65. 原発性免疫不全症候群 Primary immunodeficiency Clinical trials / Disease details

臨床試験数 : 482 / 薬物数 : 653 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 212

16 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04400045 (ClinicalTrials.gov)	May 22, 2020	19/5/2020	Low Dose Treosulfan Based Conditioning Regimen in HSCT for Nijmegen Breakage Syndrome	Clinical Open-label Phase 2 Study of Low Dose Treosulfan Based Conditioning Regimen Efficacy in Hema ...	Nijmegen Breakage Syndrome	Drug: Treosulfan	Federal Research Institute of Pediatric Hematology, Oncology and Immunology	NULL	Recruiting	3 Months	21 Years	All	10	Phase 2	Russian Federation
2	NCT03879876 (ClinicalTrials.gov)	May 13, 2020	15/3/2019	Safety and Efficacy Study of Human T Lymphoid Progenitor (HTLP) Injection After Partially HLA Compat ...	A Phase I/II Study Evaluating the Safety and the Efficacy of Human T Lymphoid Progenitor (HTLP) Inje ...	Pediatric Patients;Any Type of Severe Combined Immunodeficiency (SCID);Partial HLA Incompatible Allo ...	Drug: Human T Lymphoid Progenitor (HTLP) injection	Assistance Publique - Hôpitaux de Paris	NULL	Recruiting	2 Years	18 Years	All	12	Phase 1/Phase 2	France
3	EUCTR2018-001029-14-FR (EUCTR)	25/10/2018	02/07/2018	HTLP	A phase I/II Study evaluating the safety and the efficacy of Human T Lymphoid Progenitor (HTLP) inje ...	SCID pediatric patients (n=12 for analysis) requiring an HLA partially compatible allogeneic HSCT. M ...	Product Name: HTLP Product Code: HTLP	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	12	Phase 1;Phase 2	France
4	NCT01821781 (ClinicalTrials.gov)	March 2013	19/3/2013	Immune Disorder HSCT Protocol	A Study of Hematopoietic Stem Cell Transplantation(HSCT) in Immune Function Disorders Using a Reduce ...	Immune Deficiency Disorders;Severe Combined Immunodeficiency;Chronic Granulomatous Disease;X-linked ...	Drug: Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan	Washington University School of Medicine	NULL	Recruiting	N/A	21 Years	All	20	Phase 2	United States
5	NCT02327351 (ClinicalTrials.gov)	July 2012	18/12/2014	TCR Alpha/Beta Depletion for HSCT From Haploidentical and Unrelated Donors in the Treatment of PID	Phase II/III Study of Allogeneic Hematopoietic Stem Cell TransplantationFrom Unrelated and Haploiden ...	Primary Immune Deficiency Disorder;Hematopoietic Stem Cell Transplantation	Other: Biological: TCR alfa beta T cell depletion	Federal Research Institute of Pediatric Hematology, Oncology and Immunology	NULL	Recruiting	1 Month	18 Years	Both	60	Phase 2/Phase 3	Russian Federation
6	NCT01529827 (ClinicalTrials.gov)	February 28, 2012	6/2/2012	Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral B ...	A Phase II Trial of Reduced Intensity Allogeneic Stem Cell Transplantation With Fludarabine, Melphal ...	Accelerated Phase Chronic Myelogenous Leukemia;Adult Acute Lymphoblastic Leukemia in Remission;Adult ...	Drug: fludarabine phosphate;Drug: melphalan;Radiation: total-body irradiation;Drug: tacrolimus;Drug: ...	Roswell Park Cancer Institute	NULL	Completed	3 Years	75 Years	All	94	Phase 2	United States
7	NCT01338675 (ClinicalTrials.gov)	January 2011	4/3/2011	Targeted Busulfan, Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantationin Ch ...		Chronic Granulomatous Disease	Drug: Busulfan	Seoul National University Hospital	NULL	Recruiting	N/A	N/A	Both	5	Phase 1/Phase 2	Korea, Republic of
8	NCT01319851 (ClinicalTrials.gov)	September 2010	15/9/2010	Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation	Alefacept and Allogeneic Hematopoietic Stem Cell Transplantationfor Children With Non-Malignant Dise ...	Thalassemia;Sickle Cell Disease;Glanzmann Thrombasthenia;Wiskott-Aldrich Syndrome;Chronic-granulomat ...	Drug: Alefacept	Emory University	Children's Healthcare of Atlanta	Terminated	N/A	21 Years	All	3	N/A	United States
9	NCT01182675 (ClinicalTrials.gov)	August 2010	9/8/2010	Hematopoietic Stem Cell Transplantation(HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixaf ...	Hematopoietic Stem Cell Transplantationfor Children With Severe Combined Immunodeficiency Disease Ut ...	Severe Combined Immunodeficiency	Drug: Transplant Conditioning with Mobilization Only;Drug: Transplant Conditioning with Mobilization ...	University of California, San Francisco	NULL	Terminated	N/A	3 Years	All	7	Phase 2	United States
10	NCT02512679 (ClinicalTrials.gov)	February 2007	21/5/2015	Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells	Protocol for Related Donor Hematopoietic Stem Cell Transplantation(HSCT) for Treatment of Symptomati ...	Stem Cell Transplantation;Bone Marrow Transplantation;Peripheral Blood Stem Cell Transplantation;All ...	Drug: Cyclophosphamide Dose Level 1;Drug: Cyclophosphamide Dose Level 2;Drug: Cyclophosphamide Dose Lev ...	Children's Hospital Los Angeles	Lucile Packard Children's Hospital	Terminated	3 Months	N/A	All	20	Phase 2	NULL

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