28. 全身性アミロイドーシス Systemic amyloidosis Clinical trials / Disease details
臨床試験数 : 261 / 薬物数 : 276 - (DrugBank : 81) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 178
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | JPRN-UMIN000008396 | 2012/08/01 | 10/07/2012 | A randomized, double-blind, placebo-controlled trial of diflunisal on familial amyloid polyneuropathy | patients of familial amyloid polyneuropathy | Diflunisal, 500mg / day, PO, 1 year Parse, 500mg / day, PO, 1 year | Department of Neurology, Faculty of Life Sciences, Kumamoto University | NULL | Complete: follow-up complete | 18years-old | 65years-old | Male and Female | 1 | Phase 3 | Japan | |
| 2 | EUCTR2006-001066-16-GB (EUCTR) | 25/08/2010 | 18/06/2010 | A randomized, double-blind, placebo-controlled, international multi-center trial ofdiflunisal on neurologic disease progression in 200 familial amyloid subjects - The effect of diflunisal on familial amyloidosis | A randomized, double-blind, placebo-controlled, international multi-center trial ofdiflunisal on neurologic disease progression in 200 familial amyloid subjects - The effect of diflunisal on familial amyloidosis | Hereditary neuropathic amyloidosis MedDRA version: 11.;Level: LLT;Classification code 10019889;Term: Hereditary neuropathic amyloidosis | Trade Name: Dolobid Product Name: diflunisal (dolobid) INN or Proposed INN: diflunisal Other descriptive name: 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid | John L. Berk | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 140 | United Kingdom;Italy;Sweden | |||
| 3 | JPRN-UMIN000001825 | 2009/04/01 | 31/03/2009 | Treatment of familial amyloid polyneuropathy (FAP) using diflunisal | familial amyloid polyneuropathy (FAP) | Orally administration of diflunisal | Shinshu University | NULL | Complete: follow-up complete | 20years-old | Not applicable | Male and Female | 30 | Not selected | Japan | |
| 4 | EUCTR2006-001066-16-IT (EUCTR) | 30/01/2007 | 09/03/2007 | The effect of diflunisal IND 68092 on familial amyloidosis a randomized, double-blind, placebo-controlled, international multi-center trial of diflunisal on neurologic disease progression in 200 familial amyloid subjects. - ND | The effect of diflunisal IND 68092 on familial amyloidosis a randomized, double-blind, placebo-controlled, international multi-center trial of diflunisal on neurologic disease progression in 200 familial amyloid subjects. - ND | familial amyloidosis MedDRA version: 9.1;Level: LLT;Classification code 10016202;Term: Familial amyloidosis | Trade Name: Dolobid | Boston University- The Amyloid Treatment and Research Program | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 200 | United Kingdom;Italy;Sweden | |||
| 5 | EUCTR2006-001066-16-SE (EUCTR) | 04/01/2007 | 09/11/2006 | The effect of diflunisal (IND 68092) on familial amyloidosis - The Diflunisal Trial | The effect of diflunisal (IND 68092) on familial amyloidosis - The Diflunisal Trial | Familial Amyloid Polyneuropathy (FAP) | Trade Name: Dolobid Product Name: diflunisal (dolobid) INN or Proposed INN: diflunisal Other descriptive name: 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid | John L. Berk, M.D. | NULL | Not Recruiting | Female: yes Male: yes | 200 | United Kingdom;Italy;Sweden | |||
| 6 | NCT00294671 (ClinicalTrials.gov) | February 2006 | 21/2/2006 | The Effect of Diflunisal on Familial Amyloidosis | The Effect of Diflunisal on Familial Amyloidosis | Familial Amyloid Polyneuropathy;Familial Amyloidosis | Drug: diflunisal;Other: placebo | Boston University | Food and Drug Administration (FDA);National Institute of Neurological Disorders and Stroke (NINDS) | Completed | 18 Years | 75 Years | All | 130 | Phase 2/Phase 3 | United States;Italy;Japan;Sweden;United Kingdom;Portugal |