Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Saccharomyces cerevisiae [1] Saccharomyces---[1] 51
2 Sacubitril [2] Entresto; Sacubitril[1] D10225 [1] MME 💬[4] Alzheimer disease, Hematopoietic cell lineage, Protein digestion and absorption, Renin-angiotensin system 💬[2] 58, 222
3 Safinamide [3] Safinamida; SAFINAMIDE; Xadago[1] D10158 [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[2] 6, 17
4 Sage [1] Sage---[1] 6
5 Salbutamol [3] Albuterol; Salbutamol; Ventolin[1] D02147 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[12] 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299
6 Salicylic acid [2] 2-Hydroxybenzoic acid; Salicylic acid[1] D00097 --[1] 97
7 Salmeterol [1] Salmeterol[1] D05792 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 299
8 Salmon, unspecified [1] Salmon---[3] 96, 97, 225
9 Salsalate [1] Salsalate[1] D00428 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 5
10 Sapropterin [5] 6R-BH4; KUVAN; SAPROPTERIN; SAPROPTERIN DIHYDROCHLORIDE; Tetrahydrobiopterin[1] D08505 --[5] 51, 86, 124, 240, 299
11 Saquinavir [1] Saquinavir[1] D00429 --[2] 86, 265
12 Saracatinib [1] Saracatinib[1] D09664 [2] ABL1,
SRC 💬		[49] Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬[3] 6, 89, 272
13 Sarcosine [1] Sarcosine---[1] 6
14 Sargramostim [2] Leukine; Sargramostim[1] D05803 [1] CSF2RA 💬[4] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer 💬[7] 6, 28, 60, 62, 96, 229, 285
15 Sarilumab [4] Kevzara; REGN88; SAR153191; SARILUMAB[1] D10161 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[5] 41, 46, 84, 107, 271
16 Sarizotan [1] Sarizotan---[2] 6, 156
17 Saroglitazar [1] Saroglitazar---[1] 93
18 SARS-CoV-2 mRNA vaccine [1] SARS-COV-2 mRNA Vaccine---[1] 13
19 Satavaptan [1] Satavaptan---[1] 72
20 Satralizumab [3] Enspryng; Sapelizumab; SATRALIZUMAB[1] D11079 [1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[3] 11, 13, 86
21 Saxagliptin [1] Saxagliptin[1] D08996 [1] DPP4 💬[1] Protein digestion and absorption 💬[1] 299
22 SC12267 [1] SC12267---[3] 46, 96, 97
23 Scopolamine [1] Scopolamine[1] D00138 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[1] 2
24 Sebelipase alfa [4] KANUMA; SBC-102; Sebelipasa Alfa; Sebelipase Alfa[1] D10377 [1] LIPA 💬[3] Cholesterol metabolism, Lysosome, Steroid biosynthesis 💬[1] 19
25 Secretin human [3] Human Secretin; Secretin; Synthetic human secretin---[1] 298
26 Secukinumab [2] Cosentyx; SECUKINUMAB[1] D09967 [1] IL17A 💬[6] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation 💬[8] 13, 37, 41, 46, 107, 160, 269, 271
27 Seladelpar [1] SELADELPAR[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[2] 93, 94
28 Selegiline [2] SELEGILINE; Zelapar[1] D03731 [1] MAOB 💬[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
29 Selenium [1] Selenium---[4] 13, 96, 278, 298
30 Selexipag [2] SELEXIPAG; Uptravi[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[5] 51, 70, 84, 86, 88
31 Seliciclib [2] R-roscovitine; SELICICLIB---[2] 75, 299
32 Selinexor [1] Selinexor[1] D11222 [1] XPO1 💬[5] Human T-cell leukemia virus 1 infection, Influenza A, Nucleocytoplasmic transport, Ribosome biogenesis in eukaryotes, Viral life cycle - HIV-1 💬[1] 28
33 Selisistat [1] Selisistat---[1] 8
34 Selonsertib [1] Selonsertib[1] D10988 [1] MAP3K5 💬[20] Alcoholic liver disease, Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Huntington disease, Lipid and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Platinum drug resistance, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, Spinocerebellar ataxia, TNF signaling pathway, Thermogenesis, Tight junction 💬[1] 86
35 Selumetinib [2] Koselugo; Selumetinib[1] D09666 [2] MAP2K1,
MAP2K2 💬		[89] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, B cell receptor signaling pathway, Bladder cancer, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Cholinergic synapse, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway, Vascular smooth muscle contraction, Yersinia infection, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 34
36 Semaglutide [1] Semaglutide[1] D10025 [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 6
37 Semapimod [1] Semapimod---[1] 96
38 Senna leaf [1] Senna[1] D06751 --[1] 291
39 SEP-363856 [1] SEP-363856---[1] 6
