86. 肺動脈性肺高血圧症 Pulmonary arterial hypertension Clinical trials / Disease details
臨床試験数 : 1,181 / 薬物数 : 701 - (DrugBank : 126) / 標的遺伝子数 : 105 - 標的パスウェイ数 : 192
Showing 1 to 10 of 1,181 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05135000 (ClinicalTrials.gov) | April 4, 2022 | 16/11/2021 | Study of Efficacy and Safety of LTP001 in Pulmonary Arterial Hypertension | A Randomized, Participant- and Investigator-blinded, Placebo-controlled Study to Investigate Efficacy, Safety, and Tolerability of LTP001 in Participants With Pulmonary Arterial Hypertension A Randomized, Participant- and Investigator-blinded, Placebo-controlled Study to Investigate Efficac ... | Pulmonary Arterial Hypertension | Drug: LTP001;Drug: Placebo | Novartis Pharmaceuticals | NULL | Not yet recruiting | 18 Years | 75 Years | All | 44 | Phase 2 | NULL |
| 2 | NCT04039464 (ClinicalTrials.gov) | April 1, 2022 | 1/7/2019 | Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension | Kids MoD PAH Trial: Mono- vs. Duo-Therapy for Pediatric Pulmonary Arterial Hypertension | Pediatric Pulmonary Hypertension | Drug: Mono-Therapy with Sildenafil;Drug: Duo-Therapy with Sildenafil + Bosentan | Johns Hopkins University | NULL | Not yet recruiting | 4 Months | 18 Years | All | 100 | Phase 3 | United States |
| 3 | NCT05147805 (ClinicalTrials.gov) | March 31, 2022 | 24/11/2021 | A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Treprostinil Palmitil Inhalation Po ... | A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy ... | Pulmonary Arterial Hypertension | Drug: Treprostinil Palmitil;Drug: Placebo | Insmed Incorporated | NULL | Recruiting | 18 Years | 75 Years | All | 99 | Phase 2 | United States |
| 4 | NCT05167825 (ClinicalTrials.gov) | March 31, 2022 | 24/11/2021 | A Study of Macitentan in Japanese Pediatric Participants With Pulmonary Arterial Hypertension | A Multicenter, Open-label, Phase III Study to Assess the Efficacy, Safety, and Pharmacokinetics of Macitentan in Japanese Pediatric Patients (>=3 Months to <15 Years) With Pulmonary Arterial Hypertension A Multicenter, Open-label, Phase III Study to Assess the Efficacy, Safety, and Pharmacokinetics of M ... | Pulmonary Arterial Hypertension | Drug: Macitentan | Janssen Pharmaceutical K.K. | NULL | Not yet recruiting | 3 Months | 15 Years | All | 6 | Phase 3 | Japan |
| 5 | EUCTR2021-001633-40-DE (EUCTR) | 07/03/2022 | 06/12/2021 | Clinical trial investigating the effect of riociguat among patients with slightly elevated blood pressure in lung vessels Clinical trial investigating the effect of riociguat among patients with slightly elevated blood pre ... | Efficacy and safety of riociguat (MK-4836) in incipient pulmonary vascular disease as an indicator for early pulmonary arterial Hypertension Doubleblind, randomized, multicentre, multinational, placebo-controlled phase IIastudyESRA - ESRA Efficacy and safety of riociguat (MK-4836) in incipient pulmonary vascular disease as an indicator f ... | early pulmonary vascular disease, defined as either a) mean pulmonary arterial pressure (mPAP) =25 mmHg with pulmonary vascular resistance (PVR) =2 to <3 WU and pulmonary arterial wedge pressure (PAWP) =15 mmHg or b) mPAP 21-<25 mmHg with PVR =2 WU, and PAWP =15 mmHg associated with connective tissue disease (CTD) or as idiopathic/heritable form. MedDRA version: 20.0;Level: HLT;Classification code 10037455;Term: Pulmonary vascular disorders NEC;System Organ Class: 100000004866;Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14] early pulmonary vascular disease, defined as either a) mean pulmonary arterial pressure (mPAP) =25 m ... | Product Name: Riociguat Product Code: MK-4836 INN or Proposed INN: RIOCIGUAT Other descriptive name: BAY 63-2521 Product Name: Riociguat Product Code: MK-4836 INN or Proposed INN: RIOCIGUAT Other descriptive name: BAY 63-2521 Product Name: Riociguat Product Code: MK-4836 INN or Proposed INN: RIOCIGUAT Other descriptive name: BAY 63-2521 Product Name: Riociguat Product Code: MK-4836 INN or Proposed INN: RIOCIGUAT Other descriptive name: BAY 63-2521 Product Name: Riociguat Product Code: MK-4836 INN or Proposed INN: RIOCIGUAT Other descriptive name: BAY 63-2521 Product Name: Riociguat Product Code: MK-4836 INN or Proposed INN: RIOCIGUAT Other descriptive name: BA ... | Thoraxklinik Heidelberg gGmbH | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 70 | Phase 2 | France;Austria;Norway;Germany;United Kingdom;Switzerland;Italy | ||
