Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Diabetic cardiomyopathy 💬
1件: REN 💬 Aliskiren 💬 Aliskiren 3件: 66, 167, 222 💬
2 Renal cell carcinoma 💬
1件: BRAF 💬 Dabrafenib 💬 Dabrafenib 1件: 34 💬
3 Renal cell carcinoma 💬
2件: BRAF, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
4 Renal cell carcinoma 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
5 Renal cell carcinoma 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
6 Renal cell carcinoma 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 1件: 34 💬
7 Renal cell carcinoma 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
8 Renal cell carcinoma 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 4件:  2 , 34, 279, 280 💬
9 Renal cell carcinoma 💬
1件: MET 💬 Cabozantinib 💬 Cabozantinib 1件: 34 💬
10 Renal cell carcinoma 💬
1件: PIK3CA 💬 Alpelisib 💬 Alpelisib 1件: 138 💬
11 Renal cell carcinoma 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
12 Renal cell carcinoma 💬
1件: PIK3CD 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
13 Renal cell carcinoma 💬
3件: TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab 3件: 51, 85, 222 💬
14 Renal cell carcinoma 💬
1件: VEGFA 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬
15 Renal cell carcinoma 💬
1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 6件: 13, 34, 85, 87, 227, 280 💬
16 Renal cell carcinoma 💬
1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
17 Renin secretion 💬
1件: ACE 💬 Benazepril 💬 Benazepril 4件: 49, 57, 218, 224 💬
18 Renin secretion 💬
1件: ACE 💬 Captopril 💬 Captopril 8件:  6 , 17, 46, 86, 96, 97, 107, 271 💬
19 Renin secretion 💬
1件: ACE 💬 Cilazapril 💬 Cilazapril 1件: 66 💬
20 Renin secretion 💬
1件: ACE 💬 Cilazapril 💬 Cilazapril 1件: 66 💬
21 Renin secretion 💬
1件: ACE 💬 Enalapril 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
22 Renin secretion 💬
1件: ACE 💬 Imidapril 💬 Imidapril 1件: 67 💬
23 Renin secretion 💬
1件: ACE 💬 Lisinopril 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
24 Renin secretion 💬
1件: ACE 💬 Lisinopril 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
25 Renin secretion 💬
1件: ACE 💬 Moexipril 💬 Moexipril 1件: 93 💬
26 Renin secretion 💬
1件: ACE 💬 Perindopril 💬 Perindopril 4件: 58, 113, 167, 222 💬
27 Renin secretion 💬
1件: ACE 💬 Quinapril 💬 Quinapril 1件: 19 💬
28 Renin secretion 💬
1件: ACE 💬 Ramipril 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
29 Renin secretion 💬
1件: ADORA1 💬 Adenosine 💬 Adenosine 3件: 13, 58, 65 💬
30 Renin secretion 💬
1件: ADORA1 💬 Adenosine phosphate 💬 Adenosine phosphate 1件: 46 💬
31 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Aminophylline 💬 Aminophylline 1件: 63 💬
32 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
33 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
34 Renin secretion 💬
4件: ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
35 Renin secretion 💬
4件: ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine hydrate 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
36 Renin secretion 💬
1件: ADRB1 💬 Amiodarone 💬 Amiodarone 2件: 28, 127 💬
37 Renin secretion 💬
1件: ADRB1 💬 Atenolol 💬 Atenolol 1件: 167 💬
38 Renin secretion 💬
1件: ADRB1 💬 Bisoprolol 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
39 Renin secretion 💬
1件: ADRB1 💬 Celiprolol 💬 Celiprolol 1件: 168 💬
40 Renin secretion 💬
1件: ADRB1 💬 Dobutamine 💬 Dobutamine 4件: 57, 58, 86, 215 💬
41 Renin secretion 💬
1件: ADRB1 💬 Esmolol 💬 Esmolol 1件: 58 💬
42 Renin secretion 💬
1件: ADRB1 💬 Metoprolol 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
43 Renin secretion 💬
1件: ADRB1 💬 Nebivolol 💬 Nebivolol 4件: 17, 85, 113, 167 💬
44 Renin secretion 💬
