90. 網膜色素変性症
［臨床試験数：103，薬物数：158（DrugBank：42），標的遺伝子数：52，標的パスウェイ数：107］
Searched query = "Retinitis pigmentosa", "Rod dystrophy", "Rod-Cone Dystrophy"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT02018692 (ClinicalTrials.gov) | March 1, 2021 | 17/12/2013 | The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella Bardawil on Visual Functions in Adolescent Patients With Retinitis Pigmentosa | The Effect of Oral Administration of 9-cis ß Carotene Rich Powder of the Alga Dunaliella Bardawil on Visual Functions in Adolescent Patients With Retinitis Pigmentosa | Retinitis Pigmentosa | Dietary Supplement: Alga Dunaliella Bardawil powder;Dietary Supplement: Placebo:Starch | Sheba Medical Center | NULL | Not yet recruiting | 12 Years | 18 Years | All | 30 | Phase 1;Phase 2 | Israel |
| 2 | NCT04636853 (ClinicalTrials.gov) | December 1, 2020 | 14/11/2020 | CB-PRP in Retinitis Pigmentosa | Cord Blood Platelet-rich Plasma (CB-PRP) in Retinitis Pigmentosa | Retinitis Pigmentosa | Biological: Subretinal injection of umbilical cord blood platelet-rich plasma (CB-PRP) | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | NULL | Recruiting | 18 Years | 70 Years | All | 20 | Phase 3 | Italy |
| 3 | EUCTR2019-004547-77-GB (EUCTR) | 09/06/2020 | 26/02/2020 | Safety and Tolerability of hRPC in Retinitis Pigmentosa | First-in-human Phase I/IIa, Open-Label, Prospective Study of the Safety and Tolerability of Subretinally Transplanted Human Retinal Progenitor Cells (hRPC) in Subjects with Retinitis Pigmentosa (RP) | Retinitis Pigmentosa MedDRA version: 20.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Name: human Retinal Progenitor Cells Drug Product Product Code: hRPC DP INN or Proposed INN: ALLOGENEIC NEURAL RETINA-DERIVED HUMAN NEURAL RETINAL PROGENITOR CELLS EX VIVO EXPANDED Other descriptive name: ALLOGENEIC NEURAL RETINA-DERIVED HUMAN NEURAL RETINAL PROGENITOR CELLS EX VIVO EXPANDED | ReNeuron Ltd | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 33 | Phase 2 | United States;United Kingdom | ||
| 4 | NCT04517149 (ClinicalTrials.gov) | June 9, 2020 | 14/8/2020 | 4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP) | An Open-label, Phase 1/2 Trial of Gene Therapy 4D-125 in Males With X-linked Retinitis Pigmentosa (XLRP) Caused by Mutations in the RPGR Gene | X-Linked Retinitis Pigmentosa | Biological: 4D-125 IVT Injection;Other: Observational | 4D Molecular Therapeutics | NULL | Recruiting | 18 Years | N/A | Male | 37 | Phase 1;Phase 2 | United States |
| 5 | NCT04068207 (ClinicalTrials.gov) | February 22, 2020 | 23/8/2019 | Minocycline Treatment in Retinitis Pigmentosa | The Efficacy and Safety of Oral Minocycline in the Treatment of Retinitis Pigmentosa: An Open-label Clinical Trial | Retinitis Pigmentosa;Inherited Retinal Dystrophy;Retina Disorder | Drug: Minocycline | Sun Yat-sen University | NULL | Recruiting | 18 Years | 60 Years | All | 35 | Phase 2 | China |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT04278131 (ClinicalTrials.gov) | February 6, 2020 | 13/2/2020 | BS01 in Patients With Retinitis Pigmentosa | Phase 1/2, Safety and Efficacy Trial of BS01, a Recombinant Adeno-Associated Virus Vector Expressing ChronosFP in Patients With Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: BS01 | Bionic Sight LLC | NULL | Recruiting | 18 Years | N/A | All | 20 | Phase 1;Phase 2 | United States |
| 7 | NCT04123626 (ClinicalTrials.gov) | October 7, 2019 | 1/10/2019 | A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene | A Prospective First-In-Human Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa (adRP) Due to the P23H Mutation in the RHO Gene | Autosomal Dominant Retinitis Pigmentosa;Eye Diseases;Eye Diseases, Hereditary;Retinal Dystrophies;Retinal Disease;Retinitis;Vision Tunnel;Vision Disorders | Drug: QR-1123;Other: Sham procedure | ProQR Therapeutics | NULL | Recruiting | 18 Years | N/A | All | 35 | Phase 1;Phase 2 | United States |
| 8 | NCT04611503 (ClinicalTrials.gov) | September 24, 2019 | 20/5/2020 | PDE6A Gene Therapy for Retinitis Pigmentosa | PIGMENT - PDE6A Gene Therapy for Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: subretinal injection of rAAV.hPDE6A | STZ eyetrial | NULL | Recruiting | 18 Years | N/A | All | 9 | Phase 1;Phase 2 | Germany |
| 9 | NCT03963154 (ClinicalTrials.gov) | August 19, 2019 | 22/5/2019 | Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation | STREAM: A Phase 1/2, Open-label, Safety, Tolerability and Preliminary Efficacy Study of Implantation Into One Eye of hESC-derived RPE in Patients With Retinitis Pigmentosa Due to Monogenic Mutation | Retinitis Pigmentosa | Biological: Human Embryonic Stem Cell Derived Retinal Pigment Epithelium (RPE) | Centre d'Etude des Cellules Souches | NULL | Recruiting | 18 Years | 65 Years | All | 12 | Phase 1;Phase 2 | France |
| 10 | EUCTR2016-003705-34-DE (EUCTR) | 02/07/2019 | 26/11/2018 | Administration of a genetically modified virus particle in patients with PDE6A-linked retinitis pigmentosa | PIGMENT – PDE6A gene therapy for retinitis pigmentosa | PDE6A-linked retinitis pigmentosa;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Universitätsklinikum Tübingen | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 9 | Phase 1;Phase 2 | Germany | |||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 11 | NCT03999021 (ClinicalTrials.gov) | June 24, 2019 | 24/6/2019 | FIGHT-RP 1 Extension Study | A Phase 1 Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of N-Acetylcysteine (NAC) in Patients With Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: NAC effervescent tablets | Johns Hopkins University | NULL | Active, not recruiting | 18 Years | N/A | All | 30 | Phase 1 | United States |
| 12 | NCT04224207 (ClinicalTrials.gov) | April 1, 2019 | 6/1/2020 | Management of Retinitis Pigmentosa by Mesenchymal Stem Cells by Wharton's Jelly Derived Mesenchymal Stem Cells | Management of Retinitis Pigmentosa by Wharton's Jelly Derived Mesenchymal Stem Cells: Preliminary Clinical Results | Retinitis Pigmentosa;Inherited Retinal Dystrophy | Biological: Wharton's jelly derived mesenchymal stem cell | Ankara Universitesi Teknokent | NULL | Completed | 18 Years | 60 Years | All | 32 | Phase 3 | Turkey |
