79. 家族性高コレステロール血症（ホモ接合体） Disease details / Clinical trials / Drug dev / DR info
臨床試験数 : 145 / 薬物数 : 114 - (DrugBank : 26) / 標的遺伝子数 : 8 - 標的パスウェイ数 : 17
薬物ごとの開発者（Primary Sponsor）、臨床試験情報（抜粋）です。
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’-
Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
2013 Phase 3 EUCTR2012-002434-37-GB Australia;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
2013 - EUCTR2012-002434-37-CZ Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
2012 - EUCTR2012-002434-37-NO Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
1,2-Dihexadecanoyl-sn-Glycero-3-Phospho-(1-raac-glycerol)
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
AAV directed hLDLR gene therapy
Regenxbio Inc.
2016 Phase 1/Phase 2 NCT02651675 Canada;Italy;Netherlands;United States;
AAV8.TBG.hLDLR
REGENXBIO Inc.
2020 Phase 2 EUCTR2019-004496-39-NL Canada;Italy;Netherlands;United States;
2017 Phase 1;Phase 2 EUCTR2016-001446-25-IT Canada;Italy;Netherlands;United States;
University of Pennsylvania
2017 Phase 1;Phase 2 EUCTR2016-001446-25-NL Canada;Italy;Netherlands;United States;
AEGR-733
AEGERION PHARMACEUTICALS
2011 - EUCTR2010-023742-79-IT Italy;
Aegerion Pharmaceuticals
2009 - EUCTR2008-007058-36-IT Italy;
Aegerion Pharmaceuticals Inc.
2016 Phase 3 EUCTR2014-003806-33-GR Austria;Canada;Germany;Greece;Israel;Italy;Turkey;
Aegerion Pharmaceuticals, Inc.
2007 Phase 3 NCT00730236 Canada;Italy;South Africa;United States;
AK102
Akeso
2019 Phase 2 NCT03933293 China;
AKCEA-ANGPTL3-LRX
Akcea Therapeutics
2018 Phase 2 NCT03455777 Canada;
ALN-60212
The Medicines Company
2017 Phase 2 EUCTR2016-003376-49-NL Netherlands;South Africa;United States;
AMG 145
AMGEN INC.
2016 Phase 3 EUCTR2015-002276-25-IT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2019 Phase 3 EUCTR2015-002276-25-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2019 Phase 3 EUCTR2015-002276-25-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2015-002276-25-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2017 Phase 3 EUCTR2015-002276-25-ES Australia;Austria;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;South Africa;Spain;Turkey;
2016 Phase 3 EUCTR2015-002276-25-HU Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-GR Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-NL Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-GB Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005399-40-CZ Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2013 Phase 2 EUCTR2011-005400-15-IT Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2 EUCTR2011-005400-15-ES Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
2013 - EUCTR2011-005400-15-AT Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
2013 - EUCTR2011-005399-40-NL Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2013 - EUCTR2011-005399-40-IT Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2013 - EUCTR2011-005399-40-ES Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Malaysia;New Zealand;South Africa;Spain;Turkey;United States;
2012 Phase 2;Phase 3 EUCTR2011-005400-15-BE Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2012 Phase 2;Phase 3 EUCTR2011-005399-40-BE Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2012 Phase 2 EUCTR2011-005400-15-GR Belgium;Canada;Czech Republic;Greece;Italy;Netherlands;South Africa;Spain;United Kingdom;United States;
- Phase 3 EUCTR2015-002276-25-NO Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-GB Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- - EUCTR2011-005399-40-Outside-EU/EEA Brazil;Canada;Hong Kong;Lebanon;Malaysia;New Zealand;South Africa;Turkey;United States;
AMG145
Amgen Inc
2013 Phase 2;Phase 3 EUCTR2011-005400-15-NL Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-GB Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
2012 Phase 2;Phase 3 EUCTR2011-005400-15-BE Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
Alirocumab
REGENERON PHARMACEUTICALS, INC.
2019 Phase 3 EUCTR2017-003170-13-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-IT Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals
2017 Phase 3 NCT03156621 Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;South Africa;Taiwan;Turkey;Ukraine;United States;
Alirocumab SAR236553 (REGN727)
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Anacetrapib
Merck Sharp & Dohme Corp.
