96. クローン病 Crohn disease Clinical trials / Disease details

臨床試験数 : 2,400 / 薬物数 : 1,391 - (DrugBank : 267) / 標的遺伝子数 : 170 - 標的パスウェイ数 : 215

37 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04991324 (ClinicalTrials.gov)	September 2022	27/7/2021	Cholecalciferol Comedication in IBD - the 5C Study	Cholecalciferol Comedication in Chronic Inflammatory Bowel Diseases (Crohn's Disease or Ulcerative Colitis) - the 5C Study	Inflammatory Bowel Diseases	Drug: Vitamin D3	University Hospital, Basel, Switzerland	NULL	Not yet recruiting	18 Years	N/A	All	150	Phase 3	NULL
2	NCT04828031 (ClinicalTrials.gov)	July 1, 2021	29/3/2021	Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease	Vitamin D Regulation of a4ß7+ B Cell Immunophenotypes and Mucosal Antibody Response to Commensal Gut Bacteria in Patients With Inflammatory Bowel Disease	Inflammatory Bowel Diseases;Ulcerative Colitis;Crohn Disease	Drug: Vitamin D	Stanford University	Doris Duke Charitable Foundation	Recruiting	18 Years	N/A	All	50	Phase 1	United States
3	NCT04331639 (ClinicalTrials.gov)	November 1, 2020	23/3/2020	High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy	Implementation of High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Infliximab or Vedolizumab	Inflammatory Bowel Disease;Crohn Disease;Ulcerative Colitis;Vitamin D Deficiency	Dietary Supplement: vitamin D3	Boston Children's Hospital	NULL	Recruiting	5 Years	25 Years	All	50	Phase 2	United States
4	NCT04225819 (ClinicalTrials.gov)	October 1, 2020	3/1/2020	Adjunctive Treatment With Vitamin D3 in Patients With Active IBD	Adjunctive Treatment With Vitamin D3 in Patients With Active IBD (ACTIVATED): A Randomized, Double-blind, Placebo-controlled Trial	IBD;Inflammatory Bowel Diseases;Crohn Disease;Ulcerative Colitis;Vitamin D3 Deficiency	Dietary Supplement: Vitamin D3;Other: Placebo	Massachusetts General Hospital	NULL	Recruiting	18 Years	N/A	All	100	N/A	United States
5	NCT04308850 (ClinicalTrials.gov)	October 2020	24/2/2020	Exploring the Effects of Vitamin D Supplementation on the Chronic Course of Patients With Crohn's Disease With Vitamin D Deficiency	Exploring the Effects of Vitamin D Supplementation on the Chronic Course of Patients With Crohn's Disease With Vitamin D Deficiency,a Prospective Cohort Study	Crohn's Disease;Vitamin D Deficiency;Vitamin D Supplement	Drug: Vitamin D drops	Second Affiliated Hospital of Wenzhou Medical University	NULL	Not yet recruiting	N/A	N/A	All	60	Early Phase 1	China
6	NCT04276636 (ClinicalTrials.gov)	October 2020	17/2/2020	Exploring the Effects of Caltrate Supplement on the Chronic Course of Crohn's Disease Patients With Vitamin D Deficiency	Exploring the Effects of Caltrate Supplement on the Chronic Course of Crohn's Disease Patients With Vitamin D Deficiency,a Prospective Cohort Study	Crohn's Disease;Vitamin D Deficiency;Vitamin D Supplement	Drug: Caltrate Pill	Second Affiliated Hospital of Wenzhou Medical University	NULL	Not yet recruiting	N/A	N/A	All	60	Early Phase 1	China
7	NCT03999580 (ClinicalTrials.gov)	February 7, 2020	24/6/2019	The Vitamin D in Pediatric Crohn's Disease ( ViDiPeC-2 )	A Pragmatic Randomized Controlled Trial on High Dose Vitamin D to Prevent Relapses of Crohn's Disease in Children	Crohn Disease	Drug: vitamin D3	Jantchou Prevost	NULL	Recruiting	4 Years	18 Years	All	316	Phase 3	Canada
8	NCT04134065 (ClinicalTrials.gov)	December 1, 2019	17/10/2019	the Effect of Vitamin D in Crohn's Disease	the Effect of Target-oriented Vitamin D Treatment in Refractory Crohn's Disease	Vitamin D Deficiency;Crohn Disease	Drug: Vitamin D;Drug: Placebo oral capsule	Nanjing University School of Medicine	Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University	Not yet recruiting	20 Years	60 Years	All	30	Early Phase 1	NULL