| 13 | NCT03780257 (ClinicalTrials.gov) | March 6, 2019 | 17/12/2018 | Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene | A First-in-Human Study to Evaluate the Safety and Tolerability of QR-421a in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene | Retinitis Pigmentosa;Usher Syndrome Type 2;Deaf Blind;Retinal Disease;Eye Diseases;Eye Diseases, Hereditary;Eye Disorders Congenital;Vision Disorders | Drug: QR-421a;Other: Sham-procedure (dose cohort 1&2 only) | ProQR Therapeutics | NULL | Recruiting | 18 Years | N/A | All | 18 | Phase 1;Phase 2 | United States;Belgium;Canada;France |
| 14 | NCT04312672 (ClinicalTrials.gov) | February 18, 2019 | 15/7/2019 | Long Term Follow-Up Gene Therapy Study for XLRP RPGR | Long Term Follow-Up Study of Participants Following an Open Label, Multi-Centre, Phase I/II Dose Escalation Trial of a Recombinant Adeno-Associated Virus Vector (AAV2-RPGR) for Gene Therapy of Adults and Children With X-Linked Retinitis Pigmentosa Owing to Defects in Retinitis Pigmentosa GTPase Regulator (RPGR) | X-Linked Retinitis Pigmentosa | Biological: AAV-RPGR | MeiraGTx UK II Ltd | NULL | Recruiting | 5 Years | N/A | Male | 36 | Phase 1;Phase 2 | United Kingdom |
| 15 | EUCTR2018-002433-38-FR (EUCTR) | 15/02/2019 | 16/11/2018 | Study to evaluate QR-421a in subjects with retinitis pigmentosa (RP) due to mutations in exon 13 of the USH2A Gene | A First-in-Human Study to Evaluate the Safety and Tolerability of QR-421a in Subjects with Retinitis Pigmentosa (RP) due to Mutations in Exon 13 of the USH2A Gene - STELLAR | Retinitis Pigmentosa (RP) due to Mutations in Exon 13 of the USH2A Gene MedDRA version: 20.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | ProQR Therapeutics | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 18 | Phase 1;Phase 2 | United States;France;Canada;Belgium | |||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 16 | EUCTR2013-005393-22-NL (EUCTR) | 04/01/2019 | 20/09/2016 | A study in subjects with rare inherited eye conditions caused by gene mutations to see if treatment with QLT091001 is safe and works to improve subjects' vision. | A Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) | Inherited retinal disease (IRD) phenotypically diagnosed as Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP) caused by mutations in the retinal pigment epithelium protein 65 (RPE65) or lecithin:retinol acyltransferase (LRAT) genes MedDRA version: 19.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders MedDRA version: 19.0;Classification code 10070667;Term: Leber's congenital amaurosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | QLT Inc. | NULL | NA | Female: yes Male: yes | 48 | Phase 3 | France;United States;Canada;Brazil;Denmark;Germany;Netherlands;United Kingdom;Switzerland | |||
| 17 | NCT03772938 (ClinicalTrials.gov) | December 13, 2018 | 3/11/2018 | Stem Cells Therapy in Degenerative Diseases of the Retina | Stem Cells Therapy in Degenerative Diseases of the Retina | Retinal Degeneration;Retinitis Pigmentosa;Age Related Macular Degeneration;Stargardt Disease 1 | Biological: Stem/progenitor cells transplantation | Pomeranian Medical University Szczecin | NULL | Unknown status | 18 Years | 65 Years | All | 30 | Phase 1 | Poland |
| 18 | NCT04315025 (ClinicalTrials.gov) | October 7, 2018 | 8/3/2020 | Safety Issues of Peribulbar Injection of UC-MSC in Patients With Retinitis Pigmentosa | Safety Issues of Peribulbar Injection of Umbilical Cord Mesenchymal Stem Cell (UC-MSC) in Patients With Retinitis Pigmentosa | Retinitis Pigmentosa | Biological: Umbilical Cord Mesenchymal Stem Cell (UC-MSC);Biological: Conditioned Medium (CM) | PT. Prodia Stem Cell Indonesia | NULL | Completed | 18 Years | 65 Years | All | 18 | Phase 1;Phase 2 | Indonesia |
| 19 | EUCTR2018-000425-31-GB (EUCTR) | 30/08/2018 | 14/06/2018 | Long term follow-up study of gene therapy trial for X-linked Retinitis Pigmentosa | Long term follow-up study of participants following an open label, multicentre, Phase I/II dose escalation trial of a recombinant adeno-associated virus vector (AAV2/5-hRKp.RPGR) for gene therapy of adults and children with X-linked Retinitis Pigmentosa owing to defects in Retinitis Pigmentosa GTPase Regulator (RPGR) - Long term follow-up gene therapy study for X-linked Retinitis Pigmentosa | X-Linked Retinitis Pigmentosa caused by mutations in the RPGR gene MedDRA version: 20.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | MeiraGTx UK II Ltd | NULL | Authorised-recruitment may be ongoing or finished | Female: no Male: yes | 36 | Phase 1;Phase 2 | United States;United Kingdom | |||
| 20 | NCT03374657 (ClinicalTrials.gov) | August 22, 2018 | 11/12/2017 | A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa | An Open-label First-in-human Single Ascending Dose Study to Explore Safety, Tolerability and Efficacy of Subretinal Administration of CPK850 Gene Therapy in Patients With Retinitis Pigmentosa Due to Mutations in the Retinaldehyde Binding Protein 1 (RLBP1) Gene | Retinitis Pigmentosa | Biological: CPK850 | Novartis Pharmaceuticals | NULL | Recruiting | 18 Years | 70 Years | All | 21 | Phase 1;Phase 2 | Sweden |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 21 | EUCTR2017-003104-42-GB (EUCTR) | 26/06/2018 | 06/02/2018 | A long-term follow-up study to evaluate the safety and efficacy of retinal gene therapy in subjects with Choroideremia previously treated with AAV2-REP1 in an antecedent study and in subjects with X-Linked Retinitis Pigmentosa previously treated with AAV8-RPGR in an antecedent study | A Long-term Follow-up Study to Evaluate the Safety and Efficacy of Retinal Gene Therapy in Subjects with Choroideremia Previously Treated with Adeno-Associated Viral Vector Encoding Rab Escort Protein-1 (AAV2-REP1) and in Subjects with X-Linked Retinitis Pigmentosa Previously Treated with Adeno-Associated Viral Vector Encoding RPGR (AAV8-RPGR) in an Antecedent Study - SOLSTICE | Choroideremia (CHM)X-Linked Retinitis Pigmentosa (XLRP) MedDRA version: 20.1;Level: LLT;Classification code 10008791;Term: Choroideremia;System Organ Class: 100000004853 MedDRA version: 20.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Name: AAV2-REP1 Product Code: AAV2-REP1 INN or Proposed INN: timrepigene emparvovec Other descriptive name: AAV2-REP1 Product Name: AAV8-RPGR Product Code: AAV8-RPGR Other descriptive name: AAV8-RPGR | NightstaRx Ltd | NULL | Authorised-recruitment may be ongoing or finished | Female: no Male: yes | 440 | Phase 3 | France;United States;Canada;Finland;Denmark;Netherlands;Germany;United Kingdom | ||
