298. 遺伝性膵炎 Hereditary pancreatitis Clinical trials / Disease details
臨床試験数 : 98 / 薬物数 : 180 - (DrugBank : 57) / 標的遺伝子数 : 53 - 標的パスウェイ数 : 142
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05270434 (ClinicalTrials.gov) | March 1, 2022 | 10/1/2022 | Optimal Timing of Endoscopic Intervention in the Treatment of Chronic Pancreatitis. | Optimal Timing of Endoscopic Intervention After Extracorporeal Shock-Wave Lithotripsy in the Treatment of Chronic Pancreatitis With Pancreatic Stones. | Pancreatitis, Chronic | Procedure: time interval between ESWL and ERCP is 12h;Procedure: time interval between ESWL and ERCP is 12-36h;Procedure: time interval between ESWL and ERCP is greater than 36h;Drug: morphine, buprenorphine, pethidine, tramaldol, metamizole and acetylsalicylacid (Analgesics) | Changhai Hospital | NULL | Not yet recruiting | 18 Years | 75 Years | All | 225 | N/A | China |
| 2 | NCT05261997 (ClinicalTrials.gov) | March 2022 | 24/11/2021 | Endotherapy for Painless Chronic Pancreatitis | Effect of Endotherapy on the Progression of Chronic Pancreatitis in Painless Patients | Pancreatitis, Chronic;Exocrine Pancreatic Insufficiency;Abdominal Pain;Cholangiopancreatography, Endoscopic Retrograde | Procedure: extracorporeal shock wave lithotripsy and endoscopic drainage of the main pancreatic duct;Drug: pancreatic enzyme(Pancreatin Enteric-coated Capsules or Oryz-Aspergillus Enzyme and Pancreatin Table), antidiabetic medicine(Acarbose Tablets, Glucophage, Glimepirde Tablets) | Changhai Hospital | NULL | Recruiting | 18 Years | 70 Years | All | 60 | N/A | China |
| 3 | NCT05095532 (ClinicalTrials.gov) | December 1, 2021 | 11/10/2021 | Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT | Autologous Mesenchymal Stromal Cells and Islet Co-transplantation to Enhance Islet Survival and Function in Chronic Pancreatitis Patients Undergo Total Pancreatectomy and Islet Autotransplantation | Chronic Pancreatitis;Mesenchymal Stem Cells | Biological: Bone marrow-derived mesenchymal stem cells;Other: Placebo | Medical University of South Carolina | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Recruiting | 18 Years | N/A | All | 42 | Phase 1 | United States |
| 4 | NCT05069597 (ClinicalTrials.gov) | October 14, 2021 | 27/9/2021 | Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon | A Phase 4 Study to Assess Symptoms of Exocrine Pancreatic Insufficiency in Subjects With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon® (Pancrelipase) With an Alternate Source of Active Pharmaceutical Ingredient | Cystic Fibrosis;Chronic Pancreatitis | Drug: CREON | AbbVie | NULL | Recruiting | 18 Years | N/A | All | 30 | Phase 4 | United States |
| 5 | NCT04949828 (ClinicalTrials.gov) | September 16, 2021 | 21/6/2021 | Effect of CREON on Exocrine Pancreatic Insufficiency (EPI) Symptoms | Observational Study Assessing for Effect of CREON on Symptoms of Exocrine Pancreatic Insufficiency (EPI) in Patients With EPI Due to Chronic Pancreatitis (CP) | Chronic Pancreatitis | Drug: CREON | AbbVie | NULL | Recruiting | 18 Years | N/A | All | 90 | United States | |
| 6 | NCT04611958 (ClinicalTrials.gov) | July 1, 2021 | 27/10/2020 | Intraductal Liposomal Bupivacaine for Chronic Pancreatitis | Intraductal Liposomal Bupivacaine as a Therapeutic Trial to Determine the Contribution of Peripheral Versus Central Sensitization in the Pathogenesis of Pain in Chronic Pancreatitis- a Pilot and Feasibility Study | Chronic Pancreatitis | Drug: ERCP with Bupivacaine infusion | Johns Hopkins University | NULL | Withdrawn | 18 Years | 80 Years | All | 0 | Early Phase 1 | United States |
| 7 | ChiCTR2000037002 | 2020-10-01 | 2020-08-26 | Differential diagnosis of pancreatic cancer and chronic pancreatitis with serum miR-25 | A prospective study of serum miR-25 detection in differential diagnosis of pancreatic cancer and chronic pancreatitis | pancreatic cancer | Gold Standard:Pancreatic cancer: pancreatic ductal adenocarcinoma originating from pancreatic ductal epithelium was confirmed by pathological examination (operative biopsy, puncture biopsy, cytological examination). Chronic pancreatitis: Clinically diagnosed as chronic pancreatitis, and no evidence to support the diagnosis of pancreatic cancer.;Index test:Serum miR-25; | The First Affiliated Hospital of the Naval Medical University of the Chinese People's Liberation Army | NULL | Pending | 18 | 75 | Both | Target condition:150;Difficult condition:150 | China | |
| 8 | NCT04207060 (ClinicalTrials.gov) | July 15, 2020 | 17/12/2019 | Trial of Indomethacin in Chronic Pancreatitis | Phase 1/2 Trial of Indomethacin in Chronic Pancreatitis (The PAIR Trial) | Chronic Pancreatitis | Drug: Indomethacin;Drug: Placebos | Mayo Clinic | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Recruiting | 18 Years | 60 Years | All | 32 | Phase 2 | United States |
| 9 | NCT04315311 (ClinicalTrials.gov) | May 6, 2020 | 18/3/2020 | Study Of Effects Of Oral CREON Capsules In Adult Participants With Exocrine Pancreatic Insufficiency Not Due To Cystic Fibrosis, Chronic Pancreatitis, Pancreatectomy, Or Pancreatic Cancer | A Phase 4 Open-Label Single-Arm Study To Evaluate The Use Of CREON In Subjects With EPI Due To Etiologies Other Than Cystic Fibrosis, Chronic Pancreatitis, Pancreatectomy, Or Pancreatic Cancer | Exocrine Pancreatic Insufficiency (EPI) | Drug: CREON | AbbVie | NULL | Withdrawn | 18 Years | N/A | All | 0 | Phase 4 | United States |
| 10 | NCT03568630 (ClinicalTrials.gov) | July 26, 2018 | 13/6/2018 | Blood Markers of Early Pancreas Cancer | A Longitudinal Cohort Study to Identify Clinical and Blood Markers of Early Pancreas Cancer | Diabetes Mellitus, Type 2;PreDiabetes;Pancreas Cyst;Chronic Pancreatitis;Genetic Predisposition to Disease;Inherited Disease | Diagnostic Test: Mixed Meal Tolerance Test;Diagnostic Test: Hemoglobin A1c;Diagnostic Test: Other exploratory blood biomarkers | University of Nebraska | National Cancer Institute (NCI);Virginia Mason Hospital/Medical Center;VA Nebraska Western Iowa Health Care System | Recruiting | 19 Years | N/A | All | 1250 | United States | |
| 11 | JPRN-UMIN000030735 | 2018/01/15 | 15/01/2018 | Diagnostic accuracy of contrast enhanced endoscopic ultrasonography in pancreatbiliary disease | Diagnostic accuracy of contrast enhanced endoscopic ultrasonography in pancreatbiliary disease - A clinical trial of contrast enhanced endoscopic ultrasonography in the pancreatobiliary disease | Pancreas tumor, Chronic pancreatitis, Autoimmune pancreatitis, Gallblader polyp, Biliary tract tumor | Contrast enhanced endoscopic ultrasonography using perflubutane MRI enhanced CT endoscopic ultrasonography without perflubutane | Department of EndoscopyThe Jikei University School of Medicine | NULL | Complete: follow-up complete | 20years-old | 100years-old | Male and Female | 786 | Not selected | Japan |
| 12 | NCT03283566 (ClinicalTrials.gov) | October 3, 2017 | 13/9/2017 | Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT | Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing Total Pancreatectomy and Autologous Islet Transplantation: A Clinical, Molecular, and Genomic Study | Chronic Pancreatitis;Insulin Dependent Diabetes | Drug: Hydroxychloroquine;Drug: Placebo | The Cleveland Clinic | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute);Stanford University | Completed | 18 Years | 65 Years | All | 9 | Phase 2 | United States |
