283. 後天性赤芽球癆 Acquired pure red cell aplasia Clinical trials / Disease details

臨床試験数 : 18 / 薬物数 : 42 - (DrugBank : 22) / 標的遺伝子数 : 19 - 標的パスウェイ数 : 98

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04965597 (ClinicalTrials.gov)	March 2022	21/6/2021	Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of ...	Hematopoietic Cell Transplantation Using Treosulfan-Based Conditioning for the Treatment of Bone Mar ...	Bone Marrow Failure Syndrome;Congenital Amegakaryocytic Thrombocytopenia;Congenital Pure Red Cell Ap ...	Drug: Treosulfan;Drug: Fludarabine Phosphate;Drug: Tacrolimus;Drug: Methotrexate;Biological: Lapine T ...	Fred Hutchinson Cancer Research Center	Blood and Marrow Transplant Clinical Trials Network;National Cancer Institute (NCI);National Marrow ...	Recruiting	1 Year	49 Years	All	40	Phase 2	United States
2	NCT04423367 (ClinicalTrials.gov)	September 13, 2020	5/6/2020	Bortezomib Plus Dexamethasone for Acquired Pure Red Cell AplasiaFailure or Relapse After First-line ...	Safety and Efficacy of Bortezomib Plus Dexamethasone for Acquired Pure Red Cell AplasiaFailure or Re ...	Acquired Pure Red Cell Aplasia	Drug: bortezomib /dexamethasone	Institute of Hematology & Blood Diseases Hospital	NULL	Recruiting	18 Years	70 Years	All	17	Phase 2	China
3	NCT04470804 (ClinicalTrials.gov)	August 1, 2020	9/7/2020	Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCA	Sirolimus Treatment for Newly Diagnosed Primary Acquired Pure Red Cell Aplasia: a Single Center Pros ...	Pure Red Cell Aplasia, Acquired	Drug: Sirolimus;Drug: Cyclosporine A	Bing Han	NULL	Recruiting	18 Years	70 Years	All	40	Phase 4	China
4	NCT03966053 (ClinicalTrials.gov)	September 13, 2019	23/5/2019	The Use of Trifluoperazine in Transfusion Dependent DBA	Phase I/II, Open Label Study to Determine Safety of Trifluoperazine (TFP) in Adults With Red Blood C ...	Diamond Blackfan Anemia;Pure Red Cell Aplasia	Drug: Trifluoperazine	Adrianna Vlachos	NULL	Terminated	18 Years	65 Years	All	2	Phase 1/Phase 2	United States
5	NCT03918265 (ClinicalTrials.gov)	May 4, 2019	16/4/2019	Tacrolimus Treatment for Refractory Autoimmune Cytopenia	Tacrolimus Treatment for Refractory Autoimmune Cytopenia	Autoimmune Hemolytic Anemia;Pure Red Cell Aplasia;Evans Syndrome	Drug: Tacrolimus	Peking Union Medical College Hospital	NULL	Recruiting	18 Years	80 Years	All	80	Phase 4	China
6	NCT03540472 (ClinicalTrials.gov)	June 10, 2018	14/5/2018	Tacrolimus Treatment for Refractory PRCA	Tacrolimus Treatment for Refractory Pure Red Cell Aplasia, a Prospective Study	Pure Red Cell Aplasia	Drug: tacrolimus	Peking Union Medical College Hospital	NULL	Unknown status	18 Years	80 Years	All	30	Phase 4	China
7	NCT03364764 (ClinicalTrials.gov)	February 1, 2018	21/11/2017	Sirolimus Treatment for Refractory PRCA	Sirolimus Treatment for Refractory Pure Red Cell Aplasia, a Prospective Study	Pure Red Cell Aplasia	Drug: Sirolimus	Bing Han	NULL	Completed	18 Years	80 Years	All	64	Phase 4	China
8	NCT03333486 (ClinicalTrials.gov)	December 7, 2017	2/11/2017	Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in T ...	A Phase II Trial of Haploidentical Allogeneic Stem Cell Transplantation Utilizing Mobilized Peripher ...	Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;Acute Leukemia in Remission;Acute ...	Drug: Cyclophosphamide;Drug: Fludarabine Phosphate;Other: Laboratory Biomarker Analysis;Procedure: Pe ...	Roswell Park Cancer Institute	NULL	Recruiting	1 Year	75 Years	All	58	Phase 2	United States
9	NCT03214354 (ClinicalTrials.gov)	July 5, 2017	5/7/2017	Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompati ...	A Phase II Pilot Study of Nonmyeloablative Conditioning Hematopoietic Stem Cell Transplantation in C ...	Sickle Cell Disease;Stem Cell Transplant Complications;Red Blood Cell Disorder;Pure Red Cell Aplasia ...	Drug: Alemtuzumab;Radiation: Total Body Irradiation;Drug: Sirolimus	University of Calgary	NULL	Recruiting	1 Year	19 Years	All	12	Phase 2	Canada
10	NCT01362595 (ClinicalTrials.gov)	June 2013	20/5/2011	Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Dia ...	The Use of Novel Therapies to Reconstitute Blood Cell Production and Promote Organ Performance Using ...	Diamond Blackfan Anemia;Blackfan Diamond Syndrome;DBA;Congenital Hypoplastic Anemia;Pure Red Cell Ap ...	Drug: leucine	Northwell Health	NULL	Active, not recruiting	2 Years	N/A	All	50	Phase 1/Phase 2	United States

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