| 1 | Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)
(D00142) | [2] Abatacept Abatacept,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Abatacept
💬 | [4] CD80 CD80,
CD86,
DHFR,
DHFR2 💬 | [18] Allograft rejection Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬 | [1] 46 46 💬 |
| 2 | Abatacept + Methotrexate
(D00142) | [2] Abatacept Abatacept,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Abatacept
💬 | [4] CD80 CD80,
CD86,
DHFR,
DHFR2 💬 | [18] Allograft rejection Allograft rejection, Antifolate resistance, Autoimmune thyroid disease, Biosynthesis of cofactors, Cell adhesion molecules, Folate biosynthesis, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Metabolic pathways, One carbon pool by folate, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis, Virion - Adenovirus 💬 | [1] 46 46 💬 |
| 3 | Adalimumab with methotrexate
(D00142) | [2] Adalimumab Adalimumab,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Adalimumab
💬 | [3] DHFR DHFR,
DHFR2,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 4 | AZATHIOPRINE or METHOTREXATE
(D00142) | [2] Azathioprine Azathioprine,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Azathioprine
💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 96 96 💬 |
| 5 | BMS-582949 and Methotrexate
(D00142) | [2] BMS-582949 BMS-582949,
Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 6 | Busulfan/Fludarabine phosphate/Tacrolimus/Methotrexate/G-CSF
(D00142) | [6] Busulfan Busulfan,
Filgrastim,
Fludarabine,
Methotrexate,
Phosphate ion,
Tacrolimus | [6] Tacrolimus
Tacrolimus
,
Methotrexate
(D00142),
Busulfan
,
Filgrastim
,
Fludarabine
,
Tacrolimus
💬 | [9] CSF3R CSF3R,
DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2,
RRM1 💬 | [48] Alzheimer disease Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Drug metabolism - other enzymes, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Glutathione metabolism, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, Nucleotide metabolism, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Purine metabolism, Pyrimidine metabolism, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬 | [1] 60 60 💬 |
| 7 | Certolizumab Pegol + Methotrexate (MTX)
(D00142) | [2] Certolizumab pegol Certolizumab pegol,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Certolizumab pegol
💬 | [3] DHFR DHFR,
DHFR2,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 8 | Clobetasol propionate + Methotrexate
(D00142) | [3] Clobetasol Clobetasol,
Clobetasol propionate,
Methotrexate | [3] Methotrexate
Methotrexate
(D00142),
Clobetasol propionate
,
Clobetasol
💬 | [3] DHFR DHFR,
DHFR2,
NR3C1 💬 | [6] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬 | [1] 162 162 💬 |
| 9 | Combination Product: Exercise, and methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 10 | Combination Product: Laser, exercise, and methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 11 | Combination Product: Methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 12 | CP-690,550 + methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 13 | Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids
(D00142) | [3] Azathioprine Azathioprine,
Cyclophosphamide,
Methotrexate | [4] Methotrexate
Methotrexate
(D00142),
Azathioprine
,
Cyclophosphamide
,
Cyclophosphamide
💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 44 44 💬 |
| 14 | Cyclosporin, Methotrexate (GVHD prophylaxis)
(D00142) | [2] Cyclosporine Cyclosporine,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Cyclosporine
💬 | [7] DHFR DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 | [38] Alzheimer disease Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬 | [1] 326 326 💬 |
| 15 | DMARDs (methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 16 | Doxorubicin, methotrexate, cyclophosphamide, L-asparaginase
(D00142) | [4] Asparaginase Escherichia coli Asparaginase Escherichia coli,
Cyclophosphamide,
Doxorubicin,
Methotrexate | [4] Methotrexate
Methotrexate
(D00142),
Cyclophosphamide
,
Doxorubicin
,
Cyclophosphamide
💬 | [4] DHFR DHFR,
DHFR2,
TOP2A,
TOP2B 💬 | [6] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate, Platinum drug resistance 💬 | [1] 65 65 💬 |
| 17 | Early immunosuppressants (azathioprine, methotrexate)
(D00142) | [2] Azathioprine Azathioprine,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Azathioprine
💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 96 96 💬 |
| 18 | Etanercept + Methotrexate
(D00142) | [2] Etanercept Etanercept,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Etanercept
