65. 原発性免疫不全症候群 Primary immunodeficiency Clinical trials / Disease details

臨床試験数 : 482 / 薬物数 : 653 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 212

8 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCT2031210309	20/12/2022	13/09/2021	RALPID	Phase 2 study of the efficacy and safety of sirolumus in patients with primary immunodeficiency	Primary immunodeficiency PID, ALPS, APDS, CTLA4, IPEX, lymphoproliferative disease, enterocolitis, c ...	Administer sirolimustablets or granules once a daily. Initial dose: 2mg (tablet), 0.049 mg/kg or 0.03 ...	Imai Kohsuke	NULL	Recruiting	>= 2month old	Not applicable	Both	10	Phase 2	Japan
2	NCT04370795 (ClinicalTrials.gov)	March 24, 2022	30/4/2020	Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency ...	Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency ...	Severe Combined Immunodeficiency (SCID)	Drug: Sirolimus;Drug: Busulfan;Drug: Horse -Anti-thymocyte;Drug: G-CSF;Radiation: Total Body Irradia ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Enrolling by invitation	3 Years	40 Years	All	30	Phase 1/Phase 2	United States
3	NCT03910452 (ClinicalTrials.gov)	October 28, 2019	9/4/2019	Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Bus ...	Haploidentical Transplant for Patients With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, B ...	Chronic Granulomatous Disease	Drug: Busulfan;Drug: Alemtuzumab;Drug: Cyclophosphamide;Drug: Sirolimus;Radiation: Total Body Irradi ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Suspended	4 Years	65 Years	All	4	Early Phase 1	United States
4	NCT02629120 (ClinicalTrials.gov)	December 17, 2015	10/12/2015	High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patie ...	High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patie ...	Chronic Granulomatous Disease Transplant	Drug: Alentuzumab (Campath);Drug: Busulfan IV;Drug: Sirolimus;Drug: Cyclophosphamide;Radiation: Total ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Recruiting	4 Years	65 Years	All	50	Phase 1/Phase 2	United States
5	NCT02282904 (ClinicalTrials.gov)	October 23, 2014	4/11/2014	Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant Cyclop ...	Haploidentical Transplant for Patients With Chronic Granulomatous Disease (CGD) Using Post-Transplan ...	Chronic Granulomatous Disease	Drug: Sirolimus;Biological: Donor peripheral blood stem cells.;Drug: Cyclophosphamide post transplant ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Terminated	2 Years	65 Years	All	7	Phase 1/Phase 2	United States
6	NCT02177760 (ClinicalTrials.gov)	July 2014	19/6/2014	Sirolimus Prophylaxis for aGVHD in TME SCID	Sirolimusin Prevention of aGVHD in Maternally Engrafted (TME) Severe Combined Immunodeficiency (SCID ...	Severe Combined Immunodeficiency;Transplacental Maternal Engraftment;Stem Cell Transplant	Drug: Sirolimus	University of California, San Francisco	NULL	Withdrawn	N/A	1 Year	Both	0	Phase 2	United States
7	NCT00392951 (ClinicalTrials.gov)	December 2006	24/10/2006	Sirolimus for Autoimmune Disease of Blood Cells	Sirolimus for Patients With Chronic and/or Refractory Autoimmune Cytopenias: A Pilot Series	Autoimmune Pancytopenia;Autoimmune Lymphoproliferative Syndrome (ALPS);Evans Syndrome;Idiopathic Thr ...	Drug: sirolimus	Children's Hospital of Philadelphia	NULL	Completed	1 Year	30 Years	All	30	Phase 1/Phase 2	United States
8	NCT00358657 (ClinicalTrials.gov)	May 24, 2006	28/7/2006	Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Tr ...	HLA-Haploidentical Related Marrow Grafts for the Treatment of Primary Immunodeficiencies and Other N ...	Immunodeficiency Syndrome;Non-Cancer Diagnosis;Severe Aplastic Anemia;Donor	Procedure: Allogeneic Bone Marrow Transplantation;Drug: Cyclophosphamide;Drug: Fludarabine Phosphate; ...	Fred Hutchinson Cancer Research Center	National Cancer Institute (NCI);National Heart, Lung, and Blood Institute (NHLBI)	Active, not recruiting	N/A	55 Years	All	14	Phase 2	United States

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