa ...	Netherton syndrome MedDRA version: 20.0;Level: PT;Classification code 10062909;Term: Netherton's syn ...	Trade Name: Dupixent Product Name: DUPILUMAB Product Code: SAR231893	CHU de Toulouse	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	24	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	France
8	NCT04047732 (ClinicalTrials.gov)	August 27, 2019	29/7/2019	Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthy ...	A Phase I/II Clinical Trial of Topical KB105, a Replication-incompetent, Non-integrating HSV-1 Vecto ...	TGM-1 Related Autosomal Recessive Congenital Ichthyosis	Biological: KB105	Krystal Biotech, Inc.	NULL	Active, not recruiting	18 Years	N/A	All	6	Phase 1/Phase 2	United States
9	NCT03445650 (ClinicalTrials.gov)	July 18, 2018	14/2/2018	RESET Trial - Part 1 (Followed by Reset Trial - Part 2) - A Phase 3 Trial in Subjects With Sjögren-L ...	A Phase 3 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Trial to Evaluate the Safety ...	Sjogren-Larsson Syndrome	Drug: ADX-102 1% Topical Dermal Cream (reproxalap);Drug: Vehicle of ADX-102 Topical Dermal Cream	Aldeyra Therapeutics, Inc.	NULL	Completed	3 Years	N/A	All	11	Phase 3	United States
10	EUCTR2016-001948-19-IT (EUCTR)	05/09/2017	25/05/2021	A Study to Assess the Efficacy and Safety of Abatacept in Adults with Active Primary Sj¿grens Syndro ...	A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ...	Adults with moderately to severely Active Primary Sjogrens Syndrome MedDRA version: 20.1;Level: PT;C ...	Trade Name: Orencia INN or Proposed INN: 00305800	BRISTOL-MYERS SQUIBB INTERNATIONAL CORPORATION	NULL	Not Recruiting			Female: yes Male: yes	288	Phase 3	Czechia;Italy;France;Czech Republic;Mexico;Canada;Argentina;Brazil;Australia;Denmark;Germany;Norway; ...

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