| 13 | NCT03244683 (ClinicalTrials.gov) | August 28, 2017 | 7/8/2017 | A Study of the Efficacy of ONS to Reduce Postoperative Complications Associated With Pancreatic Surgery | A Study of the Efficacy of Oral Nutritional Supplementation to Reduce Postoperative Complications Associated With Pancreatic Surgery | Pancreatic Cancer;Chronic Pancreatitis | Dietary Supplement: Ensure Surgical;Other: Nutrition counseling;Other: Low-intensity exercise therapy | Ohio State University | Abbott Nutrition | Terminated | 40 Years | 89 Years | All | 8 | N/A | United States |
| 14 | JPRN-UMIN000028150 | 2017/07/10 | 10/07/2017 | Analysis of apolipoprotein A2 isoform as a novel pancreatic exocrine marker | Healthy volunteers, patients with chronic pancreatitis, patients with chronic hepatitis | Blood test and PFD test | Yokohama City University | NULL | Recruiting | 20years-old | 75years-old | Male and Female | 200 | Not selected | Japan | |
| 15 | EUCTR2017-000732-34-DK (EUCTR) | 21/06/2017 | 25/04/2017 | Drug Release and Absorption from Controlled Release Formulations in Patients with Gastrointestinal Dysfunctions. | Oral Controlled Release Formulations to Patients with Gastrointestinal Dysfunction – Is the Release of Drug and the Absorption Impaired? - ABOXY | Healthy (pain) and patients (pain). MedDRA version: 20.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis;System Organ Class: 100000004856 MedDRA version: 20.0;Classification code 10012594;Term: Diabetes;System Organ Class: 100000004861 MedDRA version: 20.0;Classification code 10048516;Term: Gastrointestinal disorder (NOS);Classification code 10050554;Term: Gastric bypass NOS;System Organ Class: 100000004865 ;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Oxynorm Product Name: Oxynorm INN or Proposed INN: Oxycodone Other descriptive name: OXYCODONE Trade Name: Oxycodonhydrochlorid ”Lannacher”, depot tablets Product Name: Oxycodonhydrochlorid ”Lannacher”, depot tablets INN or Proposed INN: Oxycodone Other descriptive name: OXYCODONE HYDROCHLORIDE Trade Name: Oxycodone Depot ”Sandoz”, depot tablets Product Name: Oxycodone Depot ”Sandoz”, depot tablets INN or Proposed INN: Oxycodone Other descriptive name: OXYCODONE HYDROCHLORIDE | Mech-Sense, Dept. Gastroenterology & Hepatology, Aalborg University Hospital | NULL | Not Recruiting | Female: yes Male: yes | 135 | Human pharmacology (Phase 1): yes Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): yes | Denmark | ||
| 16 | NCT03481803 (ClinicalTrials.gov) | January 27, 2017 | 6/3/2018 | A Phase IIa Study With Escalating Dose of MS1819-SD | A Multicentre Open-label Phase IIa Study With Escalating Dose of MS1819- SD, to Investigate the Efficacy and Safety of a Yarrowia Lipolytica Lipase Preparation for the Compensation of Exocrine Pancreatic Insufficiency Caused by Chronic Pancreatitis and/or Distal Pancreatectomy | Chronic Pancreatitis;Distal Pancreatectomy | Drug: MS1819-SD | AzurRx SAS | NULL | Completed | 18 Years | N/A | All | 11 | Phase 2 | Australia;France;New Zealand |
| 17 | NCT02713997 (ClinicalTrials.gov) | December 2016 | 29/2/2016 | Anti-inflammatory Therapy to Improve Outcomes After TPIAT | Anti-inflammatory Therapy to Improve Outcomes in Patients With Chronic Pancreatitis Undergoing Total Pancreatectomy Islet Autotransplantation | Pancreatitis, Chronic; Diabetes; Transplant | Drug: etanercept;Drug: Alpha 1-Antitrypsin | University of Minnesota | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Recruiting | 18 Years | 65 Years | All | 45 | Phase 4 | United States |
| 18 | NCT02971475 (ClinicalTrials.gov) | November 2016 | 5/9/2016 | ESWL Versus ESWL and Endoscopic Treatment | Extracorporeal Shock Wave Lithotripsy Versus Extracorporeal Shock Wave Lithotripsy Combined With Endoscopic Treatment for Painful Calcified Chronic Pancreatitis | Pancreatitis | Procedure: extracorporeal shock wave lithotripsy;Procedure: endoscopic drainage of the main pancreatic duct;Drug: Analgesics | Changhai Hospital | NULL | Unknown status | 18 Years | N/A | All | 62 | N/A | China |
| 19 | NCT02849704 (ClinicalTrials.gov) | October 13, 2016 | 27/7/2016 | Fat Malabsorption in Chronic Pancreatitis | Diagnosing Pancreatic-Based Malabsorption in Patients With Chronic Pancreatitis | Chronic Pancreatitis | Drug: Creon36™ | Children's Hospital of Philadelphia | AbbVie;National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);Phoenix Indian Medical Center | Completed | 30 Years | 70 Years | All | 48 | Phase 2 | United States |
| 20 | NCT02947087 (ClinicalTrials.gov) | October 2016 | 18/10/2016 | Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis | Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival | Chronic Pancreatitis | Drug: Prolastin-C;Drug: Placebo | Medical University of South Carolina | NULL | Active, not recruiting | 18 Years | N/A | All | 48 | Phase 1/Phase 2 | United States |
| 21 | NCT02743364 (ClinicalTrials.gov) | September 19, 2016 | 15/4/2016 | Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis | Statin Therapy to Reduce the Risk of Recurrent Pancreatitis | Acute Pancreatitis | Other: Laboratory Biomarker Analysis;Other: Placebo Administration;Other: Quality-of-Life Assessment;Other: Questionnaire Administration;Drug: Simvastatin | National Cancer Institute (NCI) | NULL | Active, not recruiting | 18 Years | N/A | All | 8 | Phase 2 | United States |
| 22 | NCT02965898 (ClinicalTrials.gov) | September 2016 | 23/9/2016 | The Effect of Vitamin D Substitution on the Development of Chronic Pancreatitis | The Effect of Vitamin D Substitution on Pancreatic Parenchyma and Development of Fibrosis After First Acute Alcoholic Pancreatitis: A Randomized Prospective Trial | Chronic Pancreatitis | Dietary Supplement: Vitamin D 100ug;Dietary Supplement: Vitamin D 10ug | Tampere University Hospital | Orion Corporation, Orion Pharma | Recruiting | 18 Years | 101 Years | All | 260 | N/A | Finland |
| 23 | NCT02869893 (ClinicalTrials.gov) | August 10, 2016 | 5/6/2016 | MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in Pediatrics | Magnetic Resonance Cholangiopancreatography (MRCP): A Reliable, Non Invasive Method for Staging Chronic Pancreatitis From Minimal Change Disease to the Advanced Stages in Pediatrics | Healthy Volunteers | Drug: Secretin | Children's Hospital Medical Center, Cincinnati | ChiRhoClin, Inc.;The National Pancreas Foundation | Completed | 6 Years | 15 Years | All | 57 | N/A | United States |
| 24 | NCT02706236 (ClinicalTrials.gov) | April 2016 | 27/2/2016 | Trial of Pancreatic Enzyme Supplements (Pancrelipase) for Treating Pain in Patients With Chronic Pancreatitis | A Single-Center Prospective Randomized Placebo Controlled Trial of Pancreatic Enzyme Supplements (Pancrelipase) for Treating Pain in Patients With Chronic Pancreatitis | Pancreatitis | Drug: Pancrelipase;Drug: placebo | Dartmouth-Hitchcock Medical Center | NULL | Withdrawn | 18 Years | N/A | All | 0 | Phase 2 | United States |
