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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
111C-flumazenil1件: Flumazenil1件: D00697 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 206
218F-FTC-146----1件: 206
35-Hydroxytryptophan / Vitamin B61件: Pyridoxine1件: D08454 --1件: 206
4[15-O]water1件: Water1件: D00001 --1件: 206
5[18F]flumazenil1件: Flumazenil1件: D00697 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 206
6[18F]FPEB----3件: 6, 8, 206
7[18F]FPEB PET imaging----1件: 206
8Acamprosate1件: Acamprosate1件: D07058 5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬2件: 6, 206
9Acetate1件: Acetate---41件: 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299
10Acidum ascorbicum1件: Ascorbic acid1件: D00018 --1件: 206
11ACIDUM ASCORBICUM D61件: Ascorbic acid1件: D00018 --1件: 206
12AF056----1件: 206
13AFQ056----3件: 6, 8, 206
14Alpha-tocopherol2件: Tocopherol,
Vitamin E		2件: D02331 ,
D02332 		--2件: 49, 206
15Ampalex----1件: 206
16Arbaclofen1件: Arbaclofen1件: D09791 2件: GABBR1,
GABBR2 💬		7件: Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬2件: 13, 206
17Aripiprazole1件: Aripiprazole1件: D01164 4件: DRD2,
DRD3,
HTR1A,
HTR2A 💬		12件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬2件: 6, 206
18Ascorbic acid1件: Ascorbic acid1件: D00018 --4件: 10, 97, 206, 298
19Ascorbic Acid (Vitamin C) and Alpha-tocopherol (Vitamin E)3件: Ascorbic acid,
Tocopherol,
Vitamin E		3件: D00018 ,
D02331 ,
D02332 		--1件: 206
20AZD7325----1件: 206
21AZD7325 (High-Dose)----1件: 206
22AZD7325 (Low-Dose)----1件: 206
23Baclofen1件: Baclofen1件: D00241 2件: GABBR1,
GABBR2 💬		7件: Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬8件: 2, 10, 13, 18, 65, 70, 149, 206
24BPN14770----1件: 206
25BPN14770/ zatolmilast1件: Zatolmilast1件: D12173 1件: PDE4D 💬5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 206
26Cannabidiol1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬18件: 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
27CBD----13件: 2, 6, 8, 13, 36, 46, 51, 140, 144, 145, 156, 158, 206
28CCD 1042, MD 9150000, Mepalon 1042, SPT316----2件: 152, 206
29CX5161件: CX516---1件: 206
30CX516 (Ampalex®)1件: CX516---1件: 206
31Donepezil1件: Donepezil1件: D07869 1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬9件: 5, 6, 13, 46, 78, 124, 127, 156, 206
32EGCG1件: Epigallocatechin gallate---9件: 6, 8, 13, 17, 28, 85, 113, 206, 299
33EGCG FontUp1件: Epigallocatechin gallate---1件: 206
34Ergoloid Mesylate1件: Ergoloid mesylate---1件: 206
35Flumazenil1件: Flumazenil1件: D00697 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬5件: 6, 13, 17, 18, 206
36Fluoxetin1件: Fluoxetine1件: D00326 1件: SLC6A4 💬2件: Serotonergic synapse, Synaptic vesicle cycle 💬3件: 13, 179, 206
37Gaboxadol1件: Gaboxadol1件: D04282 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 201, 206
38Gaboxadol (HLX-0206)1件: Gaboxadol1件: D04282 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 206
39Ganaxolone1件: Ganaxolone1件: D04300 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬4件: 145, 152, 158, 206
40Lovastatin1件: Lovastatin1件: D00359 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
41Lovastatin, then Minocycline/Lovastatin2件: Lovastatin,
Minocycline		2件: D00359 ,
D05045 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 206
42Mavoglurant1件: Mavoglurant---2件: 6, 206
43Memantine1件: Memantine1件: D08174 5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬8件: 2, 6, 8, 13, 49, 127, 205, 206
44Metformin1件: Metformin1件: D04966 2件: PRKAA1,
PRKAA2 💬		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