💬 | [4] DHFR DHFR,
DHFR2,
LTA,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 19 | Etanercept , Methotrexate
(D00142) | [2] Etanercept Etanercept,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Etanercept
💬 | [4] DHFR DHFR,
DHFR2,
LTA,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 20 | Etanercept, methotrexate and depomedrone
(D00142) | [2] Etanercept Etanercept,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Etanercept
💬 | [4] DHFR DHFR,
DHFR2,
LTA,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 21 | Etanercept, Methotrexate, Prednisolone
(D00142) | [3] Etanercept Etanercept,
Methotrexate,
Prednisolone | [3] Methotrexate
Methotrexate
(D00142),
Prednisolone
,
Etanercept
💬 | [5] DHFR DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 | [72] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 56 56 💬 |
| 22 | Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate)
(D00142) | [4] Azathioprine Azathioprine,
Methotrexate,
Mycophenolate mofetil,
Mycophenolic acid | [4] Methotrexate
Methotrexate
(D00142),
Azathioprine
,
Mycophenolate mofetil
,
Mycophenolic acid
💬 | [4] DHFR DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 | [8] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬 | [1] 49 49 💬 |
| 23 | Infliximab + methotrexate (MTX)
(D00142) | [2] Infliximab Infliximab,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Infliximab
💬 | [3] DHFR DHFR,
DHFR2,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 24 | Infliximab plus methotrexate
(D00142) | [2] Infliximab Infliximab,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Infliximab
💬 | [3] DHFR DHFR,
DHFR2,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 107 107 💬 |
| 25 | Infliximab, methylprednisolone, methotrexate
(D00142) | [3] Infliximab Infliximab,
Methotrexate,
Methylprednisolone | [3] Methotrexate
Methotrexate
(D00142),
Methylprednisolone
,
Infliximab
💬 | [4] DHFR DHFR,
DHFR2,
NR3C1,
TNF 💬 | [72] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 26 | Intrathecal methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 13 13 💬 |
| 27 | METHOTREXATE
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [38] 11 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 |
| 28 | Methotrexate 'Lederle' 2,5mg tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 29 | Methotrexate 'Lederle' 2.5mg Tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 30 | Methotrexate 'Lederle' Tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 31 | Methotrexate (Metoject® prefilled pen)
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 32 | Methotrexate (MTX)
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 33 | Methotrexate (stable dose)
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 34 | Methotrexate (tapering dose)
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 35 | Methotrexate + Infliximab
(D00142) | [2] Infliximab Infliximab,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Infliximab
💬 | [3] DHFR DHFR,
DHFR2,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 36 | Methotrexate + Methylprednisolone
(D00142) | [2] Methotrexate Methotrexate,
Methylprednisolone | [2] Methotrexate
Methotrexate
(D00142),
Methylprednisolone
💬 | [3] DHFR DHFR,
DHFR2,
NR3C1 💬 | [6] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Neuroactive ligand-receptor interaction, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 37 | METHOTREXATE - 20 MG/0.8 ML SOLUZIONE INIETTABILE 4 SIRINGHE PRERIEMPITE MONOUSO DA 1.25 ML
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 96 96 💬 |
| 38 | Methotrexate - Amneal
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 39 | Methotrexate - DAVA
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 40 | Methotrexate - Delay
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 41 | Methotrexate - etanercept - prednisolone arm
(D00142) | [3] Etanercept Etanercept,
Methotrexate,
Prednisolone | [3] Methotrexate
Methotrexate
(D00142),
Prednisolone
,
Etanercept
💬 | [5] DHFR DHFR,
DHFR2,
LTA,
NR3C1,
TNF 💬 | [72] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [2] 46 46, 107 💬 |
| 42 | Methotrexate - Immediate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 43 | Methotrexate 10 mg
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 44 | Methotrexate 10 mg tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 45 | Methotrexate 2.5 mg
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 44 44 💬 |
