84. サルコイドーシス Sarcoidosis Clinical trials / Disease details
臨床試験数 : 149 / 薬物数 : 227 - (DrugBank : 81) / 標的遺伝子数 : 82 - 標的パスウェイ数 : 167
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04314193 (ClinicalTrials.gov) | June 1, 2020 | 24/2/2020 | Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis | The PREDMETH Trial: Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis - A Randomized Controlled Trial | Sarcoidosis, Pulmonary | Drug: Methotrexate;Drug: Prednisolone | Erasmus Medical Center | St. Antonius Hospital;Longfonds | Recruiting | 18 Years | N/A | All | 138 | Phase 4 | Netherlands |
| 2 | NCT03593759 (ClinicalTrials.gov) | January 15, 2019 | 27/6/2018 | Cardiac Sarcoidosis Randomized Trial | Cardiac Sarcoidosis Multi-Center Randomized Controlled Trial | Cardiac Sarcoidosis;Sarcoidosis | Drug: Prednisone or Prednisolone;Drug: Methotrexate | Ottawa Heart Institute Research Corporation | Canadian Institutes of Health Research (CIHR) | Recruiting | 18 Years | N/A | All | 194 | Phase 3 | United States;Canada;Japan;United Kingdom |
| 3 | NCT03705884 (ClinicalTrials.gov) | January 1, 2018 | 8/8/2018 | PET/MR Imaging In Patients With Cardiac Sarcoidosis | Molecular Imaging in Cardiovascular Disease Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR): Cardiac Sarcoidosis | Cardiac Sarcoidosis | Other: 18F-FDG;Drug: Prednisolone | University of Edinburgh | NULL | Unknown status | 40 Years | N/A | All | 40 | N/A | United Kingdom |
| 4 | NCT03324503 (ClinicalTrials.gov) | December 8, 2017 | 12/10/2017 | A Study to Estimate the Effect Sizes of HRCT Endpoints in Response to Glucocorticoid Induction Therapy in Subjects With Pulmonary Sarcoidosis | A Multicenter, Open-Label Study to Estimate the Effect Sizes of HRCT Endpoints in Response to GLUCOCORTICOID Induction Therapy in Subjects With Pulmonary Sarcoidosis | Sarcoidosis, Pulmonary | Drug: Glucocorticoid (prednisone or prednisolone) | Celgene | NULL | Completed | 18 Years | 65 Years | All | 8 | N/A | United States;Netherlands;United Kingdom |
| 5 | JPRN-UMIN000025936 | 2017/06/12 | 20/02/2017 | Japanese AntibaCterial drug maNagemEnt for cardiac Sarcoidosis Trial | Japanese AntibaCterial drug maNagemEnt for cardiac Sarcoidosis Trial - J-ACNES | Cardiac sarcoidosis | combination therapy group: Prednisolone; Predonisolone start from 30mg/day and continue same dose for one month. After one month, prednisolone decrease 25mg, 20mg, 15mg, 10mg every 2-4 weeks. Finally, maintenance dose of predonisolone is 7.5mg. Antimicrobial agent; Clarithromycin start from 400mg/day for 24weeks. Doxycycline start 100mg/day for 22 weeks after 2 months of clarithromycin therapy. Prednisolone; Predonisolone start from 30mg/day and continue same dose for one month. After one month, prednisolone decrease 25mg, 20mg, 15mg, 10mg every 2-4 weeks. Finally, maintenance dose of predonisolone is 7.5mg. | National cerebral and cardiovascular center | NULL | Recruiting | 20years-old | Not applicable | Male and Female | 80 | Not selected | Japan |
| 6 | NCT03265405 (ClinicalTrials.gov) | April 1, 2017 | 23/8/2017 | Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis | Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis: a Randomized Controlled Trial | Sarcoidosis | Drug: Low dose prednisolone;Drug: Medium dose prednisolone | Postgraduate Institute of Medical Education and Research | NULL | Recruiting | 18 Years | 65 Years | All | 86 | Phase 4 | India |
| 7 | NCT01245036 (ClinicalTrials.gov) | January 2009 | 15/11/2010 | Efficacy of Antituberculous Therapy in Management of Sarcoidosis | Rifampicin and Isoniazid Along With Prednisolone Compared to Prednisolone Alone in Treatment of Sarcoidosis: a Pilot Randomized Controlled Trial | Sarcoidosis;Tuberculosis | Drug: Antituberculous therapy along with steroids | Postgraduate Institute of Medical Education and Research | NULL | Completed | 15 Years | 75 Years | Both | 100 | N/A | India |