40 Serine [2] L-Serine; Serine[1] D00016 --[4] 2, 6, 86, 96
41 Serlopitant [1] Serlopitant[1] D09378 [1] TACR1 💬[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction 💬[1] 36
42 Serotonin [1] Serotonin---[3] 2, 96, 97
43 Sertraline [1] Sertraline[1] D02360 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 206
44 Sesame oil [1] Sesame oil[1] D03314 --[1] 3
45 Setanaxib [1] SETANAXIB---[1] 93
46 Setmelanotide [1] Setmelanotide[1] D11927 [1] MC4R 💬[1] Neuroactive ligand-receptor interaction 💬[2] 202, 265
47 Setrusumab [1] SETRUSUMAB---[1] 274
48 Sevelamer [1] Sevelamer[1] D08512 --[2] 235, 238
49 Sevoflurane [1] Sevoflurane[1] D00547 --[7] 6, 21, 22, 34, 98, 225, 296
50 Sibofimloc [1] Sibofimloc[1] D11825 --[1] 96
51 Sifalimumab [1] Sifalimumab[1] D09668 [13] IFNA1,
IFNA10,
IFNA13,
IFNA14,
IFNA16,
IFNA17,
IFNA2,
IFNA21,
IFNA4,
IFNA5,
IFNA6,
IFNA7,
IFNA8 💬		[25] Alcoholic liver disease, Autoimmune thyroid disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, PI3K-Akt signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Tuberculosis 💬[1] 49
52 Sildenafil [6] Mysildecard; Revatio; Sildenafil; Sildenafil citrate; SILDENAFILO; VIAGRA[1] D08514 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
53 Silodosin [2] Silodosin; Silodyx[1] D01965 [1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 6, 13
54 Siltuximab [1] Siltuximab[1] D09669 [1] IL6 💬[51] AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Alcoholic liver disease, Alzheimer disease, Amoebiasis, Antifolate resistance, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Lipid and atherosclerosis, Malaria, Measles, NOD-like receptor signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Rheumatoid arthritis, Salmonella infection, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection 💬[2] 28, 331
55 Simethicone [1] Simethicone[1] D05841 --[2] 13, 96
56 Simtuzumab [2] GS-6624; Simtuzumab---[2] 85, 94
57 Simvastatin [3] Simvastatin; Simvastatina; Simvastatine[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
58 Sinecatechins [1] Veregen[1] D08997 --[1] 160
59 Sinomenine [1] Sinomenine---[2] 46, 222
60 Siponimod [2] Mayzent; SIPONIMOD[1] D11460 [2] S1PR1,
S1PR5 💬		[3] FoxO signaling pathway, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway 💬[2] 13, 50
61 Sirolimus [3] RAPAMUNE; Rapamycin; SIROLIMUS[1] D00753 [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331
62 Sirukumab [1] Sirukumab[1] D10080 [1] IL6 💬[51] AGE-RAGE signaling pathway in diabetic complications, African trypanosomiasis, Alcoholic liver disease, Alzheimer disease, Amoebiasis, Antifolate resistance, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Lipid and atherosclerosis, Malaria, Measles, NOD-like receptor signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Rheumatoid arthritis, Salmonella infection, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection 💬[2] 41, 46
63 Sitagliptin [1] Sitagliptin[1] D08516 [1] DPP4 💬[1] Protein digestion and absorption 💬[4] 6, 75, 233, 299
64 Sitaxentan [3] Sitaxentan; Sitaxsentan; Thelin[1] D07171 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86
65 Sivelestat [1] Sivelestat[1] D03788 [1] ELANE 💬[3] Neutrophil extracellular trap formation, Systemic lupus erythematosus, Transcriptional misregulation in cancer 💬[3] 13, 85, 96
66 Smilagenin [1] SMILAGENIN---[1] 6
67 Sobetirome [1] Sobetirome[1] D09381 [1] THRB 💬[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[1] 20
68 SOBI-003 [0] ---[1] 19
69 Sodium acetate [1] Sodium Acetate[1] D01779 --[2] 81, 251
70 Sodium aurothiomalate [1] Sodium aurothiomalate[1] D00992 --[1] 46
71 Sodium bicarbonate [1] Sodium Bicarbonate[1] D01203 --[1] 299
72 Sodium chloride [6] Lactated Ringers; Natriumchlorid; REBIF; Saline; Sodium chloride; Sporanox[1] D02056 --[20] 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 168, 193, 227, 228, 288, 299
73 Sodium citrate [1] Sodium citrate[2] D01781 ,
D05855 		--[4] 67, 214, 215, 235
74 Sodium dichloroacetate [1] Dichloroacetate Sodium[1] D05857 [3] PDK2,
PDK3,
PDK4 💬		[1] Diabetic cardiomyopathy 💬[1] 86
75 Sodium fluoride [1] Sodium fluoride[1] D00943 --[1] 51
76 Sodium glycerophosphate [1] Smofkabiven[1] D10489 --[1] 66
77 Sodium iodide [1] Sodium iodide[3] D04874 ,