| 6 | NCT04972656 (ClinicalTrials.gov) | March 5, 2022 | 9/7/2021 | Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension | Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension: a Multicenter, Randomized, Double-blind, Placebo-controlled Study Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension: a Multicente ... | Pulmonary Arterial Hypertension | Drug: Ambrisentan;Drug: Placebo | Nanjing First Hospital, Nanjing Medical University | Tianjin Medical University General Hospital | Not yet recruiting | 18 Years | N/A | All | 420 | N/A | NULL |
| 7 | NCT04915300 (ClinicalTrials.gov) | March 2022 | 19/5/2021 | Apabetalone for Pulmonary Arterial Hypertension | Apabetalone for Pulmonary Arterial Hypertension: a Phase 2 Clinical Study | Pulmonary Arterial Hypertension | Drug: Apabetalone;Drug: Placebo | Laval University | Canadian Institutes of Health Research (CIHR);Resverlogix Corp | Not yet recruiting | 18 Years | 75 Years | All | 72 | Phase 2 | Canada |
| 8 | NCT05208814 (ClinicalTrials.gov) | February 28, 2022 | 29/12/2021 | a Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients With Renal Insufficiency and Healthy Subjects a Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients With Renal Insuff ... | a Parallel, Open, Single-dose Administration Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients With Renal Insufficiency and Healthy Subjects a Parallel, Open, Single-dose Administration Phase I Study to Evaluate the Pharmacokinetics and Safe ... | Pulmonary Arterial Hypertension;Erectile Dysfunction | Drug: TPN171H single dose | Vigonvita Life Sciences | Shanghai Institute of Materia Medica, Chinese Academy of Sciences | Not yet recruiting | 18 Years | 70 Years | All | 56 | Phase 1 | NULL |
| 9 | EUCTR2021-001910-13-FR (EUCTR) | 21/02/2022 | 23/12/2021 | Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial (IMPAHCT) or A Phase 2b/3, Randomized, Controlled, 24-week Dose Ranging and Confirmatory Study of AV-101 in Patients with PAH. Inhaled Imatinib Pulmonary Arterial HypertensionClinical Trial (IMPAHCT) or A Phase 2b/3, Randomized ... | IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH). - IMPAHCT IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confir ... | Pulmonary Arterial Hypertension (PAH) MedDRA version: 21.1;Level: PT;Classification code 10064911;Term: Pulmonary arterial hypertension;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders MedDRA version: 20.0;Level: LLT;Classification code 10077729;Term: Pulmonary arterial hypertension WHO functional class III;Classification code 10077730;Term: Pulmonary arterial hypertension WHO functional class IV;Classification code 10077740;Term: Pulmonary arterial hypertension WHO functional class II;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14] Pulmonary Arterial Hypertension(PAH) MedDRA version: 21.1;Level: PT;Classification code 10064911;Ter ... | Product Name: AV-101 INN or Proposed INN: IMATINIB Other descriptive name: Not Available Product Name: AV-101 INN or Proposed INN: IMATINIB Other descriptive name: Not Available Product Name: AV-101 INN or Proposed INN: IMATINIB Other descriptive name: Not Available Product Name: AV-101 INN or Proposed INN: IMATINIB Other descriptive name: Not Available Product Name: ... | Aerovate Therapeutics, Inc. | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 462 | Phase 2;Phase 3 | United States;Portugal;Greece;Spain;Chile;Israel;Colombia;Italy;France;Australia;South Africa;Netherlands;China;Czechia;Turkey;Austria;United Kingdom;Mexico;Canada;Argentina;Brazil;Belgium;Poland;Singapore;Germany;Sweden United States;Portugal;Greece;Spain;Chile;Israel;Colombia;Italy;France;Australia;South Africa;Nether ... | ||
| 10 | NCT04778046 (ClinicalTrials.gov) | February 15, 2022 | 26/2/2021 | Pulmonary Hypertension SOLAR | Defining a Noninvasive Signature for Pulmonary Vascular Remodeling in Group 3 PH | Interstitial Lung Disease;COPD;Pulmonary Arterial Hypertension | Drug: Hyperpolarized 129Xe | Bastiaan Driehuys | NULL | Not yet recruiting | 18 Years | N/A | All | 30 | Phase 2 | United States |