Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. KEGG DRUG DrugBank Drug (Description in trials) KEGG GENES KEGG PATHWAY Disease ID
1 Aliskiren 💬[1] Aliskiren (Tekturna HCT)[1] Aliskiren[1] REN 💬 [3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[3] 66, 167, 222 💬
2 Amiloride 💬[1] Amiloride (Alti-amiloride Hctz)[3] Amiloride; Amiloride Hydrochloride; Midamor[3] SCNN1A,
SCNN1B,
SCNN1G 💬 		[2] Aldosterone-regulated sodium reabsorption, Taste transduction 💬[4] 13, 67, 225, 299 💬
3 Amlodipine 💬[1] Amlodipine (Exforge HCT)[1] AMLODIPINE[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬 		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 67, 298 💬
4 Benazepril 💬[1] Benazepril (Lotensin HCT)[1] Benazepril[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[4] 49, 57, 218, 224 💬
5 Candesartan cilexetil 💬[1] Candesartan cilexetil (Act Candesartan/hct)[1] CANDESARTAN[1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 67 💬
6 Cilazapril 💬[1] Cilazapril (Apo-cilazapril/hctz)[1] Cilazapril[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 66 💬
7 Cilazapril 💬[1] Cilazapril (Apo-cilazapril/hctz)[1] Cilazapril[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 66 💬
8 Enalapril 💬[1] Enalapril (Enalapril Maleate/hctz)[2] Enalapril; Enalapril Maleate[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[6] 19, 46, 66, 113, 210, 222 💬
9 Hydrochlorothiazide 💬[1] Hydrochlorothiazide (Candesartan-hctz)[2] Esidrix; HYDROCHLOROTHIAZIDE[1] SLC12A3 💬 [1] 💬[4] 13, 67, 225, 235 💬
10 Irbesartan 💬[1] Irbesartan (Ag-irbesartan Hctz)[2] Aprovel; Irbesartan[1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 66, 167, 168, 222 💬
11 Lisinopril 💬[1] Lisinopril (Ava-lisinopril HCT)[2] Lisinopril; ZESTRIL[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 19, 46, 49, 66, 67, 113, 222 💬
12 Lisinopril 💬[1] Lisinopril (Ava-lisinopril HCT)[2] Lisinopril; Zestril[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 19, 46, 49, 66, 67, 113, 222 💬
13 Losartan 💬[1] Losartan (Van-losartan-hctz)[3] Cozaar; Losartan; LOSARTAN POTASSIUM[1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
14 Metoprolol 💬[1] Metoprolol (Lopressor HCT)[2] Metoprolol; METOPROLOL SUCCINATE[1] ADRB1 💬 [11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 17, 57, 58, 113, 193, 226 💬
15 Quinapril 💬[1] Quinapril (Teva-quinapril/hctz)[1] Accuretic[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 19 💬
16 Ramipril 💬[1] Ramipril (Teva-ramipril/hctz)[1] Ramipril[1] ACE 💬 [6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 46, 49, 66, 67, 113, 218, 257 💬
17 Spironolactone 💬[1] Spironolactone (Teva-spironolactone/hctz)[1] Spironolactone[1] NR3C2 💬 [1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225 💬
18 Telmisartan 💬[1] Telmisartan (Auro-telmisartan Hctz)[1] Telmisartan[1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 66, 67 💬
19 Valsartan 💬[1] Valsartan (Copalia HCT)[3] Diovan; Entresto; Valsartan[1] AGTR1 💬 [16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[7] 57, 58, 66, 75, 218, 222, 224 💬