2件: ADRB1, ADRB2 💬 Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
45 Renin secretion 💬
2件: ADRB1, ADRB2 💬 Nadolol 💬 Nadolol 1件:  6  💬
46 Renin secretion 💬
2件: ADRB1, ADRB2 💬 Timolol 💬 Timolol 2件: 157, 227 💬
47 Renin secretion 💬
2件: ADRB1, ADRB2 💬 Timolol 💬 Timolol 2件: 157, 227 💬
48 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin 1件:  6  💬
49 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
50 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine 1件: 11 💬
51 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine 3件: 46, 70, 96 💬
52 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine 2件: 22, 296 💬
53 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
54 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine 1件: 17 💬
55 Renin secretion 💬
1件: ADRB2 💬 Clenbuterol 💬 Clenbuterol 5件:  1 ,  2 ,  6 , 13, 256 💬
56 Renin secretion 💬
1件: ADRB2 💬 Formoterol 💬 Formoterol 3件: 85, 228, 299 💬
57 Renin secretion 💬
1件: ADRB2 💬 Isoxsuprine 💬 Isoxsuprine 1件: 13 💬
58 Renin secretion 💬
1件: ADRB2 💬 Levosalbutamol 💬 Levosalbutamol 1件: 49 💬
59 Renin secretion 💬
1件: ADRB2 💬 Albuterol 💬 Salbutamol 12件:  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
60 Renin secretion 💬
1件: ADRB2 💬 Salmeterol 💬 Salmeterol 1件: 299 💬
61 Renin secretion 💬
1件: ADRB2 💬 Terbutaline 💬 Terbutaline 1件: 118 💬
62 Renin secretion 💬
1件: ADRB2 💬 Tulobuterol 💬 Tulobuterol 1件:  6  💬
63 Renin secretion 💬
1件: ADRB3 💬 Mirabegron 💬 Mirabegron 4件:  6 , 13, 53, 226 💬
64 Renin secretion 💬
1件: AGTR1 💬 Angiotensin II 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
65 Renin secretion 💬
1件: AGTR1 💬 Angiotensin II 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
66 Renin secretion 💬
1件: AGTR1 💬 Candesartan 💬 Candesartan 2件: 58, 67 💬
67 Renin secretion 💬
1件: AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil 1件: 67 💬
68 Renin secretion 💬
1件: AGTR1 💬 Irbesartan 💬 Irbesartan 4件: 66, 167, 168, 222 💬
69 Renin secretion 💬
1件: AGTR1 💬 Losartan 💬 Losartan 17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
70 Renin secretion 💬
1件: AGTR1 💬 Telmisartan 💬 Telmisartan 2件: 66, 67 💬
71 Renin secretion 💬
1件: AGTR1 💬 Valsartan 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
72 Renin secretion 💬
2件: AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan 3件: 66, 218, 222 💬
73 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine 4件: 13, 51, 67, 298 💬
74 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine 1件: 67 💬
75 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem 3件: 51, 58, 86 💬
76 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine 1件:  6  💬
77 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine 2件: 70, 86 💬
78 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine 2件: 50, 81 💬
79 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine 1件: 90 💬
80 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline 2件: 58, 272 💬
81 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine 1件: 226 💬
82 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
83 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil 4件: 58, 96, 140, 167 💬
84 Renin secretion 💬
1件: EDNRA 💬 Ambrisentan 💬 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211 💬
85 Renin secretion 💬
1件: EDNRA 💬 Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
86 Renin secretion 💬
1件: EDNRA 💬 Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
87 Renin secretion 💬
1件: EDNRA 💬 Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
88 Renin secretion 💬
1件: EDNRA 💬 Sitaxentan 💬 Sitaxentan 1件: 86 💬
89 Renin secretion 💬
1件: EDNRA 💬 Zibotentan 💬 Zibotentan 1件: 51 💬