| 25 | EUCTR2015-002570-20-ES (EUCTR) | 25/02/2016 | 18/04/2016 | Optimizing treatment of maldigestion in patients with chronic pancreatitis | Open label, randomized, crossover clinical trial to evaluate the efficacy of increasing doses of pancreatic enzymes against inhibition of acid gastric secretion in patients with exocrine pancreatic insufficiency secondary to chronic pancreatitis | Patients diagnosed of chronic pancreatitis with pancreatic exocrine insufficiency under pancreatic enzyme replacement therapy;Therapeutic area: Diseases [C] - Digestive System Diseases [C06] | Trade Name: Kreon 25000 Product Name: Creon 25000 Product Code: PL 00512/0150 | Department of gastroenterology. University Hospital of Santiago | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Spain | ||||
| 26 | NCT02693093 (ClinicalTrials.gov) | December 2015 | 12/2/2016 | A Dose Ranging Study Evaluating Efficacy and Safety of NI-03 | A Phase 1, Single Dose PK and Safety Study With NI-03 Followed by a Phase 2, Randomized, Double-Blind, Parallel-Group Dose-Ranging Study to Evaluate the Safety and Efficacy of NI-03 When Compared to Placebo in Subjects With Chronic Pancreatitis | Chronic Pancreatitis | Drug: NI-03;Drug: Placebo | Kangen Pharmaceuticals, Inc | NULL | Active, not recruiting | 18 Years | 85 Years | All | 260 | Phase 1/Phase 2 | United States;Russian Federation;Ukraine |
| 27 | NCT02538146 (ClinicalTrials.gov) | August 2015 | 26/8/2015 | Effect of Acetyl-L-carnitine on Chronic Pancreatitis | Acetyl-L-carnitine as Pain Therapy in Chronic Pancreatitis | Chronic Pancreatitis | Dietary Supplement: acetyl-L-carnitine 1000mg 2X per day for 3 months | Karin High | University of Kentucky | Terminated | 20 Years | 90 Years | All | 3 | Early Phase 1 | United States |
| 28 | NCT02577640 (ClinicalTrials.gov) | July 2015 | 7/10/2015 | Dietary Soy Isoflavones In Chronic Pancreatitis | Dietary Soy Isoflavones In Chronic Pancreatitis | Chronic Pancreatitis | Dietary Supplement: Soy bread | Ohio State University | NULL | Completed | 18 Years | N/A | All | 11 | N/A | United States |
| 29 | NCT02487225 (ClinicalTrials.gov) | May 2015 | 29/6/2015 | Pentoxifylline Treatment in Acute Pancreatitis (AP) | Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial | Acute Pancreatitis (AP);Gallstone Pancreatitis;Alcoholic Pancreatitis;Trauma Acute Pancreatitis;Hypertriglyceridemia Acute Pancreatitis;Idiopathic (Unknown) Acute Pancreatitis;Medication Induced Acute Pancreatitis;Cancer Acute Pancreatitis;Miscellaneous (i.e. Acute on Chronic Pancreatitis) | Drug: Pentoxifylline;Drug: Placebo | Mayo Clinic | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Completed | 18 Years | 100 Years | All | 83 | Phase 3 | United States |
| 30 | NCT02567240 (ClinicalTrials.gov) | January 2015 | 1/10/2015 | Carbon Monoxide-Saturated Medium for Islet Isolation | A Novel Approach to Harvest Islets for Autologous Islet Transplantation | Chronic Pancreatitis | Other: Carbon monoxide-bubbled mediums | Medical University of South Carolina | NULL | Completed | 18 Years | 69 Years | All | 16 | Phase 1/Phase 2 | United States |
| 31 | NCT02399800 (ClinicalTrials.gov) | December 2014 | 11/1/2015 | Celiac Plexus Block for Chronic Pancreatitis RCT | Prospective Randomized Trial of EUS Guided Celiac Plexus Block for Chronic Pancreatitis | Pancreatitis, Chronic;Pancreatitis | Procedure: Celiac Block with triamcinolone and bupivicaine;Procedure: No Celiac Block;Drug: Intra Plexus Triamcinolone and Bupivicaine Injection | University of Southern California | NULL | Terminated | 18 Years | N/A | All | 1 | N/A | United States |
| 32 | NCT02384018 (ClinicalTrials.gov) | December 2014 | 16/12/2014 | Mesenchymal Stem Cell and Islet Co-transplantation | A Phase I Study Evaluating Safety and Tolerability of Autologous Bone Marrow-derived Mesenchymal Stromal Cells in Chronic Pancreatitis Patients Who Undergo Total Pancreatectomy and Islet Autotransplantation. | Chronic Pancreatitis;Diabetes | Biological: autologous mesenchymal stromal cell | Medical University of South Carolina | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Active, not recruiting | 18 Years | 69 Years | All | 24 | Phase 1 | United States |
| 33 | NCT01967888 (ClinicalTrials.gov) | February 2014 | 18/10/2013 | Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation | A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Assignment Study to Assess the Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation | Pancreatectomy for Chronic Pancreatitis | Drug: Reparixin;Drug: Placebo | Dompé Farmaceutici S.p.A | NULL | Completed | 18 Years | N/A | All | 104 | Phase 2/Phase 3 | United States;Canada |
| 34 | EUCTR2013-003357-17-DK (EUCTR) | 01/11/2013 | 04/11/2013 | The Ketamine - a novel approach to treating painful chronic pancreatitis. | RESET TrialA randomized, double-blinded, single-centre, parallel-group, placebo-controlled, prospective trial of S-ketamine for pain treatment in chronic pancreatitis (RESET trial) - RESET Trial | Chronic Pancreatitis MedDRA version: 17.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis;System Organ Class: 100000004856 MedDRA version: 17.1;Level: HLT;Classification code 10033646;Term: Acute and chronic pancreatitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06] | Trade Name: S-Ketamin Product Name: S-ketamin Trade Name: Midazolam Product Name: Midazolam | Prof. Asbjørn Mohr Drewes | NULL | Not Recruiting | Female: yes Male: yes | 60 | Phase 4 | Denmark | ||
| 35 | JPRN-UMIN000013182 | 2013/10/16 | 18/02/2014 | Efficacy of the pancrelipase for early chronic pancreatitis | early chronic pancreatitis | Pancrelipase no treatment | Fukushima Medical University Aizu Medical Center | NULL | Recruiting | Not applicable | Not applicable | Male and Female | 60 | Not selected | Japan | |
| 36 | EUCTR2012-004170-26-IT (EUCTR) | 04/12/2012 | 11/10/2012 | Randomized double blinde placebo controlled trial to evaluate the efficacy of N-acetylcystein in patients with chronic pancreatitis and primary sclerosing cholangitis. | Randomized double blinde placebo controlled trial to evaluate the efficacy of N-acetylcystein in patients with chronic pancreatitis and primary sclerosing cholangitis. | Chronic pancreatitis and primary sclerosing cholangitis MedDRA version: 15.0;Level: PT;Classification code 10033649;Term: Pancreatitis chronic;System Organ Class: 10017947 - Gastrointestinal disorders MedDRA version: 15.0;Classification code 10008609;Term: Cholangitis sclerosing;System Organ Class: 10019805 - Hepatobiliary disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06] | Trade Name: FLUIMUCIL*20CPR EFF 600MG INN or Proposed INN: ACETYLCYSTEINE | POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI | NULL | Not Recruiting | Female: yes Male: yes | 200 | Italy | |||
| 37 | NCT01551511 (ClinicalTrials.gov) | October 2012 | 7/2/2012 | ?9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain | ?9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain: a Randomized, Double-blinded, Placebo-controlled, Parallel Design | Pancreatitis, Chronic;Abdominal Pain;Chronic Pain | Drug: Tetrahydrocannabinol;Drug: Placebo | Radboud University | European Union | Completed | 18 Years | N/A | Both | 29 | Phase 2 | Netherlands |