| 22 | NCT03316560 (ClinicalTrials.gov) | April 16, 2018 | 10/10/2017 | Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations | An Open-Label Dose Escalation Study to Evaluate the Safety and Efficacy of AGTC-501 (rAAV2tYF-GRK1-RPGR) in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations | X-Linked Retinitis Pigmentosa | Biological: rAAV2tYF-GRK1-RPGR | Applied Genetic Technologies Corp | NULL | Recruiting | 6 Years | N/A | Male | 30 | Phase 1;Phase 2 | United States |
| 23 | EUCTR2017-002204-27-GB (EUCTR) | 22/12/2017 | 20/10/2017 | A Phase 1/2a gene therapy clinical trial in Retinitis Pigmentosa subjects | A Phase 1/2a, Open-Label, Non-Randomized, Dose-Escalation Study to Evaluate the Safety and Tolerability of GS030 in Subjects with Retinitis Pigmentosa | Retinitis Pigmentosa;Therapeutic area: Diseases [C] - Eye Diseases [C11] | GENSIGHT-BIOLOGICS | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 18 | Phase 1;Phase 2 | United States;United Kingdom | |||
| 24 | NCT03328130 (ClinicalTrials.gov) | November 6, 2017 | 5/10/2017 | Safety and Efficacy Study in Patients With Retinitis Pigmentosa Due to Mutations in PDE6B Gene | Safety and Efficacy of a Unilateral Subretinal Administration of HORA-PDE6B in Patients With Retinitis Pigmentosa Harbouring Mutations in the PDE6B Gene Leading to a Defect in PDE6ß Expression | Retinitis Pigmentosa | Biological: AAV2/5-hPDE6B | Horama S.A. | NULL | Recruiting | 18 Years | N/A | All | 15 | Phase 1;Phase 2 | France |
| 25 | EUCTR2016-001429-16-FR (EUCTR) | 28/07/2017 | 12/09/2017 | Safety and Efficacy of a Unilateral Subretinal Administration of HORA-PDE6B in Patients Harboring Mutations in the PDE6B Gene Leading to a Defect in PDE6B Expression. | Safety and Efficacy of a Unilateral Subretinal Administration of HORA-PDE6B in Patients Harboring Mutations in the PDE6B Gene Leading to a Defect in PDE6B Expression. | Retinitis Pigmentosa;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Code: HORA-PDE6B (AAV2/5.hPDE6B) | HORAMA SA | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Phase 1;Phase 2 | France | |||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 26 | EUCTR2016-003967-21-GB (EUCTR) | 09/06/2017 | 14/09/2017 | Gene Therapy Trial for People with Retinitis Pigmentosa (progressive reduction in vision) due to a gene defect on Chromosome X. | An open label, multi-centre, Phase I/II dose escalation trial of a recombinant adeno-associated virus vector (AAV2/5-hRKp.RPGR) for gene therapy of adults and children with X-linked Retinitis Pigmentosa owing to defects in Retinitis Pigmentosa GTPase Regulator (RPGR) - Gene Therapy Trial for People with Retinitis Pigmentosa: RPGR | X-Linked Retinitis Pigmentosa caused by mutations in the RPGR gene MedDRA version: 20.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | MeiraGTx UK II Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: no Male: yes | 71 | Phase 1;Phase 2 | United States;United Kingdom | |||
| 27 | NCT03116113 (ClinicalTrials.gov) | March 16, 2017 | 29/3/2017 | A Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa | A Dose Escalation (Phase 1), and Dose Expansion (Phase 2/3) Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa Using an Adeno-Associated Viral Vector (AAV8) Encoding Retinitis Pigmentosa GTPase Regulator (RPGR) | X-Linked Retinitis Pigmentosa | Biological: AAV8-RPGR | NightstaRx Ltd, a Biogen Company | NULL | Recruiting | 10 Years | N/A | Male | 63 | Phase 2;Phase 3 | United States;United Kingdom |
| 28 | NCT03063021 (ClinicalTrials.gov) | February 15, 2017 | 16/2/2017 | The FIGHT-RP1 Study | A Phase 1 Open Label Dose Ranging Study to Assess the Safety and Tolerability of N-Acetylcysteine (NAC) in Patients With Retinitis Pigmentosa (FIGHT-RP1 Study) | Retinitis Pigmentosa | Drug: N-Acetyl Cysteine (NAC) | Johns Hopkins University | NULL | Completed | 18 Years | N/A | All | 30 | Phase 1 | United States |
| 29 | EUCTR2016-003852-60-GB (EUCTR) | 09/01/2017 | 09/11/2016 | A Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa using AAV8 | A Dose Escalation (Phase 1), and Dose Expansion (Phase 2/3) Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa Using an Adeno-Associated Viral Vector (AAV8) Encoding Retinitis Pigmentosa GTPase Regulator (RPGR) - XIRIUS Study | X-Linked retinitis pigmentosa (XLRP) MedDRA version: 20.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Name: AAV8-RPGR Product Code: AAV8-RPGR Other descriptive name: AAV8-RPGR | NightstaRx Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: no Male: yes | 63 | Phase 1;Phase 2;Phase 3 | United States;United Kingdom | ||
