149. 片側痙攣・片麻痺・てんかん症候群 Hemiconvulsion hemiplegia epilepsy syndrome Clinical trials / Disease details


臨床試験数 : 25 薬物数 : 35 - (DrugBank : 13) / 標的遺伝子数 : 16 - 標的パスウェイ数 : 22

  
No.TrialIDDate_
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PhaseCountries
1NCT05615987
(ClinicalTrials.gov)
December 1, 20222/11/2022Comparison of Botulinum Toxin Injection Techniques in SpasticityComparison of the Efficacy of 2 Different Botulinum Toxin Injection Techniques in Gastrocnemius Muscle Spasticity in Hemiplegic Patients: A Randomized Double-blind Controlled Study.Spastic HemiplegiaDrug: Onabotulinumtoxina for InjectionKonya Beyhekim Training and Research HospitalNULLNot yet recruiting18 Years90 YearsAll60Phase 4Turkey
2NCT05260125
(ClinicalTrials.gov)
March 15, 202218/2/2022Comparison of the Efficacy of Ultrasound Guided vs Non-guided Suprascapular Nerve Block Treatment in Stroke PatientsComparison of the Efficacy of Ultrasound Guided vs Non-guided Suprascapular Nerve Block Treatment in Stroke Patients With Hemiplegic Shoulder Pain.Hemiplegia;StrokeDrug: Ultrasound-guided Suprascapular Nerve Block;Drug: Anatomical Landmark-guided Suprascapular Nerve BlockAbant Izzet Baysal UniversityNULLRecruiting25 Years75 YearsAll50Phase 4Turkey
3ChiCTR2000040083
2021-01-012020-11-20Effect of Taiji Cloud Hand Visual Feedback Training on Balance Function of Stroke Patients with Subacute HemiplegiaEffect of Taiji Cloud Hand Visual Feedback Training on Balance Function of Stroke Patients with Subacute Hemiplegia StrokeExperimental group:Summative Visual Feedback Taiji Cloud Hand Training;Control Group:Summative Visual Feedback Standing Balance Training;Shanghai Baoshan district Renhe hospitalNULLPending4070BothExperimental group:45;Control Group:45;China
4JPRN-UMIN000042549
2020/12/0125/11/2020Effect of neuromuscular electrical stimulation therapy on anticipatory postural adjustments in patients with stroke hemiplegiaEffect of neuromuscular electrical stimulation therapy on anticipatory postural adjustments in patients with stroke hemiplegia - Effect of neuromuscular electrical stimulation therapy on anticipatory postural adjustments in patients with stroke hemiplegia Post-Stroke Hemiplegic PatientsIn addition to standard physiotherapy (flexibility increase, muscle strengthening, balance exercise, walking exercise), center of gravity movement exercise and step exercise using IVES (tibialis anterior muscle, soleus muscle stimulation) are performed for 2 groups of subjects.
One session is 20 minutes, 3 times a week for a total of 2 weeks.
Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental UniversityNULLPending45years-old85years-oldMale and Female20Not selectedJapan
5NCT04630873
(ClinicalTrials.gov)
November 20, 202031/10/2020Low or High Botox Dilution for the Hemiplegic Gait?Different Dilutions and Efficacy of Botulin Toxin in the Correction of the Hemiplegic GaitPost Stroke Spastic HemiplegiaDrug: Botulinum toxin;Diagnostic Test: gait analysisUniversity of IoanninaNULLRecruiting18 YearsN/AAll20Phase 1Greece
6JPRN-JapicCTI-194958
01/10/201918/09/2019A pharmacokinetic, safety, and tolerability study of padsevonil in CYP2C19 genotyped healthy male Japanese study participants.An Open-Label, Parallel Group, Single-Center Study to Investigate the Pharmacokinetic, Safety, and Tolerability Profiles of Padsevonil in CYP2C19 Genotyped Healthy Male Japanese Study Participants Epilepsy and epilepsy syndromeIntervention name : padsevonil
INN of the intervention : padsevonil
Dosage And administration of the intervention : Oral administration
Control intervention name : -
INN of the control intervention : -
Dosage And administration of the control intervention : -
UCB Japan Co., Ltd.NULLcomplete2055Male39Phase 1Japan
7JPRN-JapicCTI-194633
05/6/201915/02/2019A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled Study of T-817MA in Post-stroke Patients Undergoing Rehabilitation for Upper Limb HemiplegiaA Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled Study of T-817MA in Post-stroke Patients Undergoing Rehabilitation for Upper Limb Hemiplegia Patients with upper limb hemiplegia after cerebral infarction or cerebral hemorrhage (other than subarachnoid hemorrhage)Intervention name : T-817MA
INN of the intervention : Edonerpic
Dosage And administration of the intervention : Oral Multiple Dose
Control intervention name : -
INN of the control intervention : -
Dosage And administration of the control intervention : -
FUJIFILM Toyama Chemical Co., LtdNULLcomplete2084BOTH65Phase 2Japan
8JPRN-jRCTs042190020
03/05/201922/04/2019The Effectiveness of BEAR for hemiplegic patientsThe Effectiveness of Balance Exercise Assist Robot for convalescent patients with hemiplegia after stroke - EBEARCPHAS StrokeUsing Balance Exercise Assist RobotOtaka YoheiNULLRecruiting>= 20age old< 90age oldBoth60N/AJapan
9JPRN-JapicCTI-184137
04/1/201903/10/2018A Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam as Replaement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age with Partial Seizures With or Without Secondary GeneralizationA Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam as Replaement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age with Partial Seizures With or Without Secondary Generalization Epilepsy and epilepsy syndromeIntervention name : brivaracetam
INN of the intervention : brivaracetam
Dosage And administration of the intervention : Intravenous (iv) injection
Control intervention name : -
INN of the control intervention : -
Dosage And administration of the control intervention : -
UCB Japan Co., Ltd.NULLcomplete16BOTH10Phase 3Japan
10JPRN-UMIN000035315
2018/12/1919/12/2018Verification of effectiveness of sitting training equipment using virtual reality for patients with stroke hemiplegiaVerification of effectiveness of sitting training equipment using virtual reality for patients with stroke hemiplegia - Verification of effectiveness of sitting training equipment using virtual reality for patients with stroke hemiplegia strokeVirtual reality by viewing spatial gradientWaseda UniversityNULLPending20years-old80years-oldMale and Female10Not selectedJapan
11NCT03857607
(ClinicalTrials.gov)
September 1, 201826/2/2019Natural History Study of ATP1A3-related DiseaseNatural History of ATP1A3-related Disease: a Deep Phenotyping-genotyping ProjectATP1A3-related Disease;Alternating Hemiplegia of Childhood;Rapid Onset Dystonia Parkinsonism;CAPOSGenetic: Whole exome sequencingInstitute of Child HealthGreat Ormond Street Hospital for Children NHS Foundation Trust;University College, LondonRecruiting6 Months60 YearsAll100United Kingdom
12NCT03860662
(ClinicalTrials.gov)