| 46 | METHOTREXATE 2.5 mg tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 47 | Methotrexate 2.5mg Tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 48 | Methotrexate 2.5mg Tablets BP
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 49 | Methotrexate 25 mg
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 44 44 💬 |
| 50 | Methotrexate 50mg/ml solution for injection, pre-filled syringe
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 51 | Methotrexate ``Lederle`` 2.5mg tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 52 | Methotrexate alone
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 107 107 💬 |
| 53 | Methotrexate and folic acid
(D00142) | [2] Folic acid Folic acid,
Methotrexate | [2] Folic acid
Folic acid
,
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 49 49 💬 |
| 54 | Methotrexate as methotrexate disodium
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 55 | Methotrexate bellon
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 97 97 💬 |
| 56 | Methotrexate bellon 25mg/ml
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 97 97 💬 |
| 57 | Methotrexate capsules
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 58 | METHOTREXATE DISODIUM
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [5] 46 46, 96, 97, 107, 271 💬 |
| 59 | Methotrexate Ebewe
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 60 | METHOTREXATE HOSPIRA 2,5 mg tablety
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 61 | METHOTREXATE HOSPIRA 2.5 mg tablety
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 62 | Methotrexate injection
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [2] 96 96, 97 💬 |
| 63 | Methotrexate Lachema 5inj. sol
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 50 50 💬 |
| 64 | Methotrexate Lederle 2.5 mg Tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 65 | Methotrexate Pfizer 2,5 mg tabletter
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 66 | Methotrexate Placebo
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 67 | Methotrexate plus ENBREL or ENBREL alone
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 68 | Methotrexate plus ERB-041 for 12 weeks
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 69 | Methotrexate plus sulfasalazine
(D00142) | [2] Methotrexate Methotrexate,
Sulfasalazine | [2] Methotrexate
Methotrexate
(D00142),
Sulfasalazine
💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 70 | Methotrexate pre-filled pen
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 71 | Methotrexate prefilled pen
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 72 | Methotrexate prefilled syringe
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 73 | METHOTREXATE SODIUM
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [2] 46 46, 256 💬 |
| 74 | Methotrexate Sodium 2.5mg Tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 75 | Methotrexate Sodium Tablets 2.5 mg
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 76 | Methotrexate Sodium Tablets 2.5mg
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 77 | Methotrexate Tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [2] 40 40, 46 💬 |
| 78 | Methotrexate tablets 2.5 mg
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 79 | Methotrexate treatment
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [2] 41 41, 46 💬 |
| 80 | Methotrexate Wyeth 2,5mg
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 50 50 💬 |
| 81 | Methotrexate Wyeth 2,5mg tbl.
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 50 50 💬 |
| 82 | Methotrexate ® 2.5mg Tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 83 | Methotrexate(MTX)
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 84 | Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 85 | Methotrexate(MTX) administration is at the discretion of the rheumatologist and no tradename is fixed by the protocol.
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 86 | Methotrexate(necessary)
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 87 | METHOTREXATE*100CPR 2,5MG
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 88 | METHOTREXATE*10MG/1,33ML 4S
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 89 | METHOTREXATE*15MG/2ML 4SIR
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 90 | METHOTREXATE*2,5MG 25CPR
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 91 | METHOTREXATE*20MG/2,66ML 4S
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 92 | METHOTREXATE*25CPR 2,5MG
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [2] 46 46, 107 💬 |
| 93 | METHOTREXATE*7,5MG/ML 4SIR.