| 30 | NCT04252534 (ClinicalTrials.gov) | January 1, 2017 | 31/1/2020 | Management of Retinitis Pigmentosa Via Electromagnetic Stimulation and Platelet Rich Plasma | Management of Retinitis Pigmentosa Via Repetitive Electromagnetic Stimulation and Autologous Platelet Rich Plasma | Retinitis Pigmentosa | Combination Product: PRP combined Magnovision;Biological: PRP | Ankara Universitesi Teknokent | NULL | Completed | 18 Years | 60 Years | All | 60 | N/A | NULL |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 31 | EUCTR2013-005393-22-DK (EUCTR) | 03/11/2016 | 06/09/2016 | A study in subjects with rare inherited eye conditions caused by gene mutations to see if treatment with QLT091001 is safe and works to improve subjects' vision. | A Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) | Inherited retinal disease (IRD) phenotypically diagnosed as Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP) caused by mutations in the retinal pigment epithelium protein 65 (RPE65) or lecithin:retinol acyltransferase (LRAT) genes MedDRA version: 19.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders MedDRA version: 19.0;Classification code 10070667;Term: Leber's congenital amaurosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Name: QLT091001 Product Code: QLT091001 INN or Proposed INN: Zuretinol Acetate Other descriptive name: QLT091001 | QLT Inc. | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 48 | Phase 3 | France;United States;Canada;Brazil;Denmark;Netherlands;Germany;United Kingdom;Switzerland | ||
| 32 | EUCTR2016-002523-28-GB (EUCTR) | 16/09/2016 | 05/07/2016 | A Pilot Study Evaluating the Effect of Intravitreal Fluocinolone Acetonide (0.19mg) in Patients with Retinitis Pigmentosa. | A Pilot Study Evaluating the Effect of Intravitreal Fluocinolone Acetonide (0.19mg) in Patients with Retinitis Pigmentosa - Iluvien for IRD | Retinitis Pigmetosa. MedDRA version: 19.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Body processes [G] - Genetic Phenomena [G05] | Moorfields Eye Hospital | NULL | Not Recruiting | Female: yes Male: yes | 20 | Phase 2 | United Kingdom | |||
| 33 | NCT04238858 (ClinicalTrials.gov) | September 1, 2016 | 18/1/2020 | Effects of Subtenon-injected Autologous Platelet-rich Plasma on Visual Functions in Eyes With Retinitis Pigmentosa | Effects of Subtenon-injected Autologous Platelet-rich Plasma on Visual Functions in Eyes With Retinitis Pigmentosa | Retinitis Pigmentosa | Biological: Platelet rich plasma | Ankara Universitesi Teknokent | NULL | Completed | 18 Years | 55 Years | All | 48 | N/A | Turkey |
| 34 | JPRN-UMIN000023618 | 2016/09/01 | 01/09/2016 | Comparison of posterior capsule opacification between 2 intraocular lenses in cataract patients associated with retinitis pigmentsa | Cataract associated with patients with retinitis pigmentosa | Cataract surgery and implantation of 1P intraocular lens (PCB00V) Cataract surgery and implantation of 3P intraocular lens (VA-70AD) | Kyushu University Hospital | NULL | Complete: follow-up complete | 40years-old | Not applicable | Male and Female | 40 | Not selected | Japan | |
| 35 | JPRN-UMIN000022686 | 2016/07/01 | 01/07/2016 | The Clinical Efficacy of Carbonic Anhydrase Inhibitors and Steroids in the Management of Cystoid Macular Edema in Patients with Retinitis Pigmentosa | The Clinical Efficacy of Carbonic Anhydrase Inhibitors and Steroids in the Management of Cystoid Macular Edema in Patients with Retinitis Pigmentosa - The Clinical Efficacy in the Management of Cystoid Macular Edema in Patients with Retinitis Pigmentosa | retinitis pigmentosa | 1% dorzolamide eye drop three times daily in each eye 0.1% betamethasone sodium phosphate eye drop three times daily in each eye oral 250mg acetazolamide two tablets daily 40mg triamcinolone acetonide into the sub-Tenon capsule | Kyushu University Hospital | NULL | Complete: follow-up complete | 20years-old | Not applicable | Male and Female | 40 | Not applicable | Japan |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 36 | NCT02837640 (ClinicalTrials.gov) | June 2016 | 22/6/2016 | Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa | The Effect of L-Dopa on the Progression of Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: levodopa-carbidopa | Beirut Eye Specialist Hospital | NULL | Recruiting | 10 Years | 65 Years | Both | 50 | Phase 2 | Lebanon |
| 37 | NCT02617966 (ClinicalTrials.gov) | March 24, 2016 | 28/11/2015 | Rod and Cone Mediated Function in Retinal Disease | Rod and Cone Mediated Function in Retinal Disease | Retinal Degeneration;Retinitis Pigmentosa;Stargardt's Disease | Device: Medmont Darl Adapted Chromatic (DAC);Device: RetMap, RM Electrode;Device: MonCvONE electrophysiology | National Eye Institute (NEI) | NULL | Recruiting | 5 Years | N/A | All | 370 | N/A | United States |
| 38 | EUCTR2015-003723-65-GB (EUCTR) | 12/01/2016 | 06/01/2016 | Prospective non-randomised pilot study looking at the safety and efficacy of a drug called Eylea for patients with an eye condition called Retinitis Pigmentosa, that also have swelling at the back of the eye | Aflibercept (Eylea®) for macular oedema associated with underlying Retinitis Pigmentosa (AMOUR) - AMOUR | Retinitis Pigmentosa associated Cystoid Macular Oedema MedDRA version: 18.1;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Moorfields Eye Hospital | NULL | Not Recruiting | Female: yes Male: yes | 30 | Phase 2 | United Kingdom | |||
| 39 | NCT02556736 (ClinicalTrials.gov) | December 14, 2015 | 21/9/2015 | RST-001 Phase I/II Trial for Advanced Retinitis Pigmentosa | Phase I/IIa, Open-Label, Dose-Escalation Study of Safety and Tolerability of Intravitreal RST-001 in Patients With Advanced Retinitis Pigmentosa (RP) | Advanced Retinitis Pigmentosa | Drug: RST-001 | Allergan | NULL | Active, not recruiting | 18 Years | N/A | All | 14 | Phase 1;Phase 2 | United States |
| 40 | NCT02464436 (ClinicalTrials.gov) | December 2015 | 18/5/2015 | Safety and Tolerability of hRPC in Retinitis Pigmentosa | First-in-human Phase I/IIa, Open-Label, Prospective Study of the Safety and Tolerability of Subretinally Transplanted Human Retinal Progenitor Cells (hRPC) in Patients With Retinitis Pigmentosa (RP) | Retinitis Pigmentosa | Drug: hRPC | ReNeuron Limited | NULL | Recruiting | 18 Years | N/A | All | 33 | Phase 1;Phase 2 | United States;United Kingdom |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 41 | NCT02804360 (ClinicalTrials.gov) | January 2015 | 18/5/2016 | Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Macular Edema- a Retrospective Study | Dexamethasone in Retinitis Pigmentosa Cystoid Macular Edema | Retinitis Pigmentosa;Cystoid Macular Edema | Device: dexamethasone injection | Rafic Hariri University Hospital | NULL | Enrolling by invitation | 16 Years | 90 Years | Both | 50 | Phase 2 | NULL |