May 26, 20188/2/2019The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor ReflexDoctor, Physical Medicine and RehabilitationStroke Sequelae;Spastic HemiplegiaDiagnostic Test: Nociceptor flexor reflex;Drug: Botox;Drug: BaclofenMustafa Kemal UniversityNULLCompleted18 Years60 YearsAll29Phase 4Turkey
13JPRN-JapicCTI-173615
22/8/201715/06/2017A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Adjunctive Brivaracetam Subjects (>=16 to 80 Years of Age) With Partial Seizures With or Without Secondary GeneralizationA Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Adjunctive Brivaracetam Subjects (>=16 to 80 Years of Age) With Partial Seizures With or Without Secondary Generalization Epilepsy and epilepsy syndromeIntervention name : ucb 34714
INN of the intervention : Brivaracetam
Dosage And administration of the intervention : Oral administration
Control intervention name : Placebo
INN of the control intervention : -
Dosage And administration of the control intervention : -
UCB Japan Co., Ltd.NULLrecruiting1680BOTH444Phase 3Japan, Asia except Japan
14JPRN-JapicCTI-173687
05/8/201721/08/2017An Open-Label, Multicenter, Follow-up Study to Evaluate the Long-Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary GeneralizationAn Open-Label, Multicenter, Follow-up Study to Evaluate the Long-Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization Epilepsy and epilepsy syndromeIntervention name : brivaracetam
INN of the intervention : brivaracetam
Dosage And administration of the intervention : Oral administration
Control intervention name : -
INN of the control intervention : -
Dosage And administration of the control intervention : -
UCB Japan Co., Ltd.NULLrecruiting16BOTH214Phase 3Japan, Asia except Japan
15JPRN-JapicCTI-153104
18/3/201622/12/2015AN OPEN-LABEL, MULTICENTER EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSYAN OPEN-LABEL, MULTICENTER EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY Epilepsy and epilepsy syndromeIntervention name : SPM927
INN of the intervention : Lacosamide
Dosage And administration of the intervention : oral administration
Control intervention name : Placebo
INN of the control intervention : -
Dosage And administration of the control intervention : -
UCB Japan Co., Ltd.NULLcomplete4BOTH239Phase 3Japan, Asia except Japan, North America, Europe, Oceania
16JPRN-JapicCTI-153103
08/12/201522/12/2015A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSYA DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LACOSAMIDE AS ADJUNCTIVE THERAPY FOR UNCONTROLLED PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN SUBJECTS WITH IDIOPATHIC GENERALIZED EPILEPSY Epilepsy and epilepsy syndromeIntervention name : SPM927
INN of the intervention : Lacosamide
Dosage And administration of the intervention : oral administration
Control intervention name : Placebo
INN of the control intervention : -
Dosage And administration of the control intervention : -
UCB Japan Co., Ltd.NULLcomplete4BOTH242Phase 3Japan, Asia except Japan, North America, Europe, Oceania
17NCT02455232
(ClinicalTrials.gov)
May 20157/5/2015Determine the Main Muscle Participant in the Deformation of the Elbow in Hemiplegic PatientsDetermine the Main Muscle Participant in the Deformation of the Elbow in Hemiplegic PatientsHemiplegiaProcedure: upper limb muscle block;Drug: 4cc of lidocaïne®Centre d'Investigation Clinique et Technologique 805NULLCompleted18 Years75 YearsAll20N/AFrance
18NCT02408354
(ClinicalTrials.gov)
April 15, 201524/3/2015Pilot Study, Comparative, Single-center, Randomized, Crossover, Double-blind, Against Placebo, Testing the Effectiveness of Triheptanoin Oil in Alternating Hemiplegia of ChildhoodEtude Pilote, Comparative, Monocentrique, randomisée, en Cross Over, en Double Aveugle, Contre Placebo, Testant l'efficacité de l'Huile triheptanoïne Dans Les Hémiplégies Alternantes de l'Enfant HEMIHEPAlternating Hemiplegia of ChildhoodDrug: Triheptanoin;Drug: PlaceboInstitut National de la Santé Et de la Recherche Médicale, FranceNULLCompleted15 YearsN/AAll10Phase 2France
19ChiCTR-ICR-15007022