9	NCT03718182 (ClinicalTrials.gov)	September 17, 2019	23/10/2018	Can Vitamin D Supplementation in People With Crohn's Disease Improve Symptoms as an Adjunct Therapy?	Can Vitamin D Supplementation in People With Crohn's Disease Improve Symptoms as an Adjunct Therapy? D-CODE Feasibility Randomised Controlled Trial	Crohn Disease;Vitamin D Deficiency	Dietary Supplement: Cholecalciferol	University Hospital Birmingham NHS Foundation Trust	National Institute for Health Research, United Kingdom;University of Birmingham;Clinical Trials Research Centre	Recruiting	18 Years	N/A	All	50	Phase 4	United Kingdom
10	NCT03615378 (ClinicalTrials.gov)	August 30, 2018	16/7/2018	Maintenance Dosing of Vitamin D in Crohn's Disease	A Randomized, Double Blind, Placebo Controlled Trial Evaluating Optimal Maintenance Strategies of Vitamin D Levels in Patients With Crohn's Disease in Remission	Crohns Disease;Vitamin D Deficiency	Dietary Supplement: 5000 IU D3;Dietary Supplement: 1000 IU D3;Dietary Supplement: Placebo	Cedars-Sinai Medical Center	NULL	Terminated	18 Years	N/A	All	10	Early Phase 1	United States
11	ChiCTR1800015174	2018-05-01	2018-03-12	Effects of Vitamin D supplementation on clinical prognosis for patients with Crohn's disease	Effects of Vitamin D supplementation on clinical prognosis for patients with Crohn's disease	Crohn's disease	control group:placebo;Vitamin D:800IU Vitamin D;	Gudangdong General Hospital, Guangdong Academy of Medical Sciences	NULL	Pending	18	75	Both	control group:32;Vitamin D:32;		China
12	NCT03162432 (ClinicalTrials.gov)	August 1, 2017	15/5/2017	High Dose Interval Vitamin D Supplementation in Patients With IBD Receiving Remicade	High Dose Interval Vitamin D Supplementation in Patients With IBD Receiving Remicade	IBD;Ulcerative Colitis;Crohn Disease	Drug: Vitamin D3	Boston Children's Hospital	NULL	Completed	7 Years	25 Years	All	50	Phase 3	United States
13	NCT02704624 (ClinicalTrials.gov)	December 2016	24/2/2016	Effects of Supplementation of Vitamin D in Patients With Crohn's Disease	The Impact of Serum Vitamin D and Calcium Levels on the Body Composition, Bone Mineral Density, Muscle Strength, Exercise Tolerance, Fatigue and Inflammatory Activity in Patients With Crohn's Disease: a Randomized Controlled Trial	Crohn Disease;Vitamin D Deficiency;Fatigue;Sarcopenia;Muscle Weakness;Disorder of Bone Density and Structure, Unspecified	Dietary Supplement: Vitamin D;Other: Placebo	Federal University of Juiz de Fora	Fundação de Amparo à Pesquisa do estado de Minas Gerais	Enrolling by invitation	18 Years	50 Years	All	110	Phase 4	Brazil
14	NCT02186275 (ClinicalTrials.gov)	February 2016	4/7/2014	The Vitamin D in Pediatric Crohn's Disease	Randomized Controlled Trial of High Dose Vitamin D in Children With Newly Diagnosed Crohn's Disease for the Prevention of Relapses	Crohn's Disease	Drug: Vitamin D3 : 3000 or 4000 UI/day then 2,000 UI/day;Drug: Vitamin D3 800 UI/day then 800 UI/day	St. Justine's Hospital	Canadian Institutes of Health Research (CIHR)	Completed	9 Years	18 Years	All	25	Phase 3	Canada
15	NCT02208310 (ClinicalTrials.gov)	April 2015	1/8/2014	Trial of High Dose Vitamin D in Patient's With Crohn's Disease	A Randomized Controlled Trial of High-Dose Vitamin D in Crohn's Disease	Crohn's Disease;Vitamin D Deficiency	Drug: Cholecalciferol 10,000 IU;Drug: Cholecalciferol 400 IU	University of Michigan	Crohn's and Colitis Foundation	Terminated	18 Years	75 Years	All	11	Phase 4	United States
16	EUCTR2013-002838-20-BE (EUCTR)	09/12/2014	15/09/2014	The effect of Vitamin D to prevent post-operative relapse of Crohn's Disease	The effect of Vitamin D3 to prevent post-operative relapse of Crohn’s Disease: a placebo-controlled randomized trial (DETECT) - DETECT	Crohn's Disease MedDRA version: 19.0;Level: PT;Classification code 10011401;Term: Crohn's disease;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]	Trade Name: D-CURA Product Name: D-Cura INN or Proposed INN: Cholecalciferol Other descriptive name: CHOLECALCIFEROL CONCENTRATE (WATER-DISPERSIBLE FORM)	Academic Medical Center	NULL	Not Recruiting			Female: yes Male: yes	142	Phase 3	Belgium;Netherlands
17	NCT04606017 (ClinicalTrials.gov)	January 1, 2014	25/10/2020	Effect of Vitamin D Supplementation on Infliximab Response in Patients With Crohn's Disease	Influence of Vitamin D3 Supplementation on Infliximab Efficacy in Chinese Patients With Crohn's Disease: A Retrospective Cohort Study	Crohn Disease;Vitamin D Deficiency;Vitamin D Supplement	Drug: Caltrate Pill	Second Affiliated Hospital of Wenzhou Medical University	NULL	Completed	18 Years	N/A	All	70		China
18	NCT02615288 (ClinicalTrials.gov)	January 2014	23/11/2015	High Dose Vitamin D3 in Crohn's Disease	Impact of High Dose Vitamin D3 Supplementation in Treatment of Crohn's Disease in Remission: A Randomized Double-blind Controlled Study	Crohn's Disease	Dietary Supplement: Vitamin D3	McMaster University	Canadian Association of Gastroenterology	Completed	18 Years	70 Years	Both	40	N/A	NULL
19	EUCTR2013-002838-20-NL (EUCTR)	12/11/2013	06/09/2013	The effect of Vitamin D to prevent post-operative relapse of Crohn's Disease	The effect of Vitamin D3 to prevent post-operative relapse of Crohn’s Disease: a placebo-controlled randomized trial (DETECT) - DETECT	Crohn's Disease MedDRA version: 18.0;Level: PT;Classification code 10011401;Term: Crohn's disease;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]	Trade Name: InVita D3 INN or Proposed INN: Colecalciferol Other descriptive name: CHOLECALCIFEROL CONCENTRATE	Academic Medical Center	NULL	Not Recruiting			Female: yes Male: yes	142	Phase 3	Belgium;Netherlands
20	EUCTR2013-000971-34-DK (EUCTR)	01/08/2013	01/08/2013	High dose vitamin D treatment in Crohn's disease affects the gut immune cells	Mucosal immune regulation by high dose vitamin D treatment in Crohn’s disease - MirViDiC	Active Crohn's Disease in colon and/or terminal ileum MedDRA version: 19.0;Level: LLT;Classification code 10011408;Term: Crohns disease aggravated;System Organ Class: 100000004856 ;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]	Trade Name: Dekristol 20.000 ie INN or Proposed INN: cholecalciferol Other descriptive name: CHOLECALCIFEROL Trade Name: Remicade INN or Proposed INN: INFLIXIMAB Trade Name: Remsima INN or Proposed INN: INFLIXIMAB	Jørgen Agnholt	NULL	Not Recruiting			Female: yes Male: yes	50	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): yes Therapeutic use (Phase 4): no	Denmark
21	NCT01864616 (ClinicalTrials.gov)	July 2013	22/5/2013	The Impact of Vitamin D on Disease Activity in Crohn's Disease		Crohn Disease	Dietary Supplement: Vitamin D3	University of Saskatchewan	Dania Alrefai;Dr.Jennifer Jones;Dr.Hani Jawa;Dr.Wael El-matary;Saudi Arabian Cultural Bureau	Terminated	16 Years	70 Years	All	9	N/A	Canada;Saudi Arabia
22	NCT02010762 (ClinicalTrials.gov)	February 2013	10/12/2013	The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease	The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease: a Placebo-controlled Randomized Trial	Crohn's Disease	Drug: Vitamin D;Drug: Placebo	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	NULL	Completed	18 Years	N/A	All	142	Phase 4	Netherlands