| 42 | NCT04356716 (ClinicalTrials.gov) | November 11, 2014 | 20/4/2020 | Sildenafil for Treatment of Choroidal Ischemia | Sildenafil for Treatment of Choroidal Ischemia | Choroidal Ischemia;Vitelliform Macular Dystrophy;Age-related Macular Degeneration;Central Serous Retinopathy;Retinitis Pigmentosa | Drug: Sildenafil;Other: Standard of Care Sildenafil;Diagnostic Test: Ocular Coherence Tomography-Angiography (OCT-A);Other: Visual Acuity (VA) | Columbia University | NULL | Recruiting | 18 Years | N/A | All | 25 | Phase 2 | United States |
| 43 | EUCTR2014-000385-22-IT (EUCTR) | 07/10/2014 | 12/05/2014 | Nerve Growth Factor eye drops as a novel treatment for patients with Retinitis Pigmentosa. | Nerve Growth Factor eye drops as a novel treatment for vision loss in patients with Retinitis Pigmentosa: from preclinical toclinical Phase II trial. - NEMO | Retinitis pigmentosa with cystoid macular edema MedDRA version: 17.0;Level: LLT;Classification code 10054467;Term: Macular edema;System Organ Class: 100000004853 MedDRA version: 17.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Name: recombinant human Nerve Growth Factor (rhNGF) INN or Proposed INN: not yet assigned Other descriptive name: RECOMBINANT HUMAN NERVE GROWTH FACTOR (RHNGF) | Ospedale San Raffaele di Milano | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Phase 2 | Italy | |||
| 44 | NCT01914913 (ClinicalTrials.gov) | September 2014 | 31/7/2013 | Clinical Study to Evaluate Safety and Efficacy of BMMNC in Retinitis Pigmentosa | An Open Labeled Clinical Study to Evaluate the Safety and Efficacy OF Autologous Bone Marrow Derived Mono Nuclear Stem Cell (BMMNCs) in Retinitis Pigmentosa. It is Self Funded (Patients' Own Funding) Clinical Trial | Retinitis Pigmentosa | Biological: BMMNCs | Chaitanya Hospital, Pune | NULL | Recruiting | 18 Years | 65 Years | Both | 15 | Phase 1;Phase 2 | India |
| 45 | NCT02709876 (ClinicalTrials.gov) | April 2014 | 26/2/2016 | Autologous Bone Marrow-Derived CD34+, CD133+, and CD271+ Stem Cell Transplantation for Retinitis Pigmentosa | Retinitis Pigmentosa | Biological: Stem Cell Transplantation | Stem Cells Arabia | NULL | Active, not recruiting | 18 Years | 55 Years | All | 50 | Phase 1;Phase 2 | Jordan | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 46 | NCT02110225 (ClinicalTrials.gov) | January 2014 | 8/4/2014 | A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP) | A 24 Week Phase Ib/II, Multicenter, Randomized, Controlled, Parallel Group, Dose Ranging Study With a 24 Week Follow-up to Evaluate Safety and Potential Efficacy of 2 Doses (60, 180 µg/ml) of rhNGF Solution vs Vehicle in Patients With RP. | Retinitis Pigmentosa | Drug: rhNGF 60 µg/ml eye drops solution;Drug: rhNGF 180 µg/ml eye drops solution;Drug: Placebo | Dompé Farmaceutici S.p.A | NULL | Completed | 18 Years | N/A | All | 50 | Phase 1;Phase 2 | Italy |
| 47 | EUCTR2012-002574-31-FR (EUCTR) | 25/10/2013 | 15/05/2014 | Study of SAR421869 in Patients With Retinitis Pigmentosa associated with Usher Syndrome Type 1B | A Phase I/IIa Dose Escalation Safety Study of Subretinally Injected SAR421869, Administered to Patients with Retinitis Pigmentosa Associated with Usher Syndrome Type 1B | Retinitis Pigmentosa, associated with Ushers Syndrome Type 1B. MedDRA version: 20.0;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders MedDRA version: 20.0;Classification code 10063396;Term: Usher's syndrome;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | sanofi-aventis recherche & développement | NULL | Not Recruiting | Female: yes Male: yes | 27 | Phase 1;Phase 2 | United States;France | |||
| 48 | NCT01786395 (ClinicalTrials.gov) | March 2013 | 23/1/2013 | Phase III Efficacy and Safety Clinical Study of UF-021 for Treatment of Retinitis Pigmentosa | Phase III Clinical Study of UF-021 for Retinitis Pigmentosa - Evaluation for a Comparative Double Masked Placebo Controlled Study Period and a Continuous Administration Period | Retinitis Pigmentosa | Drug: UF-021;Drug: Placebo | R-Tech Ueno, Ltd. | NULL | Terminated | 20 Years | 70 Years | Both | 202 | Phase 3 | Japan |
| 49 | EUCTR2012-002436-82-ES (EUCTR) | 13/12/2012 | 22/10/2012 | Melatonin effects on visual and sleep patterns anomalies in subjects diagnosed with Retinitis Pigmentosa | Melatonin effects on visual and sleep patterns anomalies in subjects diagnosed with Retinitis Pigmentosa | To evaluate the sleep quality in patients with Retinitis Pigmentosa;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Trade Name: CIRCADIN 2 mg comprimidos de liberación prolongada Product Name: Circadin 2 mg INN or Proposed INN: Not answered Other descriptive name: MELATONIN | Isabel Pinilla Lozano | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Spain | ||||
| 50 | EUCTR2011-004214-42-NL (EUCTR) | 04/10/2012 | 23/05/2012 | A study in patients with rare inherited eye conditions (Leber Congenital Amaurosis or Retinitis Pigmentosa), to see if repeated treatment with the study drug, QLT091001, is safe and works to improve patients' vision | An Open-Label Study to Evaluate the Effects of Repeated Treatments of Oral QLT091001 on Safety and Vision Outcome in Subjects with Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) (Extension of Study RET IRD 01) | Leber Congenital AmaurosisRetinitis pigmentosa MedDRA version: 14.1;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders MedDRA version: 14.1;Classification code 10070667;Term: Leber's congenital amaurosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Code: QLT091001 | QLT Inc. | NULL | Not Recruiting | Female: yes Male: yes | 31 | United States;Canada;Germany;Netherlands;United Kingdom | |||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 51 | EUCTR2011-004214-42-GB (EUCTR) | 03/09/2012 | 02/05/2012 | A study in patients with rare inherited eye conditions (Leber Congenital Amaurosis or Retinitis Pigmentosa), to see if repeated treatment with the study drug, QLT091001, is safe and works to improve patients' vision | An Open-Label Study to Evaluate the Effects of Repeated Treatments of Oral QLT091001 on Safety and Vision Outcome in Subjects with Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) (Extension of Study RET IRD 01) | Leber Congenital Amaurosis Retinitis pigmentosa MedDRA version: 20.0;Level: PT;Classification code 10070667;Term: Leber's congenital amaurosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders MedDRA version: 20.0;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | QLT Inc. | NULL | Not Recruiting | Female: yes Male: yes | 31 | Phase 1 | United States;Canada;Netherlands;Germany;United Kingdom | |||
