51. 全身性強皮症 Scleroderma Clinical trials / Disease details

臨床試験数 : 523 / 薬物数 : 608 - (DrugBank : 156) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 215

22 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03053739 (ClinicalTrials.gov)	December 2016	29/12/2016	To Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in ...	Randomized Controlled Trial to Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmon ...	Associated Pulmonary Arterial Hypertension	Drug: Sildenafil 20mg and Bosentan 62.5mg;Drug: Sildenafil 20mg and Placebo	Postgraduate Institute of Medical Education and Research	NULL	Recruiting	18 Years	N/A	All	50	Phase 4	India
2	NCT02798055 (ClinicalTrials.gov)	September 30, 2016	3/6/2016	Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis	A National, Observational, Multi-center Registry to Examine the Characteristics of Patients With Sys ...	Systematic Sclerosis;Digital Ulcer;Scleroderma	Drug: Bosentan group	Elpen Pharmaceutical Co. Inc.	NULL	Completed	18 Years	80 Years	All	148		Greece
3	EUCTR2014-002796-28-NL (EUCTR)	12/04/2016	23/04/2015	Does therapy with bosentantablets have positive effects on the stiffness of the vessels in patients ...	The Clinical Efficacy And Subclinical Effects on arterial STIFFNESS of bosentantherapy added to usua ...	Systemic sclerosis (SSc) is characterized by skin fibrosis and visceral disease, mainly of the lungs ...	Trade Name: Tracleer INN or Proposed INN: bosentan Other descriptive name: BOSENTAN MONOHYDRATE	University Medical Center Groningen (UMCG)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Netherlands
4	NCT02480335 (ClinicalTrials.gov)	June 26, 2015	15/6/2015	The Clinical And Subclinical Effects on Arterial Stiffness of Bosentanin Patients With Systemic Scle ...	The Clinical Efficacy And Subclinical Effects on Arterial STIFFNESS of BosentanTherapy Added to Usua ...	Scleroderma, Systemic	Drug: bosentan	University Medical Center Groningen	Actelion	Completed	18 Years	N/A	All	20	Phase 4	Netherlands
5	JPRN-JapicCTI-132176	01/6/2013		Bosentan DU	A prospective, multicenter, single arm, open-label, phase III study to assess the safety and efficac ...	Digital ulcers associated with systemic sclerosis	Intervention name : Ro47-0203 / ACT-050088 INN of the intervention : Bosentan Dosage And administratio ...	Actelion Pharmaceuticals Japan Ltd.	NULL		18		BOTH	20	Phase 3	NULL
6	EUCTR2011-005303-32-NL (EUCTR)	05/03/2012	26/01/2012	The effect of bosentan in scleroderma patients with a specific nailfold pattern (HOME II)	Effects of bosentanin a HOMogenEous population of SSc subjects with an early or active SSc nailfold ...	Digital Ulcera in Systemic Sclerodermia patients MedDRA version: 14.1;Level: PT;Classification code ...	Trade Name: Tracleer INN or Proposed INN: Bosentan	Actelion Pharmaceuticals Nederland bv	NULL	Not Recruiting			Female: yes Male: yes			Netherlands
7	NCT01395732 (ClinicalTrials.gov)	March 2011	6/7/2011	Bosentan in Systemic Sclerosis	Effects of Bosentanin a Homogenous Population of Systemic Sclerosis Subjects With a Predefined Restr ...	Systemic Sclerosis;Digital Ulcers	Drug: Bosentan	Actelion	NULL	Completed	18 Years	N/A	Both	18	Phase 4	Netherlands
8	NCT01241383 (ClinicalTrials.gov)	December 2010	12/11/2010	Effect of Bosentan in Scleroderma Renal Crisis	Effect of Bosentan in the Course of Scleroderma Renal Crisis	Scleroderma Renal Crisis	Drug: Bosentan	Assistance Publique - Hôpitaux de Paris	Actelion	Completed	18 Years	N/A	Both	16	Phase 2	France
9	EUCTR2010-021452-26-FR (EUCTR)	20/09/2010	09/07/2010	Crise Rénale sclérodermique : amélioration du pronostic par adjonction de Bosentanau traitement de r ...	Crise Rénale sclérodermique : amélioration du pronostic par adjonction de Bosentanau traitement de r ...	Les patients inclus dans l'étude seront des patients atteints de sclérodermie systémique (définie se ...	Trade Name: Tracleer Product Name: Tracleer INN or Proposed INN: bosentan Trade Name: Tracleer Product N ...	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)	NULL	Not Recruiting			Female: yes Male: yes		Phase 3	France
10	NCT00909337 (ClinicalTrials.gov)	January 2008	27/5/2009	Early Therapy of Pulmonary Arterial Hypertension	Early Therapy of Pulmonary Arterial Hypertension	Pulmonary Hypertension;Systemic Sclerosis	Drug: Bosentan	Medical University of Graz	Actelion	Completed	18 Years	90 Years	Both	10	N/A	Austria

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