2013 Phase 3 NCT01841684 Canada;Germany;Israel;Italy;Norway;United Kingdom;United States;
Atorvastatin
Organon and Co
2000 Phase 3 NCT03885921 -
2000 Phase 3 NCT03884452 -
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
CER-001
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
Cerenis Therapeutics, SA
2011 Phase 2 NCT01412034 Canada;Italy;Netherlands;United Kingdom;United States;
Cholestyramine
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Comparator: ezetimibe
Organon and Co
2002 Phase 3 NCT00092833 United States;
Crestor Film-Coated Tablet
AstraZeneca AB
2015 Phase 3 EUCTR2014-004746-99-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2015 Phase 3 EUCTR2014-004746-99-BE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
- Phase 3 EUCTR2014-004746-99-SE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
Crestor Tablets (calcium rosuvastatin) Film-Coated tablets
AstraZeneca AB
2014 Phase 3 EUCTR2014-000972-24-BE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-SE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-NL Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2014 - EUCTR2014-000972-24-DE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
DPPG
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
Dextran sulfate adsorption
Laval University
2013 - NCT02286596 Canada;
Evinacumab
REGENERON PHARMACEUTICALS, INC.
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals
2020 Phase 3 NCT04233918 Australia;Austria;Netherlands;Taiwan;Ukraine;United States;
2018 Phase 3 NCT03409744 Australia;Austria;Canada;Czechia;France;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United States;
2018 Phase 3 NCT03399786 Australia;Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.(ICCC: PAREXEL International)
2018 - JPRN-JapicCTI-184099 Japan, North America, Europe, Oceania, Africa;
Evinacumab (REGN1500)
REGENERON PHARMACEUTICALS, INC.
2019 Phase 3 EUCTR2017-003170-13-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
Regeneron Pharmaceuticals Inc.
2018 Phase 3 EUCTR2017-001388-19-GR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-DE Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.
2019 Phase 3 EUCTR2017-003170-13-GR Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2019 Phase 3 EUCTR2017-003170-13-GB Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
2019 Phase 3 EUCTR2017-003170-13-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-003170-13-NL Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-003170-13-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2017-003170-13-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
Evolocumab
Amgen
2018 Phase 4 NCT03403374 India;
2012 Phase 2/Phase 3 NCT01588496 Belgium;Canada;Czech Republic;Czechia;France;Hong Kong;Italy;Lebanon;Netherlands;New Zealand;South Africa;Spain;United States;
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
Kanazawa University Hospital
2016 - JPRN-UMIN000022603 Japan;
LIB Therapeutics LLC
2019 Phase 3 NCT04034485 India;Israel;Norway;South Africa;Turkey;United States;
Evolocumab (AMG 145)
Amgen
2016 Phase 3 NCT02624869 Australia;Austria;Belgium;Brazil;Canada;Colombia;Czechia;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;United States;
Ezetimibe
Akeso
2019 Phase 2 NCT03933293 China;
Organon and Co
2006 - NCT00704535 Philippines;
2000 Phase 3 NCT03885921 -
2000 Phase 3 NCT03884452 -
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Fenofibrate
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Fluvastatin
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Gemcabene
NeuroBo Pharmaceuticals Inc.
2016 Phase 2 NCT02722408 Canada;Israel;United States;
Heparin-induced extracorporeal LDL precipitation
Laval University
2013 - NCT02286596 Canada;
IBI306
Innovent Biologics (Suzhou) Co. Ltd.
2019 Phase 2/Phase 3 NCT04031742 China;
Shenzhen People's Hospital
2019 Phase 2/Phase 3 NCT04948008 China;
ISIS 301012
Kastle Therapeutics, LLC
2006 Phase 2 NCT00280995 Netherlands;United States;
ISIS 301012 phosphorothioate oligonucleotide
Genzyme Europe B.V.
2007 Phase 3 EUCTR2005-003449-15-GB United Kingdom;
ISIS 703802
Ionis Pharmaceuticals, Inc.
2016 Phase 1;Phase 2 EUCTR2015-004003-23-IT Canada;Italy;Netherlands;
Implitapide
Medical Research Laboratories International
2003 Phase 2 NCT00079846 Canada;Israel;Netherlands;Norway;United States;
Inclisiran
Novartis Pharmaceuticals
2021 Phase 3 NCT04659863 Canada;France;Greece;Lebanon;Netherlands;Slovenia;Switzerland;Turkey;United States;
Inclisiran Sodium
Novartis Pharmaceuticals
2019 Phase 3 NCT03814187 Canada;Czechia;Denmark;Germany;Hungary;Netherlands;Poland;South Africa;Spain;Sweden;Ukraine;United Kingdom;United States;
Inclisiran for injection
Novartis Pharmaceuticals
2019 Phase 3 NCT03851705 Czechia;Hong Kong;Israel;Russian Federation;Serbia;South Africa;Taiwan;Turkey;Ukraine;
Inclisiran sodium
Novartis Pharma AG
2021 Phase 3 EUCTR2020-002755-38-NL Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2021 Phase 3 EUCTR2020-002755-38-GR Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2020 Phase 3 EUCTR2020-002755-38-SI Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Turkey;United States;
JS002
Shanghai Junshi Bioscience Co., Ltd.