| 38 | EUCTR2012-000730-19-NL (EUCTR) | 23/08/2012 | 12/03/2012 | ?9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain | The analgesic efficacy of ?9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain: a Randomized, Double-blinded, Placebo-controlled, Parallel Design - Delta-Pain II | Chronic pancreatitis with persistant abdominal pain MedDRA version: 14.1;Level: PT;Classification code 10033649;Term: Pancreatitis chronic;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | Product Name: Namisol Product Code: A04AD10 INN or Proposed INN: DRONABINOL Other descriptive name: Tetrahydro-6,6,9-tri methyl-3-penthyl-6 H-dibenzo[ b,d ]pyran-1-ol | Radboud University Nijmegen Medical Centre | NULL | Not Recruiting | Female: yes Male: yes | 68 | Phase 2 | Netherlands | ||
| 39 | JPRN-UMIN000008340 | 2012/08/01 | 04/07/2012 | pancreatic exocrine function with non-contrast MRI:Visualization by Means of MRCP with Spatially Selective Inversion-Recovery Pulse | Chronic pancreatitis | MRCP/PFD test MRCP | the Department of Diagnostic Radiology Kawasaki Medical School | NULL | Complete: follow-up complete | Not applicable | Not applicable | Male and Female | 40 | Not selected | Japan | |
| 40 | JPRN-UMIN000009547 | 2012/08/01 | 01/01/2013 | Prospectivestudy on the treatment effect of pancrelipase on chronic pancreatitis patient's alubumin concentration | Chronic pancreatitis | 600mg of Pancrelipase (granules or capsels) to be taken three times a day (1800mg /day) after meals for 4 weeks. | Department of Internal Medicine Second Teaching Hospital Fujita Health University School of Medicine | NULL | Recruiting | 20years-old | Not applicable | Male and Female | 83 | Not applicable | Japan | |
| 41 | NCT02458118 (ClinicalTrials.gov) | June 2012 | 27/5/2015 | Pancreatic Perfusion Using Secretin and MRI | Study to Assess Pancreatic Blood Flow at Rest and During Stimulation Using Magnetic Resonance Imaging (fMRI) in Patients With Chronic Pancreatitis | Chronic Pancreatitis | Drug: Secretin | University of Nottingham | NULL | Recruiting | 18 Years | 80 Years | Both | 15 | Phase 1/Phase 2 | United Kingdom |
| 42 | NCT01528540 (ClinicalTrials.gov) | April 2012 | 27/1/2012 | Evaluation of Efficacy of Combination of Pregabalin and Antioxidant in Reducing Pain in Chronic Pancreatitis: a Randomized Control Trial | Evaluation of Efficacy of Combination of Pregabalin and Antioxidant in Reducing Pain in Chronic Pancreatitis: a RCT | Chronic Pancreatitis | Drug: Placebo;Drug: Antioxidant plus Pregabalin | Asian Institute of Gastroenterology, India | NULL | Completed | 18 Years | 65 Years | Both | 87 | N/A | India |
| 43 | NCT01318590 (ClinicalTrials.gov) | November 18, 2011 | 17/3/2011 | Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis | Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis | Pancreatitis, Chronic | Drug: EUS procedure with drug injection;Other: EUS procedure | Centre hospitalier de l'Université de Montréal (CHUM) | Centre de Recherche du Centre Hospitalier de l'Université de Montréal;Erasme University Hospital | Terminated | 18 Years | N/A | All | 2 | Phase 3 | Belgium;Canada |
| 44 | NCT01430234 (ClinicalTrials.gov) | October 2011 | 1/9/2011 | Enzyme Suppletion in Exocrine Pancreatic Dysfunction | Enzyme Substitution in Exocrine Pancreatic Insufficiency; Self Administration Against a Fixed Dose Regimen | Chronic Pancreatitis;Exocrine Pancreatic Insufficiency | Drug: Panzytrat 25.000 FIP-E units of Lipase | Foundation for Liver Research | Axcan Pharma | Completed | 18 Years | 90 Years | Both | 10 | Phase 4 | Netherlands |
| 45 | NCT01318369 (ClinicalTrials.gov) | October 2011 | 9/3/2011 | Efficacy Study of ?9-THC to Treat Chronic Abdominal Pain | The Safety, Tolerability, and Analgesic Efficacy of ?9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain | Cannabinoid;Tetrahydrocannabinol;Chronic Pancreatitis;Abdominal Pain | Drug: Namisol;Drug: Diazepam | Radboud University | NULL | Completed | 18 Years | N/A | Both | 24 | Phase 2 | Netherlands |
| 46 | EUCTR2010-020303-69-NL (EUCTR) | 19/09/2011 | 19/09/2011 | Enzyme substitution in exocrine pancreatic insufficiency; Self administration against a fixed dose regimen. - SAPES | Enzyme substitution in exocrine pancreatic insufficiency; Self administration against a fixed dose regimen. - SAPES | Exocrine pancreatic insufficiency in patients with chronic pancreatitis MedDRA version: 12.1;Level: LLT;Classification code 10041969;Term: Steatorrhoea | Trade Name: Panzytrat Product Name: Panzytrat Product Code: RVG 13760 INN or Proposed INN: pancreatic enzymes Other descriptive name: LIPASE | Erasmus MC | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 20 | Netherlands | |||
| 47 | EUCTR2011-000647-24-NL (EUCTR) | 26/07/2011 | 12/05/2011 | Efficacy study of ?9-THC to treat persistent abdominal pain as a result of chronic pancreas inflammation | The safety, tolerability, and analgesic efficacy of ?9-THC (Namisol®) in chronic pancreatitis patients suffering from persistent abdominal pain - ?9-THC in chronic pain | patients with abdominal pain as a result of chronic pancreatitis MedDRA version: 13.1;Level: PT;Classification code 10033649;Term: Pancreatitis chronic;System Organ Class: 10017947 - Gastrointestinal disorders MedDRA version: 13.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06] | Product Name: Namisol Product Code: A04AD10 INN or Proposed INN: DRONABINOL | Radboud University Nijmegen Medical Centre | NULL | Not Recruiting | Female: no Male: yes | Netherlands | ||||
| 48 | NCT04574297 (ClinicalTrials.gov) | January 1, 2011 | 27/9/2020 | An Observational Study on the Natural Course of Chronic Pancreatitis | The Impact of Genetic and Environmental Factors on the Progression of Chronic Pancreatitis:An Observational Study | Chronic Pancreatitis;Genetic Mutation;Smoking, Tobacco;Drinking, Alcohol | Behavioral: smoking and alcohol assumption;Diagnostic Test: genetic sequencing | Changhai Hospital | NULL | Active, not recruiting | N/A | N/A | All | 965 | NULL | |
| 49 | NCT01265875 (ClinicalTrials.gov) | December 2010 | 22/12/2010 | Secretin Infusion for Pain Due to Chronic Pancreatitis | Secretin Infusion for Pain Due to Chronic Pancreatitis | Chronic Pancreatitis | Drug: Human Secretin | ChiRhoClin, Inc. | Dartmouth-Hitchcock Medical Center | Completed | 18 Years | 70 Years | All | 12 | Phase 1/Phase 2 | United States |
| 50 | NCT01146561 (ClinicalTrials.gov) | October 13, 2010 | 24/5/2010 | Safety And Efficacy Of Tanezumab In Patients With Chronic Pancreatitis | A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY OF THE ANALGESIC EFFICACY AND SAFETY OF TANEZUMAB IN PATIENTS WITH CHRONIC PANCREATITIS | Chronic Pancreatitis | Biological: Tanezumab;Other: Placebo | Pfizer | NULL | Terminated | 18 Years | 99 Years | All | 2 | Phase 2 | United States |
| 51 | NCT01452217 (ClinicalTrials.gov) | September 2010 | 10/10/2011 | Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers | The Use of Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy Volunteers | Chronic Pancreatitis | Drug: Secretin | University of Nottingham | NULL | Completed | 18 Years | 75 Years | Male | 12 | Phase 1 | United Kingdom |
