227. オスラー病 Osler disease Clinical trials / Disease details
臨床試験数 : 54 / 薬物数 : 73 - (DrugBank : 21) / 標的遺伝子数 : 23 - 標的パスウェイ数 : 136
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | EUCTR2018-004179-11-IT (EUCTR) | 03/09/2021 | 17/08/2021 | Effectiveness of somatostatin analogues for GI bleeding in patients with hereditaryhemorrhagic telangiectasia | Effectiveness of Somatostatin Analogues in Patients with hereditary hemorrhagictelangiectasia and symptomatic gastrointestinal bleeding, SAIPAN-trial: a multicentre,randomized, open-label, parallel-group, superiority trial. - SAIPAN study | Hereditary hemorrhagic telangiectasia (HHT), also known as Osler–Weber–Rendu disease(in specific patients with gastrointestinal bleeding and transfusion dependency) MedDRA version: 21.0;Level: PT;Classification code 10019883;Term: Hereditary haemorrhagic telangiectasia;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: octreotide a azione pronta 0,1 mg Product Code: [OCTREOTIDE ACETATO] INN or Proposed INN: OCTREOTIDE ACETATO | RADBOUD UNIVERSITY MEDICAL CENTER | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 38 | Phase 3 | France;Denmark;Netherlands;Germany;United Kingdom;Italy | ||
| 2 | EUCTR2018-004179-11-FR (EUCTR) | 20/01/2021 | 26/11/2020 | The effectiveness of Octreotide in hereditary hemorrhagic telangiectasia (a.k.a. Rendu-Osler-Weber disease) patients who suffer from gastrointestinal bleeding. | Effectiveness of Somatostatin Analogues in Patients with hereditary hemorrhagic telangiectasia and symptomatic gastrointestinal bleeding, the SAIPAN-trial: a multicenter, randomized, open-label, parallelgroup, superiority trial. - SAIPAN-trial | Hereditary hemorrhagic telangiectasia (HHT);Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Trade Name: Octreotide INN or Proposed INN: OCTREOTIDE | Radboudumc | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 38 | Phase 3 | France;Germany;Netherlands | ||
| 3 | EUCTR2018-004179-11-DE (EUCTR) | 12/08/2020 | 12/03/2020 | The effectiveness of Octreotide in hereditary hemorrhagic telangiectasia(a.k.a. Rendu-Osler-Weber disease) patients who suffer fromgastrointestinal bleeding. | Effectiveness of Somatostatin Analogues in Patients with hereditaryhemorrhagic telangiectasia and symptomatic gastrointestinal bleeding,the SAIPAN-trial: a multicenter, randomized, open-label, parallel-group,superiority trial. - SAIPAN-trial | Hereditary hemorrhagic telangiectasia (HHT), also known as Osler–Weber–Rendu disease (in specific patients with gastrointestinalbleedings);Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Other descriptive name: OCTREOTIDE ACETATE | Radboudumc | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 38 | Phase 3 | Italy;United Kingdom;Germany;Netherlands;France | ||
| 4 | EUCTR2018-004179-11-NL (EUCTR) | 03/06/2019 | 14/05/2019 | The effectiveness of Octreotide in hereditary hemorrhagic telangiectasia (a.k.a. Rendu-Osler-Weber disease) patients who suffer from gastrointestinal bleeding. | Effectiveness of Somatostatin Analogues in Patients with hereditary hemorrhagic telangiectasia and symptomatic gastrointestinal bleeding, the SAIPAN-trial: a multicenter, randomized, open-label, parallelgroup, superiority trial. - SAIPAN-trial | Hereditary hemorrhagic telangiectasia (HHT);Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Trade Name: Octreotide INN or Proposed INN: OCTREOTIDE | Radboudumc | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 38 | Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): yes Therapeutic use (Phase 4): no | Netherlands | ||
| 5 | NCT02874326 (ClinicalTrials.gov) | October 2016 | 17/8/2016 | Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber | An Uncontrolled, Pilot-study Assessing the Efficacy of Octreotide Long-acting Release to Decrease Transfusion Requirements and Endoscopy Frequency in Patients With Rendu-Osler-Weber and Gastrointestinal Bleeding | Hereditary Hemorrhagic Telangiectasia;Gastrointestinal Hemorrhage;Anemia | Drug: Octreotide LAR | Radboud University | St. Antonius Hospital | Unknown status | 18 Years | N/A | All | 15 | Phase 2 | Netherlands |
| 6 | EUCTR2016-001340-19-NL (EUCTR) | 21/07/2016 | 11/07/2016 | The effectiveness of the drug octreotide LAR to anemia in patients with gastrointestinal bleeding due to Rendu-Osler-Weber disease. | An uncontrolled, pilot-study assessing the efficacy of octreotide LAR to decrease transfusion requirements and endoscopy frequency in patients with Rendu-Osler-Weber and gastrointestinal bleeding - ROW | Patients with Rendu-Osler-Weber disease (which is also called: Hereditary hemorrhagic telangiectasia);Therapeutic area: Diseases [C] - Digestive System Diseases [C06] | Trade Name: Sandostatin LAR 20 mg Product Name: Sandostatin LAR Product Code: RVG 18236 | Radboud University Medical Center | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Phase 2 | Netherlands | |||
| 7 | NCT00004327 (ClinicalTrials.gov) | January 1995 | 18/10/1999 | Phase II Pilot Study of Octreotide, a Somatostatin Octapeptide Analog, for Gastrointestinal Hemorrhage in Hormone-Refractory Hereditary Hemorrhagic Telangiectasia and Senile Ectasia | Hereditary Hemorrhagic Telangiectasia;Ectasia | Drug: octreotide | National Center for Research Resources (NCRR) | Yale University | Completed | N/A | N/A | Both | 8 | Phase 2 | NULL |