Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Aliskiren
(Rasilez HCT)		[1] Aliskiren[1] Aliskiren 💬 [1] REN 💬 [3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[3] 66, 167, 222 💬
2 Amiloride
(Alti-amiloride Hctz)		[3] AMILORIDE; Amiloride Hydrochloride; Midamor[1] Amiloride 💬 [3] SCNN1A,
SCNN1B,
SCNN1G 💬 		[2] Aldosterone-regulated sodium reabsorption, Taste transduction 💬[4] 13, 67, 225, 299 💬
3 Amlodipine
(Copalia HCT)		[1] Amlodipine[1] Amlodipine 💬 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 13, 51, 67, 298 💬
4 Benazepril
(Lotensin HCT)		[1] Benazepril[1] Benazepril 💬 [1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[4] 49, 57, 218, 224 💬
5 Candesartan cilexetil
(Candesartan HCT)		[1] CANDESARTAN[1] Candesartan cilexetil 💬 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 67 💬
6 Cilazapril
(Teva-cilazapril/hctz)		[1] Cilazapril[2] Cilazapril ,
Cilazapril 💬 		[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 66 💬
7 Enalapril
(Enalapril Maleate/hctz)		[2] Enalapril; Enalapril Maleate[1] Enalapril 💬 [1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[6] 19, 46, 66, 113, 210, 222 💬
8 Hydrochlorothiazide
(Act Losartan/hct)		[2] Esidrix; HYDROCHLOROTHIAZIDE[1] Hydrochlorothiazide 💬 [1] SLC12A3 💬 -[4] 13, 67, 225, 235 💬
9 Irbesartan
(Act Irbesartan/hct)		[2] Aprovel; IRBESARTAN[1] Irbesartan 💬 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 66, 167, 168, 222 💬
10 Lisinopril
(Mylan-lisinopril Hctz)		[2] Lisinopril; Zestril[2] Lisinopril ,
Lisinopril 💬 		[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 19, 46, 49, 66, 67, 113, 222 💬
11 Losartan
(Losartan HCT)		[3] Cozaar; Losartan; LOSARTAN POTASSIUM[1] Losartan 💬 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
12 Metoprolol
(Lopressor HCT)		[2] Metoprolol; METOPROLOL SUCCINATE[1] Metoprolol 💬 [1] ADRB1 💬 [11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 17, 57, 58, 113, 193, 226 💬
13 Quinapril
(Auro-quinapril Hctz)		[1] Accuretic[1] Quinapril 💬 [1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 19 💬
14 Ramipril
(Ramipril-hctz)		[1] Ramipril[1] Ramipril 💬 [1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 46, 49, 66, 67, 113, 218, 257 💬
15 Spironolactone
(Teva-spironolactone/hctz)		[1] SPIRONOLACTONE[1] Spironolactone 💬 [1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225 💬
16 Telmisartan
(Alembic-telmisartan/hctz)		[1] Telmisartan[1] Telmisartan 💬 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 66, 67 💬
17 Valsartan
(Auro-valsartan HCT)		[3] Diovan; Entresto; Valsartan[1] Valsartan 💬 [1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[7] 57, 58, 66, 75, 218, 222, 224 💬