90 Renin secretion 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Amyl nitrite 💬 Amyl Nitrite 1件: 58 💬
91 Renin secretion 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
92 Renin secretion 💬
1件: NPR1 💬 Erythrityl tetranitrate 💬 Erythrityl tetranitrate 1件: 46 💬
93 Renin secretion 💬
1件: NPR1 💬 Nesiritide 💬 Nesiritide 2件: 46, 58 💬
94 Renin secretion 💬
5件: PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Bucladesine 💬 Bucladesine 1件: 246 💬
95 Renin secretion 💬
5件: PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Flavoxate 💬 Flavoxate 1件: 226 💬
96 Renin secretion 💬
2件: PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol 3件: 46, 51, 70 💬
97 Renin secretion 💬
2件: PDE3A, PDE3B 💬 Ibudilast 💬 Ibudilast 2件:  2 , 13 💬
98 Renin secretion 💬
2件: PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan 1件:  2  💬
99 Renin secretion 💬
2件: PDE3A, PDE3B 💬 Milrinone 💬 Milrinone 1件: 294 💬
100 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
101 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
102 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
103 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
104 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
105 Renin secretion 💬
2件: PTGER2, PTGER4 💬 Misoprostol 💬 Misoprostol 3件: 46, 70, 271 💬
106 Renin secretion 💬
1件: REN 💬 Aliskiren 💬 Aliskiren 3件: 66, 167, 222 💬
107 Renin-angiotensin system 💬
1件: ACE 💬 Benazepril 💬 Benazepril 4件: 49, 57, 218, 224 💬
108 Renin-angiotensin system 💬
1件: ACE 💬 Captopril 💬 Captopril 8件:  6 , 17, 46, 86, 96, 97, 107, 271 💬
109 Renin-angiotensin system 💬
1件: ACE 💬 Cilazapril 💬 Cilazapril 1件: 66 💬
110 Renin-angiotensin system 💬
1件: ACE 💬 Cilazapril 💬 Cilazapril 1件: 66 💬
111 Renin-angiotensin system 💬
1件: ACE 💬 Enalapril 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
112 Renin-angiotensin system 💬
1件: ACE 💬 Imidapril 💬 Imidapril 1件: 67 💬
113 Renin-angiotensin system 💬
1件: ACE 💬 Lisinopril 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
114 Renin-angiotensin system 💬
1件: ACE 💬 Lisinopril 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
115 Renin-angiotensin system 💬
1件: ACE 💬 Moexipril 💬 Moexipril 1件: 93 💬
116 Renin-angiotensin system 💬
1件: ACE 💬 Perindopril 💬 Perindopril 4件: 58, 113, 167, 222 💬
117 Renin-angiotensin system 💬
1件: ACE 💬 Quinapril 💬 Quinapril 1件: 19 💬
118 Renin-angiotensin system 💬
1件: ACE 💬 Ramipril 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
119 Renin-angiotensin system 💬
1件: AGTR1 💬 Candesartan 💬 Candesartan 2件: 58, 67 💬
120 Renin-angiotensin system 💬
1件: AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil 1件: 67 💬
121 Renin-angiotensin system 💬
1件: AGTR1 💬 Irbesartan 💬 Irbesartan 4件: 66, 167, 168, 222 💬
122 Renin-angiotensin system 💬
1件: AGTR1 💬 Losartan 💬 Losartan 17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
123 Renin-angiotensin system 💬
1件: AGTR1 💬 Sparsentan 💬 Sparsentan 3件: 66, 218, 222 💬
124 Renin-angiotensin system 💬
1件: AGTR1 💬 Telmisartan 💬 Telmisartan 2件: 66, 67 💬
125 Renin-angiotensin system 💬
1件: AGTR1 💬 Valsartan 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
126 Renin-angiotensin system 💬
2件: AGTR1, AGTR2 💬 Angiotensin II 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
127 Renin-angiotensin system 💬
2件: AGTR1, AGTR2 💬 Angiotensin II 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
128 Renin-angiotensin system 💬
1件: ANPEP 💬 Ubenimex 💬 Ubenimex 1件: 86 💬
129 Renin-angiotensin system 💬
1件: MME 💬 Sacubitril 💬 Sacubitril 2件: 58, 222 💬
130 Renin-angiotensin system 💬
1件: REN 💬 Aliskiren 💬 Aliskiren 3件: 66, 167, 222 💬