23	NCT01692808 (ClinicalTrials.gov)	October 2012	17/9/2012	Bioavailability of Vitamin D in Children and Adolescents With Crohn's Disease	Bioavailability of Vitamin D in Children and Adolescents With Crohn's Disease.	Crohn's Disease	Drug: Vitamin D3 3000 UI daily;Drug: Vitamin D3 4000 UI daily	St. Justine's Hospital	NULL	Completed	10 Years	18 Years	Both	20	Phase 2	Canada
24	NCT01877577 (ClinicalTrials.gov)	April 2012	11/6/2013	Supplementation of Vitamin D3 in Patients With Inflammatory Bowel Diseases and Hypovitaminosis D	Supplementation of Vitamin D3 (Cholecalciferol) in Patients With Inflammatory Bowel Diseases (IBD) and Hypovitaminosis D: A Prospective Randomized Controlled Trial.	Crohn's Disease (CD);Ulcerative Colitis (UC)	Dietary Supplement: Vitamin D3	University of California, San Francisco	NULL	Completed	18 Years	N/A	Both	30	N/A	United States
25	NCT01369667 (ClinicalTrials.gov)	April 2012	7/6/2011	Vitamin D Supplementation in Adult Crohn's Disease	Vitamin D and Immunomodulation: Effects in Crohn's Disease	Crohn's Disease	Dietary Supplement: Vitamin D3;Other: Placebo	University of Dublin, Trinity College	Queen Mary University of London	Completed	18 Years	75 Years	Both	117	Phase 4	Ireland
26	NCT01792388 (ClinicalTrials.gov)	December 2011	19/12/2012	Vitd and Barrier Function in IBD	Vitamin D and Its Effects on Inflammation and Intestinal Permeability in Crohn's Disease in Remission	Crohn's Disease	Dietary Supplement: Vitamin D;Dietary Supplement: Soya Bean oil	University of Dublin, Trinity College	University of Calgary;Queen Mary University of London	Completed	18 Years	70 Years	Both	30	Phase 4	Ireland
27	NCT01187459 (ClinicalTrials.gov)	September 2010	20/8/2010	Vitamin D in Pediatric Crohn's Disease	Vitamin D in Pediatric Crohn's Disease	Vitamin D Deficiency	Dietary Supplement: Vitamin D	University of British Columbia	McMaster University	Completed	8 Years	18 Years	Both	87	Phase 4	Canada
28	NCT01215890 (ClinicalTrials.gov)	September 2010	5/10/2010	Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease	A Randomized, Data Collection Program To Determine the Efficacy and Safety of Risedronate (Actonel) Therapy Plus Calcium and Vitamin D Supplementation Versus Placebo Plus Calcium and Vitamin D Supplementation in the Treatment of Low Bone Mineral Density in Crohn's Disease Patients	Crohn's Disease;Low Bone Mineral Density	Drug: risedronate;Drug: placebo	University of Alberta	NULL	Completed	18 Years	N/A	Both		Phase 4	Canada
29	NCT01046773 (ClinicalTrials.gov)	January 2010	11/1/2010	Vitamin D Supplementation as Non-toxic Immunomodulation in Children With Crohn's Disease	Vitamin D Supplementation as Non-toxic Immunomodulation in Children With Crohn's Disease	Crohn's Disease;Vitamin D Deficiency	Drug: Cholecalciferol	University of California, Los Angeles	The Broad Foundation	Terminated	8 Years	18 Years	All	3	Phase 1	United States
30	NCT00742781 (ClinicalTrials.gov)	May 2009	26/8/2008	Vitamin D Supplementation in Crohn's Patients	Vitamin D and Crohn's Disease From the Bench to the Clinic	Inflammatory Bowel Disease	Dietary Supplement: Vitamin D	Penn State University	NULL	Completed	18 Years	70 Years	All	21	Phase 1	United States
31	NCT00672763 (ClinicalTrials.gov)	May 2008	2/5/2008	Adjuvant Vitamin D With Corticosteroids in Active Crohn's Disease	The Immunomodulatory Role of Vitamin D in Inflammatory Bowel Disease (The IBDVit Study): Double-Blind, Placebo-Controlled Trial of Adjuvant Vitamin D (Colecalciferol) With Corticosteroids in Active Crohn's Disease	Crohn's Disease	Drug: Colecalciferol D3 (Vigantol Oil);Drug: Medium chain triglycerides	Imperial College London	NULL	Withdrawn	18 Years	N/A	Both	0	Phase 4	United Kingdom