| 52 | NCT01159119 (ClinicalTrials.gov) | August 2, 2010 | 5/7/2010 | A Study of EUR-1066 in Subjects With Chronic Pancreatitis, Exocrine Pancreatic Insufficiency and Chronic Abdominal Pain | Single Center Randomized Single Blind Crossover Group Active Control Study to Evaluate Safety and Efficacy of EUR-1066 a Pancreatic Enzyme Product in Patients With Chronic Pancreatitis Exocrine Pancratic Insufficiency,Chronic Abdominal Pain | Chronic Pancreatitis | Drug: EUR-1066-A;Drug: Zenpep;Drug: EUR-1066-B | Forest Laboratories | University of Florida | Terminated | 18 Years | N/A | All | 15 | Phase 1 | United States |
| 53 | NCT01236053 (ClinicalTrials.gov) | June 2010 | 14/10/2010 | Cancer in Patients With Gabapentin (GPRD) | Risk of Cancer in Patients Exposed to Gabapentin in the GPRD | Pain, Neuropathic;Epilepsy;Renal Pelvis Cancer;Pancreatic Cancer;Breast Cancer;Nervous System Cancer;Chronic Pancreatitis;Stomach Cancer;Renal Cell Carcinoma;Diabetes;Bladder Cancer;Bone and Joint Cancer;Penis Cancer;Anal Cancer;Cancer;Renal Cancer | Drug: Gabapentin prescriptions | GlaxoSmithKline | NULL | Completed | N/A | N/A | All | 2323608 | N/A | NULL |
| 54 | EUCTR2010-018900-10-FR (EUCTR) | 11/05/2010 | 19/03/2010 | Safety and preliminary clinical activity of Yarrowia lipolytica lipase (MS1819) in patients with malabsorption syndrome due to exocrine pancreatic insufficiency resulting from chronic pancreatitis | Safety and preliminary clinical activity of Yarrowia lipolytica lipase (MS1819) in patients with malabsorption syndrome due to exocrine pancreatic insufficiency resulting from chronic pancreatitis | Exocrine pancreatic insufficiency resulting from chronic pancreatitis MedDRA version: 12.1;Level: LLT;Classification code 10033628;Term: Pancreatic insufficiency | Product Name: MS1819 Product Code: MS1819 INN or Proposed INN: Yarrowia lipolytica lipase | Laboratoires Mayoly Spindler | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 12 | France | |||
| 55 | EUCTR2005-000562-38-DE (EUCTR) | 20/04/2010 | 29/09/2005 | RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED PHASE IV TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF A GASTRO-RESISTANT FILM-COATED PANCREATIN TABLET FOR LIPID DIGESTION AND ABSORPTION IN PATIENTS WITH PANCREATIC EXOCRINE INSUFFICIENCY DUE TO CHRONIC PANCREATITIS BY MEANS OF13C-MIXED TRIGLYCERIDE BREATH TEST - CPI 002 | RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED PHASE IV TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF A GASTRO-RESISTANT FILM-COATED PANCREATIN TABLET FOR LIPID DIGESTION AND ABSORPTION IN PATIENTS WITH PANCREATIC EXOCRINE INSUFFICIENCY DUE TO CHRONIC PANCREATITIS BY MEANS OF13C-MIXED TRIGLYCERIDE BREATH TEST - CPI 002 | The purpose of this trial is to evaluate the clinical efficacy and safety of a gastro-resistant film-coated tablet in comparison to placebo in the treatment of pancreatic exocrine insufficiency due to chronic pancreatitis MedDRA version: 7.0;Level: LLT;Classification code 10033628 | Trade Name: Mezym F Product Name: Mezym F Product Code: Pancreatin INN or Proposed INN: Pancreatin | Berlin-Chemie AG | NULL | Not Recruiting | Female: yes Male: yes | 20 | Phase 4 | Germany | ||
| 56 | EUCTR2009-016082-29-BE (EUCTR) | 10/03/2010 | 25/11/2009 | Role of Lanreotide in the Management of Paraduodenal Pancreatitis - LPP | Role of Lanreotide in the Management of Paraduodenal Pancreatitis - LPP | Paraduodenal pancreatitis MedDRA version: 12.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis | Trade Name: Somatuline Autogel 90 mg Other descriptive name: LANREOTIDE ACETATE | Erasme hospital | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 60 | Belgium | |||
| 57 | NCT01138124 (ClinicalTrials.gov) | March 2010 | 3/6/2010 | Gabapentin and Risk of Pancreatic Cancer and Renal Cancer (GPRD) | Risk of Pancreatic Cancer and Renal Cancer in Patients Exposed to Gabapentin in the United Kingdom General Practice Research Database | Renal Pelvis Cancer;Restless Legs Syndrome;Epilepsy;Neuropathic Pain;Chronic Pancreatitis;Hypertension;Pancreatic Cancer;Diabetes;Renal Cancer;Renal Cell Carcinoma | Drug: Gabapentin prescriptions | GlaxoSmithKline | NULL | Completed | N/A | N/A | All | 54202 | N/A | NULL |
| 58 | JPRN-UMIN000003020 | 2010/01/01 | 13/01/2010 | Establishment of pancreatic exocrine function assaay usin real time 13C breath test. | Chronic pancreatitis, state after pancreatectomy | Expiratory 13CO2 measurement after oral intake of 13C incorporated fatty acids and amino acids in healthy volunteers. Expiratory 13CO2 measurement after oral intake of 13C incorporated fatty acids and amino acids in patients after total pancreatectomy. Expiratory 13CO2 measurement after oral intake of 13C incorporated fatty acids and amino acids in patients after pancreatico duodenectomy. Expiratory 13CO2 measurement after oral intake of 13C incorporated fatty acids and amino acids in patients with chronic pancreatits. | Tohoku University Hospital | NULL | Recruiting | 20years-old | 80years-old | Male and Female | 8 | Not applicable | Japan | |
| 59 | NCT01001923 (ClinicalTrials.gov) | December 2009 | 26/10/2009 | Single Injection of REGN475/SAR164877 in the Treatment of Chronic Pancreatitis Pain | Randomized, Double-blind, Placebo-controlled Study of the Effect of a Single Injection of SAR164877 (REGN475) on Reduction of Pain From Chronic Pancreatitis | Abdominal Pain Upper | Drug: REGN475/SAR164877;Drug: Placebo (for REGN475/SAR164877) | Regeneron Pharmaceuticals | NULL | Terminated | 18 Years | 80 Years | Both | 15 | Phase 2 | United States |
| 60 | NCT01141998 (ClinicalTrials.gov) | December 2009 | 10/6/2010 | Vitamin D Substitution for Patients With Chronic Pancreatitis and Malabsorption | Vitamin D Substitution for Patients With Chronic Pancreatitis and Malabsorption | Chronic Pancreatitis;Malabsorption Syndromes | Drug: Calcium, Dietary;Drug: Cholecalciferol;Radiation: UVB;Radiation: UV-filtered light. | Hvidovre University Hospital | NULL | Completed | 18 Years | N/A | Both | 27 | N/A | Denmark |
| 61 | EUCTR2009-010266-28-NL (EUCTR) | 21/07/2009 | 29/01/2009 | Een gerandomiseerde dubbelblinde, placebogecontroleerde, klinische parallelle groep studie van pregabaline in patiënten met chronische pancreatitis - Effect van pregabaline therapie bij patiënten met chronische pancreatitis | Een gerandomiseerde dubbelblinde, placebogecontroleerde, klinische parallelle groep studie van pregabaline in patiënten met chronische pancreatitis - Effect van pregabaline therapie bij patiënten met chronische pancreatitis | chronische pancreatitis MedDRA version: 9.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis | Trade Name: Lyrica® | Afdeling heelkunde, Universitair Medisch Centrum Sint Radboud | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 30 | Netherlands | |||
