Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 cGMP-PKG signaling pathway 💬
 2件: ADORA1, ADORA3 💬 Adenosine 💬 Adenosine 3件: 13, 58, 65 💬
2 cGMP-PKG signaling pathway 💬
 2件: ADORA1, ADORA3 💬 Adenosine phosphate 💬 Adenosine phosphate 1件: 46 💬
3 cGMP-PKG signaling pathway 💬
 4件: ADORA1, PDE2A, PDE3A, PDE3B 💬 Aminophylline 💬 Aminophylline 1件: 63 💬
4 cGMP-PKG signaling pathway 💬
 4件: ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
5 cGMP-PKG signaling pathway 💬
 4件: ADORA1, PDE2A, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
6 cGMP-PKG signaling pathway 💬
 5件: ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
7 cGMP-PKG signaling pathway 💬
 5件: ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 Caffeine hydrate 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
8 cGMP-PKG signaling pathway 💬
 1件: ADORA3 💬 Piclidenoson 💬 Piclidenoson 1件: 46 💬
9 cGMP-PKG signaling pathway 💬
 1件: ADRA1A 💬 Alfuzosin 💬 Alfuzosin 1件: 13 💬
10 cGMP-PKG signaling pathway 💬
 1件: ADRA1A 💬 Silodosin 💬 Silodosin 2件:  6 , 13 💬
11 cGMP-PKG signaling pathway 💬
 3件: ADRA1A, ADRA1B, ADRA1D 💬 Doxazosin 💬 Doxazosin 2件: 57, 67 💬
12 cGMP-PKG signaling pathway 💬
 3件: ADRA1A, ADRA1B, ADRA1D 💬 Midodrine 💬 Midodrine 3件:  6 , 17, 58 💬
13 cGMP-PKG signaling pathway 💬
 3件: ADRA1A, ADRA1B, ADRA1D 💬 Olanzapine 💬 Olanzapine 2件:  2 ,  8  💬
14 cGMP-PKG signaling pathway 💬
 3件: ADRA1A, ADRA1B, ADRA1D 💬 Phenylephrine 💬 Phenylephrine 1件: 22 💬
15 cGMP-PKG signaling pathway 💬
 3件: ADRA1A, ADRA1B, ADRA1D 💬 Tamsulosin 💬 Tamsulosin 1件: 13 💬
16 cGMP-PKG signaling pathway 💬
 3件: ADRA1A, ADRA1B, ADRA1D 💬 Terazosin 💬 Terazosin 1件:  6  💬
17 cGMP-PKG signaling pathway 💬
 6件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 Methylergometrine 💬 Methylergometrine 1件: 280 💬
18 cGMP-PKG signaling pathway 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin 1件:  6  💬
19 cGMP-PKG signaling pathway 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
20 cGMP-PKG signaling pathway 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine 1件: 11 💬
21 cGMP-PKG signaling pathway 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine 3件: 46, 70, 96 💬
22 cGMP-PKG signaling pathway 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine 2件: 22, 296 💬
23 cGMP-PKG signaling pathway 💬
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine 1件: 17 💬
24 cGMP-PKG signaling pathway 💬
 5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬
25 cGMP-PKG signaling pathway 💬
 5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNJ8 💬 Amiodarone 💬 Amiodarone 2件: 28, 127 💬
26 cGMP-PKG signaling pathway 💬
 1件: ADRA2A 💬 Guanfacine 💬 Guanfacine 1件: 193 💬
27 cGMP-PKG signaling pathway 💬
 1件: ADRA2A 💬 Pimozide 💬 Pimozide 1件:  2  💬
28 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Apraclonidine 💬 Apraclonidine 1件: 11 💬
29 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Brimonidine 💬 Brimonidine 2件: 13, 90 💬
30 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
31 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Clonidine 💬 Clonidine 4件:  6 , 65, 70, 78 💬
32 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Clozapine 💬 Clozapine 1件:  6  💬
33 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine 14件:  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
34 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Guanabenz 💬 Guanabenz 2件:  2 , 13 💬
35 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Rilmenidine 💬 Rilmenidine 1件:  8  💬
36 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Tizanidine 💬 Tizanidine 1件: 13 💬
37 cGMP-PKG signaling pathway 💬
 3件: ADRA2A, ADRA2B, ADRA2C 💬 Yohimbine 💬 Yohimbine 1件:  6  💬
38 cGMP-PKG signaling pathway 💬
 1件: ADRB1 💬 Atenolol 💬 Atenolol 1件: 167 💬
39 cGMP-PKG signaling pathway 💬
 1件: ADRB1 💬 Bisoprolol 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
40 cGMP-PKG signaling pathway 💬
 1件: ADRB1 💬 Celiprolol 💬 Celiprolol 1件: 168 💬