2020 Phase 2 NCT04515927 China;
KJX839
Novartis Pharma AG
2021 Phase 3 EUCTR2020-002755-38-NL Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2021 Phase 3 EUCTR2020-002755-38-GR Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2020 Phase 3 EUCTR2020-002755-38-SI Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Turkey;United States;
LIB003
LIB Therapeutics, LLC
2021 Phase 3 EUCTR2020-004394-49-NO Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2019-003611-62-NO Israel;Norway;South Africa;Turkey;United States;
- Phase 3 EUCTR2020-004394-49-DE Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
Lapaquistat acetate and current lipid-lowering treatment
Takeda
2005 Phase 3 NCT00263081 Canada;France;Israel;Poland;United Kingdom;United States;
Lerodalcibep
LIB Therapeutics LLC
2019 Phase 3 NCT04034485 India;Israel;Norway;South Africa;Turkey;United States;
LIB Therapeutics, LLC
2021 Phase 3 EUCTR2020-004394-49-NO Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2020-004394-49-DE Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
Lojuxta 10 mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lojuxta 20 mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lojuxta 5 mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lomitapide
AEGERION PHARMACEUTICALS
2011 - EUCTR2010-023742-79-IT Italy;
Aegerion Pharmaceuticals, Inc.
2016 Phase 3 NCT02765841 -
2015 - NCT02399852 -
2014 Phase 3 NCT02173158 Japan;
2009 Phase 3 NCT00943306 Canada;Italy;South Africa;United States;
2003 Phase 2 NCT01556906 United States;
Amryt Pharma
2020 Phase 3 NCT04681170 Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;
2014 - NCT02135705 United States;
Lomitapide 2mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lovastatin
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
MBX-8025
CymaBay Therapeutics, Inc.
2015 Phase 2 EUCTR2014-004856-68-NO France;Netherlands;Norway;
2015 Phase 2 EUCTR2014-004856-68-FR France;Netherlands;Norway;
2015 - EUCTR2014-004856-68-NL France;Netherlands;Norway;
MBX-8025 50 mg (Dose Escalation Period 1)
CymaBay Therapeutics, Inc.
2015 Phase 2 NCT02472535 Canada;France;Netherlands;Norway;
MBX-8025 50 mg or 100 mg (Dose Escalation Period 2)
CymaBay Therapeutics, Inc.
2015 Phase 2 NCT02472535 Canada;France;Netherlands;Norway;
MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)
CymaBay Therapeutics, Inc.
2015 Phase 2 NCT02472535 Canada;France;Netherlands;Norway;
MK-0859
Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
2013 Phase 3 EUCTR2012-002434-37-IT Brazil;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
2013 Phase 3 EUCTR2012-002434-37-GB Australia;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
2013 - EUCTR2012-002434-37-CZ Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
2012 - EUCTR2012-002434-37-NO Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
Mipomersen
Kastle Therapeutics, LLC
2007 Phase 3 NCT00607373 Brazil;Canada;Netherlands;Singapore;South Africa;Taiwan;United Kingdom;United States;
Nicotinic acid
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Omega-3 fatty acids
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
PLACEBO
Regeneron Pharmaceuticals, Inc.(ICCC: PAREXEL International)
2018 - JPRN-JapicCTI-184099 Japan, North America, Europe, Oceania, Africa;
PRD7255830
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
PRD7255977
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
PRD7256003
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Praluent
REGENERON PHARMACEUTICALS, INC.
2019 Phase 3 EUCTR2017-003170-13-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-IT Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals Inc.
2018 Phase 3 EUCTR2017-001388-19-GR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-DE Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.
2019 Phase 3 EUCTR2017-003170-13-GR Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2019 Phase 3 EUCTR2017-003170-13-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-003170-13-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2017-000351-95-GR Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-FR Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;France;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2017-000351-95-DE Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-AT Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-003170-13-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2017-000351-95-CZ Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States;
Sanofi-Aventis Recherche & Développement
2018 Phase 3 EUCTR2017-002297-39-DK Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Pravastatin
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Prednisone
REGENXBIO Inc.
2017 Phase 1;Phase 2 EUCTR2016-001446-25-IT Canada;Italy;Netherlands;United States;
R727
REGENERON PHARMACEUTICALS, INC.