32	EUCTR2008-001466-93-GB (EUCTR)	30/04/2008	28/03/2008		Trial of adjuvant vitamin D with Infliximab in active Crohn's Disease (IBDVit2). - IBDVit2	Active Crohn's Disease MedDRA version: 9.1;Level: LLT;Classification code 10011401;Term: Crohn's disease	Trade Name: Vigantol Oel Product Name: Vigantol Oel TM	Imperial College London	NULL	Not Recruiting			Female: yes Male: yes	40		United Kingdom
33	EUCTR2008-001467-10-GB (EUCTR)	30/04/2008	28/03/2008		Trial of Adjuvant Vitamin D with Standard Maintenance Therapy in Preventing Relapse of Inflammatory Bowel Disease - IBDVit3	Ulcerative colitis - in remissionCrohn's Disease - in remission MedDRA version: 9.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis MedDRA version: 9.1;Classification code 10011401;Term: Crohn's disease	Trade Name: Vigantol Oel Product Name: Vigantol Oel TM	Imperial College London	NULL	Not Recruiting			Female: yes Male: yes	120		United Kingdom
34	EUCTR2007-006692-37-GB (EUCTR)	10/04/2008	25/01/2008	The Immunomodulatory Role of Vitamin D in Inflammatory Bowel Disease (IBDVit): IBDVit1 - Trial of Adjuvant Vitamin D with Corticosteroids in Active Crohn’s Disease; IBDVit2 - Trial of Adjuvant Vitamin D with Infliximab in Active Crohn's Disease; IBDVit3 - Trial of Adjuvant Vitamin D with standard maintenance therapy in preventing relapse of Inflammatory Bowel Disease. - IBDVit	The Immunomodulatory Role of Vitamin D in Inflammatory Bowel Disease (IBDVit): IBDVit1 - Trial of Adjuvant Vitamin D with Corticosteroids in Active Crohn’s Disease; IBDVit2 - Trial of Adjuvant Vitamin D with Infliximab in Active Crohn's Disease; IBDVit3 - Trial of Adjuvant Vitamin D with standard maintenance therapy in preventing relapse of Inflammatory Bowel Disease. - IBDVit	IBDVit1 - Active Crohn's Disease IBDVit2 - Active Crohn's Disease IBDVit3 - Crohn's Disease in remission / Ulcerative Colitis in remission MedDRA version: 9.1;Level: LLT;Classification code 10011401;Term: Crohn's disease MedDRA version: 9.1;Classification code 10045365;Term: Ulcerative colitis	Trade Name: Vigantol Oel Product Name: Vigantol Oel TM	Imperial College London	NULL	Not Recruiting			Female: yes Male: yes	210	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): yes	United Kingdom
35	NCT00621257 (ClinicalTrials.gov)	January 2008	11/2/2008	Vitamin D Levels in Children With IBD	Optimization of Vitamin D Stores and Its Impact on the Bone Health and Disease Outcomes of Children and Adolescents With IBD.	Inflammatory Bowel Disease;Crohn's Disease;Ulcerative Colitis	Dietary Supplement: ergocalciferol;Dietary Supplement: Cholecalciferol	Boston Children’s Hospital	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);Crohn's and Colitis Foundation;NASPGHAN Foundation	Terminated	5 Years	21 Years	All	134	N/A	United States
36	NCT00427804 (ClinicalTrials.gov)	January 2007	25/1/2007	Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium Absorption	Tumor Necrosis Factor-a Induces Vitamin D Resistance in Small Intestinal Calcium Absorption	Rheumatoid Arthritis;Crohn's Disease	Drug: calcitriol	Atlanta VA Medical Center	Emory University	Completed	18 Years	50 Years	Male	9	N/A	United States
37	NCT00132184 (ClinicalTrials.gov)	September 2005	18/8/2005	Vitamin D Treatment for Crohn´s Disease	Remission Keeping and Remission Inducing Effect by Vitamin-D in Crohns Disease, and in Vitro Vitamin-D Mediated T-Cell Immunomodulation	Crohns Disease	Drug: Vitamin D	University of Aarhus	NULL	Active, not recruiting	18 Years	90 Years	Both	110	Phase 2/Phase 3	Denmark

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