62. 発作性夜間ヘモグロビン尿症 Paroxysmal nocturnal hemoglobinuria Clinical trials / Disease details

臨床試験数 : 271 / 薬物数 : 163 - (DrugBank : 49) / 標的遺伝子数 : 22 - 標的パスウェイ数 : 106

12 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04729062 (ClinicalTrials.gov)	April 5, 2021	25/1/2021	Pegcetacoplan Early Access Program for PNH	Early Access Program (EAP) For The Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) With Pegce ...	Paroxysmal Nocturnal Hemoglobinuria (PNH)	Drug: Pegcetacoplan	Apellis Pharmaceuticals, Inc.	NULL	No longer available	18 Years	N/A	All			United States
2	NCT04901936 (ClinicalTrials.gov)	February 4, 2021	8/3/2021	A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)	An Open Label, Single-Arm, Phase 2 Study to Evaluate the Safety, Pharmacokinestics, and Biologic Act ...	Paroxysmal Nocturnal Hemoglobinuria (PNH);Paroxysmal Hemoglobinuria	Drug: Pegcetacoplan	Apellis Pharmaceuticals, Inc.	NULL	Recruiting	12 Years	17 Years	All	12	Phase 2	United States
3	EUCTR2019-001106-23-FR (EUCTR)	04/02/2020	15/10/2019	An Open Label, Non-Randomized, Multi-Center Extension Study to Evaluate the Long Term Safety and Eff ...	An Open Label, Non-Randomized, Multi-Center Extension Study to Evaluate the Long Term Safety and Eff ...	Paroxysmal Nocturnal Hemoglobinuria MedDRA version: 21.1;Level: LLT;Classification code 10055629;Ter ...	Product Name: APL-2 Product Code: APL-2 INN or Proposed INN: pegcetacoplan Other descriptive name: APL- ...	Apellis Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	119	Phase 3	France;Canada;Belgium;Malaysia;Poland;Australia;Bulgaria;Germany;Japan;Korea, Republic of;United Kin ...
4	EUCTR2019-001106-23-ES (EUCTR)	22/01/2020	14/01/2020	An Open Label, Non-Randomized, Multi-Center Extension Study to Evaluate the Long Term Safety and Eff ...	An Open Label, Non-Randomized, Multi-Center Extension Study to Evaluate the Long Term Safety and Eff ...	Paroxysmal Nocturnal Hemoglobinuria MedDRA version: 21.1;Level: LLT;Classification code 10055629;Ter ...	Product Name: APL-2 Product Code: APL-2 INN or Proposed INN: pegcetacoplan Other descriptive name: APL- ...	Apellis Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	119	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (P ...	Serbia;United States;Hong Kong;Spain;Thailand;Russian Federation;United Kingdom;France;Canada;Poland ...
5	EUCTR2019-001106-23-GB (EUCTR)	19/12/2019	30/09/2019	An Open Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long Term Safety and Effic ...	An Open Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long Term Safety and Effic ...	Paroxysmal Nocturnal Hemoglobinuria MedDRA version: 21.1;Level: LLT;Classification code 10055629;Ter ...	Product Name: Pegcetacoplan (APL-2) Product Code: Pegcetacoplan (APL-2) INN or Proposed INN: pegcetacopl ...	Apellis Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	Serbia;United States;Hong Kong;Spain;Thailand;Russian Federation;United Kingdom;France;Canada;Malays ...
6	NCT04085601 (ClinicalTrials.gov)	August 15, 2019	9/9/2019	A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With PNH	A Phase 3, Randomized, Multicenter, Open-Label, Controlled Study to Evaluate the Efficacy and Safety ...	Paroxysmal Nocturnal Hemoglobinuria	Drug: APL-2	Apellis Pharmaceuticals, Inc.	NULL	Completed	18 Years	N/A	All	53	Phase 3	Colombia;Hong Kong;Malaysia;Mexico;Peru;Philippines;Poland;Serbia;Singapore;Thailand
7	EUCTR2019-001106-23-BG (EUCTR)	09/08/2019	09/05/2019	An Open-label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Effic ...	An Open-label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Effic ...	Paroxysmal Nocturnal Hemoglobinuria MedDRA version: 21.1;Level: LLT;Classification code 10055629;Ter ...	Product Name: pegcetacoplan Product Code: pegcetacoplan INN or Proposed INN: pegcetacoplan Other descri ...	Apellis Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	160	Phase 3	Serbia;United States;Hong Kong;Spain;Thailand;Ireland;Russian Federation;United Kingdom;Italy;France ...
8	EUCTR2018-004220-11-PL (EUCTR)	23/07/2019	13/05/2019	A Research Study to Gather Scientific Information About the Efficacy and Safety of the Investigation ...	A Phase 3, Randomized, Multicenter, Open-Label, Controlled Study to Evaluate the Efficacy and Safety ...	Paroxysmal Nocturnal Hemoglobinuria (PNH) MedDRA version: 20.1;Level: LLT;Classification code 100556 ...	Product Name: APL-2 Product Code: APL-2 INN or Proposed INN: pegcetacoplan Other descriptive name: APL- ...	Apellis Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	54	Phase 3	Serbia;Philippines;Hungary;Hong Kong;Mexico;Argentina;Thailand;Malaysia;Brazil;Poland;Peru;Colombia
9	EUCTR2017-004268-36-GB (EUCTR)	08/01/2019	21/08/2018	A Research Study to Gather Scientific Information About the Efficacy, Safety, and Tolerability of th ...	A Phase III, Randomized, Multi-Center, Open-Label, Active-Comparator Controlled Study to Evaluate th ...	PNH is an acquired, rare, clonal, non-malignant hematologic disease characterized by complement-medi ...	Product Name: Pegcetacoplan (APL-2) Product Code: Pegcetacoplan (APL-2) INN or Proposed INN: n/a Other de ...	Apellis Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	70	Phase 3	United States;Spain;Russian Federation;United Kingdom;Italy;France;Canada;Belgium;Australia;Germany; ...
10	NCT03531255 (ClinicalTrials.gov)	August 27, 2018	9/5/2018	Pegcetacoplan Long Term Safety and Efficacy Extension Study	An Open Label, Non-Randomized, Multi-Center Extension Study to Evaluate the Long-Term Safety and Eff ...	PNH	Drug: Pegcetacoplan	Apellis Pharmaceuticals, Inc.	NULL	Active, not recruiting	18 Years	N/A	All	160	Phase 3	United States;Australia;Belgium;Bulgaria;Canada;France;Germany;Hong Kong;Japan;Korea, Republic of;Ma ...

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