41 cGMP-PKG signaling pathway 💬
 1件: ADRB1 💬 Dobutamine 💬 Dobutamine 4件: 57, 58, 86, 215 💬
42 cGMP-PKG signaling pathway 💬
 1件: ADRB1 💬 Esmolol 💬 Esmolol 1件: 58 💬
43 cGMP-PKG signaling pathway 💬
 1件: ADRB1 💬 Metoprolol 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
44 cGMP-PKG signaling pathway 💬
 1件: ADRB1 💬 Nebivolol 💬 Nebivolol 4件: 17, 85, 113, 167 💬
45 cGMP-PKG signaling pathway 💬
 2件: ADRB1, ADRB2 💬 Nadolol 💬 Nadolol 1件:  6  💬
46 cGMP-PKG signaling pathway 💬
 2件: ADRB1, ADRB2 💬 Timolol 💬 Timolol 2件: 157, 227 💬
47 cGMP-PKG signaling pathway 💬
 2件: ADRB1, ADRB2 💬 Timolol 💬 Timolol 2件: 157, 227 💬
48 cGMP-PKG signaling pathway 💬
 3件: ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬
49 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Clenbuterol 💬 Clenbuterol 5件:  1 ,  2 ,  6 , 13, 256 💬
50 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Formoterol 💬 Formoterol 3件: 85, 228, 299 💬
51 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Isoxsuprine 💬 Isoxsuprine 1件: 13 💬
52 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Levosalbutamol 💬 Levosalbutamol 1件: 49 💬
53 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Albuterol 💬 Salbutamol 12件:  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
54 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Salmeterol 💬 Salmeterol 1件: 299 💬
55 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Terbutaline 💬 Terbutaline 1件: 118 💬
56 cGMP-PKG signaling pathway 💬
 1件: ADRB2 💬 Tulobuterol 💬 Tulobuterol 1件:  6  💬
57 cGMP-PKG signaling pathway 💬
 1件: ADRB3 💬 Mirabegron 💬 Mirabegron 4件:  6 , 13, 53, 226 💬
58 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Angiotensin II 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
59 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Angiotensin II 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
60 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Candesartan 💬 Candesartan 2件: 58, 67 💬
61 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil 1件: 67 💬
62 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Irbesartan 💬 Irbesartan 4件: 66, 167, 168, 222 💬
63 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Losartan 💬 Losartan 17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
64 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Telmisartan 💬 Telmisartan 2件: 66, 67 💬
65 cGMP-PKG signaling pathway 💬
 1件: AGTR1 💬 Valsartan 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
66 cGMP-PKG signaling pathway 💬
 2件: AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan 3件: 66, 218, 222 💬
67 cGMP-PKG signaling pathway 💬
 4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digitoxin 💬 Digitoxin 1件: 299 💬
68 cGMP-PKG signaling pathway 💬
 4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digoxin 💬 Digoxin 3件:  8 , 46, 210 💬
69 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine 4件: 13, 51, 67, 298 💬
70 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine 1件: 67 💬
71 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem 3件: 51, 58, 86 💬
72 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine 1件:  6  💬
73 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine 2件: 70, 86 💬
74 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine 2件: 50, 81 💬
75 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine 1件: 90 💬
76 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline 2件: 58, 272 💬
77 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine 1件: 226 💬
78 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
79 cGMP-PKG signaling pathway 💬
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil 4件: 58, 96, 140, 167 💬
80 cGMP-PKG signaling pathway 💬
 1件: EDNRA 💬 Ambrisentan 💬 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211 💬
81 cGMP-PKG signaling pathway 💬
 1件: EDNRA 💬 Sitaxentan 💬 Sitaxentan 1件: 86 💬
82 cGMP-PKG signaling pathway 💬
 1件: EDNRA 💬 Zibotentan 💬 Zibotentan 1件: 51 💬
83 cGMP-PKG signaling pathway 💬