D05328 ,
D05863 		--[1] 34
78 Sodium lauryl sulfate [0] [1] D01045 --[1] 2
79 Sodium nitrate [1] Sodium Nitrate---[2] 58, 113
80 Sodium oxybate [1] Sodium Oxybate[1] D05866 --[2] 6, 149
81 Sodium sulfate [1] Sodium sulfate[1] D05877 --[1] 28
82 Sodium tetradecyl sulfate [0] [1] D06882 --[2] 50, 51
83 Sofosbuvir [1] Sofosbuvir[1] D10366 --[1] 19
84 Solifenacin [2] Solifenacin; Solifenacin Succinate[1] D08522 [1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[3] 6, 13, 53
85 Somapacitan [2] Sogroya; Somapacitan[1] D11194 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[2] 78, 195
86 Somatorelin [2] GHRH; Somatorelin[1] D08523 [1] GHRHR 💬[2] Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction 💬[2] 13, 78
87 Somatostatin [1] Somatostatin[1] D07431 [5] SSTR1,
SSTR2,
SSTR3,
SSTR4,
SSTR5 💬		[4] Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[2] 67, 78
88 Somatotropin [17] Genotropin; Growth hormone; Human growth hormone; Humatrope; Norditropin; Norditropin SimpleXx; NUTROPIN; Nutropin AQ; NutropinAq; OMNITROPE; Recombinant human growth hormone; RhGH; SAIZEN; Somatotropin; Somatropin; SOMATROPINA; Zomacton---[25] 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 246, 265, 274, 276, 299, 337
89 Somatrogon [2] Ngenla; Somatrogon[1] D10990 --[1] 78
90 Somatropin pegol [1] NNC126-0083---[1] 78
91 Somavaratan [1] Somavaratan[1] D11193 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 78
92 Sonlicromanol [1] Sonlicromanol---[1] 21
93 Sorafenib [2] Nexavar; Sorafenib[1] D08524 [8] BRAF,
FLT3,
FLT4,
KDR,
KIT,
PDGFRB,
RAF1,
RET 💬		[89] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 34, 86
94 Sorbitol [3] D-glucitol; D-SORBITOL; Sorbitol[1] D00096 --[3] 10, 28, 299
95 Sotatercept [1] SOTATERCEPT[1] D09670 [1] ACVR2A 💬[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[2] 86, 284
96 Soticlestat [1] SOTICLESTAT[1] D11590 [1] CYP46A1 💬[1] Primary bile acid biosynthesis 💬[2] 140, 144
97 Sotrastaurin [1] Sotrastaurin[1] D09671 [4] PRKCD,
PRKCE,
PRKCH,
PRKCQ 💬		[29] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Aldosterone synthesis and secretion, Apelin signaling pathway, Autophagy - animal, C-type lectin receptor signaling pathway, Chemical carcinogenesis - reactive oxygen species, Chemokine signaling pathway, Diabetic cardiomyopathy, Estrogen signaling pathway, Fc gamma R-mediated phagocytosis, GnRH signaling pathway, Inflammatory mediator regulation of TRP channels, Insulin resistance, MicroRNAs in cancer, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Prion disease, Shigellosis, Sphingolipid signaling pathway, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 97
98 Soybean [1] Soybean---[1] 97
99 Sparsentan [1] SPARSENTAN[1] D11776 [2] AGTR1,
EDNRA 💬		[17] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 66, 218, 222
100 Spectinomycin [0] [1] D08526 --[1] 13
101 Spesolimab [1] Spesolimab[1] D12066 [1] IL1RL2 💬[1] Cytokine-cytokine receptor interaction 💬[3] 37, 96, 97
102 Spheramine [1] Spheramine---[1] 6
103 Spironolactone [1] Spironolactone[1] D00443 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225
104 SRP-9003 [1] SRP-9003---[1] 113
105 SRT-2104 [0] ---[1] 97
106 SRX-246 [0] ---[1] 8
107 ST-36 [0] ---[2] 6, 49
108 Stamulumab [1] MYO-029[1] D05917 [1] MSTN 💬[1] Cytokine-cytokine receptor interaction 💬[1] 113
109 Stannsoporfin [1] Tin mesoporphyrin[1] D05922 [2] HMOX1,
HMOX2 💬		[10] Chemical carcinogenesis - reactive oxygen species, Ferroptosis, Fluid shear stress and atherosclerosis, HIF-1 signaling pathway, Hepatocellular carcinoma, Metabolic pathways, MicroRNAs in cancer, Mineral absorption, Pathways in cancer, Porphyrin metabolism 💬[1] 254
110 Stanozolol [1] Stanozolol[1] D00444 [1] AR 💬[4] Chemical carcinogenesis - receptor activation, Oocyte meiosis, Pathways in cancer, Prostate cancer 💬[1] 60
111 Starch, corn [1] Cornstarch[1] D05297 --[2] 90, 257
112 Stavudine [1] Stavudine[1] D00445 --[1] 265
113 STG-001 [1] STG-001---[1] 301
114 Stiripentol [2] DIACOMIT; Stiripentol[1] D05928 --[1] 140
115 Streptococcus pneumoniae type 1 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
116 Streptococcus pneumoniae type 10a capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
