28. 全身性アミロイドーシス Systemic amyloidosis Clinical trials / Disease details
臨床試験数 : 261 / 薬物数 : 276 - (DrugBank : 81) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 178
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | EUCTR2016-000276-23-GB (EUCTR) | 06/12/2016 | 11/07/2016 | Study to look at the affect of anti-SAP treatment in patients with cardiac amyloidosis | A multiple treatment session, open label phase 2 clinical study of GSK2398852 administered following and together with GSK2315698 in cohorts of patients with cardiac amyloidosis | Systemic amyloidosis MedDRA version: 20.0;Level: SOC;Classification code 10021428;Term: Immune system disorders;System Organ Class: 10021428 - Immune system disorders MedDRA version: 20.0;Level: PT;Classification code 10002022;Term: Amyloidosis;System Organ Class: 10021428 - Immune system disorders ;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Product Name: GSK2315698 Product Code: GSK2315698 INN or Proposed INN: miridesap Other descriptive name: CPHC (carboxy pyrrolidine hexanoyl pyrrolidone carboxylate) Product Name: GSK2398852 Product Code: GSK2398852 INN or Proposed INN: dezamizumab | GlaxoSmithKline Research & Development Ltd | NULL | Not Recruiting | Female: yes Male: yes | 30 | Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): no | United States;United Kingdom | ||
| 2 | NCT01777243 (ClinicalTrials.gov) | May 13, 2013 | 24/1/2013 | A Study to Evaluate the Safety of GSK2398852 When Co-administered With GSK2315698 in Patients With Systemic Amyloidosis | A Single Dose First in Human Study of GSK2398852 Co-Administered With GSK2315698 in Patients With Systemic Amyloidosis | Amyloidosis | Drug: GSK2398852;Drug: GSK2315698 | GlaxoSmithKline | Imperial College London;Heart Hospital;Royal Free Hospital NHS Foundation Trust;Quintiles, Inc. | Completed | 18 Years | 70 Years | All | 25 | Phase 1 | United Kingdom |
| 3 | NCT01406314 (ClinicalTrials.gov) | October 13, 2011 | 26/7/2011 | SAP Depleter Dose Assessment Study in Patients | A Phase 1, Open Label, Dose Characteristic Study to Investigate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Intravenous and Subcutaneous Doses of GSK2315698A in Patients With Systemic Amyloidosis | Amyloidosis | Drug: GSK2315698 | GlaxoSmithKline | NULL | Completed | 18 Years | 80 Years | All | 17 | Phase 1 | United Kingdom |