296. 胆道閉鎖症 Biliary atresia Clinical trials / Disease details
臨床試験数 : 63 / 薬物数 : 65 - (DrugBank : 37) / 標的遺伝子数 : 45 - 標的パスウェイ数 : 63
Showing 1 to 10 of 63 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05072626 (ClinicalTrials.gov) | October 11, 2021 | 13/9/2021 | High Medium-chain Triglyceride Nutritional Support in Infants With Biliary Atresia | Study on High Medium-chain Triglyceride Nutritional Support in Infants With Biliary Atresia After Kasai Portoenterostomy Study on High Medium-chain Triglyceride Nutritional Support in Infants With Biliary AtresiaAfter Kas ... | Biliary Atresia;Infant;Nutrition Support;Medium-chain Triglyceride | Combination Product: high MCT formula;Dietary Supplement: MCT powder | Children's Hospital of Fudan University | NULL | Recruiting | N/A | 3 Months | All | 300 | N/A | China |
| 2 | NCT04524390 (ClinicalTrials.gov) | July 8, 2021 | 20/8/2020 | Evaluation of Maralixibat in Biliary Atresia Response Post-Kasai | Randomized, Double-Blind, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects With Biliary Atresia After Hepatoportoenterostomy Randomized, Double-Blind, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Ma ... | Biliary Atresia | Drug: Maralixibat;Other: Placebo | Mirum Pharmaceuticals, Inc. | NULL | Recruiting | 31 Days | 111 Days | All | 72 | Phase 2 | United States;Germany;Poland;United Kingdom |
| 3 | ChiCTR2100044533 | 2021-06-01 | 2021-03-23 | Multicenter study of non-invasive diagnostic scoring system for biliary atresia | Multicenter study of non-invasive diagnostic scoring system for biliary atresia | Biliary atresia | Gold Standard:Intraoperative cholangiography;Index test:Non-invasive diagnostic scoring system for biliary atresia (Biochemicaltests, blood routine, CRP, blood ammonia, AFP, hepatobiliary B ultrasound); GoldStandard:Intraoperative cholangiography;Index test:Non-invasive diagnostic scoring system for bi ... | Children's Hospital Affiliated to Zhejiang University Medical College | NULL | Recruiting | Both | Target condition:200;Difficult condition:0 | China | |||
| 4 | ChiCTR2100046985 | 2021-06-01 | 2021-06-06 | A clinical study of biliary atresia treatment with Belimumab | Immune pathogenesis and treatment of biliary atresia | biliary atresia | Control Group:Conventional therapy;Experimental group:Belimumab; | Guangzhou Women and Children Medical Center | NULL | Recruiting | 0.1 | 0.3 | Both | Control Group:6;Experimental group:6; | Phase 4 | China |
| 5 | JPRN-jRCTs031210066 | 06/05/2021 | 06/05/2021 | bezafibrate for post operated bilirary atresia | Prospective study of bezafibrate for post operated bilirary atresia | Biliary Atresia Obstructive jaundice;D001656 | Bezafibrate 400 mg/day is orally administered to patients after biliary atresia in two divided doses after breakfast and dinner. Bezafibrate400 mg/day is orally administered to patients after biliary atresia in two divided doses ... | Terui Keita | NULL | Recruiting | >= 18age old | < 80age old | Both | 10 | Phase 2 | Japan |
| 6 | EUCTR2020-000974-22-IT (EUCTR) | 22/03/2021 | 24/05/2021 | Clinical study to evaluate the Efficacy and Safety of Maralixibat used in treatment of Biliary Atresia subjects after Hepatoportoenterostomy Clinical study to evaluate the Efficacy and Safety of Maralixibat used in treatment of Biliary Atres ... | Randomized, Double-blind, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects with Biliary Atresia after Hepatoportoenterostomy - EMBARK: Evaluation of Maralixibat in Biliary Atresia Response post Kasai Randomized, Double-blind, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Ma ... | Biliary atresia (BA) is a rare, inflammatory condition of the biliary tree that presents in the first weeks of life and leads to bile duct obstruction and consequent liver injury, fibrosis and cirrhosis which lead to portal hypertension and a decline in hepatic synthetic function. Untreated, the outcome of BA is uniformly fatal. The 2 most important improvements inthe care of BA patients to date are the Kasai hepatoportoenterostomy (HPE; Kasai procedure) and orthotopic liver transplantation. MedDRA version: 20.0;Level: LLT;Classification code 10004653;Term: Biliary atresia;System Organ Class: 100000004850;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Biliary atresia(BA) is a rare, inflammatory condition of the biliary tree that presents in the first ... | Product Name: Maralixibat Product Code: [Maralixibat] INN or Proposed INN: Maralixibat cloruro Other descriptive name: MARALIXIBAT CHLORIDE Product Name: Maralixibat Product Code: [Maralixibat] INN or Proposed INN: Maralixibat cloruro Other descriptive name: MARALIXIBAT CHLORIDE Product Name: Maralixibat Product Code: [Maralixibat] INN or Proposed INN: Maralixibat cloruro Other descriptive name: MARALIXIBAT CHLORIDE Product Name: Maralixibat Product Code: [Maralixibat] INN or Proposed INN: Maralixibat cloruro Other descriptive name: MARALIXIBAT CHLORIDE Product Name: Maralixibat Product Code: [Maralixibat] INN or Proposed INN: Maralixibatcloruro Other des ... | Mirum Pharmaceuticals Inc. | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 72 | Phase 2 | France;United States;Canada;Poland;Germany;United Kingdom;Italy | ||
