36. 表皮水疱症 Epidermolysis bullosa Clinical trials / Disease details

臨床試験数 : 160 / 薬物数 : 195 - (DrugBank : 47) / 標的遺伝子数 : 50 - 標的パスウェイ数 : 124

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04173650 (ClinicalTrials.gov)	April 2022	18/11/2019	MSC EVs in Dystrophic Epidermolysis Bullosa	A Safety Study of the Administration of Mesenchymal Stem Cell Extracellular Vesicles in the Treatmen ...	Dystrophic Epidermolysis Bullosa	Drug: AGLE 102	Aegle Therapeutics	NULL	Not yet recruiting	6 Years	N/A	All	10	Phase 1/Phase 2	NULL
2	EUCTR2021-000214-42-ES (EUCTR)	08/03/2022	17/12/2021	INM-755 cream for patients with EB.	A Randomised, Double-Blind, Vehicle-Controlled Phase 2 Study of Topically Applied INM-755 (cannabino ...	Epidermolysis bullosa MedDRA version: 20.0;Level: PT;Classification code 10014989;Term: Epidermolysi ...	Product Name: Cannabinol (CBN) Product Code: INM-755 INN or Proposed INN: CANNABINOL	InMed Pharmaceuticals Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 2	France;Serbia;Greece;Spain;Austria;Israel;Germany;Italy
3	NCT05111600 (ClinicalTrials.gov)	March 2022	1/9/2021	Open-label, Pivotal Clinical Trial to Confirm Efficacy and Safety of Autologous Grafts Containing St ...	Multicentre, Open-label, Uncontrolled, Pivotal Clinical Trial to Confirm the Efficacy and Safety of ...	Junctional Epidermolysis Bullosa Non-Herlitz Type	Drug: Transplantation	Holostem Terapie Avanzate s.r.l.	IRCCS San Raffaele;University of Modena and Reggio Emilia	Not yet recruiting	6 Months	65 Years	All	6	Phase 2/Phase 3	France;Germany;Italy
4	NCT05062070 (ClinicalTrials.gov)	November 15, 2021	21/9/2021	Safety and Efficacy of Topical TolaSure Targeting Aggregated Mutant Keratin in Severe Epidermolysis ...	A Phase I/II, Closed Label, Randomized, Pilot Study for the Safety and Efficacy of TolaSure Gel, 5% ...	Epidermolysis Bullosa Simplex	Drug: TolaSure Topical Gel;Drug: Vehicle Topical Gel	BioMendics, LLC	NULL	Not yet recruiting	18 Years	N/A	All	5	Phase 1	United States
5	EUCTR2018-000261-36-IT (EUCTR)	07/09/2021	07/10/2020	Gene Therapy for patient with Junctional Epidermolysis Bullosa	MULTICENTRE, OPEN-LABEL, UNCONTROLLED, PIVOTAL CLINICAL TRIAL TO CONFIRM THE EFFICACY AND SAFETY OF ...	Inherited Epidermolysis Bullosa(EB) is a group of rare, devastating genetic disorders characterized ...	Product Name: Hologene 5 Product Code: [Hologene 5 DS] Other descriptive name: Ex-vivo expanded autolog ...	HOLOSTEM TERAPIE AVANZATE S.R.L.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	6	Phase 2;Phase 3	France;Germany;Italy
6	NCT04177498 (ClinicalTrials.gov)	August 24, 2021	7/11/2019	Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCC	A Pilot, Open Study to Assess Efficacy and Safety of Rigosertib in Patients With Recessive Dystrophi ...	Recessive Dystrophic Epidermolysis Bullosa	Drug: Rigosertib Sodium;Other: Quality-of-Life Assessment	Thomas Jefferson University	Onconova Therapeutics, Inc.	Recruiting	18 Years	79 Years	All	6	Early Phase 1	United States
7	EUCTR2021-000214-42-AT (EUCTR)	01/08/2021	29/04/2021	INM-755 cream for patients with EB.	A Randomised, Double-Blind, Vehicle-Controlled Phase 2 Study of Topically Applied INM-755 (cannabino ...	Epidermolysis bullosa MedDRA version: 20.0;Level: PT;Classification code 10014989;Term: Epidermolysi ...	Product Name: Cannabinol (CBN) Product Code: INM-755 INN or Proposed INN: CANNABINOL	InMed Pharmaceuticals Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 2	France;Serbia;Greece;Austria;Israel;Germany;Italy
8	NCT04908215 (ClinicalTrials.gov)	August 2021	26/5/2021	INM-755 (Cannabinol) Cream for Treatment of Epidermolysis Bullosa	A Randomised, Double-Blind, Vehicle-Controlled Phase 2 Study of Topically Applied INM-755 (Cannabino ...	Epidermolysis Bullosa Simplex;Epidermolysis Bullosa, Junctional;Epidermolysis Bullosa Dystrophica;Ki ...	Drug: INM-755 (cannabinol) cream;Drug: Vehicle Cream	InMed Pharmaceuticals Inc.	NULL	Not yet recruiting	12 Years	N/A	All	20	Phase 2	NULL
9	EUCTR2021-000214-42-GR (EUCTR)	22/07/2021	22/06/2021	INM-755 cream for patients with EB.	A Randomised, Double-Blind, Vehicle-Controlled Phase 2 Study of Topically Applied INM-755 (cannabino ...	Epidermolysis bullosa MedDRA version: 20.0;Level: PT;Classification code 10014989;Term: Epidermolysi ...	Product Name: Cannabinol (CBN) Product Code: INM-755 INN or Proposed INN: CANNABINOL	InMed Pharmaceuticals Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 2	France;Serbia;Greece;Austria;Israel;Germany;Italy
10	NCT04917874 (ClinicalTrials.gov)	May 25, 2021	2/6/2021	A Long-term Treatment With B-VEC for Dystrophic Epidermolysis Bullosa	Open Label Treatment of Beremagene Geperpavec (B-VEC)	Dystrophic Epidermolysis Bullosa;DEB- Dystrophic Epidermolysis Bullosa;Recessive Dystrophic Epidermo ...	Biological: Open Label Topical Beremagene Geperpavec (B-VEC)	Krystal Biotech, Inc.	NULL	Recruiting	6 Months	N/A	All	30	Phase 3	United States

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