117 Streptococcus pneumoniae type 11a capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
118 Streptococcus pneumoniae type 12f capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
119 Streptococcus pneumoniae type 14 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
120 Streptococcus pneumoniae type 15b capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
121 Streptococcus pneumoniae type 17f capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
122 Streptococcus pneumoniae type 18c capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
123 Streptococcus pneumoniae type 19a capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
124 Streptococcus pneumoniae type 19f capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
125 Streptococcus pneumoniae type 2 capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
126 Streptococcus pneumoniae type 20 capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
127 Streptococcus pneumoniae type 22f capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
128 Streptococcus pneumoniae type 23f capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
129 Streptococcus pneumoniae type 3 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
130 Streptococcus pneumoniae type 33f capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
131 Streptococcus pneumoniae type 4 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
132 Streptococcus pneumoniae type 5 capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
133 Streptococcus pneumoniae type 6b capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
134 Streptococcus pneumoniae type 7f capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
135 Streptococcus pneumoniae type 8 capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
136 Streptococcus pneumoniae type 9n capsular polysaccharide antigen [1] Pneumovax 23---[2] 46, 50
137 Streptococcus pneumoniae type 9v capsular polysaccharide antigen [2] Pneumovax 23; Prevenar 13---[6] 13, 14, 46, 50, 96, 222
138 Strontium ranelate [1] Strontium ranelate[1] D08468 --[1] 78
139 STX-107 [0] ---[1] 206
140 Succimer [1] DMSA[1] D00572 --[1] 171
141 Sucralfate [1] Sucralfate[1] D00446 --[1] 98
142 Sucrose [1] Sucrose[1] D00025 --[3] 62, 96, 97
143 Sufentanil [1] Sufentanil[1] D05938 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[2] 70, 280
144 Sulfachlorpyridazine [0] [1] D05948 --[1] 6
145 Sulfadoxine [1] Sulfadoxine[1] D00580 --[1] 65
146 Sulfamethoxazole [3] Bactrim; Sulfamethoxazole; Sulphamethoxazole[1] D00447 --[5] 44, 49, 61, 85, 299
147 Sulfanilamide [0] [1] D08543 --[4] 6, 30, 60, 298
148 Sulfasalazine [3] Salazosulfapyridine; Salicylazosulfapyridine; SULFASALAZINE[1] D00448 --[6] 46, 86, 94, 107, 270, 271
149 Sulfate ion [1] Sulfate---[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 85, 86, 96, 111, 218, 222, 224, 226, 265, 296, 297, 299
150 Sulforaphane [1] Sulforaphane---[2] 6, 205
151 Sulfur hexafluoride [3] SonoVue; Sulfur hexafluoride; Sulphur hexafluoride[1] D05962 --[2] 96, 215
152 Sulindac [1] Sulindac[1] D00120 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 206
153 Sulodexide [0] [1] D08547 [2] SERPINC1,
SERPIND1 💬		[1] Complement and coagulation cascades 💬[2] 51, 271
154 Sulpiride [0] [1] D01226 [1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 70
155 Sumanirole [1] Sumanirole---[1] 6
156 Sunflower oil [1] Sunflower Oil[1] D09006 --[2] 46, 299
157 Sunitinib [2] Sunitinib; Sunitinib malate[1] D08552 [9] CSF1R,
FLT1,
FLT3,
FLT4,
KDR,
KIT,
PDGFRA,
PDGFRB,
RET 💬		[36] Acute myeloid leukemia, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, Gap junction, Glioma, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, Thyroid cancer, Transcriptional misregulation in cancer, VEGF signaling pathway, Viral protein interaction with cytokine and cytokine receptor 💬[2] 28, 34
158 Suramin [1] Suramin---[1] 331
159 Susoctocog alfa [1] OBIZUR[1] D10831 --[1] 288
160 Sutimlimab [1] Sutimlimab[1] D11530 [1] C1S 💬[5] Complement and coagulation cascades, Coronavirus disease - COVID-19, Pertussis, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[1] 61
161 Suvorexant [1] Suvorexant[1] D10082 [2] HCRTR1,
HCRTR2 💬		[1] Neuroactive ligand-receptor interaction 💬[3] 5, 6, 13