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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
MAP2K1
💬
1.
MAP2K1
×
Name
Full Name
MAP2K1
mitogen-activated protein kinase kinase 1
89件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
Apoptosis
,
Cellular senescence
,
Vascular smooth muscle contraction
,
VEGF signaling pathway
,
Apelin signaling pathway
,
Osteoclast differentiation
,
Focal adhesion
,
Gap junction
,
Signaling pathways regulating pluripotency of stem cells
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Fc gamma R-mediated phagocytosis
,
TNF signaling pathway
,
Long-term potentiation
,
Neurotrophin signaling pathway
,
Cholinergic synapse
,
Serotonergic synapse
,
Long-term depression
,
Regulation of actin cytoskeleton
,
Insulin signaling pathway
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Estrogen signaling pathway
,
Melanogenesis
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
GnRH secretion
,
Cushing syndrome
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Alcoholism
,
Salmonella infection
,
Yersinia infection
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Thyroid cancer
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
89件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Selumetinib
Selumetinib
💬
1.
MAP2K1
×
Name
Other Names
Selumetinib
Selumetinib (USAN/INN)
セルメチニブ
Selumetinib
1件:
34
34
💬
1.
MAP2K1
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis
2
MAP2K1
💬
2.
MAP2K1
×
Name
Full Name
MAP2K1
mitogen-activated protein kinase kinase 1
89件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
Apoptosis
,
Cellular senescence
,
Vascular smooth muscle contraction
,
VEGF signaling pathway
,
Apelin signaling pathway
,
Osteoclast differentiation
,
Focal adhesion
,
Gap junction
,
Signaling pathways regulating pluripotency of stem cells
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Fc gamma R-mediated phagocytosis
,
TNF signaling pathway
,
Long-term potentiation
,
Neurotrophin signaling pathway
,
Cholinergic synapse
,
Serotonergic synapse
,
Long-term depression
,
Regulation of actin cytoskeleton
,
Insulin signaling pathway
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Estrogen signaling pathway
,
Melanogenesis
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
GnRH secretion
,
Cushing syndrome
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Alcoholism
,
Salmonella infection
,
Yersinia infection
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Thyroid cancer
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
89件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Trametinib
Trametinib
💬
2.
MAP2K1
×
Name
Other Names
Trametinib
Trametinib (USAN)
トラメチニブ
Trametinib
4件:
2
2
,
34
,
279
,
280
💬
2.
MAP2K1
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
34
神経線維腫症
Neurofibromatosis
279
巨大静脈奇形（頚部口腔咽頭びまん性病変）
Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280
巨大動静脈奇形（頚部顔面又は四肢病変）
Huge arteriovenous malformation with cervicofacial or limb lesion
3
MAP2K1
💬
3.
MAP2K1
×
Name
Full Name
MAP2K1
mitogen-activated protein kinase kinase 1
89件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
Apoptosis
,
Cellular senescence
,
Vascular smooth muscle contraction
,
VEGF signaling pathway
,
Apelin signaling pathway
,
Osteoclast differentiation
,
Focal adhesion
,
Gap junction
,
Signaling pathways regulating pluripotency of stem cells
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Fc gamma R-mediated phagocytosis
,
TNF signaling pathway
,
Long-term potentiation
,
Neurotrophin signaling pathway
,
Cholinergic synapse
,
Serotonergic synapse
,
Long-term depression
,
Regulation of actin cytoskeleton
,
Insulin signaling pathway
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Estrogen signaling pathway
,
Melanogenesis
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
GnRH secretion
,
Cushing syndrome
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Alcoholism
,
Salmonella infection
,
Yersinia infection
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Thyroid cancer
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
89件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Cobimetinib
Cobimetinib
💬
3.
MAP2K1
×
Name
Other Names
Cobimetinib
Cobimetinib (USAN/INN)
コビメチニブ
Cobimetinib
1件:
280
280
💬
3.
MAP2K1
×
告示番号
日本語名
英語名
280
巨大動静脈奇形（頚部顔面又は四肢病変）
Huge arteriovenous malformation with cervicofacial or limb lesion
4
MAP2K1
💬
4.
MAP2K1
×
Name
Full Name
MAP2K1
mitogen-activated protein kinase kinase 1
89件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
Apoptosis
,
Cellular senescence
,
Vascular smooth muscle contraction
,
VEGF signaling pathway
,
Apelin signaling pathway
,
Osteoclast differentiation
,
Focal adhesion
,
Gap junction
,
Signaling pathways regulating pluripotency of stem cells
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Fc gamma R-mediated phagocytosis
,
TNF signaling pathway
,
Long-term potentiation
,
Neurotrophin signaling pathway
,
Cholinergic synapse
,
Serotonergic synapse
,
Long-term depression
,
Regulation of actin cytoskeleton
,
Insulin signaling pathway
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Estrogen signaling pathway
,
Melanogenesis
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
GnRH secretion
,
Cushing syndrome
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Alcoholism
,
Salmonella infection
,
Yersinia infection
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Thyroid cancer
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
89件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Binimetinib
Binimetinib
💬
4.
MAP2K1
×
Name
Other Names
Binimetinib
Binimetinib (JAN/USAN)
Mektovi (TN)
ビニメチニブ
メクトビ
Binimetinib
1件:
34
34
💬
4.
MAP2K1
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis
5
MAP2K1
💬
5.
MAP2K1
×
Name
Full Name
MAP2K1
mitogen-activated protein kinase kinase 1
89件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
Apoptosis
,
Cellular senescence
,
Vascular smooth muscle contraction
,
VEGF signaling pathway
,
Apelin signaling pathway
,
Osteoclast differentiation
,
Focal adhesion
,
Gap junction
,
Signaling pathways regulating pluripotency of stem cells
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
B cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Fc gamma R-mediated phagocytosis
,
TNF signaling pathway
,
Long-term potentiation
,
Neurotrophin signaling pathway
,
Cholinergic synapse
,
Serotonergic synapse
,
Long-term depression
,
Regulation of actin cytoskeleton
,
Insulin signaling pathway
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Estrogen signaling pathway
,
Melanogenesis
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
GnRH secretion
,
Cushing syndrome
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Alcoholism
,
Salmonella infection
,
Yersinia infection
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Thyroid cancer
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
89件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Mirdametinib
Mirdametinib
💬
5.
MAP2K1
×
Name
Other Names
Mirdametinib
Mirdametinib (USAN)
ミルダメチニブ
Mirdametinib
1件:
34
34
💬
5.
MAP2K1
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis