28. 全身性アミロイドーシス Systemic amyloidosis Clinical trials / Disease details

臨床試験数 : 261 / 薬物数 : 276 - (DrugBank : 81) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 178

14 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02994784 (ClinicalTrials.gov)	January 8, 2018	18/11/2016	Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients	A Phase II Single-Center, Open-Label, Safety and Efficacy Study of Propylene Glycol-Free Melphalan H ...	Amyloidosis; Systemic	Drug: Propylene Glycol -Free Melphalan Hydrochloride	Boston Medical Center	Spectrum Pharmaceuticals, Inc	Recruiting	18 Years	N/A	All	43	Phase 2	United States
2	NCT03315026 (ClinicalTrials.gov)	December 14, 2017	13/10/2017	Siltuximab to Decrease Symptom Burden After Autologous Stem Cell Transplantation for Patients With M ...	Phase II Study of Interleukin 6 Blockade With Siltuximab to Decrease Symptom Burden in Patients Age ...	Multiple Myeloma;AL Amyloidosis	Drug: Siltuximab;Behavioral: The M.D. Anderson Symptom Inventory (MDASI)	Memorial Sloan Kettering Cancer Center	Janssen Scientific Affairs, LLC	Active, not recruiting	60 Years	75 Years	All	30	Phase 2	United States
3	NCT01849783 (ClinicalTrials.gov)	April 4, 2013	6/5/2013	Autologous Stem Cell TransplantFollowed By Maintenance Therapy in Treating Elderly Patients With Mul ...	Single Autologous Transplant Followed by Consolidation and Maintenance for Participants = 65 Years o ...	Extramedullary Plasmacytoma;Isolated Plasmacytoma of Bone;Light Chain Deposition Disease;Primary Sys ...	Drug: dexamethasone;Drug: cisplatin;Drug: doxorubicin;Drug: cyclophosphamide;Drug: etoposide;Drug: b ...	Yogesh Jethava	National Cancer Institute (NCI)	Active, not recruiting	65 Years	85 Years	All	41	Phase 2	United States
4	EUCTR2010-021445-42-BE (EUCTR)	10/05/2012	10/10/2011	A study in which is investigated if the medicine bortezomib is effective in patietns with AL amylodo ...	A multicenter, randomized phase II study of bortezomib and dexamethasone as induction treatment foll ...	AL Amyloidosis MedDRA version: 20.0;Level: PT;Classification code 10002022;Term: Amyloidosis;System ...	Trade Name: Velcade INN or Proposed INN: BORTEZOMIB	HOVON Foundation	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 2	Belgium;Germany;Netherlands
5	EUCTR2010-021445-42-DE (EUCTR)	09/05/2012	23/01/2012	A study to investigated whether bortezomib is effective in patients with AL amyloidosis	A multicenter, prospective study of bortezomib and dexamethasone as induction treatment followed by ...	AL Amyloidosis MedDRA version: 17.0;Level: PT;Classification code 10002022;Term: Amyloidosis;System ...	Trade Name: Velcade INN or Proposed INN: BORTEZOMIB Trade Name: Fortecortin Product Name: Fortecortin IN ...	HOVON Foundation	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 3	Belgium;Netherlands;Germany
6	EUCTR2010-021445-42-NL (EUCTR)	31/08/2011	27/01/2011	A study in which is investigated if the medicine bortezomib is effective in patients with AL amyloid ...	A multicenter, phase II study of bortezomib and dexamethasone as induction treatment followed by hig ...	AL Amyloidosis MedDRA version: 16.1;Level: PT;Classification code 10002022;Term: Amyloidosis;System ...	Trade Name: Velcade INN or Proposed INN: BORTEZOMIB	HOVON Foundation	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 2	Belgium;Germany;Netherlands
7	NCT01383759 (ClinicalTrials.gov)	June 24, 2011	27/6/2011	Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bort ...	Pilot Study of Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and M ...	Light Chain Deposition Disease (LCDD or MIDD);Light Chain and Heavy Chain Deposition Disease (LHCDD ...	Drug: Bortezomib /Dexamethasone (BD), Followed By Autologous STC & Maintenance Bortezomib/Dexamethaso ...	Memorial Sloan Kettering Cancer Center	Millennium Pharmaceuticals, Inc.	Completed	18 Years	N/A	All	20	N/A	United States
8	NCT01998503 (ClinicalTrials.gov)	December 2007	15/11/2013	Bortezomib and Dexamethasone Followed by ASCT Compared With ASCT Alone in Treating Patients With AL ...	Induction Therapy With Bortezomib and Dexamethasone Followed by Autologous Stem Cell Transplantation ...	Amyloidosis	Drug: Bortezomib;Drug: dexamethasone;Biological: filgrastim;Procedure: autologous hematopoietic stem ...	Nanjing University School of Medicine	NULL	Completed	18 Years	65 Years	Both	56	Phase 3	China
9	NCT00458822 (ClinicalTrials.gov)	February 2007	9/4/2007	Melphalan and Autologous Stem Cell TransplantFollowed By Bortezomib and Dexamethasone in Treating Pa ...	Risk-Adapted Intravenous Melphalan With Stem Cell Transplant and Adjuvant Bortezomib and Dexamethaso ...	Multiple Myeloma and Plasma Cell Neoplasm	Drug: bortezomib;Drug: dexamethasone	Memorial Sloan Kettering Cancer Center	National Cancer Institute (NCI)	Completed	18 Years	70 Years	All	40	Phase 2	United States
10	NCT00536601 (ClinicalTrials.gov)	June 29, 2006	27/9/2007	High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Trans ...	Autologous Blood and Marrow Transplantation for Hematologic Malignancies and Selected Solid Tumors	Adult Acute Lymphoblastic Leukemia in Remission;Adult Acute Myeloid Leukemia in Remission;Adult Acut ...	Drug: etoposide;Drug: cyclophosphamide;Drug: carmustine;Drug: melphalan;Drug: busulfan;Drug: carbopl ...	Roswell Park Cancer Institute	National Cancer Institute (NCI)	Completed	4 Years	N/A	All	174	N/A	United States

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