| 52 | NCT01680510 (ClinicalTrials.gov) | September 2012 | 4/9/2012 | The Effect of Oral Administration of 9-cis ß Carotene Rich Powder of the Alga Dunaliella Bardawil | The Effect of Oral Administration of 9-cis ß Carotene Rich Powder of the Alga Dunaliella Bardawil on Visual Functions in Patients With Retinitis Pigmentosa | Retinitis Pigmentosa | Dietary Supplement: Alga Dunaliella Bardawil;Other: Placebo (starch) | Sheba Medical Center | NULL | Recruiting | 18 Years | N/A | All | 100 | Phase 2;Phase 3 | Israel |
| 53 | EUCTR2011-004214-42-DE (EUCTR) | 06/08/2012 | 03/05/2012 | A study in patients with rare inherited eye conditions (Leber Congenital Amaurosis or Retinitis Pigmentosa), to see if repeated treatment with the study drug, QLT091001, is safe and works to improve patients' vision | An Open-Label Study to Evaluate the Effects of Repeated Treatments of Oral QLT091001 on Safety and Vision Outcome in Subjects with Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) (Extension of Study RET IRD 01) | Leber Congenital AmaurosisRetinitis pigmentosa MedDRA version: 14.1;Level: PT;Classification code 10038914;Term: Retinitis pigmentosa;System Organ Class: 10010331 - Congenital, familial and genetic disorders MedDRA version: 14.1;Classification code 10070667;Term: Leber's congenital amaurosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Product Code: QLT091001 | QLT Inc. | NULL | Not Recruiting | Female: yes Male: yes | 31 | United States;Canada;Netherlands;Germany;United Kingdom | |||
| 54 | NCT01736059 (ClinicalTrials.gov) | July 2012 | 25/7/2012 | Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy | A Pilot Clinical Trial of the Feasibility and Safety of Intravitreal Autologous Adult Bone Marrow Stem Cells in Treating Eyes With Vision Loss From Retinopathy | Non-exudative Age-related Macular Degeneration;Diabetic Retinopathy;Retina Vein Occlusion;Retinitis Pigmentosa;Hereditary Macular Degeneration | Drug: CD34+ bone marrow stem cells intravitreal | University of California, Davis | NULL | Enrolling by invitation | 18 Years | 100 Years | All | 15 | Phase 1 | United States |
| 55 | NCT01505062 (ClinicalTrials.gov) | March 26, 2012 | 4/1/2012 | Study of SAR421869 in Participants With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B | A Phase I/IIA Dose Escalation Safety Study of Subretinally Injected SAR421869, Administered to Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B | Usher Syndrome;Retinitis Pigmentosa | Drug: SAR421869 | Sanofi | NULL | Terminated | 6 Years | N/A | All | 9 | Phase 1;Phase 2 | United States;France |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 56 | NCT01543906 (ClinicalTrials.gov) | February 2012 | 17/2/2012 | Oral QLT091001 in Retinitis Pigmentosa (RP) Subjects With an Autosomal Dominant Mutation in Retinal Pigment Epithelial 65 Protein (RPE65) | An Open-Label, Phase 1b, Safety/Proof-of-Concept Study to Evaluate the Effects of Oral QLT091001 in Retinitis Pigmentosa (RP) Subjects With an Autosomal Dominant Mutation in Retinal Pigment Epithelial 65 Protein (RPE65) | Retinitis Pigmentosa (RP) | Drug: QLT091001 | QLT Inc. | NULL | Completed | 18 Years | 70 Years | Both | 5 | Phase 1 | Canada;Ireland |
| 57 | NCT01521793 (ClinicalTrials.gov) | January 2012 | 6/1/2012 | Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01) | An Open-Label Study to Evaluate the Effects of Repeated Treatments of Oral QLT091001 on Safety and Vision Outcome in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin: Retinol Acyltransferase (LRAT) (Extension of Study RET IRD 01) | LCA (Leber Congenital Amaurosis);RP (Retinitis Pigmentosa) | Drug: QLT091001 | QLT Inc. | NULL | Completed | 5 Years | 65 Years | Both | 27 | Phase 1 | United States;Canada;Germany;Netherlands;United Kingdom |
| 58 | NCT01560715 (ClinicalTrials.gov) | June 2011 | 19/3/2012 | Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa | Phase 2 Study Of Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa | Retinitis Pigmentosa | Biological: intravitreal injection of autologous bone marrow stem cells | University of Sao Paulo | NULL | Completed | 18 Years | 75 Years | All | 50 | Phase 2 | Brazil |
| 59 | NCT01399515 (ClinicalTrials.gov) | March 2011 | 3/5/2011 | Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa | Retinitis Pigmentosa;Retinal Diseases;Eye Diseases;Eye Disease, Hereditary;Retinal Degeneration | Drug: Valproic Acid | Seoul National University Hospital | NULL | Completed | 18 Years | N/A | Both | 200 | Phase 2 | Korea, Republic of | |