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 94 | Methotrexate, Leucovorin and BMS-986142
(D00142) | [3] BMS-986142 BMS-986142,
Leucovorin,
Methotrexate | [3] Methotrexate
Methotrexate
(D00142),
Folinic acid
,
Folinic acid calcium salt pentahydrate
💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 95 | Methotrexate,Adalimumab
(D00142) | [2] Adalimumab Adalimumab,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Adalimumab
💬 | [3] DHFR DHFR,
DHFR2,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 96 | Methotrexate-Lachema
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 97 | Methotrexate-Sulfasalazine-Hydroxychloroquine
(D00142) | [3] Hydroxychloroquine Hydroxychloroquine,
Methotrexate,
Sulfasalazine | [3] Methotrexate
Methotrexate
(D00142),
Sulfasalazine
,
Hydroxychloroquine
💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 98 | Methotrexate® 2.5 mg tablets
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 99 | MP-435(dose1) + Methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 100 | Mycophenolate mofetil,methotrexate
(D00142) | [3] Methotrexate Methotrexate,
Mycophenolate mofetil,
Mycophenolic acid | [3] Methotrexate
Methotrexate
(D00142),
Mycophenolate mofetil
,
Mycophenolic acid
💬 | [4] DHFR DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬 | [8] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬 | [3] 42 42, 43, 45 💬 |
| 101 | Oral methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 102 | Phase 1: Methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 103 | Response to anakinra associated with methotrexate
(D00142) | [2] Anakinra Anakinra,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Anakinra
💬 | [4] DHFR DHFR,
DHFR2,
IL1R1,
IL1R2 💬 | [20] Amoebiasis Amoebiasis, Antifolate resistance, Biosynthesis of cofactors, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Folate biosynthesis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Metabolic pathways, NF-kappa B signaling pathway, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬 | [1] 46 46 💬 |
| 104 | Response to infliximab associated with methotrexate
(D00142) | [2] Infliximab Infliximab,
Methotrexate | [2] Methotrexate
Methotrexate
(D00142),
Infliximab
💬 | [3] DHFR DHFR,
DHFR2,
TNF 💬 | [71] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬 | [1] 46 46 💬 |
| 105 | Stable weekly dose of methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 106 | Tacrolimus with Methotrexate
(D00142) | [2] Methotrexate Methotrexate,
Tacrolimus | [3] Tacrolimus
Tacrolimus
,
Methotrexate
(D00142),
Tacrolimus
💬 | [7] DHFR DHFR,
DHFR2,
PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬 | [38] Alzheimer disease Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Antifolate resistance, Axon guidance, B cell receptor signaling pathway, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Folate biosynthesis, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Natural killer cell mediated cytotoxicity, One carbon pool by folate, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬 | [1] 46 46 💬 |
| 107 | TAK-715 and methotrexate
(D00142) | [2] Methotrexate Methotrexate,
TAK-715 | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 108 | TAK-783 and methotrexate
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |
| 109 | Tasocitinib plus Methotrexate
(D00142) | [2] Methotrexate Methotrexate,
Tofacitinib | [2] Methotrexate
Methotrexate
(D00142),
Tofacitinib
💬 | [6] DHFR DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 | [42] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬 | [1] 46 46 💬 |
| 110 | Tocilizumab + methotrexate(MTX)
(D00142) | [2] Methotrexate Methotrexate,
Tocilizumab | [2] Methotrexate
Methotrexate
(D00142),
Tocilizumab
💬 | [3] DHFR DHFR,
DHFR2,
IL6R 💬 | [17] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬 | [1] 46 46 💬 |
| 111 | Tocilizumab plus methotrexate
(D00142) | [2] Methotrexate Methotrexate,
Tocilizumab | [2] Methotrexate
Methotrexate
(D00142),
Tocilizumab
💬 | [3] DHFR DHFR,
DHFR2,
IL6R 💬 | [17] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬 | [1] 46 46 💬 |
| 112 | Tocilizumab+Methotrexate(MTX)
(D00142) | [2] Methotrexate Methotrexate,
Tocilizumab | [2] Methotrexate
Methotrexate
(D00142),
Tocilizumab
💬 | [3] DHFR DHFR,
DHFR2,
IL6R 💬 | [17] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Folate biosynthesis, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Metabolic pathways, Non-alcoholic fatty liver disease, One carbon pool by folate, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬 | [1] 46 46 💬 |
| 113 | Tofacitinib with methotrexate
(D00142) | [2] Methotrexate Methotrexate,
Tofacitinib | [2] Methotrexate
Methotrexate
(D00142),
Tofacitinib
💬 | [6] DHFR DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 | [42] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬 | [1] 46 46 💬 |
| 114 | Tofacitinib without methotrexate
(D00142) | [2] Methotrexate Methotrexate,
Tofacitinib | [2] Methotrexate
Methotrexate
(D00142),
Tofacitinib
💬 | [6] DHFR DHFR,
DHFR2,
JAK1,
JAK2,
JAK3,
TYK2 💬 | [42] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Antifolate resistance, Biosynthesis of cofactors, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Folate biosynthesis, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, Metabolic pathways, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, One carbon pool by folate, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬 | [1] 46 46 💬 |
| 115 | Treatment with systemic therapy (methotrexate)
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 162 162 💬 |
| 116 | Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
(D00142) | [1] Methotrexate Methotrexate | [1] Methotrexate
Methotrexate
(D00142) 💬 | [2] DHFR DHFR,
DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [1] 46 46 💬 |