88. 慢性血栓塞栓性肺高血圧症 Chronic thromboembolic pulmonary hypertension Clinical trials / Disease details

臨床試験数 : 159 / 薬物数 : 118 - (DrugBank : 23) / 標的遺伝子数 : 13 - 標的パスウェイ数 : 53

69 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCT2051200150	12/07/2021	11/03/2021	A study to evaluate efficacy and safety of macitentan 75 mg in inoperable or persistent/recurrent ch ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension	Macitentan Participant will receive macitentanat a dose of 10 milligram (mg) once daily (OD) for 4 we ...	Nakano Masayoshi	NULL	Recruiting	>= 18age old	<= 80age old	Both	144	Phase 3	USA;Germany;Hungary;South Korea;Japan
2	JPRN-jRCTs041200052	30/06/2021	22/10/2020	THERAPY-HYBRID-BPA trial	The Effect of Riociguat for Peak Cardiac Index on Cardiopulmonary Exercise Test in Chronic Thromboem ...	chronic thromboembolic pulmonary hypertension CTEPH;D000081029	In this study, we will perform continuous verification by allocating the Chronic Thromboembolic Pulm ...	Shimokawahara Hiroto	NULL	Recruiting	>= 18age old	< 85age old	Both	72	Phase 2	Japan
3	NCT04780932 (ClinicalTrials.gov)	June 14, 2021	15/2/2021	Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Ball ...	Initial Dual Oral coMbination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Ball ...	Thromboembolic Pulmonary Hypertension;Chronic Disease;Inoperable Disease	Drug: Macitentan 10mg;Drug: Placebo	Assistance Publique - Hôpitaux de Paris	Janssen, LP	Recruiting	18 Years	80 Years	All	96	Phase 2/Phase 3	France
4	JPRN-jRCT2071200098	09/04/2021	08/02/2021	Phase III Investigator-Initiated Trial to Investigate Safety and Efficacy of Edoxaban in Patients wi ...	An Investigator-initiated, multicenter, phase 3, randomized, single-blind, double-dummy, parallel-gr ...	Chronic Thromboembolic Pulmonary Hypertension CTEPH, DOAC, warfarin	Oral administeration of (1) or (2) (1) Edoxabangroup - Edoxaban30 mg/60 mg tablet according to body w ...	Abe Kohtaro	NULL	Recruiting	>= 20age old	<= 85age old	Both	74	Phase 3	Japan
5	NCT04730037 (ClinicalTrials.gov)	April 9, 2021	25/1/2021	Clinical Trial to Investigate Safety and Efficacy of Edoxaban in Patients With CTEPH (KABUKI)	An Investigator-initiated, Multicenter, Phase 3, Randomized, Single-blind, Double-dummy, Parallel-gr ...	CTEPH	Drug: Edoxaban;Drug: Warfarin Potassium;Drug: Warfarin Potassium placebo;Drug: Edoxaban placebo	Kyushu University	Daiichi Sankyo Co., Ltd.	Recruiting	20 Years	85 Years	All	74	Phase 3	Japan
6	EUCTR2019-004131-24-GB (EUCTR)	23/11/2020	26/05/2020	A Phase 3 study to evaluate whether macitentan 75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	United States;United Arab Emirates;Serbia;Taiwan;Saudi Arabia;Slovakia;Spain;Ukraine;Israel;Russian ...
7	EUCTR2019-004131-24-LT (EUCTR)	10/11/2020	22/09/2020	A Phase 3 study to evaluate whether macitentan 75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Serbia;United States;Saudi Arabia;Taiwan;Slovakia;Spain;Ukraine;Russian Federation;Israel;Colombia;I ...
8	EUCTR2019-004131-24-DE (EUCTR)	10/08/2020	26/05/2020	A Phase 3 study to evaluate whether macitentan 75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Serbia;United States;Saudi Arabia;Taiwan;Slovakia;Spain;Ukraine;Russian Federation;Israel;Colombia;I ...
9	EUCTR2019-004131-24-HU (EUCTR)	27/07/2020	28/05/2020	A Phase 3 study to evaluate whether macitentan 75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Serbia;United States;United Arab Emirates;Saudi Arabia;Taiwan;Slovakia;Spain;Ukraine;Russian Federat ...
10	NCT04271475 (ClinicalTrials.gov)	July 7, 2020	13/2/2020	A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Ch ...	A Prospective, Randomized, Double-blind, Multicenter, Placebo-controlled, Parallel Group, Adaptive P ...	Chronic Thromboembolic Pulmonary Hypertension	Drug: Macitentan;Drug: Placebo	Actelion	NULL	Recruiting	18 Years	80 Years	All	144	Phase 3	United States;Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;France;Germany;Hung ...

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