44. 多発血管炎性肉芽腫症 Wegener granulomatosis Clinical trials / Disease details

臨床試験数 : 92 / 薬物数 : 106 - (DrugBank : 27) / 標的遺伝子数 : 22 - 標的パスウェイ数 : 78

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05263934 (ClinicalTrials.gov)	March 14, 2022	28/2/2022	Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory ...	A 52-week, Randomized, Double-blind, Double-dummy, Parallel-group, Multi-centre, Non-inferiority Stu ...	Eosinophilic Granulomatosis With Polyangiitis	Biological: Depemokimab;Biological: Mepolizumab;Drug: Placebo matching mepolizumab;Drug: Placebo mat ...	GlaxoSmithKline	NULL	Not yet recruiting	18 Years	N/A	All	160	Phase 3	NULL
2	NCT05030155 (ClinicalTrials.gov)	December 2021	31/7/2021	Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients With Eo ...	Evaluation of MEpolizumab-based Regimen Compared to Conventional Therapeutic Strategy For Remission ...	Eosinophilic Granulomatosis With Polyangiitis	Drug: Mepolizumab;Drug: cyclophosphamide /azathioprine;Drug: Placebo	Assistance Publique - Hôpitaux de Paris	French Vasculitis Study Group;URC-CIC Paris Descartes Necker Cochin	Not yet recruiting	18 Years	N/A	All	100	Phase 3	France
3	EUCTR2021-000679-35-FR (EUCTR)	07/09/2021	25/06/2021	SATELITE Salvage Therapy for Patients with Inadequate Response to Standard of Care Therapy in Granul ...	SATELITE Salvage Therapy for Patients with Inadequate Response to Standard of Care Therapy in Granul ...	Granulomatosis with Polyangiitis;Therapeutic area: Diseases [C] - Blood and lymphatic diseases [C15] ...	Trade Name: Rituximab INN or Proposed INN: RITUXIMAB Trade Name: ROACTEMRA INN or Proposed INN: TOCILIZ ...	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	42	Phase 2	France
4	NCT04871191 (ClinicalTrials.gov)	September 2021	26/2/2021	Study of Salvage Therapy to Treat Patients With Granulomatosis With Polyangiitis	Salvage Therapy for Patients With Inadequate Response to Standard of Care Therapy in Granulomatosis ...	Granulomatosis With Polyangiitis;Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis	Drug: Rituximab;Drug: Tocilizumab;Drug: Abatacept	Assistance Publique - Hôpitaux de Paris	URC-CIC Paris Descartes Necker Cochin	Not yet recruiting	18 Years	N/A	All	42	Phase 2	France
5	NCT04944524 (ClinicalTrials.gov)	July 1, 2021	22/6/2021	Comparison of Tofacitinib and Methotrexate in the Maintained Treatment of GPA	Randomized Trial of Tofacitinib Versus Methotrexate for Maintenance Therapy in Granulomatosis With P ...	Granulomatosis With Polyangiitis	Drug: Tofacitinib;Drug: Methotrexate	Shanghai Zhongshan Hospital	NULL	Recruiting	18 Years	75 Years	All	66	Phase 4	China
6	NCT04316494 (ClinicalTrials.gov)	December 17, 2020	25/2/2020	Hydroxychloroquine in ANCA Vasculitis Evaluation	Hydroxychloroquine in ANCA Vasculitis Evaluation - A Multicentre, Randomised, Double-blind, Placebo- ...	ANCA Associated Vasculitis;Microscopic Polyangiitis;Churg-Strauss Syndrome;Wegener Granulomatosis	Drug: Hydroxychloroquine;Drug: Placebo	Guy's and St Thomas' NHS Foundation Trust	Medical Research Council	Recruiting	18 Years	N/A	All	76	Phase 4	United Kingdom
7	NCT04280601 (ClinicalTrials.gov)	August 1, 2020	18/2/2020	PRagmatic Analysis of Vitamin D in ANCA-Associated Vasculitis	A Local Interventional Study in a Cohort of Patients With GPA, MPA and EGPA (PART 2 of Vitamin D Sta ...	ANCA-associated Vasculitis;Granulomatosis With Polyangiitis;Microscopic Polyangiitis;Eosinophilic Gr ...	Dietary Supplement: vitamin D	Christian Pagnoux	NULL	Active, not recruiting	18 Years	N/A	All	100	N/A	Canada
8	EUCTR2019-001832-77-IT (EUCTR)	25/02/2020	15/06/2021	A study to evaluate if benralizumab compared to mepolizumab may be beneficial in the treatment of Eo ...	A Randomized, Double-blind, Active-controlled 52-week Study with an Open-label Extension to Evaluate ...	Eosinophilic Granulomatosis with Polyangiitis(EGPA) MedDRA version: 20.1;Level: LLT;Classification c ...	Trade Name: NUCALA Product Name: mepolizumab Product Code: [L04AC06] INN or Proposed INN: Mepolizumab Pr ...	ASTRAZENECA AB	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	140	Phase 3	France;United States;Canada;Belgium;Israel;Germany;United Kingdom;Japan;Italy
9	EUCTR2018-001268-40-GB (EUCTR)	23/01/2020	13/09/2019	Hydroxychloroquine in ANCA vasculitis	Hydroxychloroquine in ANCA Vasculitis Evaluation - A Multicentre, Randomised, Double-blind, Placebo- ...	The term ANCA-associated vasculitis (AAV) describes a subset of primary small vessel vasculitides ch ...	Trade Name: Plaquenil - Hydroxychloroquine 200mg Film coated tablets	Guy's and St. Thomas' NHS Foundation Trust	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	76	Phase 4	United Kingdom
10	EUCTR2019-001832-77-DE (EUCTR)	15/01/2020	21/08/2019	Efficacy and Safety of Benralizumab in EGPA compared to mepolizumab.	A Randomized, Double-blind, Active-controlled 52-week Study with an Open-label Extension to Evaluate ...	Eosinophilic Granulomatosis with Polyangiitis(EGPA) MedDRA version: 20.1;Level: LLT;Classification c ...	Trade Name: Fasenra Product Name: benralizumab Product Code: MEDI-563 INN or Proposed INN: benralizumab ...	AstraZeneca AB	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	140	Phase 3	France;United States;Canada;Belgium;Israel;Germany;United Kingdom;Italy;Japan

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