224. 紫斑病性腎炎 Purpura nephritis Clinical trials / Disease details


臨床試験数 : 13 薬物数 : 42 - (DrugBank : 20) / 標的遺伝子数 : 15 - 標的パスウェイ数 : 57

  
2 trials found
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1ChiCTR2000039686
2020-12-012020-11-05To evaluate the efficacy and safety of tacrolimus in the treatment of children with Henoch Schonlein purpura nephritisA multicentre, randomized, prospective, observational study evaluating the efficacy and safety of tacrolimus in the treatment of Henoch Schonlein purpura nephritis in children at 24 weeks Henoch Schonlein purpura nephritisExperimental drug treatment group:Tacroximus capsule (trade name: Saifu X R), 0.1mg /kg/d, orally taken 1 hour before or 2-3 hours after meals twice a day for 24 weeks;Prednisone 1.5-2mg/kg/d was taken orally for 4 weeks and then changed to oral administration every other day for 4 weeks, gradually reducing the amount.;Control treatment group:Cyclophosphamide 8-10mg/ kg/d was given intravenously for 2 consecutive days, once every 2-4 weeks for 4 consecutive times, and once every 3 weeks for 2 consecutive times for 6 times in total.Prednisone 1.5-2mg/kg/d was taken orally with breakfast in the morning. ;Shengjing Hospital of China Medical UniversityNULLRecruitingBothExperimental drug treatment group:156;Control treatment group:78;Phase 4China
2NCT03222687
(ClinicalTrials.gov)
September 1, 20157/7/2017Tacrolimus in Children With Henoch-Schönlein Purpura NephritisOff-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and SafetyHenoch-Schönlein Purpura NephritisDrug: tacrolimus;Drug: prednisoneShandong UniversityNULLCompletedN/A18 YearsAll25Phase 4NULL