4. 原発性側索硬化症 Primary lateral sclerosis Clinical trials / Disease details
臨床試験数 : 7 / 薬物数 : 17 - (DrugBank : 9) / 標的遺伝子数 : 19 - 標的パスウェイ数 : 32
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04825613 (ClinicalTrials.gov) | June 1, 2021 | 25/3/2021 | Individual Patient Expanded Access IND to Treat Primary Lateral Sclerosis | Individual Patient Expanded Access IND to Evaluate the Safety and Efficacy of HB-adMSCs for the Treatment of Primary Lateral Sclerosis | Primary Lateral Sclerosis, Adult, 1 | Biological: HB-adMSCs | Hope Biosciences Stem Cell Research Foundation | Hope Biosciences | Temporarily not available | 18 Years | N/A | Male | United States | ||
| 2 | NCT03929068 (ClinicalTrials.gov) | May 13, 2019 | 10/4/2019 | Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis | Sinemet in ALS and PLS | Amyotrophic Lateral Sclerosis;Motor Neuron Disease | Drug: carbidopa-levodopa;Drug: Placebo Oral Tablet | Washington University School of Medicine | NULL | Enrolling by invitation | 18 Years | N/A | All | 15 | Phase 1 | United States |
| 3 | EUCTR2018-000142-18-FI (EUCTR) | 09/05/2018 | 08/05/2018 | Feasibility and effects of subcutaneously given combination of dexmedetomidine and ketamine in ALS patients receiving palliative care | Feasibility and pharmacodynamics of subcutaneously given combination of dexmedetomidine and ketamine infusion in ALS patients receiving palliative care | Amyotrophic lateral sclerosis (ALS) MedDRA version: 20.1;Level: LLT;Classification code 10036704;Term: Primary lateral sclerosis;System Organ Class: 100000004852;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Dexdor INN or Proposed INN: DEXMEDETOMIDINE Trade Name: Ketanest-S INN or Proposed INN: ESKETAMINE | Turku University Hospital | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 20 | Phase 4 | Finland | ||
| 4 | NCT03067857 (ClinicalTrials.gov) | September 2016 | 25/2/2017 | Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease | Autologous Purified Bone-Marrow-Derived Stem Cell Therapy for Motor Neuron Disease | Motor Neuron Disease;Amyotrophic Lateral Sclerosis;Primary Lateral Sclerosis;Progressive Muscular Atrophy;Progressive Bulbar Palsies | Biological: Stem Cells | Stem Cells Arabia | NULL | Unknown status | 24 Years | 70 Years | All | 40 | Phase 1/Phase 2 | NULL |
| 5 | NCT02868567 (ClinicalTrials.gov) | March 2016 | 17/3/2016 | Use of Dalfampridine in Primary Lateral Sclerosis | A Multicenter, 18-week Open Label Safety and Efficacy Trial of Dalfampridine in Primary Lateral Sclerosis | Motor Neuron Disease, Upper | Drug: dalfampridine | Weill Medical College of Cornell University | Hospital for Special Surgery, New York | Recruiting | 18 Years | 99 Years | All | 35 | Phase 1 | United States |
| 6 | EUCTR2011-004798-99-DE (EUCTR) | 27/02/2013 | 27/12/2012 | Safety and Efficacy of SOD1 Inhibition By Pyrimethamine in Familial (ALS) | Safety and Efficacy of SOD1 Inhibition By Pyrimethamine in Familial (ALS) - Pyrimethamine In Familial ALS | Familial amyotrophic lateral sclerosis (FALS) MedDRA version: 14.1;Level: LLT;Classification code 10036704;Term: Primary lateral sclerosis;System Organ Class: 100000004852;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Daraprim INN or Proposed INN: PYRIMETHAMINE | Weill Medical College of Cornell University | NULL | Not Recruiting | Female: yes Male: yes | 40 | United States;Germany;Italy | |||
| 7 | NCT00324454 (ClinicalTrials.gov) | May 2006 | 9/5/2006 | Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease | A Pilot Trial of Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease | Motor Neuron Disease;Amyotrophic Lateral Sclerosis;Primary Lateral Sclerosis;Progressive Muscular Atrophy | Biological: Levetiracetam | Duke University | UCB Pharma | Completed | 18 Years | N/A | Both | 20 | Phase 2 | United States |