| 7 | EUCTR2020-000974-22-FR (EUCTR) | 07/12/2020 | 25/09/2020 | Clinical study to evaluate the Efficacy and Safety of Maralixibat used in treatment of Biliary Atresia subjects after Hepatoportoenterostomy Clinical study to evaluate the Efficacy and Safety of Maralixibat used in treatment of Biliary Atres ... | Randomized, Double-blind, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Subjects with Biliary Atresia after Hepatoportoenterostomy - EMBARK: Evaluation of Maralixibat in Biliary Atresia Response post Kasai Randomized, Double-blind, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Ma ... | Biliary atresia (BA) is a rare, inflammatory condition of the biliary tree that presents in the first weeks of life and leads to bile duct obstruction and consequent liver injury, fibrosis and cirrhosis which lead to portal hypertension and a decline in hepatic synthetic function. Untreated, the outcome of BA is uniformly fatal. The 2 most important improvements in the care of BA patients to date are the Kasai hepatoportoenterostomy (HPE; Kasai procedure) and orthotopic liver transplantation. MedDRA version: 20.0;Level: LLT;Classification code 10004653;Term: Biliary atresia;System Organ Class: 100000004850;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Biliary atresia(BA) is a rare, inflammatory condition of the biliary tree that presents in the first ... | Product Name: Maralixibat INN or Proposed INN: MARALIXIBAT CHLORIDE Product Name: Maralixibat INN or Proposed INN: MARALIXIBAT CHLORIDE Product Name: Maralixibat INN or Proposed INN: MARALIXIBAT CHLORIDE Product Name: Maralixibat INN or Proposed INN: MARALIXIBAT CHLORIDE Product Name: Maralixibat INN or Proposed INN: MARALIXIBATCHLORIDE Product Name: Maralixibat INN or Pro ... | Mirum Pharmaceuticals Inc. | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 72 | Phase 2 | United States;France;Canada;Poland;Germany;United Kingdom;Italy | ||
| 8 | ChiCTR2000040505 | 2020-12-01 | 2020-12-01 | N-acetylcysteine in children with biliary atresia: a clinical trial | Treatment of biliary atresia with N-acetylcysteine and its mechanism | biliary atresia | Preoperative intervention group:N-Acetylcysteine;Postoperative intervention group:N-Acetylcysteine;Preoperative control group:Conventional therapy;postoperative control group:Conventional therapy; Preoperative intervention group:N-Acetylcysteine;Postoperative intervention group:N-Acetylcysteine;P ... | Guangzhou Women and Children Medical Center | NULL | Pending | Both | Preoperative intervention group:20;Postoperative intervention group:20;Preoperative control group:20;postoperative control group:20; | Phase 4 | China | ||
| 9 | EUCTR2019-003807-37-NL (EUCTR) | 01/12/2020 | 28/04/2020 | This Study Will Investigate the Efficacy and Safety of Odevixibat in Children with Biliary Atresia Who Have Undergone a Kasai HPE This Study Will Investigate the Efficacy and Safety of Odevixibat in Children with Biliary AtresiaWh ... | A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Odevixibat (A4250) in Children with Biliary Atresia Who Have Undergone a Kasai Hepatoportoenterostomy (BOLD) A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Odevixib ... | Biliary Atresia MedDRA version: 20.0;Level: LLT;Classification code 10004653;Term: Biliary atresia;System Organ Class: 100000004850;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Biliary Atresia MedDRA version: 20.0;Level: LLT;Classification code 10004653;Term: Biliary atresia;S ... | Product Name: Odevixibat Product Code: A4250 INN or Proposed INN: Odevixibat Product Name: Odevixibat Product Code: A4250 INN or Proposed INN: Odevixibat Product Name: Odevixibat Product Code: A4250 INN or Proposed INN: Odevixibat Product Name: Odevixibat Product Code: A4250 INN or Proposed INN: Odevixibat Product Name: Odevixibat Pr ... | Albireo AB | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 200 | Phase 3 | United States;Taiwan;Spain;Turkey;Israel;United Kingdom;Italy;France;Hungary;Canada;Poland;Malaysia;Belgium;Australia;Germany;Netherlands;China;New Zealand;Korea, Republic of United States;Taiwan;Spain;Turkey;Israel;United Kingdom;Italy;France;Hungary;Canada;Poland;Malaysia; ... | ||
| 10 | ChiCTR2000035667 | 2020-10-01 | 2020-08-16 | Efficacy and safety study of dimethyl fumarate in adjuvant therapy for biliary atresia | Efficacy and safety study of dimethyl fumarate in adjuvant therapy for biliary atresia | Biliary Atresia | control group:Take a placebo;Experimental group:Take dimethyl fumarate; | Children's Hospital of Fudan University | NULL | Pending | Both | control group:120;Experimental group:120; | Phase 4 | China |