229. 肺胞蛋白症（自己免疫性又は先天性） Autoimmune pulmonary alveolar proteinosis Clinical trials / Disease details

臨床試験数 : 43 / 薬物数 : 34 - (DrugBank : 8) / 標的遺伝子数 : 3 - 標的パスウェイ数 : 14

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2020-001263-85-NL (EUCTR)	19/07/2021	08/10/2020	A clinical trial where patients with the lung disease autoimmunePulmonary Alveolar Proteinosis will ...	A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim neb ...	Autoimmune Pulmonary Alveolar Proteinosis(aPAP) MedDRA version: 21.1;Level: LLT;Classification code ...	Product Name: Molgramostim 300 µg nebulizer solution INN or Proposed INN: Molgramostim	Savara ApS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	United States;Ireland;Turkey;United Kingdom;Italy;France;Canada;Belgium;Poland;Romania;Netherlands;G ...
2	NCT04811274 (ClinicalTrials.gov)	June 7, 2021	19/3/2021	Macrophages, GM-CSF and MARS Proteinosis	Study of Macrophage Function and of the GM-CSF Signaling Pathway in Alveolar Proteinosis by Mutation ...	Pulmonary Alveolar Proteinosis (PAP);MARS;Genetic Mutation	Biological: Blood collection;Biological: Bronchoalveolar lavage fluid collection	Assistance Publique - Hôpitaux de Paris	NULL	Recruiting	N/A	17 Years	All	20		France
3	NCT04544293 (ClinicalTrials.gov)	May 10, 2021	3/9/2020	Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinos ...	A Randomized, Double-blind, Placebo-controlled Clinical Trial of Once-daily Inhaled Molgramostim Neb ...	Autoimmune Pulmonary Alveolar Proteinosis	Drug: Molgramostim;Drug: Placebo	Savara Inc.	NULL	Recruiting	18 Years	N/A	All	160	Phase 3	United States;Australia;Belgium;Canada;France;Germany;Greece;Ireland;Italy;Japan;Korea, Republic of; ...
4	EUCTR2020-001263-85-BE (EUCTR)	08/03/2021	04/12/2020	A clinical trial where patients with the lung disease autoimmunePulmonary Alveolar Proteinosis will ...	A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim neb ...	Autoimmune Pulmonary Alveolar Proteinosis(aPAP) MedDRA version: 21.1;Level: LLT;Classification code ...	Product Name: Molgramostim 300 µg nebulizer solution INN or Proposed INN: Molgramostim	Savara ApS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	United States;Ireland;Turkey;United Kingdom;Italy;France;Canada;Belgium;Poland;Romania;Germany;Nethe ...
5	EUCTR2020-001263-85-IE (EUCTR)	08/02/2021	08/10/2020	A clinical trial where patients with the lung disease autoimmunePulmonary Alveolar Proteinosis will ...	A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim neb ...	Autoimmune Pulmonary Alveolar Proteinosis(aPAP) MedDRA version: 21.1;Level: LLT;Classification code ...	Product Name: Molgramostim 300 µg nebulizer solution INN or Proposed INN: Molgramostim	Savara ApS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	United States;Ireland;Turkey;Italy;United Kingdom;France;Canada;Belgium;Poland;Romania;Germany;Nethe ...
6	EUCTR2020-001263-85-DE (EUCTR)	27/01/2021	16/10/2020	A clinical trial where patients with the lung disease autoimmunePulmonary Alveolar Proteinosis will ...	A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim neb ...	Autoimmune Pulmonary Alveolar Proteinosis(aPAP) MedDRA version: 21.1;Level: LLT;Classification code ...	Product Name: Molgramostim 300 µg nebulizer solution INN or Proposed INN: Molgramostim	Savara ApS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	United States;Ireland;Turkey;Italy;United Kingdom;France;Canada;Belgium;Poland;Romania;Germany;Nethe ...
7	EUCTR2020-001263-85-PL (EUCTR)	16/12/2020	19/11/2020	A clinical trial where patients with the lung disease autoimmunePulmonary Alveolar Proteinosis will ...	A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim neb ...	Autoimmune Pulmonary Alveolar Proteinosis(aPAP) MedDRA version: 21.1;Level: LLT;Classification code ...	Product Name: Molgramostim 300 µg nebulizer solution INN or Proposed INN: Molgramostim	Savara ApS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	Canada;Poland;Belgium;Romania;Germany;Netherlands;Japan;Korea, Republic of;France;Italy;United Kingd ...
8	EUCTR2020-001263-85-IT (EUCTR)	18/11/2020	24/05/2021	A clinical trial where patients with the lung disease autoimmune Pulmonary Alveolar Proteinosiswill ...	A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim neb ...	Autoimmune Pulmonary Alveolar Proteinosis(aPAP) MedDRA version: 21.1;Level: LLT;Classification code ...	Product Name: Molgramostim 300 µg nebulizer solution Product Code: [na] INN or Proposed INN: 00201600	SAVARA APS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	United States;Korea, Democratic People's Republic of;Ireland;Turkey;United Kingdom;Italy;France;Cana ...
9	NCT04326036 (ClinicalTrials.gov)	March 25, 2020	26/3/2020	Use of cSVF Via IV Deployment for Residual Lung Damage After Symptomatic COVID-19 Infection	Use of cSVF For Residual Lung Damage (COPD/Fibrotic Lung Disease After Symptomatic COVID-19 Infectio ...	Pulmonary Alveolar Proteinosis;COPD;Idiopathic Pulmonary Fibrosis;Viral Pneumonia;Coronavirus Infect ...	Procedure: Microcannula Harvest Adipose Derived tissue stromal vascular fraction (tSVF);Device: Cent ...	Black Tie Medical, Inc.	Robert W. Alexander, MD	Enrolling by invitation	18 Years	90 Years	All	10	Early Phase 1	United States
10	NCT03887169 (ClinicalTrials.gov)	September 16, 2019	12/3/2019	Administration of Methionine in Patients With Pulmonary Alveolar Proteinosisby Mutation of the MARS ...	Oral or Enteral Administration of Methionine in Patients With Pulmonary Alveolar Proteinosisby Mutat ...	Pulmonary Alveolar Proteinosis;Mutation Ala393Thr of the MARS Gene;mutationSer567Leu of the MARS Gen ...	Drug: Methionine;Drug: Vitamin B12 , B9, B6, C supplementation;Diagnostic Test: Methionine/homocystei ...	Assistance Publique - Hôpitaux de Paris	NULL	Completed	N/A	18 Years	All	3	Phase 1/Phase 2	France

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