88. 慢性血栓塞栓性肺高血圧症 Chronic thromboembolic pulmonary hypertension Clinical trials / Disease details

臨床試験数 : 159 / 薬物数 : 118 - (DrugBank : 23) / 標的遺伝子数 : 13 - 標的パスウェイ数 : 53

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05133713 (ClinicalTrials.gov)	December 1, 2021	1/11/2021	Ventilation and Perfusion Scan in Pulmonary Embolism Following Catheter Directed Thrombectomy Versus ...	Ventilation and Perfusion Imaging in Acute Pulmonary Embolism Following Catheter Directed Aspiration ...	Pulmonary Embolism;Pulmonary Hypertension;Chronic Thromboembolic Pulmonary Hypertension	Device: Catheter directed therapy;Drug: Systemic anticoagulation	University of Arizona	Inari Medical	Not yet recruiting	18 Years	N/A	All	50		United States
2	NCT04954742 (ClinicalTrials.gov)	September 2021	29/6/2021	Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH	An Open-label, Prospective, Single Centre Study of the Effects of Riociguat on RIght VEntricular Siz ...	Primary Pulmonary Arterial Hypertension;Chronic Thromboembolic Pulmonary Hypertension	Drug: Riociguat	Heidelberg University	Merck Sharp & Dohme Corp.	Not yet recruiting	18 Years	N/A	All	30	Phase 4	Germany
3	ChiCTR2100052570	2021-08-01	2021-10-31	A randomized controlled study of the effectiveness of percutaneous pulmonary thrombotic tissue aspir ...	A randomized controlled study of the effectiveness of percutaneous pulmonary thrombotic tissue aspir ...	Chronic Thromboembolic Pulmonary Hypertension	Control group:Traditional simple BPAprocedure;Experimental group:Traditional simple BPA+ thrombotic ...	Fuwai Hospital, Chinese Academy of Medical Sciences	NULL	Recruiting	18	80	Both	Control group:20;Experimental group:20;		China
4	JPRN-jRCT2051200150	12/07/2021	11/03/2021	A study to evaluate efficacy and safety of macitentan 75 mg in inoperable or persistent/recurrent ch ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension	Macitentan Participant will receive macitentanat a dose of 10 milligram (mg) once daily (OD) for 4 we ...	Nakano Masayoshi	NULL	Recruiting	>= 18age old	<= 80age old	Both	144	Phase 3	USA;Germany;Hungary;South Korea;Japan
5	JPRN-jRCTs041200052	30/06/2021	22/10/2020	THERAPY-HYBRID-BPA trial	The Effect of Riociguat for Peak Cardiac Index on Cardiopulmonary Exercise Test in Chronic Thromboem ...	chronic thromboembolic pulmonary hypertension CTEPH;D000081029	In this study, we will perform continuous verification by allocating the Chronic Thromboembolic Pulm ...	Shimokawahara Hiroto	NULL	Recruiting	>= 18age old	< 85age old	Both	72	Phase 2	Japan
6	EUCTR2017-003934-10-PL (EUCTR)	23/06/2021	26/07/2019	A clinical study to investigate the long term safety of the drug macitentan in patients with pulmona ...	mUlticenter, single-arM, open-laBel, long-teRm safety study with macitEntan in patients with puLmona ...	Pulmonary arterial hypertension (PAH)Chronic thromboembolic pulmonary hypertension(CTEPH) MedDRA ver ...	Trade Name: Opsumit Product Name: Macitentan Product Code: ACT-064992 INN or Proposed INN: MACITENTAN	Actelion Pharmaceuticals Ltd	NULL	Not Recruiting			Female: yes Male: yes	176	Phase 3	France;Belarus;Belgium;Poland;Ukraine;Turkey;Russian Federation;Germany
7	EUCTR2020-005462-34-DE (EUCTR)	23/06/2021	25/02/2021	Study to investigate the effect of riociguat on right heart size and function in pulmonary hypertens ...	An open-label, prospective, single centre study of the effects of Riociguat on RIght VEntricular siz ...	Symptomatic pulmonary arterial hypertension with a mean pulmonary artery pressure >20 mmHg and pulmo ...	Trade Name: Adempas (active agent riociguat)	Thoraxklinik Heidelberg gGmbH	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	30	Phase 4	Germany
8	NCT04780932 (ClinicalTrials.gov)	June 14, 2021	15/2/2021	Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Ball ...	Initial Dual Oral coMbination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Ball ...	Thromboembolic Pulmonary Hypertension;Chronic Disease;Inoperable Disease	Drug: Macitentan 10mg;Drug: Placebo	Assistance Publique - Hôpitaux de Paris	Janssen, LP	Recruiting	18 Years	80 Years	All	96	Phase 2/Phase 3	France
9	JPRN-jRCT2071200098	09/04/2021	08/02/2021	Phase III Investigator-Initiated Trial to Investigate Safety and Efficacy of Edoxaban in Patients wi ...	An Investigator-initiated, multicenter, phase 3, randomized, single-blind, double-dummy, parallel-gr ...	Chronic Thromboembolic Pulmonary Hypertension CTEPH, DOAC, warfarin	Oral administeration of (1) or (2) (1) Edoxabangroup - Edoxaban30 mg/60 mg tablet according to body w ...	Abe Kohtaro	NULL	Recruiting	>= 20age old	<= 85age old	Both	74	Phase 3	Japan
10	NCT04730037 (ClinicalTrials.gov)	April 9, 2021	25/1/2021	Clinical Trial to Investigate Safety and Efficacy of Edoxaban in Patients With CTEPH (KABUKI)	An Investigator-initiated, Multicenter, Phase 3, Randomized, Single-blind, Double-dummy, Parallel-gr ...	CTEPH	Drug: Edoxaban;Drug: Warfarin Potassium;Drug: Warfarin Potassium placebo;Drug: Edoxaban placebo	Kyushu University	Daiichi Sankyo Co., Ltd.	Recruiting	20 Years	85 Years	All	74	Phase 3	Japan

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