2014-05-012015-09-06A research of biomechanic stimulation and healing of hemiplegia gaitA research of biomechanic stimulation and healing of hemiplegia gait strokebotulinum toxin A type group:inject botulinum toxin A type;conventional treatment A group :conventional treatment;Dynamic electrical stimulation treatment group:Dynamic electrical stimulation;conventional treatment B group :conventional treatment;blank control group:null;validation group :botulinum toxin A type ;Nanjing Sports InstitudeNULLRecruiting4070Bothbotulinum toxin A type group:30;conventional treatment A group :30;Dynamic electrical stimulation treatment group:30;conventional treatment B group :30;blank control group:30;validation group :30;China
20NCT01623622
(ClinicalTrials.gov)
July 201218/6/2012Study of HC-58 in Upper Limb Hemiplegic Patients After StrokeA Phase 2 Study of HC-58 in Patients With Severe Upper Limb Hemiplegia After StrokeSevere Upper Limb HemiplegiaDrug: HC-58;Drug: PlaceboAsahi Kasei Pharma CorporationNULLCompleted20 YearsN/AAll270Phase 2Japan
21EUCTR2009-015620-29-BE
(EUCTR)
08/03/201009/02/2010The efficacy of the Botulinum toxin-A on the manual abilities in children with congenital spastic hemiplegia. Interest of the measure of the bimanual task performance.The efficacy of the Botulinum toxin-A on the manual abilities in children with congenital spastic hemiplegia. Interest of the measure of the bimanual task performance. The main objective of this study is to investigate the effect of Botulinum toxin A to improve the Upper Limb dysfunction in Hemiplegic Cerebral Palsy Children and in particular, its impact on Upper limb activity performance and how this might be translate in bimanual activities.
MedDRA version: 12.0;Level: LLT;Classification code 10019475;Term: Hemiplegic infantile cerebral palsy
Trade Name: BOTOX
Product Name: BOTOX
Product Code: 9060X
Other descriptive name: BOTULINUM TOXIN TYPE A
NULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
30Belgium
22NCT00931164
(ClinicalTrials.gov)
August 200930/6/2009Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO)Single-center Phase I/II Trial of Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO Trial)Alternating Hemiplegia of ChildhoodDrug: Sodium OxybateUniversity of UtahAlternating Hemiplegia of Childhood Foundation;Jazz PharmaceuticalsCompleted6 Months25 YearsAll6Phase 1/Phase 2United States
23NCT00632528
(ClinicalTrials.gov)
March 200828/2/2008MEOPA to Improve Physical Therapy Results After Multilevel SurgeryEvaluation of the Efficacy of MEOPA Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia.Cerebral Palsy;Spastic Diplegia;Quadriplegia;HemiplegiaDrug: MEOPA;Drug: Medicinal airAssistance Publique - Hôpitaux de ParisNULLCompleted6 Years20 YearsAll64Phase 3France
24NCT00276185
(ClinicalTrials.gov)
December 200512/1/2006HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After StrokeEffect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After StrokeHemiplegiaDrug: Time delay treatment of botulinum toxinUniversity Hospital, Clermont-FerrandJ. Rebeyrol Hospital in Limoges;Rennes University Hospital;Center of Physical Medicine and Rehabilitation (Notre Dame de Lourdes Center in Rennes);Saint Jacques Hospital in Nantes;Centre Hospitalier Universitaire de Saint Etienne;Centre Régional de Département de médecine physique et réadaptation CHU-C3RF in Angers;Centre Hospitalier Universitaire de BesanconRecruiting18 YearsN/ABoth180Phase 3France
25EUCTR2011-004114-42-BE
(EUCTR)
06/04/2021Fenfluramine as anti-epilepticum in a difficult to treat epilepsy syndrome.Fenfluramine as anti-epilepticum in Dravet syndrome. Fenfluramine is an amphetamine which was in the past used as anorexigan. Their are a few publications of effectivness of this medication in epilepsy.We want to investigate was is the exact place of fenfluramine in the treatment of a therapy resitant epilepsy named Dravet syndrome.
MedDRA version: 21.0;Level: PT;Classification code 10015037;Term: Epilepsy;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Product Name: fenfluramine
INN or Proposed INN: FENFLURAMINE
University Hospital AntwerpNULLNAFemale: yes
Male: yes
50Phase 3Belgium