| 62 | NCT01142128 (ClinicalTrials.gov) | February 2009 | 9/6/2010 | Viokase 16, Viokase16 Plus Nexium and Nexium Alone | A Randomized, Single Site, Double Blind, Fixed Dose, Cross Over Study of Viokase 16, Viokase16 Plus Nexium and Nexium Alone in the Reduction of Abdominal Pain in Patients With Chronic Pancreatitis | Chronic Pancreatitis | Drug: Nexium (esomeprazole magnesium);Drug: Placebo to Nexium;Drug: Viokase 16 (pancrelipase) + Nexium;Drug: Viokase 16 + placebo to Nexium | University of Florida | AstraZeneca | Terminated | 18 Years | 75 Years | All | 12 | Phase 1 | United States |
| 63 | NCT01259544 (ClinicalTrials.gov) | January 2009 | 12/12/2010 | BreathID® Test: A Non-invasive Modality to Detect Pancreatic Exocrine Insufficiency | Chronic Pancreatitis;Healthy Volunteers | Drug: benzoyl-L-tyrosyl-[1-13C]alanine (Bz-Tyr-Ala) | Exalenz Bioscience LTD. | Virginia Commonwealth University;Asian Institute of Gastroenterology, Hyderabad, India | Completed | 18 Years | N/A | Both | 33 | Phase 2 | India | |
| 64 | EUCTR2006-000087-83-GB (EUCTR) | 19/12/2008 | 04/12/2007 | EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2 | EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2 | Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis MedDRA version: 13.1;Level: HLT;Classification code 10033646;Term: Acute and chronic pancreatitis;System Organ Class: 10017947 - Gastrointestinal disorders MedDRA version: 13.1;Level: PT;Classification code 10056976;Term: Hereditary pancreatitis;System Organ Class: 10010331 - Congenital, familial and genetic disorders | Trade Name: Magnesiocard 2.5mmol Other descriptive name: MAGNESIUM ASPARTATE HYDROCHLORIDE Product Name: ANTOX (vers) 1.2 Product Code: ANTOX Other descriptive name: TOCOPHEROL INN or Proposed INN: ASCORBIC ACID Other descriptive name: SELENIUM INN or Proposed INN: METHIONINE | University of Liverpool | The Royal Liverpool and Broadgreen University Hospitals NHS Trust | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 240 | Phase 3 | United Kingdom | ||
| 65 | NCT00782795 (ClinicalTrials.gov) | November 2008 | 29/10/2008 | Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality | Phase II Study of Chronic Pancreatitis and the Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality | Chronic Pancreatitis;Insulin Resistance;Normal or Mildly Abnormal Stool Fat Levels | Drug: Pioglitazone;Drug: Placebo | University of Michigan | National Institute on Alcohol Abuse and Alcoholism (NIAAA);Takeda Pharmaceuticals North America, Inc. | Completed | 18 Years | 75 Years | All | 64 | Phase 2 | United States |
| 66 | NCT00755573 (ClinicalTrials.gov) | October 2008 | 18/9/2008 | Pain and Chronic Pancreatitis - Clinical End Experimental Studies | A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Clinical and Experimental Pilot Study of Pregabalin in Patients With Chronic Pancreatitis | Chronic Pancreatitis | Drug: Pregabalin;Drug: placebo | Aalborg Universitetshospital | Radboud University | Completed | 18 Years | 75 Years | Both | 64 | Phase 2/Phase 3 | Denmark;Netherlands |
| 67 | NCT00744250 (ClinicalTrials.gov) | August 2008 | 28/8/2008 | Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control | Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control in Patients With Pancreatic Insufficiency | Exocrine Pancreatic Insufficiency;Chronic Pancreatitis;Cystic Fibrosis | Drug: Pancrelipase | Digestive Care, Inc. | University of North Carolina, Chapel Hill | Terminated | 18 Years | N/A | Both | 3 | Phase 4 | United States |
| 68 | EUCTR2008-002671-27-DK (EUCTR) | 14/07/2008 | 30/05/2008 | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP CLINICAL AND EXPERIMENTAL PILOTSTUDY OF PREGABALIN IN PATIENTS WITH CHRONIC PANCREATITIS | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP CLINICAL AND EXPERIMENTAL PILOTSTUDY OF PREGABALIN IN PATIENTS WITH CHRONIC PANCREATITIS | Chronic pancreatitis MedDRA version: 9.1;Level: LLT;Classification code 10033649;Term: Pancreatitis chronic | Trade Name: Lyrica INN or Proposed INN: pregabalin INN or Proposed INN: Pregabalin | Department of Medical Gastroenterology | NULL | Not Recruiting | Female: yes Male: yes | 45 | Phase 3 | Denmark | ||
| 69 | NCT00401076 (ClinicalTrials.gov) | July 2008 | 16/11/2006 | A Open-label Study to Assess the Safety of Oral Long-term Use of SA-001 in Pancreatic Exocrine Insufficiency | A One-year Open-label Study to Assess the Safety of Oral Long-term Use of SA-001 in Patients With Pancreatic Exocrine Insufficiency Caused by Chronic Pancreatitis or by Pancreatectomy | Pancreatic Exocrine Insufficiency, Chronic Pancreatitis, Pancreatectomy | Drug: SA-001 | Abbott | NULL | Completed | 20 Years | N/A | Both | 80 | Phase 3 | Japan |
| 70 | NCT00705978 (ClinicalTrials.gov) | June 2008 | 26/6/2008 | Creon 40,000 for Treatment of PEI (Pancreatic Exocrine Insufficiency) Due to Chronic Pancreatitis | A One Week Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multi-Center Study With Creon 40,000 MMS in Subjects With Pancreatic Exocrine Insufficiency Due to Chronic Pancreatitis, Followed by an Open-Label Long-Term Extension | Pancreatic Insufficiency | Drug: Pancreatin;Drug: Placebo | Abbott Products | Quintiles, Datamap | Completed | 18 Years | N/A | Both | 62 | Phase 3 | India |
| 71 | EUCTR2007-000375-42-HU (EUCTR) | 07/04/2008 | 14/12/2007 | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | Pancreatic exocrine insufficiency due to chronic pancreatitis MedDRA version: 9.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis | Product Name: Recombinant microbial lipase Product Code: SLV339 | Solvay Pharmaceuticals GmbH | NULL | Not Recruiting | Female: yes Male: yes | 112 | Hungary;Czech Republic;Denmark;Latvia;Sweden | |||
| 72 | EUCTR2008-000061-37-IT (EUCTR) | 02/04/2008 | 08/05/2008 | A Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of two doses of Zentase? (EUR-1008) in Chronic Pancreatitis (CP) patients with Exocrine Pancreatic Insufficiency (EPI) - PR-002 | A Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of two doses of Zentase? (EUR-1008) in Chronic Pancreatitis (CP) patients with Exocrine Pancreatic Insufficiency (EPI) - PR-002 | Chronic Pancreatitis (CP) with Exocrine Pancreatic Insufficiency (EPI) MedDRA version: 9.1;Level: SOC;Classification code 10017947;Term: Gastrointestinal disorders | Product Name: ZENTASE INN or Proposed INN: Multienzymes (lipase, protease etc.) | EURAND SPA | NULL | Not Recruiting | Female: yes Male: yes | 72 | Italy | |||
| 73 | NCT00559052 (ClinicalTrials.gov) | March 2008 | 14/11/2007 | An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI) | An Open-Label Cross-over Study to Evaluate the Intraduodenal Delivery of Lipase, Protease and Amylase From Administration of VIOKASE16 in Chronic Pancreatitis Subjects With Exocrine Pancreatic Insufficiency (EPI). | Exocrine Pancreatic Insufficiency | Drug: VIOKASE 16 | Axcan Pharma | AAIPharma;Mayo Clinical Services;City Hospital Laboratory Birmingham | Completed | 18 Years | N/A | Both | 22 | Phase 2 | United States;Czech Republic |
| 74 | NCT00658736 (ClinicalTrials.gov) | March 2008 | 9/4/2008 | Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis | A Randomized, Triple-Blinded Study of Endoscopic Ultrasound Guided Celiac Plexus Blockade (EUS-CPB) With Bupivicaine and Triamcinolone vs. Bupivicaine Alone for the Treatment of Pain in Chronic Pancreatitis | Chronic Pancreatitis | Drug: Triamcinolone;Drug: Bupivicaine alone | The Cleveland Clinic | American Society for Gastrointestinal Endoscopy;TAP Pharmaceutical Products Inc. | Completed | 18 Years | N/A | All | 40 | Phase 3 | United States |
