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No.	KEGG PATHWAY	KEGG GENES	KEGG DRUG	DrugBank	指定難病告示番号
1	Vascular smooth muscle contraction 💬	1件: ADORA2A 💬	Caffeine 💬	Caffeine	8件: 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬
2	Vascular smooth muscle contraction 💬	1件: ADORA2A 💬	Caffeine hydrate 💬	Caffeine	8件: 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬
3	Vascular smooth muscle contraction 💬	1件: ADORA2A 💬	Istradefylline 💬	Istradefylline	1件: 6 💬 💬
4	Vascular smooth muscle contraction 💬	1件: ADORA2A 💬	Preladenant 💬	Preladenant	1件: 6 💬 💬
5	Vascular smooth muscle contraction 💬	1件: ADORA2A 💬	Regadenoson 💬	Regadenoson	1件: 58 💬 💬
6	Vascular smooth muscle contraction 💬	1件: ADORA2A 💬	Regadenoson 💬	Regadenoson	1件: 58 💬 💬
7	Vascular smooth muscle contraction 💬	1件: ADORA2A 💬	Tozadenant 💬	Tozadenant	1件: 6 💬 💬
8	Vascular smooth muscle contraction 💬	2件: ADORA2A, ADORA2B 💬	Adenosine 💬	Adenosine	3件: 13, 58, 65 💬 💬
9	Vascular smooth muscle contraction 💬	2件: ADORA2A, ADORA2B 💬	Adenosine phosphate 💬	Adenosine phosphate	1件: 46 💬 💬
10	Vascular smooth muscle contraction 💬	1件: ADORA2B 💬	Aminophylline 💬	Aminophylline	1件: 63 💬 💬
11	Vascular smooth muscle contraction 💬	1件: ADORA2B 💬	Theophylline 💬	Theophylline	2件: 236, 299 💬 💬
12	Vascular smooth muscle contraction 💬	1件: ADORA2B 💬	Theophylline 💬	Theophylline	2件: 236, 299 💬 💬
13	Vascular smooth muscle contraction 💬	1件: ADRA1A 💬	Alfuzosin 💬	Alfuzosin	1件: 13 💬 💬
14	Vascular smooth muscle contraction 💬	1件: ADRA1A 💬	Silodosin 💬	Silodosin	2件: 6 , 13 💬 💬
15	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Amiodarone 💬	Amiodarone	2件: 28, 127 💬 💬
16	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Carvedilol 💬	Carvedilol	4件: 57, 86, 113, 210 💬 💬
17	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Dipivefrin 💬	Dipivefrin	1件: 6 💬 💬
18	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Doxazosin 💬	Doxazosin	2件: 57, 67 💬 💬
19	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Droxidopa 💬	Droxidopa	5件: 5 , 6 , 17, 169, 170 💬 💬
20	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Ephedrine 💬	Ephedrine	1件: 11 💬 💬
21	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Epinephrine 💬	Epinephrine	3件: 46, 70, 96 💬 💬
22	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Methylergometrine 💬	Methylergometrine	1件: 280 💬 💬
23	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Midodrine 💬	Midodrine	3件: 6 , 17, 58 💬 💬
24	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Noradrenaline 💬	Norepinephrine	2件: 22, 296 💬 💬
25	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Olanzapine 💬	Olanzapine	2件: 2 , 8 💬 💬
26	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Phenylephrine 💬	Phenylephrine	1件: 22 💬 💬
27	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Pseudoephedrine 💬	Pseudoephedrine	1件: 17 💬 💬
28	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Tamsulosin 💬	Tamsulosin	1件: 13 💬 💬
29	Vascular smooth muscle contraction 💬	3件: ADRA1A, ADRA1B, ADRA1D 💬	Terazosin 💬	Terazosin	1件: 6 💬 💬
30	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Angiotensin II 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬 💬
31	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Angiotensin II 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬 💬
32	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Candesartan 💬	Candesartan	2件: 58, 67 💬 💬
33	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Candesartan cilexetil 💬	Candesartan cilexetil	1件: 67 💬 💬
34	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Irbesartan 💬	Irbesartan	4件: 66, 167, 168, 222 💬 💬
35	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Losartan 💬	Losartan	17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬
36	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Telmisartan 💬	Telmisartan	2件: 66, 67 💬 💬
37	Vascular smooth muscle contraction 💬	1件: AGTR1 💬	Valsartan 💬	Valsartan	7件: 57, 58, 66, 75, 218, 222, 224 💬 💬
38	Vascular smooth muscle contraction 💬	2件: AGTR1, EDNRA 💬	Sparsentan 💬	Sparsentan	3件: 66, 218, 222 💬 💬
39	Vascular smooth muscle contraction 💬	1件: AVPR1A 💬	Conivaptan 💬	Conivaptan	1件: 86 💬 💬
40	Vascular smooth muscle contraction 💬	2件: AVPR1A, AVPR1B 💬	Terlipressin 💬	Terlipressin	1件: 299 💬 💬