2017 Phase 3 EUCTR2017-000351-95-IT Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
REGN1500
REGENERON PHARMACEUTICALS, INC.
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.
2020 Phase 1;Phase 3 EUCTR2019-001931-30-NL Australia;Austria;Belgium;Canada;France;Germany;Italy;Jordan;Lebanon;Netherlands;Norway;Taiwan;Ukraine;United States;
2020 Phase 1;Phase 3 EUCTR2019-001931-30-AT Australia;Austria;Belgium;Canada;France;Germany;Italy;Jordan;Lebanon;Netherlands;Norway;Taiwan;Ukraine;United States;
2016 Phase 2 EUCTR2016-000411-32-NL Canada;Netherlands;United States;
REGN1500 250 mg SC/15 mg/kg IV/450 mg SC
Regeneron Pharmaceuticals
2015 Phase 2 NCT02265952 Canada;Netherlands;United States;
REGN7272
REGENERON PHARMACEUTICALS, INC.
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Recombinant Human Apolipoprotein A-I
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Recombinant Human Apolipoprotein A-I/Phospholipids Complex
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
Recombinant human apolipoprotein a1
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
Repatha (evolocumab)
LIB Therapeutics, LLC
2020 Phase 3 EUCTR2019-003611-62-NO Israel;Norway;South Africa;Turkey;United States;
Repatha 140 mg Solution for Injection in Pre-filled Pen
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2019 Phase 3 EUCTR2015-002276-25-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2019 Phase 3 EUCTR2015-002276-25-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2015-002276-25-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2017 Phase 3 EUCTR2015-002276-25-ES Australia;Austria;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;South Africa;Spain;Turkey;
2016 Phase 3 EUCTR2015-002276-25-HU Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-GR Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-NO Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-GB Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
Repatha 140 mg solution for injection in pre-filled pen
Amgen Inc
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
Repatha 140 mg soluzione per iniezione in penna preriempita.
AMGEN INC.
2016 Phase 3 EUCTR2015-002276-25-IT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Repatha 420 mg solution for injection in cartridge
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2019 Phase 3 EUCTR2015-002276-25-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2019 Phase 3 EUCTR2015-002276-25-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2015-002276-25-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-NO Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-GB Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
Repatha 420 mg soluzione per iniezione in cartuccia
AMGEN INC.
2016 Phase 3 EUCTR2015-002276-25-IT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Rosuvastatin
AstraZeneca
2015 Phase 3 NCT02434497 Belgium;Canada;Denmark;Israel;Malaysia;Taiwan;
2014 Phase 3 NCT02226198 Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Rosuvastatin calcium
AstraZeneca AB
2015 Phase 3 EUCTR2014-004746-99-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2015 Phase 3 EUCTR2014-004746-99-BE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
- Phase 3 EUCTR2014-004746-99-SE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
SAR236553
Sanofi-Aventis Recherche & Développement
2018 Phase 3 EUCTR2017-002297-39-SI Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-NO Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-NL Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-IT Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-FR Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-ES Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-DK Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-BG Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-AT Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
SHR-1209
Jiangsu HengRui Medicine Co., Ltd.
2020 Phase 2 NCT04455581 -
Sfingomielina
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Simvastatin
Organon and Co
2000 Phase 3 NCT03885921 -
2000 Phase 3 NCT03884452 -
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy
Regenxbio Inc.
2019 - NCT04080050 Canada;Italy;Netherlands;United States;
Sphingomyelin
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
Statins
Akeso
2019 Phase 2 NCT03933293 China;
TAK-475
Takeda Europe R&D Centre Ltd
2006 - EUCTR2005-003626-26-GB United Kingdom;
ZD4522
AstraZeneca AB
2015 Phase 3 EUCTR2014-004746-99-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2015 Phase 3 EUCTR2014-004746-99-BE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2014 Phase 3 EUCTR2014-000972-24-BE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-SE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-NL Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2014 - EUCTR2014-000972-24-DE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
- Phase 3 EUCTR2014-004746-99-SE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
2013 Phase 3 EUCTR2012-002434-37-GB Australia;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
2013 - EUCTR2012-002434-37-CZ Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
2012 - EUCTR2012-002434-37-NO Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
1,2-Dihexadecanoyl-sn-Glycero-3-Phospho-(1-raac-glycerol)
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
AAV directed hLDLR gene therapy
Regenxbio Inc.
2016 Phase 1/Phase 2 NCT02651675 Canada;Italy;Netherlands;United States;
AAV8.TBG.hLDLR
REGENXBIO Inc.
