235. 副甲状腺機能低下症 Hypoparathyroidism Clinical trials / Disease details
臨床試験数 : 88 / 薬物数 : 128 - (DrugBank : 25) / 標的遺伝子数 : 5 - 標的パスウェイ数 : 7
Showing 1 to 10 of 88 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT03878953 (ClinicalTrials.gov) | March 31, 2022 | 15/3/2019 | A Clinical Study of rhPTH(1-84) Treatment in Japanese Participants With Chronic Hypoparathyroidism | A Phase 3, Open-label Clinical Study of rhPTH(1-84) Treatment in Japanese Subjects With Chronic Hypoparathyroidism A Phase 3, Open-label Clinical Study of rhPTH(1-84) Treatment in Japanese Subjects With Chronic Hypo ... | Chronic Hypoparathyroidism | Drug: rhPTH(1-84) | Shire | NULL | Not yet recruiting | 20 Years | 85 Years | All | 12 | Phase 3 | Japan |
| 2 | NCT05186883 (ClinicalTrials.gov) | March 1, 2022 | 1/12/2021 | Treatment of Postoperative Hypoparathyroidism Using Cultured Allogenic Parathyroid Cells | Treatment of Postoperative Hypoparathyroidism Using Cultured Allogenic Parathyroid Cells | Postoperative Hypoparathyroidism | Biological: Allogenic parathyroid cells;Other: Standard treatment according to the Clinical protocols Biological: Allogenic parathyroid cells;Other: Standard treatment according to the Clinical protocol ... | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | Belarusian State Medical University | Not yet recruiting | 18 Years | 70 Years | All | 20 | Phase 1/Phase 2 | NULL |
| 3 | NCT05117853 (ClinicalTrials.gov) | November 1, 2021 | 21/10/2021 | Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Thyroidectomy | The Use of Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Total Thyroidectomy: A Randomized Clinical Trial The Use of Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Total Thyroidectomy: A ... | Thyroid Disease;Hypoparathyroidism Postprocedural | Drug: Autofluorescent detection + Injection of indocyanine green;Procedure: Gold standard of visual identification and evaluation of viability of the parathyroid glands. Drug: Autofluorescent detection + Injection of indocyanine green;Procedure: Goldstandard of visual i ... | Onze Lieve Vrouw Hospital | NULL | Not yet recruiting | 18 Years | N/A | All | 300 | Phase 3 | Belgium |
| 4 | NCT05130476 (ClinicalTrials.gov) | October 1, 2021 | 8/11/2021 | Near-infrared Imaging Techniques for Identifying and Preserving Viable Parathyroid Glands During Thyroidectomy Near-infrared Imaging Techniques for Identifying and Preserving Viable Parathyroid Glands During Thy ... | Intraoperative Near-infrared Imaging Techniques for Identifying and Preserving Viable Parathyroid Glands During Total and Completion Thyroidectomy: a Matched Cohort Study Intraoperative Near-infrared Imaging Techniques for Identifying and Preserving Viable Parathyroid Gl ... | Hypoparathyroidism Postprocedural | Procedure: Near-infrared-induced autofluorescence and indocyanine green near-infrared angiography | Odense University Hospital | NULL | Recruiting | 18 Years | N/A | All | 139 | N/A | Denmark |
| 5 | JPRN-jRCT2051210058 | 02/08/2021 | 30/07/2021 | A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Japanese Adults With Hypoparathyroidism A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Ja ... | A Phase 3, Multicenter, Single Arm, Open-Label Trial, Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Subcutaneously Daily in Japanese Adult Subjects with Hypoparathyroidism - PaTHway Japan Trial A Phase 3, Multicenter, Single Arm, Open-Label Trial, Investigating the Safety, Tolerability and Eff ... | Hypoparathyroidism | TransCon PTH drug product is supplied as a solution with a concentration of 0.3 mg/mL in a single-patient-use prefilled pen intended for SC injection. All subjects will start with study drug 18 microgram/day and will be administered study drug once daily subcutaneously. Subjects will be individually and progressively titrated to an optimal dose in dose increments (increase or decrease) of 3 microgram/day. TransCon PTHdrug product is supplied as a solution with a concentration of 0.3 mg/mL in a single-pat ... | Chessler D. Steven | NULL | Recruiting | >= 18age old | Not applicable | Both | 12 | Phase 3 | Japan |
| 6 | ChiCTR2100047758 | 2021-07-01 | 2021-06-26 | A medical records based study for observation of Teriparatidec in the treatment of congenital hypoparathyroidism A medical records based study for observation of Teriparatidec in the treatment of congenital hypopa ... | The observation of Teriparatide in the treatment of congenital hypoparathyroidism | Congenital Hypoparathyroidism | Teriparatide group:No;Control group:No; | The Seventh Medical Center, PLA General Hospital | NULL | Pending | 0 | 18 | Both | Teriparatide group:5;Control group:5; | China | |
