224. 紫斑病性腎炎 Purpura nephritis Clinical trials / Disease details


臨床試験数 : 13 薬物数 : 42 - (DrugBank : 20) / 標的遺伝子数 : 15 - 標的パスウェイ数 : 57

  
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1ChiCTR2000040625
2021-01-012020-12-04Therapeutic effect of hydroxychloroquine on children Henoch-Schonlein purpura nephritisTherapeutic effect of hydroxychloroquine on children Henoch-Schonlein purpura nephritis Henoch-Schonlein purpura nephritisA:Basic treatment + hydroxychloroquine (5mg/kg.d, taken orally in 2 doses);B:Basic treatment;Shengjing Hospital of China Medical UniversityNULLPending314BothA:20;B:20;N/AChina
2ChiCTR2000039686
2020-12-012020-11-05To evaluate the efficacy and safety of tacrolimus in the treatment of children with Henoch Schonlein purpura nephritisA multicentre, randomized, prospective, observational study evaluating the efficacy and safety of tacrolimus in the treatment of Henoch Schonlein purpura nephritis in children at 24 weeks Henoch Schonlein purpura nephritisExperimental drug treatment group:Tacroximus capsule (trade name: Saifu X R), 0.1mg /kg/d, orally taken 1 hour before or 2-3 hours after meals twice a day for 24 weeks;Prednisone 1.5-2mg/kg/d was taken orally for 4 weeks and then changed to oral administration every other day for 4 weeks, gradually reducing the amount.;Control treatment group:Cyclophosphamide 8-10mg/ kg/d was given intravenously for 2 consecutive days, once every 2-4 weeks for 4 consecutive times, and once every 3 weeks for 2 consecutive times for 6 times in total.Prednisone 1.5-2mg/kg/d was taken orally with breakfast in the morning. ;Shengjing Hospital of China Medical UniversityNULLRecruitingBothExperimental drug treatment group:156;Control treatment group:78;Phase 4China
3ChiCTR2000039700
2020-11-062020-11-06A single center randomized controlled clinical study on the treatment of Children with Purpura nephritis with Huai-Qi-Huang GranulesA single center randomized controlled clinical study on the treatment of Children with Purpura nephritis with Huai-Qi-Huang Granules Children with purpura nephritisexperimental group:Huaiqihuang;control group:valsartan;Children's Hospital, Zhejiang University School of MedicineNULLRecruiting614Maleexperimental group:5;control group:5;China
4NCT04623866
(ClinicalTrials.gov)
November 1, 202025/10/2020Study on the Treatment of Children With Purpura Nephritis With Huaiqihuang GranulesA Single Center Randomized Controlled Clinical Study on the Treatment of Children With Purpura Nephritis With Huaiqihuang GranulesHenoch Schönlein Purpura NephritisDrug: Huaiqinhuang;Drug: valsartanThe Children's Hospital of Zhejiang University School of MedicineNULLNot yet recruiting6 Years14 YearsAll10Early Phase 1China
5ChiCTR2000037540
2020-09-302020-08-28Effects and safety of MMF combined with short course steriods therapy in children Henoch-Schnlein purpura nephritisEffects and safety of MMF combined with short course steriods therapy in children Henoch-Schnlein purpura nephritis children Henoch-Schnlein purpura nephritisexperimental group:mycophenolate mofetil;control group:traditional course steriod;Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineNULLPending214Bothexperimental group:30;control group:30;N/AChina
6ChiCTR1800017046
2018-07-152018-07-10The research of Gd - IgA1 with purpura nephritisThe research of Gd - IgA1 with purpura nephritis Henoch-Schnlein purpura nephritis;D69.005+Gold Standard:Allergic purpura diagnostic criteria: 1) the tangibility purpura; 2) the onset age < 20 years old; 3) with acute abdominal pain; 4) biopsy showed small veins and arteries around a neutrophil infiltration. In the above four standard, conform to article 2 or above can be diagnosed as allergic purpura.