2020 Phase 2 EUCTR2019-004496-39-NL Canada;Italy;Netherlands;United States;
2017 Phase 1;Phase 2 EUCTR2016-001446-25-IT Canada;Italy;Netherlands;United States;
University of Pennsylvania
2017 Phase 1;Phase 2 EUCTR2016-001446-25-NL Canada;Italy;Netherlands;United States;
AEGR-733
AEGERION PHARMACEUTICALS
2011 - EUCTR2010-023742-79-IT Italy;
Aegerion Pharmaceuticals
2009 - EUCTR2008-007058-36-IT Italy;
Aegerion Pharmaceuticals Inc.
2016 Phase 3 EUCTR2014-003806-33-GR Austria;Canada;Germany;Greece;Israel;Italy;Turkey;
Aegerion Pharmaceuticals, Inc.
2007 Phase 3 NCT00730236 Canada;Italy;South Africa;United States;
AK102
Akeso
2019 Phase 2 NCT03933293 China;
AKCEA-ANGPTL3-LRX
Akcea Therapeutics
2018 Phase 2 NCT03455777 Canada;
ALN-60212
The Medicines Company
2017 Phase 2 EUCTR2016-003376-49-NL Netherlands;South Africa;United States;
AMG 145
AMGEN INC.
2016 Phase 3 EUCTR2015-002276-25-IT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2019 Phase 3 EUCTR2015-002276-25-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2019 Phase 3 EUCTR2015-002276-25-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2015-002276-25-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2017 Phase 3 EUCTR2015-002276-25-ES Australia;Austria;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;South Africa;Spain;Turkey;
2016 Phase 3 EUCTR2015-002276-25-HU Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-GR Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-NL Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-GB Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005399-40-CZ Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2013 Phase 2 EUCTR2011-005400-15-IT Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2 EUCTR2011-005400-15-ES Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
2013 - EUCTR2011-005400-15-AT Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
2013 - EUCTR2011-005399-40-NL Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2013 - EUCTR2011-005399-40-IT Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2013 - EUCTR2011-005399-40-ES Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Malaysia;New Zealand;South Africa;Spain;Turkey;United States;
2012 Phase 2;Phase 3 EUCTR2011-005400-15-BE Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2012 Phase 2;Phase 3 EUCTR2011-005399-40-BE Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
2012 Phase 2 EUCTR2011-005400-15-GR Belgium;Canada;Czech Republic;Greece;Italy;Netherlands;South Africa;Spain;United Kingdom;United States;
- Phase 3 EUCTR2015-002276-25-NO Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-GB Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- - EUCTR2011-005399-40-Outside-EU/EEA Brazil;Canada;Hong Kong;Lebanon;Malaysia;New Zealand;South Africa;Turkey;United States;
AMG145
Amgen Inc
2013 Phase 2;Phase 3 EUCTR2011-005400-15-NL Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-GB Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
2012 Phase 2;Phase 3 EUCTR2011-005400-15-BE Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
Alirocumab
REGENERON PHARMACEUTICALS, INC.
2019 Phase 3 EUCTR2017-003170-13-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-IT Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals
2017 Phase 3 NCT03156621 Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;South Africa;Taiwan;Turkey;Ukraine;United States;
Alirocumab SAR236553 (REGN727)
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Anacetrapib
Merck Sharp & Dohme Corp.
2013 Phase 3 NCT01841684 Canada;Germany;Israel;Italy;Norway;United Kingdom;United States;
Atorvastatin
Organon and Co
2000 Phase 3 NCT03885921 -
2000 Phase 3 NCT03884452 -
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
CER-001
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
Cerenis Therapeutics, SA
2011 Phase 2 NCT01412034 Canada;Italy;Netherlands;United Kingdom;United States;
Cholestyramine
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Comparator: ezetimibe
Organon and Co
2002 Phase 3 NCT00092833 United States;
Crestor Film-Coated Tablet
AstraZeneca AB
2015 Phase 3 EUCTR2014-004746-99-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2015 Phase 3 EUCTR2014-004746-99-BE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
- Phase 3 EUCTR2014-004746-99-SE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
Crestor Tablets (calcium rosuvastatin) Film-Coated tablets
AstraZeneca AB
2014 Phase 3 EUCTR2014-000972-24-BE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-SE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-NL Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2014 - EUCTR2014-000972-24-DE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
DPPG
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
Dextran sulfate adsorption
Laval University
2013 - NCT02286596 Canada;
Evinacumab
REGENERON PHARMACEUTICALS, INC.