| 7 | NCT04785443 (ClinicalTrials.gov) | June 22, 2021 | 25/2/2021 | Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyro ... | Contribution of Indocyanine Green Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy Contribution of Indocyanine Green Angiography in the Detection of Parathyroids and the Prevention of ... | Thyroid Diseases | Drug: ICG;Procedure: Control group | University Hospital, Brest | NULL | Recruiting | 18 Years | N/A | All | 242 | Phase 3 | France |
| 8 | JPRN-JapicCTI-194828 | 31/3/2021 | 25/06/2019 | A Clinical Study of rhPTH (1-84) Treatment in Japanese Participants With Chronic Hypoparathyroidism | A Phase 3, Open-label Clinical Study of rhPTH (1-84) Treatment in Japanese Subjects With Chronic Hypoparathyroidism A Phase 3, Open-label Clinical Study of rhPTH (1-84) Treatment in Japanese Subjects With Chronic Hyp ... | Chronic Hypoparathyroidism | Intervention name : rhPTH (1-84) INN of the intervention : Parathyroid hormone Dosage And administration of the intervention : rhPTH (1-84) will be administered at 25, 50, 75 and 100 micrograms once daily in one of the thighs (alternate thigh every day) as a subcutaneous injection. Control intervention name : - INN of the control intervention : - Dosage And administration of the control intervention : - Intervention name : rhPTH(1-84) INN of the intervention : Parathyroid hormone Dosage And administratio ... | Takeda Pharmaceutical Company Limited | NULL | pending | 20 | 85 | BOTH | 12 | Phase 3 | Japan |
| 9 | EUCTR2020-003380-26-FR (EUCTR) | 15/03/2021 | 27/10/2020 | PaTHway TRIAL: A Clinical Trial to Investigate the Safety and Effectiveness of TransCon PTH Administered as an Injection Under the Skin in Adults with Hypoparathyroidism. PaTHway TRIAL: A Clinical Trial to Investigate the Safety and Effectiveness of TransCon PTH Administ ... | A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial, with an Open-Label Extension, Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Subcutaneously Daily in Adults with Hypoparathyroidism A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial, with an ... | Hypoparathyroidism in Adults MedDRA version: 20.0;Level: PT;Classification code 10021041;Term: Hypoparathyroidism;System Organ Class: 10014698 - Endocrine disorders;Therapeutic area: Diseases [C] - Hormonal diseases [C19] Hypoparathyroidismin Adults MedDRA version: 20.0;Level: PT;Classification code 10021041;Term: Hypopa ... | Product Name: TransCon PTH low-dose pen INN or Proposed INN: Teriparatide conjugated to a multiarm polyethylene glycol carrier molecule through a cleavable linker Other descriptive name: POLY(OXY-1,2-ETHANEDIYL), ALPHA-HYDRO-OMEGA-METHOXY, ETHER WITH N-[[[2-[[6-[[1-[3-[[3-(2,3-DIHYDROXYPROPOXY)PROPYL]AMINO]-3-OXOPROPYL]-2,5-DIOXO-3-PYRROLIDINYL]THIO]HEXYL]AMINO]ETHYL]AMINO]CARBONYL]-2-METHYLALANYL-TERIPARATIDE (2:1) Product Name: TransCon PTH mid-dose pen INN or Proposed INN: Teriparatide conjugated to a multiarm polyethylene glycol carrier molecule through a cleavable linker Other descriptive name: POLY(OXY-1,2-ETHANEDIYL), ALPHA-HYDRO-OMEGA-METHOXY, ETHER WITH N-[[[2-[[6-[[1-[3-[[3-(2,3-DIHYDROXYPROPOXY)PROPYL]AMINO]-3-OXOPROPYL]-2,5-DIOXO-3-PYRROLIDINYL]THIO]HEXYL]AMINO]ETHYL]AMINO]CARBONYL]-2-METHYLALANYL-TERIPARATIDE (2:1) Product Name: TransCon PTH high-dose pen INN or Proposed INN: Teriparatide conjugated to a multiarm polyethylene glycol carrier molecule through a cleava Product Name: TransCon PTHlow-dose pen INN or Proposed INN: Teriparatideconjugated to a multiarm poly ... | Ascendis Pharma Bone Diseases A/S | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 76 | Phase 3 | United States;France;Hungary;Canada;Denmark;Norway;Germany;United Kingdom;Italy | ||
| 10 | NCT04671719 (ClinicalTrials.gov) | March 10, 2021 | 11/12/2020 | Determination of Circulating Autotaxin in Patients With GNAS or PTH Abnormalities | Autotaxin in Patients With GNAS/PTH Abnormalities | Fibrous Dysplasia;Albright Syndrome;Adult Children;Hypoparathyroidism;Hyperparathyroidism;Pseudo Hypoparathyroidism Fibrous Dysplasia;Albright Syndrome;Adult Children;Hypoparathyroidism;Hyperparathyroidism;Pseudo Hyp ... | Biological: blood sample | Hospices Civils de Lyon | NULL | Recruiting | 10 Years | N/A | All | 110 | France |