| 75 | EUCTR2007-004004-12-BG (EUCTR) | 28/02/2008 | 05/02/2008 | A STUDY TO INVESTIGATE THE EFFECT OF PANCRELIPASE DELAYED RELEASE CAPSULES ON MALDIGESTION IN PATIENTS WITH EXOCRINE PANCREATIC INSUFFICIENCY DUE TO CHRONIC PANCREATITIS AND PANCREATECTOMY | A STUDY TO INVESTIGATE THE EFFECT OF PANCRELIPASE DELAYED RELEASE CAPSULES ON MALDIGESTION IN PATIENTS WITH EXOCRINE PANCREATIC INSUFFICIENCY DUE TO CHRONIC PANCREATITIS AND PANCREATECTOMY | Pancreatic enzyme replacement therapy is the cornerstone of nutritional management of pancreatic exocrine insufficiency (PEI) due to e.g. cystic fibrosis, chronic pancreatitis, partial or complete pancreatectomy or gastrectomy. Without pancreatic enzyme replacement the patients suffer from severe symptoms of maldigestion as manifested by steatorrhea, abdominal pain, body weight loss etc. MedDRA version: 9.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis MedDRA version: 9.1;Classification code 10033596;Term: Pancreatectomy | Trade Name: Creon 10000 Product Name: Pancrelipase Delayed Release Capsule Other descriptive name: Pancrelipase/Pancreas Powder Trade Name: Creon 25000 Product Name: Pancrelipase Delayed Release Capsule Other descriptive name: Pancrelipase/Pancreas Powder | Solvay Pharmaceuticals GmbH | NULL | Not Recruiting | Female: yes Male: yes | 52 | Bulgaria | |||
| 76 | EUCTR2007-000375-42-DK (EUCTR) | 21/02/2008 | 23/10/2007 | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | Pancreatic exocrine insufficiency due to chronic pancreatitis MedDRA version: 9.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis | Product Name: Recombinant microbial lipase Product Code: SLV339 | Solvay Pharmaceuticals GmbH | NULL | Not Recruiting | Female: yes Male: yes | 80 | Hungary;Czech Republic;Denmark;Latvia;Sweden | |||
| 77 | EUCTR2007-000375-42-CZ (EUCTR) | 08/02/2008 | 17/12/2007 | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | Pancreatic exocrine insufficiency due to chronic pancreatitis MedDRA version: 9.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis | Product Name: Recombinant microbial lipase Product Code: SLV339 | Solvay Pharmaceuticals GmbH | NULL | Not Recruiting | Female: yes Male: yes | 80 | Hungary;Czech Republic;Denmark;Latvia;Sweden | |||
| 78 | EUCTR2007-000375-42-LV (EUCTR) | 05/02/2008 | 12/02/2008 | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | Pancreatic exocrine insufficiency due to chronic pancreatitis MedDRA version: 9.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis | Product Name: Recombinant microbial lipase Product Code: SLV339 | Solvay Pharmaceuticals GmbH | NULL | Not Recruiting | Female: yes Male: yes | 80 | Hungary;Czech Republic;Denmark;Latvia;Sweden | |||
| 79 | NCT00621283 (ClinicalTrials.gov) | February 2008 | 22/1/2008 | Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric Population | RG1068 (Synthetic Human Secretin) Enhanced MRCP for Morphological Evaluation of the Pancreatic Duct in the Pediatric Population | Acute Recurrent Pancreatitis;Chronic Pancreatitis | Drug: RG1068 (Synthetic Human Secretin) | Massachusetts General Hospital | NULL | Terminated | 2 Years | 18 Years | Both | 0 | Phase 1 | United States |
| 80 | NCT00620919 (ClinicalTrials.gov) | February 2008 | 22/1/2008 | Secretin Enhanced Multidetector CT Pancreatography for Evaluation of Known or Suspected Chronic Pancreatitis | RG1068 (Synthetic Human Secretin) Enhanced Multidetector CT Pancreatography: Evaluation of the Pancreatic Duct in Patients With Known or Suspected Chronic Pancreatitis | Chronic Pancreatitis | Drug: RG1068 (Synthetic Human Secretin) | Massachusetts General Hospital | NULL | Terminated | 18 Years | 90 Years | Both | 0 | Phase 1 | United States |
| 81 | NCT00630279 (ClinicalTrials.gov) | February 2008 | 22/2/2008 | Dose-ranging Study to Evaluate Efficacy of SLV339 in Pancreatic Exocrine Insufficiency Due to Chronic Pancreatitis | A Multi-center, Single-blind, Parallel-design, Randomized, Placebo-controlled, Dose-ranging Study to Evaluate Oral Recombinant Microbial Lipase Efficacy in Patients With Pancreatic Exocrine Insufficiency Due to Chronic Pancreatitis | Pancreatic Exocrine Insufficiency Due to Chronic Pancreatitis | Drug: Placebo;Drug: Recombinant Microbial Lipase SLV339 | Solvay Pharmaceuticals | NULL | Terminated | 18 Years | N/A | Both | 56 | Phase 2 | Czech Republic;Denmark;Hungary;Latvia;Poland;Russian Federation;Sweden |
| 82 | NCT00788593 (ClinicalTrials.gov) | January 2008 | 10/11/2008 | A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI) | A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 in Chronic Pancreatitis (CP) Patients With Exocrine Pancreatic Insufficiency (EPI) | Chronic Pancreatitis;Exocrine Pancreatic Insufficiency | Drug: Placebo;Drug: EUR-1008 (APT-1008) High Dose;Drug: EUR-1008 (APT-1008) Low Dose | Forest Laboratories | NULL | Completed | 18 Years | N/A | All | 82 | Phase 3 | United States;Italy;Ukraine |
| 83 | EUCTR2007-000375-42-SE (EUCTR) | 21/12/2007 | 26/10/2007 | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | A multi-center, double-blind, parallel-design, randomized,placebo-controlled, dose-ranging study to assess the efficacy andsafety of oral recombinant microbial lipase (SLV339) in subjectswith pancreatic exocrine insufficiency due to chronic pancreatitis | Pancreatic exocrine insufficiency due to chronic pancreatitis MedDRA version: 9.1;Level: LLT;Classification code 10009093;Term: Chronic pancreatitis | Product Name: Recombinant microbial lipase Product Code: SLV339 | Solvay Pharmaceuticals GmbH | NULL | Not Recruiting | Female: yes Male: yes | 80 | Hungary;Czech Republic;Denmark;Latvia;Sweden | |||
| 84 | NCT00500084 (ClinicalTrials.gov) | December 2007 | 10/7/2007 | Phase III ALTU-135 CP Safety Trial | An Open-Label Clinical Study Evaluating the Long Term Safety of ALTU-135 in the Treatment of Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis or Pancreatectomy | Exocrine Pancreatic Insufficiency | Drug: Liprotamase | Anthera Pharmaceuticals | NULL | Terminated | 18 Years | N/A | Both | 39 | Phase 3 | United States |
| 85 | NCT00559364 (ClinicalTrials.gov) | November 2007 | 14/11/2007 | Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea | A Multicenter, Randomized, Double-blind, Parallel, Placebo-controlled, Phase III Study to Assess the Safety and Efficacy of Viokase® 16 for the Correction of Steatorrhea in Patients With Exocrine Pancreatic Insufficiency | Exocrine Pancreatic Insufficiency;Chronic Pancreatitis;Pancreatectomy | Drug: Viokase® 16;Drug: Placebo;Drug: Proton pump inhibitor (PPI);Drug: Omeprazole | Forest Laboratories | NULL | Completed | 18 Years | 80 Years | All | 50 | Phase 3 | United States;Canada;Poland;Slovakia;Germany |
