65. 原発性免疫不全症候群 Primary immunodeficiency Clinical trials / Disease details

臨床試験数 : 482 / 薬物数 : 653 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 212

10 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03879876 (ClinicalTrials.gov)	May 13, 2020	15/3/2019	Safety and Efficacy Study of Human T Lymphoid Progenitor (HTLP) Injection After Partially HLA Compat ...	A Phase I/II Study Evaluating the Safety and the Efficacy of Human T Lymphoid Progenitor (HTLP) Inje ...	Pediatric Patients;Any Type of Severe Combined Immunodeficiency (SCID);Partial HLA Incompatible Allo ...	Drug: Human T Lymphoid Progenitor (HTLP) injection	Assistance Publique - Hôpitaux de Paris	NULL	Recruiting	2 Years	18 Years	All	12	Phase 1/Phase 2	France
2	EUCTR2018-001029-14-FR (EUCTR)	25/10/2018	02/07/2018	HTLP	A phase I/II Study evaluating the safety and the efficacy of Human T Lymphoid Progenitor (HTLP) inje ...	SCID pediatric patients (n=12 for analysis) requiring an HLA partially compatible allogeneic HSCT. M ...	Product Name: HTLP Product Code: HTLP	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	12	Phase 1;Phase 2	France
3	NCT02327351 (ClinicalTrials.gov)	July 2012	18/12/2014	TCR Alpha/Beta Depletion for HSCT From Haploidentical and Unrelated Donors in the Treatment of PID	Phase II/III Study of Allogeneic Hematopoietic Stem Cell TransplantationFrom Unrelated and Haploiden ...	Primary Immune Deficiency Disorder;Hematopoietic Stem Cell Transplantation	Other: Biological: TCR alfa beta T cell depletion	Federal Research Institute of Pediatric Hematology, Oncology and Immunology	NULL	Recruiting	1 Month	18 Years	Both	60	Phase 2/Phase 3	Russian Federation
4	NCT01529827 (ClinicalTrials.gov)	February 28, 2012	6/2/2012	Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral B ...	A Phase II Trial of Reduced Intensity Allogeneic Stem Cell Transplantation With Fludarabine, Melphal ...	Accelerated Phase Chronic Myelogenous Leukemia;Adult Acute Lymphoblastic Leukemia in Remission;Adult ...	Drug: fludarabine phosphate;Drug: melphalan;Radiation: total-body irradiation;Drug: tacrolimus;Drug: ...	Roswell Park Cancer Institute	NULL	Completed	3 Years	75 Years	All	94	Phase 2	United States
5	NCT01319851 (ClinicalTrials.gov)	September 2010	15/9/2010	Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation	Alefacept and Allogeneic Hematopoietic Stem Cell Transplantationfor Children With Non-Malignant Dise ...	Thalassemia;Sickle Cell Disease;Glanzmann Thrombasthenia;Wiskott-Aldrich Syndrome;Chronic-granulomat ...	Drug: Alefacept	Emory University	Children's Healthcare of Atlanta	Terminated	N/A	21 Years	All	3	N/A	United States
6	NCT00358657 (ClinicalTrials.gov)	May 24, 2006	28/7/2006	Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Tr ...	HLA-Haploidentical Related Marrow Grafts for the Treatment of Primary Immunodeficiencies and Other N ...	Immunodeficiency Syndrome;Non-Cancer Diagnosis;Severe Aplastic Anemia;Donor	Procedure: Allogeneic Bone Marrow Transplantation;Drug: Cyclophosphamide;Drug: Fludarabine Phosphate; ...	Fred Hutchinson Cancer Research Center	National Cancer Institute (NCI);National Heart, Lung, and Blood Institute (NHLBI)	Active, not recruiting	N/A	55 Years	All	14	Phase 2	United States
7	NCT00295971 (ClinicalTrials.gov)	April 2005	23/2/2006	Donor Stem Cell Transplant in Treating Young Patients With Myelodysplastic Syndrome, Leukemia, Bone ...	Stem Cell Enriched, T Cell Depleted Haplocompatible Peripheral Blood Transplantation for Children Wi ...	Congenital Amegakaryocytic Thrombocytopenia;Leukemia;Myelodysplastic Syndromes;Severe Congenital Neu ...	Biological: anti-thymocyte globulin;Biological: therapeutic allogeneic lymphocytes;Drug: fludarabine ...	University of California, San Francisco	National Cancer Institute (NCI)	Completed	1 Year	17 Years	Both	21	Phase 1	United States
8	NCT00301834 (ClinicalTrials.gov)	January 2005	9/3/2006	Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Pati ...	Evaluation of Fludarabine, Busulfan and Alemtuzumab as a Reduced Toxicity Ablative Bone Marrow Stem ...	Congenital Amegakaryocytic Thrombocytopenia;Diamond-blackfan Anemia;Leukemia;Myelodysplastic Syndrom ...	Biological: alemtuzumab;Drug: busulfan;Drug: cyclosporine;Drug: fludarabine phosphate;Drug: methotrex ...	University of California, San Francisco	National Cancer Institute (NCI)	Completed	N/A	21 Years	All	35	Phase 2	United States
9	NCT00006056 (ClinicalTrials.gov)	March 2000	5/7/2000	Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threate ...		Chediak-Higashi Syndrome;Graft Versus Host Disease;X-Linked Lymphoproliferative Syndrome;Familial Er ...	Drug: anti-thymocyte globulin;Drug: busulfan;Drug: cyclophosphamide;Drug: cyclosporine;Drug: etoposi ...	Fairview University Medical Center	NULL	Active, not recruiting	N/A	55 Years	Both	40	N/A	United States
10	NCT00008450 (ClinicalTrials.gov)	August 11, 1997	6/1/2001	Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With ...	Induction of Mixed Hematopoietic Chimerism in Patients With Severe Combined Immunodeficiency Disorde ...	Adenosine Deaminase Deficiency;Autosomal Recessive Disorder;Immune System Disorder;Purine-Nucleoside ...	Procedure: Allogeneic Bone Marrow Transplantation;Drug: Cyclosporine;Other: Laboratory Biomarker Ana ...	Fred Hutchinson Cancer Research Center	National Cancer Institute (NCI);National Heart, Lung, and Blood Institute (NHLBI)	Completed	N/A	N/A	All	6	Phase 1	United States

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