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals
2020 Phase 3 NCT04233918 Australia;Austria;Netherlands;Taiwan;Ukraine;United States;
2018 Phase 3 NCT03409744 Australia;Austria;Canada;Czechia;France;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United States;
2018 Phase 3 NCT03399786 Australia;Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.(ICCC: PAREXEL International)
2018 - JPRN-JapicCTI-184099 Japan, North America, Europe, Oceania, Africa;
Evinacumab (REGN1500)
REGENERON PHARMACEUTICALS, INC.
2019 Phase 3 EUCTR2017-003170-13-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
Regeneron Pharmaceuticals Inc.
2018 Phase 3 EUCTR2017-001388-19-GR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-DE Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.
2019 Phase 3 EUCTR2017-003170-13-GR Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2019 Phase 3 EUCTR2017-003170-13-GB Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
2019 Phase 3 EUCTR2017-003170-13-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-003170-13-NL Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-003170-13-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2017-003170-13-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
Evolocumab
Amgen
2018 Phase 4 NCT03403374 India;
2012 Phase 2/Phase 3 NCT01588496 Belgium;Canada;Czech Republic;Czechia;France;Hong Kong;Italy;Lebanon;Netherlands;New Zealand;South Africa;Spain;United States;
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
Kanazawa University Hospital
2016 - JPRN-UMIN000022603 Japan;
LIB Therapeutics LLC
2019 Phase 3 NCT04034485 India;Israel;Norway;South Africa;Turkey;United States;
Evolocumab (AMG 145)
Amgen
2016 Phase 3 NCT02624869 Australia;Austria;Belgium;Brazil;Canada;Colombia;Czechia;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;United States;
Ezetimibe
Akeso
2019 Phase 2 NCT03933293 China;
Organon and Co
2006 - NCT00704535 Philippines;
2000 Phase 3 NCT03885921 -
2000 Phase 3 NCT03884452 -
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Fenofibrate
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Fluvastatin
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Gemcabene
NeuroBo Pharmaceuticals Inc.
2016 Phase 2 NCT02722408 Canada;Israel;United States;
Heparin-induced extracorporeal LDL precipitation
Laval University
2013 - NCT02286596 Canada;
IBI306
Innovent Biologics (Suzhou) Co. Ltd.
2019 Phase 2/Phase 3 NCT04031742 China;
Shenzhen People's Hospital
2019 Phase 2/Phase 3 NCT04948008 China;
ISIS 301012
Kastle Therapeutics, LLC
2006 Phase 2 NCT00280995 Netherlands;United States;
ISIS 301012 phosphorothioate oligonucleotide
Genzyme Europe B.V.
2007 Phase 3 EUCTR2005-003449-15-GB United Kingdom;
ISIS 703802
Ionis Pharmaceuticals, Inc.
2016 Phase 1;Phase 2 EUCTR2015-004003-23-IT Canada;Italy;Netherlands;
Implitapide
Medical Research Laboratories International
2003 Phase 2 NCT00079846 Canada;Israel;Netherlands;Norway;United States;
Inclisiran
Novartis Pharmaceuticals
2021 Phase 3 NCT04659863 Canada;France;Greece;Lebanon;Netherlands;Slovenia;Switzerland;Turkey;United States;
Inclisiran Sodium
Novartis Pharmaceuticals
2019 Phase 3 NCT03814187 Canada;Czechia;Denmark;Germany;Hungary;Netherlands;Poland;South Africa;Spain;Sweden;Ukraine;United Kingdom;United States;
Inclisiran for injection
Novartis Pharmaceuticals
2019 Phase 3 NCT03851705 Czechia;Hong Kong;Israel;Russian Federation;Serbia;South Africa;Taiwan;Turkey;Ukraine;
Inclisiran sodium
Novartis Pharma AG
2021 Phase 3 EUCTR2020-002755-38-NL Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2021 Phase 3 EUCTR2020-002755-38-GR Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2020 Phase 3 EUCTR2020-002755-38-SI Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Turkey;United States;
JS002
Shanghai Junshi Bioscience Co., Ltd.
2020 Phase 2 NCT04515927 China;
KJX839
Novartis Pharma AG
2021 Phase 3 EUCTR2020-002755-38-NL Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2021 Phase 3 EUCTR2020-002755-38-GR Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
2020 Phase 3 EUCTR2020-002755-38-SI Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Turkey;United States;
LIB003
LIB Therapeutics, LLC
2021 Phase 3 EUCTR2020-004394-49-NO Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
2020 Phase 3 EUCTR2019-003611-62-NO Israel;Norway;South Africa;Turkey;United States;
- Phase 3 EUCTR2020-004394-49-DE Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
Lapaquistat acetate and current lipid-lowering treatment
Takeda
2005 Phase 3 NCT00263081 Canada;France;Israel;Poland;United Kingdom;United States;
Lerodalcibep
LIB Therapeutics LLC
2019 Phase 3 NCT04034485 India;Israel;Norway;South Africa;Turkey;United States;
LIB Therapeutics, LLC
2021 Phase 3 EUCTR2020-004394-49-NO Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
- Phase 3 EUCTR2020-004394-49-DE Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
Lojuxta 10 mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lojuxta 20 mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lojuxta 5 mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lomitapide
AEGERION PHARMACEUTICALS
2011 - EUCTR2010-023742-79-IT Italy;
Aegerion Pharmaceuticals, Inc.