Purpur;Index test:Gd-IgA1, IgA, IgG, C3;
College of Pediatrics, University of South China/Children's Hospital of Hu'nan ProvinceNULLRecruiting114BothTarget condition:250;Difficult condition:24China
7NCT02878018
(ClinicalTrials.gov)
September 201617/8/2016Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura NephritisCohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura NephritisHenoch-Schonlein Purpura NephritisDrug: Qi-Ji Shen-Kang formula; Zhu-Bai formula; Yu-Shen formula;Drug: angiotensin-converting enzyme (ACE) inhibitor; adrenergic receptor binder (ARB); adrenal cortical hormone; Tripterygium wilfordii polyglycosidium; immunosuppressantLiaoning University of Traditional Chinese MedicineFirst Hospital of China Medical University;Shengjing HospitalActive, not recruiting5 Years18 YearsAll600China
8ChiCTR-IPC-16008619
2016-07-012016-06-09Efficacy of Mizoribine for Children with Henoch-Schnlein Purpura Nephritis Presenting with Nephrotic Range Proteinuria: A Prospective and Controlled Study in ChinaEfficacy of Mizoribine for Children with Henoch-Schnlein Purpura Nephritis Presenting with Nephrotic Range Proteinuria: A Prospective and Controlled Study in China Children with Henoch-Sch?nlein Purpura Nephritismizoribine:5 mg/kg body weight daily (maximum total dose: 150 mg);Nanjing General Hospital of Nanjing Military CommandNULLPending518Bothmizoribine:180;China
9NCT03222687
(ClinicalTrials.gov)
September 1, 20157/7/2017Tacrolimus in Children With Henoch-Schönlein Purpura NephritisOff-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and SafetyHenoch-Schönlein Purpura NephritisDrug: tacrolimus;Drug: prednisoneShandong UniversityNULLCompletedN/A18 YearsAll25Phase 4NULL
10NCT02532790
(ClinicalTrials.gov)
August 201520/8/2015The Research of Standard Diagnosis and Treatment for HSPN With Mild Proteinuria in ChildrenThe Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis With Mild Proteinuria in ChildrenHenoch-Schoenlein Purpura NephritisDrug: Prednisone;Drug: ACEINanjing Children's HospitalNULLRecruiting2 Years16 YearsAll100Phase 2China
11NCT02532777
(ClinicalTrials.gov)
August 201520/8/2015The Research of Standard Diagnosis and Treatment for HSPN in ChildrenThe Research of Standard Diagnosis and Treatment for Henoch-Schonlein Purpura Nephritis in ChildrenHenoch-Schoenlein Purpura NephritisDrug: Prednisone;Drug: Cyclophosphamide(CTX);Drug: Mycophenolate mofetil(MMF);Drug: Leflunomide(LEF);Drug: Angiotensin-converting enzyme inhibitor(ACEI);Drug: MethylprednisoloneNanjing Children's HospitalNULLRecruiting2 Years16 YearsAll100Phase 2China
12NCT03591471
(ClinicalTrials.gov)
September 20149/12/2014Study on Children Henoch-Schönlein Purpura Nephritis With TCM Multistep TreatmentDemonstrated Study on Children Henoch-Schönlein Purpura Nephritis With Multistep Treatment of Traditional Chinese Medicine Combined Disease and Syndrome DifferentiationHenoch-Schönlein Purpura NephritisDrug: Glycosides Of Tripterygium Wilfordii Hook(GTW);Drug: Sulfotanshinone Sodium Injection;Drug: Chinese herbs based on syndrome differentiation;Drug: Prednisone Acetate Tablets;Drug: Benazepril Hydrochloride Tablets;Drug: Low Molecular Weight Heparin Calcium Injection;Drug: Dipyridamole Tab 25 MG;Drug: Chinese medicine placeboHenan University of Traditional Chinese MedicinePeking University First Hospital;Children's Hospital of Fudan University;Shanghai Children's Hospital;Chengdu University of Traditional Chinese Medicine;Affiliated Hospital of Yunnan University of Traditional Chinese MedicineUnknown status2 Years18 YearsAll500Phase 1/Phase 2China
13NCT00301613
(ClinicalTrials.gov)
January 200310/3/2006Mycophenolate Mofetil (MMF) Versus Intravenous CTX Pulses in the Treatment of Adult Severe HSPNMMF Versus Intravenous CTX Pulses in the Treatment of Adult Severe Henoch-Schonlein Purpura NephritisHenoch-Schoenlein Purpura;NephritisDrug: Mycophenolate mofetilNanjing University School of MedicineNULLCompleted16 Years50 YearsBoth60N/AChina