8. ハンチントン病 Huntington disease Clinical trials / Disease details
臨床試験数 : 229 / 薬物数 : 193 - (DrugBank : 60) / 標的遺伝子数 : 84 - 標的パスウェイ数 : 158
Showing 1 to 10 of 229 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | EUCTR2020-000105-92-LT (EUCTR) | 02/03/2022 | 28/10/2021 | A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patients with Huntington's Disease A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patie ... | A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LMI070/branaplam when Administered as Weekly Oral Doses in Participants with Early Manifest Huntington’s Disease A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to ... | Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's ... | Product Name: branaplam Product Code: LMI070 INN or Proposed INN: BRANAPLAM | Novartis Pharma AG | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 75 | Phase 2 | France;United States;Hungary;Canada;Spain;Belgium;Lithuania;Russian Federation;Germany;United Kingdom;Italy France;United States;Hungary;Canada;Spain;Belgium;Lithuania;Russian Federation;Germany;United Kingdo ... | ||
| 2 | EUCTR2020-004556-15-NL (EUCTR) | 01/03/2022 | 11/02/2022 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administered Intrathecally in Patients With Huntington’s Disease A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administer ... | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administered Intrathecally in Patients With Huntington’s Disease A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administer ... | Huntington's Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Huntington's Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's ... | Product Name: WVE-003 Product Code: WVE-003 INN or Proposed INN: WVE-003 | Wave Life Sciences UK Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 36 | Phase 1;Phase 2 | France;Canada;Spain;Poland;Denmark;Australia;Germany;Netherlands;United Kingdom;Switzerland;Italy | ||
| 3 | NCT05238701 (ClinicalTrials.gov) | February 28, 2022 | 9/1/2022 | A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in He ... | A Randomized, Double-blinded, Placebo-controlled, Dose-escalation Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 Sustained-release Tablets in Healthy Subjects A Randomized, Double-blinded, Placebo-controlled, Dose-escalation Phase I Study to Evaluate the Safe ... | Huntington Disease;Tardive Dyskinesia | Drug: LPM3770164 sustained release tablet;Drug: LPM3770164 sustained release tablet simulant | Luye Pharma Group Ltd. | NULL | Not yet recruiting | 18 Years | 45 Years | All | 104 | Phase 1 | China |
| 4 | NCT04478734 (ClinicalTrials.gov) | January 1, 2022 | 11/2/2020 | Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease | Multicentric Trial on the Use of Combined Therapy of Thiamine and Biotine in Patients With Huntington´s Disease Multicentric Trial on the Use of Combined Therapy of Thiamine and Biotine in Patients With Huntingto ... | Huntington Disease | Drug: Moderate doses of Thiamine y Biotin;Drug: High doses of Thiamine y Biotin | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | Ciberned (Centro de Investigación Biomédica en Red) | Not yet recruiting | 18 Years | N/A | All | 24 | Phase 2 | Spain |
| 5 | EUCTR2020-004556-15-IT (EUCTR) | 13/12/2021 | 06/10/2021 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administered Intrathecally in Patients With Huntington’s Disease A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administer ... | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administered Intrathecally in Patients With Huntington’s Disease - - A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-003 Administer ... | Huntington's Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Huntington's Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's ... | Product Name: WVE-003 Product Code: [WVE-003] INN or Proposed INN: WVE-003 | Wave Life Sciences UK Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 36 | Phase 1;Phase 2 | France;Canada;Spain;Poland;Denmark;Australia;Germany;United Kingdom;Italy | ||
| 6 | NCT05111249 (ClinicalTrials.gov) | December 8, 2021 | 15/10/2021 | A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam ... | A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study With Open-Label Extension to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of LMI070/Branaplam Administered as Weekly Oral Doses in Participants With Early Manifest Huntington's Disease A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study With Open-Label Extension to ... | Early Manifest Huntington Disease | Drug: Branaplam;Drug: Placebo | Novartis Pharmaceuticals | NULL | Recruiting | 25 Years | 75 Years | All | 75 | Phase 2 | Canada;France;Germany;Hungary;Spain |
| 7 | EUCTR2020-000105-92-IT (EUCTR) | 26/11/2021 | 20/09/2021 | A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patients with Huntington's Disease A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patie ... | A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LMI070/branaplam when Administered as Weekly Oral Doses in Participants with Early Manifest Huntington's Disease - - A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to ... | Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's ... | Product Name: branaplam Product Code: [LMI070] INN or Proposed INN: BRANAPLAM Product Name: branaplam Product Code: [LMI070] INN or Proposed INN: BRANAPLAM Product Name: branaplam Product Code: [LMI070] INN or Proposed INN: BRANAPLAM Product Name: branaplam Product Code: [LMI070] INN or Proposed INN: BRANAPLAM Product Name: branaplam Product Code: [LMI070] INN or Proposed INN: BRANAPLAM Product Name: branaplam Product Code: [LMI070] INN or Proposed INN: BRANAPLAM Product Name: branaplam Pr ... | NOVARTIS PHARMA AG | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 75 | Phase 2 | France;United States;Hungary;Canada;Spain;Belgium;Lithuania;Russian Federation;Germany;United Kingdom;Italy France;United States;Hungary;Canada;Spain;Belgium;Lithuania;Russian Federation;Germany;United Kingdo ... | ||
| 8 | NCT04713982 (ClinicalTrials.gov) | November 19, 2021 | 6/1/2021 | Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease | Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease | Huntington Disease | Drug: Deutetrabenazine | Vanderbilt University Medical Center | Teva Branded Pharmaceutical Products R&D, Inc. | Recruiting | 18 Years | N/A | All | 30 | Phase 2/Phase 3 | United States |
| 9 | EUCTR2020-000105-92-FR (EUCTR) | 18/11/2021 | 03/09/2021 | A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patients with Huntington's Disease A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patie ... | A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LMI070/branaplam when Administered as Weekly Oral Doses in Participants with Early Manifest Huntington’s Disease A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to ... | Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's ... | Product Name: branaplam Product Code: LMI070 INN or Proposed INN: BRANAPLAM | Novartis Pharma AG | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 75 | Phase 2 | Spain;Belgium;Lithuania;Russian Federation;Germany;United Kingdom;Italy;United States;France;Hungary;Canada Spain;Belgium;Lithuania;Russian Federation;Germany;United Kingdom;Italy;United States;France;Hungary ... | ||
| 10 | EUCTR2020-000105-92-ES (EUCTR) | 02/11/2021 | 26/08/2021 | A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patients with Huntington's Disease A study to evaluate the safety, tolerability and efficacy of weekly oral doses of branaplam in patie ... | A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LMI070/branaplam when Administered as Weekly Oral Doses in Participants with Early Manifest Huntington’s Disease A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to ... | Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] Huntington's disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's ... | Product Name: branaplam Product Code: LMI070 INN or Proposed INN: BRANAPLAM | Novartis Farmacéutica S.A. | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 75 | Phase 2 | France;United States;Hungary;Canada;Belgium;Spain;Lithuania;Russian Federation;Germany;United Kingdom;Italy France;United States;Hungary;Canada;Belgium;Spain;Lithuania;Russian Federation;Germany;United Kingdo ... |