| 60 | JPRN-UMIN000005852 | 2010/06/01 | 27/06/2011 | The Clinical Efficacy of a Topical Dorzolamide in the Management of Cystoid Macular Edema in Patients with Retinitis Pigmentosa | retinitis pigmentosa | 1% dorzolamide three times daily in each eye during the follow-up period | Kyushu university hospital | NULL | Complete: follow-up complete | 20years-old | Not applicable | Male and Female | 20 | Not applicable | Japan | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 61 | EUCTR2010-019079-32-PT (EUCTR) | 19/05/2010 | 05/04/2010 | A Multicenter, Patient-Masked, Safety Extension Study to Evaluate the Biodegradation of the Brimonidine Tartrate Posterior Segment Drug Delivery System | A Multicenter, Patient-Masked, Safety Extension Study to Evaluate the Biodegradation of the Brimonidine Tartrate Posterior Segment Drug Delivery System | Patients who participated in a previous intravitreal Brimo PS DDS study, including 190342-028D (Retinitis pigmentosa) and 190342-032D (Geographic Atrophy from Age-related Macular Degeneration). | Product Name: Brimonidine Tartrate Posterior Segment Drug Delivery System (Brimo PS DDS) Applicator System Product Code: 9715X INN or Proposed INN: Brimonidine Tartrate Product Name: Brimonidine Tartrate Posterior Segment Drug Delivery System (Brimo PS DDS) Applicator System Product Code: 9742X INN or Proposed INN: Brimonidine Tartrate Product Name: Brimonidine Tartrate Posterior Segment Drug Delivery System (Brimo PS DDS) Applicator System Product Code: 9741X INN or Proposed INN: Brimonidine Tartrate | Allergan Limited | NULL | Not Recruiting | Female: yes Male: yes | 290 | Portugal;Czech Republic;Germany;Italy;United Kingdom | |||
| 62 | EUCTR2010-019079-32-DE (EUCTR) | 12/05/2010 | 13/04/2010 | A Multicenter, Patient-Masked, Safety Extension Study to Evaluate the Biodegradation of the Brimonidine Tartrate Posterior Segment Drug Delivery System | A Multicenter, Patient-Masked, Safety Extension Study to Evaluate the Biodegradation of the Brimonidine Tartrate Posterior Segment Drug Delivery System | Patients who participated in a previous intravitreal Brimo PS DDS study, including 190342-028D (Retinitis pigmentosa) and 190342-032D (Geographic Atrophy from Age-related Macular Degeneration). | Product Name: Brimonidine Tartrate Posterior Segment Drug Delivery System (Brimo PS DDS) Applicator System Product Code: 9715X INN or Proposed INN: Brimonidine Tartrate Product Name: Brimonidine Tartrate Posterior Segment Drug Delivery System (Brimo PS DDS) Applicator System Product Code: 9742X INN or Proposed INN: Brimonidine Tartrate Product Name: Brimonidine Tartrate Posterior Segment Drug Delivery System (Brimo PS DDS) Applicator System Product Code: 9741X INN or Proposed INN: Brimonidine Tartrate | Allergan Limited | NULL | Not Recruiting | Female: yes Male: yes | 290 | Portugal;Czech Republic;Germany;Italy;United Kingdom | |||
| 63 | NCT01014052 (ClinicalTrials.gov) | November 2009 | 12/11/2009 | Safety/Proof of Concept Study of Oral QLT091001 in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) Mutations | Phase 1b Study to Evaluate QLT091001 in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) | LCA (Leber Congenital Amaurosis);RP (Retinitis Pigmentosa) | Drug: QLT091001 | QLT Inc. | NULL | Completed | 5 Years | 65 Years | Both | 32 | Phase 1 | United States;Canada;Germany;Netherlands;United Kingdom |
| 64 | EUCTR2008-004561-26-IT (EUCTR) | 01/06/2009 | 11/11/2008 | Inner Retinal Dysfunction of the Cone System in Inherited Photoreceptor Degenerations: A Study of Disease Sequence and Assessment of Novel Therapeutic Strategies. - ND | Inner Retinal Dysfunction of the Cone System in Inherited Photoreceptor Degenerations: A Study of Disease Sequence and Assessment of Novel Therapeutic Strategies. - ND | retinitis pigmentosa MedDRA version: 9.1;Level: LLT;Classification code 10038914;Term: Retinitis pigmentosa MedDRA version: 9.1;Level: PT;Term: Retinitis pigmentosa | Product Name: Nerve Growt Factor - 2.5S INN or Proposed INN: COQUN | POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Italy | ||||
| 65 | NCT01068561 (ClinicalTrials.gov) | May 2009 | 10/2/2010 | Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa | Phase 1 Study Of Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa | Retinitis Pigmentosa | Biological: intravitreal injection of autologous bone marrow stem cells | University of Sao Paulo | NULL | Completed | 18 Years | N/A | Both | 5 | Phase 1 | Brazil |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 66 | JPRN-UMIN000006820 | 2009/02/01 | 02/12/2011 | Neuroprotective efficacy of topical unoprostone isopropyl or nipradilol in patients with retinitis pigmentosa | retinitis pigmentosa | 0.12% topical unoprostone isopropyl twice daily 0.25% topical nipradilol twice daily | Kyushu university hospital | NULL | Complete: follow-up complete | Not applicable | Not applicable | Male and Female | 50 | Not selected | Japan | |
| 67 | NCT01773278 (ClinicalTrials.gov) | December 2008 | 3/12/2012 | Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS) | Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS) | Smith-Lemli-Opitz Syndrome;Cone-Rod Dystrophy;Hearing Loss | Drug: Antioxidants;Drug: Cholesterol | University of Colorado, Denver | NULL | Recruiting | N/A | 65 Years | All | 100 | Phase 2 | United States |
| 68 | JPRN-JapicCTI-090748 | 01/10/2008 | 20/04/2009 | Phase II Study of 0.15% UF-021 in patients with retinitis pigmentosa | Phase II Study of 0.15% UF-021 in patients with retinitis pigmentosa | retinitis pigmentosa | Intervention name : UF-021 (isopropyl unoprostone) Dosage And administration of the intervention : Eye drop | R-Tech Ueno, Ltd | NULL | 20 | 65 | BOTH | 105 | Phase 2 | NULL | |
| 69 | NCT01256697 (ClinicalTrials.gov) | August 2008 | 25/2/2010 | The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella Bardawil on Visual Functions im Patients With Retinitis Pigmentosa | The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella | Retinitis Pigmentosa | Dietary Supplement: Alga Dunaliella Bardawil;Dietary Supplement: Alga Dunaliella Bardawill;Other: Sugar pill | Sheba Medical Center | NULL | Completed | 18 Years | N/A | Female | 34 | N/A | Israel |