41	Vascular smooth muscle contraction 💬	2件: AVPR1A, AVPR1B 💬	Vasopressin 💬	Vasopressin	1件: 210 💬 💬
42	Vascular smooth muscle contraction 💬	1件: BRAF 💬	Dabrafenib 💬	Dabrafenib	1件: 34 💬 💬
43	Vascular smooth muscle contraction 💬	2件: BRAF, RAF1 💬	Sorafenib 💬	Sorafenib	2件: 34, 86 💬 💬
44	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Amlodipine 💬	Amlodipine	4件: 13, 51, 67, 298 💬 💬
45	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Cilnidipine 💬	Cilnidipine	1件: 67 💬 💬
46	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Diltiazem 💬	Diltiazem	3件: 51, 58, 86 💬 💬
47	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Isradipine 💬	Isradipine	1件: 6 💬 💬
48	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Nicardipine 💬	Nicardipine	2件: 70, 86 💬 💬
49	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Nifedipine 💬	Nifedipine	2件: 50, 81 💬 💬
50	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Nilvadipine 💬	Nilvadipine	1件: 90 💬 💬
51	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Perhexiline 💬	Perhexiline	2件: 58, 272 💬 💬
52	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Propiverine 💬	Propiverine	1件: 226 💬 💬
53	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Topiramate 💬	Topiramate	6件: 6 , 97, 140, 144, 156, 193 💬 💬
54	Vascular smooth muscle contraction 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	Verapamil 💬	Verapamil	4件: 58, 96, 140, 167 💬 💬
55	Vascular smooth muscle contraction 💬	1件: CALCA 💬	Fremanezumab 💬	Fremanezumab	2件: 124, 226 💬 💬
56	Vascular smooth muscle contraction 💬	1件: EDNRA 💬	Ambrisentan 💬	Ambrisentan	7件: 51, 84, 85, 86, 88, 210, 211 💬 💬
57	Vascular smooth muscle contraction 💬	1件: EDNRA 💬	Bosentan 💬	Bosentan	10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬
58	Vascular smooth muscle contraction 💬	1件: EDNRA 💬	Bosentan 💬	Bosentan	10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬
59	Vascular smooth muscle contraction 💬	1件: EDNRA 💬	Macitentan 💬	Macitentan	5件: 51, 85, 86, 88, 210 💬 💬
60	Vascular smooth muscle contraction 💬	1件: EDNRA 💬	Sitaxentan 💬	Sitaxentan	1件: 86 💬 💬
61	Vascular smooth muscle contraction 💬	1件: EDNRA 💬	Zibotentan 💬	Zibotentan	1件: 51 💬 💬
62	Vascular smooth muscle contraction 💬	3件: GUCY1A1, GUCY1A2, GUCY1B1 💬	Amyl nitrite 💬	Amyl Nitrite	1件: 58 💬 💬
63	Vascular smooth muscle contraction 💬	3件: GUCY1A1, GUCY1A2, GUCY1B1 💬	Riociguat 💬	Riociguat	6件: 51, 84, 86, 88, 225, 299 💬 💬
64	Vascular smooth muscle contraction 💬	2件: MAP2K1, MAP2K2 💬	Binimetinib 💬	Binimetinib	1件: 34 💬 💬
65	Vascular smooth muscle contraction 💬	2件: MAP2K1, MAP2K2 💬	Cobimetinib 💬	Cobimetinib	1件: 280 💬 💬
66	Vascular smooth muscle contraction 💬	2件: MAP2K1, MAP2K2 💬	Mirdametinib 💬	Mirdametinib	1件: 34 💬 💬
67	Vascular smooth muscle contraction 💬	2件: MAP2K1, MAP2K2 💬	Selumetinib 💬	Selumetinib	1件: 34 💬 💬
68	Vascular smooth muscle contraction 💬	2件: MAP2K1, MAP2K2 💬	Trametinib 💬	Trametinib	4件: 2 , 34, 279, 280 💬 💬
69	Vascular smooth muscle contraction 💬	1件: NPR1 💬	Nesiritide 💬	Nesiritide	2件: 46, 58 💬 💬
70	Vascular smooth muscle contraction 💬	2件: NPR1, NPR2 💬	Erythrityl tetranitrate 💬	Erythrityl tetranitrate	1件: 46 💬 💬
71	Vascular smooth muscle contraction 💬	1件: NPR2 💬	Vosoritide 💬	Vosoritide	1件: 276 💬 💬
72	Vascular smooth muscle contraction 💬	1件: PRKCB 💬	Enzastaurin 💬	Enzastaurin	1件: 168 💬 💬
73	Vascular smooth muscle contraction 💬	4件: PRKCD, PRKCE, PRKCH, PRKCQ 💬	Sotrastaurin 💬	Sotrastaurin	1件: 97 💬 💬
74	Vascular smooth muscle contraction 💬	1件: PTGIR 💬	Beraprost 💬	Beraprost	1件: 86 💬 💬
75	Vascular smooth muscle contraction 💬	1件: PTGIR 💬	Epoprostenol 💬	Epoprostenol	1件: 86 💬 💬
76	Vascular smooth muscle contraction 💬	1件: PTGIR 💬	Ibudilast 💬	Ibudilast	2件: 2 , 13 💬 💬
77	Vascular smooth muscle contraction 💬	1件: PTGIR 💬	Iloprost 💬	Iloprost	4件: 51, 84, 85, 86 💬 💬
78	Vascular smooth muscle contraction 💬	1件: PTGIR 💬	Ralinepag 💬	Ralinepag	1件: 86 💬 💬
79	Vascular smooth muscle contraction 💬	1件: PTGIR 💬	Selexipag 💬	Selexipag	5件: 51, 70, 84, 86, 88 💬 💬
80	Vascular smooth muscle contraction 💬	1件: PTGIR 💬	Treprostinil 💬	Treprostinil	6件: 51, 84, 85, 86, 88, 210 💬 💬
81	Vascular smooth muscle contraction 💬	2件: ROCK1, ROCK2 💬	Fasudil 💬	Fasudil	4件: 2 , 5 , 7 , 51 💬 💬
82	Vascular smooth muscle contraction 💬	1件: ROCK2 💬	Belumosudil 💬	Belumosudil	2件: 51, 85 💬 💬