Trametinib ( DrugBank: Trametinib )

3 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
2	筋萎縮性側索硬化症	1
34	神経線維腫症	7
279	巨大静脈奇形（頚部口腔咽頭びまん性病変）	1

2. 筋萎縮性側索硬化症

臨床試験数 : 624 / 薬物数 : 611 - (DrugBank : 160) / 標的遺伝子数 : 172 - 標的パスウェイ数 : 225

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04326283 (ClinicalTrials.gov)	April 2, 2020	24/3/2020	Trial of Safety, Tolerability and Efficacy of Trametinib(SNR1611) in Patients With Amyotrophic Later ...	A Sequential Dose-Escalation, Randomized, Active-Controlled, Multi-Center, Phase 1/2a Clinical Trial ...	Amyotrophic Lateral Sclerosis	Drug: Trametinib (0.5 mg);Drug: Trametinib (1 mg);Drug: Trametinib (2 mg);Drug: Riluzole (100 mg)	GENUV Inc.	NULL	Recruiting	19 Years	75 Years	All	30	Phase 1/Phase 2	Korea, Republic of

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34. 神経線維腫症

臨床試験数 : 137 / 薬物数 : 213 - (DrugBank : 76) / 標的遺伝子数 : 87 - 標的パスウェイ数 : 200

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04201457 (ClinicalTrials.gov)	November 20, 2019	12/12/2019	A Trial of Dabrafenib, Trametiniband Hydroxychloroquine for Patients With Recurrent LGG or HGG With ...	Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine (HCQ) for BRAF V600E-mutant or Tr ...	Low Grade Glioma (LGG) of Brain With BRAF Aberration;High Grade Glioma (HGG) of the Brain With BRAF ...	Drug: Dabrafenib;Drug: Trametinib;Drug: Hydroxychloroquine	Pediatric Brain Tumor Consortium	NULL	Recruiting	1 Year	30 Years	All	75	Phase 1/Phase 2	United States
2	NCT03975829 (ClinicalTrials.gov)	November 4, 2019	30/5/2019	Pediatric Long-Term Follow-up and Rollover Study	An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated ...	Diffuse Astrocytoma;Anaplastic Astrocytoma;Astrocytoma;Oligodendroglioma, Childhood;Anaplastic Oligo ...	Drug: dabrafenib;Drug: trametinib	Novartis Pharmaceuticals	NULL	Recruiting	1 Year	N/A	All	250	Phase 4	United States;Canada;France;Spain;United Kingdom
3	EUCTR2019-001317-16-NL (EUCTR)	30/10/2019	16/10/2019	The TRAIN study: TRAmetinib In Neurofibromatosis type 1 related symptomatic plexiform neurofibromas	The TRAIN study: TRAmetinibIn Neurofibromatosis type 1 related symptomatic plexiform neurofibromas - ...	Adult patients (age >17 years) with (mosaic) NF1 with inoperable symptomatic plexiform neurofibromas ...	Trade Name: Mekinist	ErasmusMC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	30	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	Netherlands
4	NCT03741101 (ClinicalTrials.gov)	June 10, 2019	5/11/2018	Treatment of NF1-related Plexiform Neurofibroma With Trametinib	Treatment of NF1-related Plexiform Neurofibroma With Trametinib; a Single Arm, Open-label Trial With ...	Neurofibromatosis 1;Child;Neurofibroma, Plexiform	Drug: Trametinib	Region Skane	Novartis	Recruiting	1 Year	17 Years	All	15	Phase 2	Sweden
5	EUCTR2018-001846-32-SE (EUCTR)	18/09/2018	31/07/2018	Treatment of symptomatic plexiform neurofibromas, a benign tumour associated with the disorder Neuro ...	Treatment of NF1-related plexiform neurofibroma with trametinib; a single arm, open-label trial with ...	NF1-related plexiform neurofibroma;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neon ...	Trade Name: Mekinist Product Name: Mekinist	VO Barnmedicin, Skånes University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	15	Phase 2	Sweden
6	NCT03232892 (ClinicalTrials.gov)	February 13, 2018	14/7/2017	Trametinibin Patients With Advanced Neurofibromatosis Type 1 (NF1)-Mutant Non-small Cell Lung Cancer ...	Phase II Trial to Evaluate Trametinibin Patients With Advanced NF1-mutant Non-small Cell Lung Cancer ...	Non-small Cell Lung Cancer	Drug: Trametinib	University of California, San Francisco	Novartis Pharmaceuticals;American Cancer Society, Inc.	Terminated	18 Years	N/A	All	1	Phase 2	United States
7	NCT03190915 (ClinicalTrials.gov)	October 6, 2017	16/6/2017	Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia	A Phase 2 Study of the MEK Inhibitor Trametinib(NSC# 763093) in Children With Relapsed or Refractory ...	Juvenile Myelomonocytic Leukemia;Neurofibromatosis Type 1	Drug: Trametinib	National Cancer Institute (NCI)	Children's Oncology Group	Recruiting	1 Month	21 Years	All	24	Phase 2	United States

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279. 巨大静脈奇形（頚部口腔咽頭びまん性病変）

臨床試験数 : 14 / 薬物数 : 24 - (DrugBank : 9) / 標的遺伝子数 : 3 - 標的パスウェイ数 : 105

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04258046 (ClinicalTrials.gov)	March 31, 2020	16/1/2020	Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation	Phase II Clinical Trial of MEK Inhibitor Trametinibin the Treatment of Complicated Extracranial Arte ...	Venous Malformation;Arterial Disease	Drug: Trametinib tablet	Stanford University	Boston Children's Hospital	Not yet recruiting	12 Years	60 Years	All	30	Phase 2	United States

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