294. 先天性横隔膜ヘルニア Congenital diaphragmatic hernia Clinical trials / Disease details


臨床試験数 : 15 薬物数 : 36 - (DrugBank : 6) / 標的遺伝子数 : 5 - 標的パスウェイ数 : 14

  
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PhaseCountries
1NCT05213676
(ClinicalTrials.gov)
January 1, 202327/1/2022Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) - The NoNO Trial - a Multi-center, De-implementation, Stepped-wedge, Cluster-randomized Trial Within an Established CollaborativeInhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) - The NoNO Trial - a Multi-center, De-implementation, Stepped-wedge, Cluster-randomized Trial Within an Established CollaborativeCongenital Diaphragmatic HerniaDrug: Inhaled Nitric Oxide (iNO) use;Other: De-implementation of Inhaled Nitric Oxide (iNO) useThe University of Texas Health Science Center, HoustonNULLNot yet recruitingN/A1 MonthAll600Phase 4United States
2ChiCTR2000037331
2020-09-012020-08-28AI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hernia disease databaseAI-assisted diagnosis and treatment engine based on a fully structured congenital diaphragmatic hernia disease database Congenital diaphragmatic herniaintervention group:sildenafil + conventional therapy;control group:conventional therapy;Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineNULLRecruiting05Bothintervention group:100;control group:100;China
3EUCTR2017-000421-13-IT
(EUCTR)
20/03/202006/10/2020Newborns with Congenital diaphragmatic hernia; iNO versus sildenafilNewborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS Trial Congenital diaphragmatic hernia with pulmonary hypertension
MedDRA version: 20.0;Level: SOC;Classification code 10038738;Term: Respiratory, thoracic and mediastinal disorders;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trade Name: REVATIO - 0.8 MG/ML - SOLUZIONE INIETTABILE - USO ENDOVENOSO - FLACONCINO(VETRO) 1 FLACONCINO DA 20 ML
Product Name: Sildenafil
Product Code: [na]
INN or Proposed INN: Sildenafil
Trade Name: INALOSSIN - 800 PPM MOL/MOL GAS MEDICINALE COMPRESSO BOMBOLA IN ALLUMINIO CON VALVOLA VI DA 20 LITRI
Product Name: INALOSSIN 800 PPM MOL/MOL GAS MEDICINALE COMPRESSO
Product Code: [na]
INN or Proposed INN: OSSIDO DI AZOTO
Other descriptive name: Nitric oxide
ERASMUS MEDICAL CENTERNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
330Phase 3Spain;Belgium;Austria;Norway;Netherlands;Germany;Italy;Sweden
4EUCTR2017-000421-13-BE
(EUCTR)
07/02/201919/02/2019Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil. Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trial Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Trade Name: revatio 0.8mg/ml solution for injection
Trade Name: INOmax 800ppm mol/mol inhalatiegas
INN or Proposed INN: NITRIC OXIDE
Trade Name: Neophyr 1000ppm mol/mol
Erasmus MCNULLAuthorised-recruitment may be ongoing or finished Female: yes
Male: yes
330 Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): yes Therapeutic use (Phase 4): noBelgium;Austria;Netherlands
5NCT03526588
(ClinicalTrials.gov)
August 1, 201827/4/2018Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)Congenital Diaphragmatic HerniaBiological: Autologous umbilical cord bloodThe University of Texas Health Science Center, HoustonTexas Medical Center Regenerative Medicine ConsortiumRecruitingN/A7 DaysAll20Phase 1United States
6EUCTR2017-000421-13-AT
(EUCTR)
13/07/201808/05/2018Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trial Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Trade Name: revatio 0.8mg/ml solution for injection
INN or Proposed INN: Sildenafil
Trade Name: INOmax 800ppm mol/mol inhalatiegas
INN or Proposed INN: NITRIC OXIDE
Erasmus MCNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
330Phase 4Austria;Netherlands
7NCT03787160
(ClinicalTrials.gov)
March 22, 201810/7/2018Microbiome and Volatile Organic Compounds in Patients With CDHDetermining the Effect of Probiotics on Microbiome and Volatile Organic Compounds in Patients After Surgical Repair of Congenital Diaphragmatic HerniaCongenital Diaphragmatic HerniaDiagnostic Test: initial VOC;Diagnostic Test: initial fecal microbiome;Diagnostic Test: initial pulmonary microbiome;Diagnostic Test: Maximum oxygen uptake;Diagnostic Test: Functional residual capacity;Dietary Supplement: Probiotic treatment;Diagnostic Test: VOC probiotic;Diagnostic Test: Fecal microbiome probiotic;Diagnostic Test: Pulmonary microbiome probioticMedical University of GrazUniversity of RostockCompleted6 Years16 YearsAll18N/AAustria