| 70 | NCT00661479 (ClinicalTrials.gov) | July 2008 | 29/10/2007 | An Exploratory Study to Evaluate the Safety of Brimonidine Intravitreal Implant in Patients With Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: 400 µg Brimonidine Tartrate Implant;Drug: 200 µg Brimonidine Tartrate Implant;Drug: 100 µg Brimonidine Tartrate Implant;Other: Sham (no implant) | Allergan | NULL | Completed | 18 Years | N/A | All | 21 | Phase 1;Phase 2 | United States;France;Germany;Portugal | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 71 | NCT00458575 (ClinicalTrials.gov) | April 2007 | 10/4/2007 | A Study to Evaluate the Safety of CNTO 2476 in Patients With Advanced Retinitis Pigmentosa | A Phase I Open Label Non-comparative Study Evaluating the Safety of a Single, Unilateral, Subretinal Administration of CNTO 2476 in Advanced Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: CNTO 2476 | Centocor, Inc. | NULL | Terminated | 18 Years | N/A | Both | 7 | Phase 1 | United States |
| 72 | NCT00433277 (ClinicalTrials.gov) | February 2007 | 6/2/2007 | Autoimmunity in Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: twice-daily dosage with 0.5% cyclosporine-A eyedrops | Semmelweis University | NULL | Active, not recruiting | N/A | N/A | Both | N/A | Hungary | ||
| 73 | NCT00447993 (ClinicalTrials.gov) | January 2007 | 9/3/2007 | A Study of Encapsulated Cell Technology (ECT) Implant for Patients With Late Stage Retinitis Pigmentosa | A Phase II/III Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) for Participants With Retinitis Pigmentosa Using Visual Acuity as the Primary Outcome | Retinitis Pigmentosa | Drug: NT-501 | Neurotech Pharmaceuticals | NULL | Completed | 18 Years | 68 Years | Both | 65 | Phase 2 | United States |
| 74 | NCT00447980 (ClinicalTrials.gov) | January 2007 | 9/3/2007 | A Study of Encapsulated Cell Technology (ECT) Implant for Participants With Early Stage Retinitis Pigmentosa | A Phase II/III Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) for Participants With Retinitis Pigmentosa Using Visual Field Sensitivity as the Primary Outcome | Retinitis Pigmentosa | Drug: NT-501 | Neurotech Pharmaceuticals | NULL | Completed | 18 Years | 64 Years | Both | 68 | Phase 2 | United States |
| 75 | NCT00461435 (ClinicalTrials.gov) | January 2004 | 17/4/2007 | Slowing the Degenerative Process, Long Lasting Effect of Hyperbaric Oxygen Therapy in Retinitis Pigmentosa | Slowing the Degenerative Process, Long Lasting Effect of Hyperbaric Oxygen Therapy in Retinitis Pigmentosa | Retinitis Pigmentosa | Procedure: hyperbaric oxygen therapy | Azienda Policlinico Umberto I | NULL | Completed | 20 Years | 70 Years | Both | N/A | Italy | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 76 | NCT00065455 (ClinicalTrials.gov) | July 17, 2003 | 23/7/2003 | Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa | Pilot Study on the Effect of Vitamin A Supplementation on Cone Function in Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: Vitamin A | National Eye Institute (NEI) | NULL | Completed | 18 Years | N/A | All | 11 | Phase 1 | United States |
| 77 | NCT00346333 (ClinicalTrials.gov) | July 2003 | 27/6/2006 | Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A | Randomized Clinical Trial for Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: Lutein;Dietary Supplement: Cornstarch control | National Eye Institute (NEI) | NULL | Completed | 18 Years | 60 Years | All | 240 | Phase 3 | United States |
| 78 | NCT00063765 (ClinicalTrials.gov) | June 2003 | 3/7/2003 | Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye | A Phase I Study of NT-501-10 and NT-501-6A.02, Implants of Encapsulated Human NTC-210 Cells Releasing Ciliary Neurotrophic Factor (CNTF), in Patients With Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: Ciliary Neurotrophic Factor Implant NT-501 | National Eye Institute (NEI) | NULL | Completed | N/A | N/A | Both | 10 | Phase 1 | United States |
| 79 | JPRN-UMIN000007895 | 2001/07/01 | 01/06/2012 | Effects of nilvadipine on the progression of visual field defects in patients with retinitis pigmentosa | retinitis pigmentosa | Treated group: oral administration of nilvadipine 4mg per day Control group: herenien, tocoferol or no medication as patients' requests | Department of Ophthalmology, Hirosaki University Graduate School of Medicine | NULL | Complete: follow-up complete | 20years-old | 80years-old | Male and Female | 40 | Phase 2 | Japan | |
| 80 | NCT00029289 (ClinicalTrials.gov) | April 2001 | 9/1/2002 | Effects of Lutein in Retinitis Pigmentosa | Effects of Lutein in Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: Lutein (10 or 30 mg/day) capsules | National Center for Complementary and Integrative Health (NCCIH) | NULL | Completed | Phase 1;Phase 2 | United States | ||||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 81 | NCT00000116 (ClinicalTrials.gov) | May 1996 | 23/9/1999 | Randomized Trial for Retinitis Pigmentosa | Randomized Trial for Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: Vitamin A;Drug: Nutritional Supplement | National Eye Institute (NEI) | NULL | Completed | 18 Years | 56 Years | Both | Phase 3 | United States | |
| 82 | NCT00004827 (ClinicalTrials.gov) | March 1996 | 24/2/2000 | Study of Docosahexaenoic Acid (DHA) Supplementation in Patients With X-Linked Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: docosahexaenoic acid | Retina Foundation of the Southwest | NULL | Completed | N/A | N/A | Male | 46 | N/A | NULL | |
| 83 | NCT00000114 (ClinicalTrials.gov) | May 1984 | 23/9/1999 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | Retinitis Pigmentosa | Drug: Vitamin E;Drug: Vitamin A | National Eye Institute (NEI) | NULL | Completed | 18 Years | 49 Years | Both | Phase 3 | NULL | ||
| 84 | JPRN-JapicCTI-132079 | Phase 3 Clinical Study of UF-021 for Retinitis Pigmentosa - Evaluation for a Comparative Double Masked Placebo Controlled Study Period and a Continuous Administration Period | Phase 3 Clinical Study of UF-021 for Retinitis Pigmentosa - Evaluation for a Comparative Double Masked Placebo Controlled Study Period and a Continuous Administration Period | Retinitis Pigmentosa | Intervention name : UF-021(isopropyl unoprostone) Dosage And administration of the intervention : Eye drop Control intervention name : null | R-Tech Ueno, Ltd | NULL | 20 | 70 | BOTH | Phase 3 | NULL |