2016 Phase 3 NCT02765841 -
2015 - NCT02399852 -
2014 Phase 3 NCT02173158 Japan;
2009 Phase 3 NCT00943306 Canada;Italy;South Africa;United States;
2003 Phase 2 NCT01556906 United States;
Amryt Pharma
2020 Phase 3 NCT04681170 Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;
2014 - NCT02135705 United States;
Lomitapide 2mg hard capsules
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
2020 Phase 3 EUCTR2019-002278-30-DE Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lovastatin
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
MBX-8025
CymaBay Therapeutics, Inc.
2015 Phase 2 EUCTR2014-004856-68-NO France;Netherlands;Norway;
2015 Phase 2 EUCTR2014-004856-68-FR France;Netherlands;Norway;
2015 - EUCTR2014-004856-68-NL France;Netherlands;Norway;
MBX-8025 50 mg (Dose Escalation Period 1)
CymaBay Therapeutics, Inc.
2015 Phase 2 NCT02472535 Canada;France;Netherlands;Norway;
MBX-8025 50 mg or 100 mg (Dose Escalation Period 2)
CymaBay Therapeutics, Inc.
2015 Phase 2 NCT02472535 Canada;France;Netherlands;Norway;
MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)
CymaBay Therapeutics, Inc.
2015 Phase 2 NCT02472535 Canada;France;Netherlands;Norway;
MK-0859
Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
2013 Phase 3 EUCTR2012-002434-37-IT Brazil;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
2013 Phase 3 EUCTR2012-002434-37-GB Australia;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
2013 - EUCTR2012-002434-37-CZ Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
2012 - EUCTR2012-002434-37-NO Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
Mipomersen
Kastle Therapeutics, LLC
2007 Phase 3 NCT00607373 Brazil;Canada;Netherlands;Singapore;South Africa;Taiwan;United Kingdom;United States;
Nicotinic acid
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Omega-3 fatty acids
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
PLACEBO
Regeneron Pharmaceuticals, Inc.(ICCC: PAREXEL International)
2018 - JPRN-JapicCTI-184099 Japan, North America, Europe, Oceania, Africa;
PRD7255830
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
PRD7255977
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
PRD7256003
Amryt Pharmaceuticals DAC
2020 Phase 3 EUCTR2019-002278-30-IT Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Praluent
REGENERON PHARMACEUTICALS, INC.
2019 Phase 3 EUCTR2017-003170-13-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-IT Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals Inc.
2018 Phase 3 EUCTR2017-001388-19-GR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-DE Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
2018 Phase 3 EUCTR2017-001388-19-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-001388-19-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.
2019 Phase 3 EUCTR2017-003170-13-GR Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2019 Phase 3 EUCTR2017-003170-13-AT Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2018 Phase 3 EUCTR2017-003170-13-CZ Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2017-000351-95-GR Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-FR Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;France;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2017-000351-95-DE Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
2017 Phase 3 EUCTR2017-000351-95-AT Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
- Phase 3 EUCTR2017-003170-13-FR Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
- Phase 3 EUCTR2017-000351-95-CZ Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States;
Sanofi-Aventis Recherche & Développement
2018 Phase 3 EUCTR2017-002297-39-DK Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Pravastatin
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Prednisone
REGENXBIO Inc.
2017 Phase 1;Phase 2 EUCTR2016-001446-25-IT Canada;Italy;Netherlands;United States;
R727
REGENERON PHARMACEUTICALS, INC.
2017 Phase 3 EUCTR2017-000351-95-IT Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
REGN1500
REGENERON PHARMACEUTICALS, INC.
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Regeneron Pharmaceuticals, Inc.