8NCT02951130
(ClinicalTrials.gov)
August 22, 201714/10/2016Milrinone in Congenital Diaphragmatic HerniaMilrinone in Congenital Diaphragmatic HerniaCongenital Diaphragmatic Hernia;Persistent Pulmonary Hypertension of the Newborn;Hypoxemic Respiratory Failure;Pulmonary HypoplasiaDrug: Milrinone;Drug: Placebo (5% Dextrose)NICHD Neonatal Research NetworkEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)RecruitingN/A168 HoursAll66Phase 2United States
9EUCTR2017-000421-13-NL
(EUCTR)
27/07/201707/06/2017Treatment of high blood pressure in the lungs in newborns with a defect inthe diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxideversus intravenous Sildenafil:an international randomized controlled trial - CoDiNOS trial Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Trade Name: revatio 0.8mg/ml solution for injection
Trade Name: INOmax 800ppm mol/mol inhalatiegas
Erasmus MCNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
90Phase 3Belgium;Austria;Norway;Netherlands;Sweden
10EUCTR2013-002026-22-NL
(EUCTR)
24/10/201327/06/2013Adminstration of omeprazole by rectiole or oral tablet for the treatment of reflux disease in neonates and infants with a closure of the esophagus or a congenital opening in the diaphragm.Rectal and oral omeprazole treatment of gastroesophageal reflux in infants with esophageal atresia or congenital diaphragmatic hernia.A pharmacodynamic and pharmacokinetic study - NEOPREMEC GORD,;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]Trade Name: Losec
Product Name: Omeprazol
Product Code: NA
Trade Name: Losec
Product Name: Omeprazol
Product Code: NA
ErasmusMCNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Netherlands
11NCT02453750
(ClinicalTrials.gov)
February 201221/5/2015Airway Inflammation in Congenital Diaphragmatic Hernia PatientsInvestigation of Airway Inflammation in Congenital Diaphragmatic Hernia PatientsCongenital Diaphragmatic HerniaDrug: Hypersaline;Drug: Bronchodilator ResponseThe Hospital for Sick ChildrenNULLCompleted6 Years18 YearsAll21N/ACanada
12NCT00257946
(ClinicalTrials.gov)
December 200522/11/2005Type of Material in Repair of Congenital Diaphragmatic HerniaProspective Randomized Trial Comparing Type of Material in Repair of Congenital Diaphragmatic HerniaCongenital Diaphragmatic HerniaProcedure: Repair of CDH w/SIS Gold;Procedure: Repair of CDH w/AllodermChildren's Mercy Hospital Kansas CityNULLTerminatedN/A2 MonthsBoth50Phase 3United States
13NCT00226044
(ClinicalTrials.gov)
September 200522/9/2005Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.Rectal and Oral Omeprazole Treatment of Gastroesophageal Reflux in Infants With Esophageal Atresia or Congenital Diaphragmatic Hernia; A Pharmacodynamic and Pharmacokinetic Study.Gastroesophageal Reflux;Esophageal Atresia;Hernia, DiaphragmaticDrug: Omeprazole rectally 1mg/kgRijnstate HospitalErasmus Medical CenterCompleted6 Weeks3 MonthsAll17Phase 3Netherlands
14EUCTR2017-000421-13-NO
(EUCTR)
11/01/2018Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trial Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Trade Name: revatio 0.8mg/ml solution for injection
Trade Name: INOmax 800ppm mol/mol inhalatiegas
INN or Proposed INN: NITRIC OXIDE
Trade Name: Neophyr 1000ppm mol/mol
Erasmus MCNULLNAFemale: yes
Male: yes
330Phase 3Belgium;Austria;Netherlands;Norway
15EUCTR2017-000421-13-SE
(EUCTR)
11/09/2018Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.Newborns with Congenital Diaphragmatic hernia: inhaled Nitric Oxide versus intravenous Sildenafil: an international randomized controlled trial - CoDiNOS trial Congenital diaphragmatic hernia with pulmonary hypertension;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Trade Name: revatio 0.8mg/ml solution for injection
Trade Name: INOmax 800ppm mol/mol inhalatiegas
INN or Proposed INN: NITRIC OXIDE
Erasmus MCNULLNAFemale: yes
Male: yes
330Phase 3Belgium;Austria;Norway;Netherlands;Sweden