 2件: EDNRA, EDNRB 💬 Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
84 cGMP-PKG signaling pathway 💬
 2件: EDNRA, EDNRB 💬 Bosentan 💬 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
85 cGMP-PKG signaling pathway 💬
 2件: EDNRA, EDNRB 💬 Macitentan 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
86 cGMP-PKG signaling pathway 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Amyl nitrite 💬 Amyl Nitrite 1件: 58 💬
87 cGMP-PKG signaling pathway 💬
 3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
88 cGMP-PKG signaling pathway 💬
 1件: INSR 💬 Insulin detemir 💬 Insulin detemir 1件: 299 💬
89 cGMP-PKG signaling pathway 💬
 1件: INSR 💬 Insulin glargine 💬 Insulin glargine 1件: 299 💬
90 cGMP-PKG signaling pathway 💬
 1件: INSR 💬 Insulin human 💬 Insulin human 2件: 96, 156 💬
91 cGMP-PKG signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
92 cGMP-PKG signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
93 cGMP-PKG signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 1件: 34 💬
94 cGMP-PKG signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
95 cGMP-PKG signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 4件:  2 , 34, 279, 280 💬
96 cGMP-PKG signaling pathway 💬
 1件: MYH7 💬 Mavacamten 💬 Mavacamten 1件: 58 💬
97 cGMP-PKG signaling pathway 💬
 1件: NPR1 💬 Nesiritide 💬 Nesiritide 2件: 46, 58 💬
98 cGMP-PKG signaling pathway 💬
 2件: NPR1, NPR2 💬 Erythrityl tetranitrate 💬 Erythrityl tetranitrate 1件: 46 💬
99 cGMP-PKG signaling pathway 💬
 1件: NPR2 💬 Vosoritide 💬 Vosoritide 1件: 276 💬
100 cGMP-PKG signaling pathway 💬
 1件: OPRD1 💬 Loperamide 💬 Loperamide 2件: 13, 97 💬
101 cGMP-PKG signaling pathway 💬
 1件: OPRD1 💬 Nalbuphine 💬 Nalbuphine 1件: 85 💬
102 cGMP-PKG signaling pathway 💬
 1件: OPRD1 💬 Nalmefene 💬 Nalmefene 1件:  6  💬
103 cGMP-PKG signaling pathway 💬
 1件: OPRD1 💬 Naloxone 💬 Naloxone 2件:  6 , 226 💬
104 cGMP-PKG signaling pathway 💬
 1件: OPRD1 💬 Naltrexone 💬 Naltrexone 13件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
105 cGMP-PKG signaling pathway 💬
 1件: OPRD1 💬 Oxycodone 💬 Oxycodone 5件:  6 , 13, 70, 226, 298 💬
106 cGMP-PKG signaling pathway 💬
 3件: PDE2A, PDE3A, PDE3B 💬 Bucladesine 💬 Bucladesine 1件: 246 💬
107 cGMP-PKG signaling pathway 💬
 3件: PDE2A, PDE3A, PDE3B 💬 Flavoxate 💬 Flavoxate 1件: 226 💬
108 cGMP-PKG signaling pathway 💬
 2件: PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol 3件: 46, 51, 70 💬
109 cGMP-PKG signaling pathway 💬
 2件: PDE3A, PDE3B 💬 Ibudilast 💬 Ibudilast 2件:  2 , 13 💬
110 cGMP-PKG signaling pathway 💬
 2件: PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan 1件:  2  💬
111 cGMP-PKG signaling pathway 💬
 2件: PDE3A, PDE3B 💬 Milrinone 💬 Milrinone 1件: 294 💬
112 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 Dipyridamole 💬 Dipyridamole 6件: 46, 49, 51, 66, 96, 224 💬
113 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 Sildenafil 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
114 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 Tadalafil 💬 Tadalafil 7件:  6 , 51, 75, 84, 86, 113, 210 💬
115 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 Udenafil 💬 Udenafil 2件: 86, 210 💬
116 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 Vardenafil 💬 Vardenafil 3件: 13, 86, 299 💬
117 cGMP-PKG signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
118 cGMP-PKG signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
119 cGMP-PKG signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
120 cGMP-PKG signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
121 cGMP-PKG signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
122 cGMP-PKG signaling pathway 💬
 1件: PRKCE 💬 Sotrastaurin 💬 Sotrastaurin 1件: 97 💬
123 cGMP-PKG signaling pathway 💬
 1件: RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
124 cGMP-PKG signaling pathway 💬
 2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 4件:  2 ,  5 ,  7 , 51 💬
125 cGMP-PKG signaling pathway 💬
 1件: ROCK2 💬 Belumosudil 💬 Belumosudil 2件: 51, 85 💬