45Methylphenidate1件: Methylphenidate1件: D04999 2件: SLC6A2,
SLC6A3 💬		7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬7件: 6, 13, 34, 84, 113, 179, 206
46Methylphenidate Oral Solution1件: Methylphenidate1件: D04999 2件: SLC6A2,
SLC6A3 💬		7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬1件: 206
47Methylphenidate, fluoxetin, risperidone3件: Fluoxetine,
Methylphenidate,
Risperidone		3件: D00326 ,
D00426 ,
D04999 		5件: DRD2,
HTR2A,
SLC6A2,
SLC6A3,
SLC6A4 💬		14件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Rap1 signaling pathway, Serotonergic synapse, Synaptic vesicle cycle, cAMP signaling pathway 💬2件: 179, 206
48MG01CI extended-release tablet1件: Manganese citrate---1件: 206
49MGlu5 antagonist----1件: 206
50Minocycline1件: Minocycline1件: D05045 --13件: 2, 6, 8, 13, 46, 85, 90, 94, 162, 201, 206, 280, 299
51Minocycline Hydrochloride1件: Minocycline1件: D05045 --4件: 13, 201, 206, 299
52Minocycline, then Minocycline/Lovastatin2件: Lovastatin,
Minocycline		2件: D00359 ,
D05045 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 206
53NNZ-2566----2件: 156, 206
54Non invasive prenatal diagnosis----3件: 8, 113, 206
55NPL-2009----1件: 206
56OV101----2件: 201, 206
57OV101 (gaboxadol)1件: Gaboxadol1件: D04282 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 206
58Oxytocin1件: Oxytocin1件: D00089 1件: OXTR 💬4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬7件: 6, 72, 127, 168, 193, 206, 226
59Oxytocin 24IU1件: Oxytocin1件: D00089 1件: OXTR 💬4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬1件: 206
60Oxytocin 48IU1件: Oxytocin1件: D00089 1件: OXTR 💬4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬1件: 206
61Release1件: Manganese citrate---12件: 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
62RILUZOLE1件: Riluzole1件: D00775 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
63Risperidone1件: Risperidone1件: D00426 2件: DRD2,
HTR2A 💬		11件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬5件: 8, 156, 179, 187, 206
64Ro 491-7523/F18----1件: 206
65Ro 491-7523/F19----1件: 206
66RO4917523----1件: 206
67RO4917523 0.5 mg----1件: 206
68RO4917523 1.5 mg----1件: 206
69Roflumilast1件: Roflumilast1件: D05744 4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬4件: 84, 97, 206, 299
70Sertraline1件: Sertraline1件: D02360 1件: SLC6A4 💬2件: Serotonergic synapse, Synaptic vesicle cycle 💬2件: 6, 206
71STX107----1件: 206
72STX209----1件: 206
73Sugar pill----8件: 5, 6, 49, 67, 70, 86, 206, 210
74Sulindac1件: Sulindac1件: D00120 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 206
75Sulindac (HLX-0201), dose strength 11件: Sulindac1件: D00120 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 206
76Sulindac (HLX-0201), dose strength 21件: Sulindac1件: D00120 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 206
77Tocopherol1件: Tocopherol1件: D02332 --5件: 13, 49, 206, 257, 298
78TOCOPHERYL ACETATE2件: Acetate,
alpha-Tocopherol acetate		---1件: 206
79Vitamin B61件: Pyridoxine1件: D08454 --2件: 6, 206
80Vitamin C1件: Ascorbic acid1件: D00018 --6件: 10, 192, 206, 210, 211, 212
81Vitamin E1件: Vitamin E1件: D02331 --11件: 2, 6, 13, 20, 46, 90, 96, 97, 206, 299, 317
82Water1件: Water1件: D00001 --21件: 2, 5, 6, 13, 17, 22, 35, 46, 53, 57, 63, 65, 67, 78, 84, 96, 97, 206, 226, 278, 299
83Zatolmilast1件: Zatolmilast1件: D12173 1件: PDE4D 💬5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 206
84Zatolmilast/ BPN147701件: Zatolmilast1件: D12173 1件: PDE4D 💬5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬1件: 206
85ZYN002----2件: 203, 206
86ZYN002 - CBD Transdermal Gel----1件: 206
87ZYN002 - transdermal gel----1件: 206