Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

[2] C1R, C1S 💬

Conestat alfa 💬

[1] 61 💬

2

[1] C1S 💬

Sutimlimab 💬

[1] 61 💬

3

[1] C3 💬

Pegcetacoplan 💬

[4] 2 , 61, 62, 222 💬

4

[1] C5 💬

Crovalimab 💬

[2] 62, 109 💬

5

[1] C5 💬

Eculizumab 💬

[7] 11, 13, 14, 61, 62, 109, 222 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
109	Atypical hemolytic uremic syndrome;aHUS;
222	Primary nephrotic syndrome;

6

[1] C5 💬

[3] 62, 109, 162 💬

7

[1] C5 💬

[2] 11, 62 💬

8

[1] C5 💬

Ravulizumab 💬

[7] 2 , 11, 13, 50, 62, 66, 109 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
50	Dermatomyositis;Polymyositis;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
109	Atypical hemolytic uremic syndrome;aHUS;

9

[1] C5 💬

Vilobelimab 💬

[3] 43, 44, 269 💬

Disease ID	Name
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;

10

[1] C5 💬

Zilucoplan 💬

[3] 2 , 11, 62 💬

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