| 86 | NCT00414908 (ClinicalTrials.gov) | October 2007 | 21/12/2006 | A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and Pancreatectomy | A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and Pancreatectomy | Chronic Pancreatitis;Pancreatectomy;Pancreatic Exocrine Insufficiency | Drug: Pancrelipase delayed release capsule;Drug: Placebo Comparator | Solvay Pharmaceuticals | NULL | Completed | 18 Years | N/A | All | 52 | Phase 3 | United States;Bulgaria;Poland;Puerto Rico;Russian Federation;Serbia;South Africa;Ukraine;Former Serbia and Montenegro |
| 87 | EUCTR2006-006958-10-GB (EUCTR) | 26/09/2007 | 01/08/2007 | Anticipate Trial - Randomized, Double blind, placebo-controlled, multicentre Trial of Anti-oxidant therapy in painful chronic pancreatitis. - Aniticipate trial | Anticipate Trial - Randomized, Double blind, placebo-controlled, multicentre Trial of Anti-oxidant therapy in painful chronic pancreatitis. - Aniticipate trial | Chronic Pancreatitis | Product Name: Antox version 1.2 | Pharmanord, UK, LTD | NULL | Not Recruiting | Female: yes Male: yes | 60 | Phase 2 | United Kingdom | ||
| 88 | NCT00400842 (ClinicalTrials.gov) | May 2007 | 16/11/2006 | A Study of SA-001 to Treat Pancreatic Exocrine Insufficiency | A Double-blind, Placebo-controlled, Parallel-group, Comparative Study to Confirm the Safety and Efficacy of Oral 1.5 g/Day and 3.0 g/Day of SA-001 in Patients With Pancreatic Exocrine Insufficiency Caused by Chronic Pancreatitis or by Pancreatectomy | Exocrine Pancreatic Insufficiency, Chronic Pancreatitis | Drug: SA-001;Drug: Placebo | Abbott | NULL | Completed | 20 Years | N/A | Both | 274 | Phase 3 | Japan |
| 89 | NCT00588367 (ClinicalTrials.gov) | April 2006 | 24/12/2007 | CT Pancreas Perfusion | CT Perfusion of Pancreatic Cancer and Chronic Pancreatitis: Feasibility Study | Pancreatic Ductal Adenocarcinoma;Chronic Pancreatitis;Autoimmune Pancreatitis | Device: Mayo Interactive Breath Hold Monitor | Mayo Clinic | NULL | Completed | 18 Years | N/A | Both | 30 | N/A | United States |
| 90 | NCT00156403 (ClinicalTrials.gov) | August 2005 | 8/9/2005 | A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis | Hereditary Pancreatitis Amlodipine Trial(H-PAT): A Pilot Study | Pancreatitis | Drug: amlodipine (drug) | University of Pittsburgh | National Center for Research Resources (NCRR) | Completed | 6 Years | N/A | Both | 8 | Phase 1/Phase 2 | United States |
| 91 | NCT00469703 (ClinicalTrials.gov) | August 2005 | 3/5/2007 | Safety and Efficacy Study of Thalomid in Patients With Chronic Pancreatitis | A Phase II, Open-Label, Single Center Pilot Study to Determine the Safety and Efficacy of THALOMID (Thalidomide) in Patients With Chronic Pancreatitis. | Chronic Pancreatitis | Drug: Thalidomide | Winthrop University Hospital | Celgene Corporation | Terminated | 18 Years | 75 Years | Both | 10 | Phase 2 | United States |
| 92 | EUCTR2005-000736-24-DE (EUCTR) | 14/07/2005 | 13/05/2005 | RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED PHASE IV TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF AN ENTERIC-COATED PANCREATIN TABLET FOR LIPID DIGESTION AND ABSORPTION IN PATIENTS WITH PANCREATIC EXOCRINE INSUFFICIENCY DUE TO CHRONIC PANCREATITIS BY MEANS OF 13C-MIXED TRIGLYCERIDE BREATH TEST - CPI 003 | RANDOMISED, DOUBLE BLIND, PLACEBO CONTROLLED PHASE IV TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF AN ENTERIC-COATED PANCREATIN TABLET FOR LIPID DIGESTION AND ABSORPTION IN PATIENTS WITH PANCREATIC EXOCRINE INSUFFICIENCY DUE TO CHRONIC PANCREATITIS BY MEANS OF 13C-MIXED TRIGLYCERIDE BREATH TEST - CPI 003 | The purpose of this trial is to evaluate the clinical efficacy and safety of an enteric-coated pancreatin tablet in comparison to placebo in the treatment of pancreatic exocrine insufficiency due to chronic pancreatitis. MedDRA version: 7.0;Level: LLT;Classification code 10033628 | Trade Name: Helopanflat Mono® Product Name: Helopanflat Mono® Product Code: Pancreatin INN or Proposed INN: Pancreatin | Berlin-Chemie AG | NULL | Not Recruiting | Female: yes Male: yes | 20 | Phase 4 | Germany | ||
| 93 | NCT00142233 (ClinicalTrials.gov) | June 6, 2005 | 31/8/2005 | EUROPAC-2 - Pain Treatment of Hereditary and Idiopathic Pancreatitis | Double Blind Randomised Controlled Trial to Investigate the Efficacy of ANTOX (Vers) 1.2 and MGCT (Magnesiocard) for the Treatment of Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis | Pancreatitis | Dietary Supplement: ANTOX (vers.)1.2;Drug: Magnesium;Other: Placebo ANTOX (vers)1.2;Other: Placebo Magnesiocard (2.5 mmol) | University Medicine Greifswald | NULL | Completed | 5 Years | 75 Years | All | 295 | Phase 3 | Germany |
| 94 | NCT01154608 (ClinicalTrials.gov) | April 2005 | 30/6/2010 | Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis | Pancreatitis | Drug: Creon;Other: No enzyme therapy | Institut National de la Recherche Agronomique | National Research Agency, France;Solvay Pharmaceuticals | Completed | 18 Years | N/A | Both | 11 | N/A | France | |
| 95 | EUCTR2004-002468-89-DE (EUCTR) | 28/10/2004 | 23/09/2004 | A RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED PHASE IV TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF PANCREATIN VS. PLACEBO FOR LIPID DIGESTION AND ABSORPTION IN PATIENTS WITH PANCREATIC EXOCRINE INSUFFICIENCY - Pancreatin vs. Placebo in Patients with Pancreatic Exocrine Insufficiency | A RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED PHASE IV TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF PANCREATIN VS. PLACEBO FOR LIPID DIGESTION AND ABSORPTION IN PATIENTS WITH PANCREATIC EXOCRINE INSUFFICIENCY - Pancreatin vs. Placebo in Patients with Pancreatic Exocrine Insufficiency | The purpose of this clinical trial is to evaluate the clinical efficacy and safety of a capsule containing enteric-coated porcine pancreatin microfilm tablets in comparison with placebo in the treatment of pancreatic exocrine insufficiency due to chronic pancreatitis. MedDRA version: 7.0;Level: LLT;Classification code 10033622 | Trade Name: Panzytrat 25.000 Product Name: Panzytrat 25.000 Product Code: Pancreatin INN or Proposed INN: Pancreatin | Axcan Pharma S.A. | NULL | Not Recruiting | Female: yes Male: yes | 20 | Phase 4 | Germany | ||
| 96 | NCT00957151 (ClinicalTrials.gov) | April 2004 | 11/8/2009 | Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis | Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis | Chronic Pancreatitis | Drug: Creon | Hospital Avicenne | Solvay Pharmaceuticals | Completed | 18 Years | 65 Years | Both | 12 | Phase 4 | France |
| 97 | NCT00319358 (ClinicalTrials.gov) | October 2003 | 26/4/2006 | Role of Antioxidants Supplementation in Chronic Pancreatitis | Effect of Antioxidant Supplementation on Pain, Antioxidant Profile and Oxidative Stress in Patients With Chronic Pancreatitis | Chronic Pancreatitis | Dietary Supplement: Antioxidants;Dietary Supplement: Placebo | All India Institute of Medical Sciences, New Delhi | NULL | Completed | 12 Years | 70 Years | Both | 127 | Phase 3 | India |
| 98 | NCT00583271 (ClinicalTrials.gov) | June 2002 | 20/12/2007 | A Prospective Study of EUS Guided Celiac Block | A Prospective Study of Endoscopic Ultrasound-guided Celiac (CB) Effectiveness | Chronic Pancreatitis;Pancreatic Cancer | Drug: triamcinolone;Drug: 98% dehydrated alcohol | Indiana University | NULL | Completed | 18 Years | N/A | Both | 127 | N/A | United States |