2020 Phase 1;Phase 3 EUCTR2019-001931-30-NL Australia;Austria;Belgium;Canada;France;Germany;Italy;Jordan;Lebanon;Netherlands;Norway;Taiwan;Ukraine;United States;
2020 Phase 1;Phase 3 EUCTR2019-001931-30-AT Australia;Austria;Belgium;Canada;France;Germany;Italy;Jordan;Lebanon;Netherlands;Norway;Taiwan;Ukraine;United States;
2016 Phase 2 EUCTR2016-000411-32-NL Canada;Netherlands;United States;
REGN1500 250 mg SC/15 mg/kg IV/450 mg SC
Regeneron Pharmaceuticals
2015 Phase 2 NCT02265952 Canada;Netherlands;United States;
REGN7272
REGENERON PHARMACEUTICALS, INC.
2018 Phase 3 EUCTR2017-001388-19-IT Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Recombinant Human Apolipoprotein A-I
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Recombinant Human Apolipoprotein A-I/Phospholipids Complex
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
Recombinant human apolipoprotein a1
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
Repatha (evolocumab)
LIB Therapeutics, LLC
2020 Phase 3 EUCTR2019-003611-62-NO Israel;Norway;South Africa;Turkey;United States;
Repatha 140 mg Solution for Injection in Pre-filled Pen
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2019 Phase 3 EUCTR2015-002276-25-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2019 Phase 3 EUCTR2015-002276-25-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2015-002276-25-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2017 Phase 3 EUCTR2015-002276-25-ES Australia;Austria;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;South Africa;Spain;Turkey;
2016 Phase 3 EUCTR2015-002276-25-HU Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-GR Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-DE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-NO Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-GB Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
Repatha 140 mg solution for injection in pre-filled pen
Amgen Inc
2013 Phase 2;Phase 3 EUCTR2011-005400-15-CZ Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
Repatha 140 mg soluzione per iniezione in penna preriempita.
AMGEN INC.
2016 Phase 3 EUCTR2015-002276-25-IT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Repatha 420 mg solution for injection in cartridge
Amgen Europe B.V.
2019 Phase 3 EUCTR2015-002276-25-SI Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
Amgen Inc
2019 Phase 3 EUCTR2015-002276-25-PT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2019 Phase 3 EUCTR2015-002276-25-PL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
2017 Phase 3 EUCTR2015-002276-25-NL Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-CZ Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-BE Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
2016 Phase 3 EUCTR2015-002276-25-AT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-NO Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
- Phase 3 EUCTR2015-002276-25-GB Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
Repatha 420 mg soluzione per iniezione in cartuccia
AMGEN INC.
2016 Phase 3 EUCTR2015-002276-25-IT Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Rosuvastatin
AstraZeneca
2015 Phase 3 NCT02434497 Belgium;Canada;Denmark;Israel;Malaysia;Taiwan;
2014 Phase 3 NCT02226198 Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Rosuvastatin calcium
AstraZeneca AB
2015 Phase 3 EUCTR2014-004746-99-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2015 Phase 3 EUCTR2014-004746-99-BE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
- Phase 3 EUCTR2014-004746-99-SE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
SAR236553
Sanofi-Aventis Recherche & Développement
2018 Phase 3 EUCTR2017-002297-39-SI Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-NO Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-NL Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-IT Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-FR Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-ES Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-DK Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-BG Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
2018 Phase 3 EUCTR2017-002297-39-AT Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
SHR-1209
Jiangsu HengRui Medicine Co., Ltd.
2020 Phase 2 NCT04455581 -
Sfingomielina
CERENIS THERAPEUTICS SA
2012 - EUCTR2011-003998-28-IT Canada;Italy;Netherlands;United Kingdom;United States;
Simvastatin
Organon and Co
2000 Phase 3 NCT03885921 -
2000 Phase 3 NCT03884452 -
Sanofi
2018 Phase 3 NCT03510715 Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy
Regenxbio Inc.
2019 - NCT04080050 Canada;Italy;Netherlands;United States;
Sphingomyelin
Cerenis Therapeutics
2012 Phase 2 EUCTR2011-003998-28-GB Canada;Italy;Netherlands;United Kingdom;United States;
2012 - EUCTR2011-003998-28-NL Canada;France;Italy;Netherlands;United Kingdom;United States;
Statins
Akeso
2019 Phase 2 NCT03933293 China;
TAK-475
Takeda Europe R&D Centre Ltd
2006 - EUCTR2005-003626-26-GB United Kingdom;
ZD4522
AstraZeneca AB
2015 Phase 3 EUCTR2014-004746-99-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2015 Phase 3 EUCTR2014-004746-99-BE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2014 Phase 3 EUCTR2014-000972-24-BE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-SE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-NL Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
2014 - EUCTR2014-000972-24-DK Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
2014 - EUCTR2014-000972-24-DE Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
- Phase 3 EUCTR2014-004746-99-SE Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;