159. 色素性乾皮症 Xeroderma pigmentosum Clinical trials / Disease details
臨床試験数 : 11 / 薬物数 : 17 - (DrugBank : 5) / 標的遺伝子数 : 5 - 標的パスウェイ数 : 15
Showing 1 to 10 of 11 diseases
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
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1 | NCT05370235 (ClinicalTrials.gov) | March 28, 2022 | 21/4/2022 | A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma PigmentosumC ... | A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous Implants of Afamelanotide in Patients With Xeroderma Pigmentosum C and V (XPC and XPV) A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous ... | Xeroderma Pigmentosum | Drug: Afamelanotide | Clinuvel Europe Limited | NULL | Recruiting | 18 Years | 75 Years | All | 6 | Phase 2 | Belgium;Spain |
2 | EUCTR2021-001419-10-ES (EUCTR) | 31/01/2022 | 17/11/2021 | Study to evaluate the safety and the efficacy of the photoprotective drug, afamelanotide in patients with Xeroderma Pigmentosum C and V Study to evaluate the safety and the efficacy of the photoprotective drug, afamelanotide in patients ... | A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous Implants of Afamelanotide in Patients with Xeroderma Pigmentosum C and V (XPC and XPV) - Phase IIa XPC and XPV Study A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous ... | Patients with Xeroderma Pigmentosum C and V;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] Patients with Xeroderma PigmentosumC and V;Therapeutic area: Diseases [C] - Congenital, Hereditary, ... | Trade Name: SCENESSE Product Name: Afamelanotide (16 mg implant) | CLINUVEL EUROPE LIMITED | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 6 | Phase 2 | Belgium;Spain | ||
3 | NCT05159752 (ClinicalTrials.gov) | October 19, 2021 | 9/11/2021 | A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP) A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum( ... | A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous Implants of Afamelanotide in Patients With Xeroderma Pigmentosum (XP) A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous ... | Xeroderma Pigmentosum | Drug: Afamelanotide | Clinuvel Europe Limited | NULL | Recruiting | 18 Years | 75 Years | All | 6 | Phase 2 | Germany |
4 | EUCTR2021-003642-20-DE (EUCTR) | 27/09/2021 | 09/07/2021 | Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients withXeroderma Pigmentosum (XP) Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients withXeroderma Pigmentosum (XP ... | A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety andEfficacy of Subcutaneous Implants of Afamelanotide in Patients withXeroderma Pigmentosum (XP) - Phase IIa XP Study A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety andEfficacy of Subcutaneous I ... | xeroderma pigmentosum;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] xeroderma pigmentosum;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases ... | Trade Name: SCENESSE Product Name: SCENESSE INN or Proposed INN: Afamelanotide | CLINUVEL EUROPE LTD | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 6 | Phase 2 | Germany | ||
5 | EUCTR2019-000597-34-DE (EUCTR) | 01/06/2021 | 11/01/2021 | Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients withXeroderma Pigmentosum (XP) Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients withXeroderma Pigmentosum (XP ... | A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety andEfficacy of Subcutaneous Implants of Afamelanotide in Patients withXeroderma Pigmentosum (XP) - Phase IIa XP Study A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety andEfficacy of Subcutaneous I ... | xeroderma pigmentosum;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] xeroderma pigmentosum;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases ... | Trade Name: SCENESSE Product Name: SCENESSE INN or Proposed INN: AFAMELANOTIDE | CLINUVEL EUROPE LIMITED | NULL | Not Recruiting | Female: yes Male: yes | 6 | Phase 2 | Germany | ||
6 | NCT04500548 (ClinicalTrials.gov) | January 28, 2021 | 4/8/2020 | Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescen ... | 3CI Study: Childhood Cancer Combination Immunotherapy. Phase Ib and Expansion Study of Nivolumab Combination Immunotherapy in Children, Adolescent and Young Adult (CAYA) Patients With Relapsed/Refractory Hypermutant Cancers 3CI Study: Childhood Cancer Combination Immunotherapy. Phase Ib and Expansion Study of Nivolumab Com ... | Constitutional Mismatch Repair Deficiency Syndrome;Hematopoietic and Lymphoid Cell Neoplasm;Lynch Syndrome;Recurrent Lymphoma;Recurrent Malignant Solid Neoplasm;Recurrent Neuroblastoma;Recurrent Primary Central Nervous System Neoplasm;Refractory Lymphoma;Refractory Malignant Solid Neoplasm;Refractory Neuroblastoma;Refractory Primary Central Nervous System Neoplasm;Xeroderma Pigmentosum Constitutional Mismatch Repair Deficiency Syndrome;Hematopoietic and Lymphoid Cell Neoplasm;Lynch Sy ... | Procedure: Biospecimen Collection;Biological: Ipilimumab;Biological: Nivolumab | National Cancer Institute (NCI) | NULL | Withdrawn | 12 Months | 25 Years | All | 0 | Phase 1 | United States;Canada |
7 | EUCTR2010-022968-13-ES (EUCTR) | 22/03/2011 | 25/01/2011 | Estudio clínico de fase II, multicéntrico, abierto de trabectedina (Yondelis®) en pacientes con cáncer de mama avanzado, HER2 negativo, positivo para receptores hormonales, con sobreexpresión o subexpresión del gen xeroderma pigmentosum de clase G (XPG). Estudio clínico de fase II, multicéntrico, abierto de trabectedina (Yondelis®) en pacientes con cánc ... | Estudio clínico de fase II, multicéntrico, abierto de trabectedina (Yondelis®) en pacientes con cáncer de mama avanzado, HER2 negativo, positivo para receptores hormonales, con sobreexpresión o subexpresión del gen xeroderma pigmentosum de clase G (XPG). Estudio clínico de fase II, multicéntrico, abierto de trabectedina (Yondelis®) en pacientes con cánc ... | Cáncer de mama avanzado. MedDRA version: 13;Level: LLT;Classification code 10006204;Term: Carcinoma de mama Cáncer de mama avanzado. MedDRA version: 13;Level: LLT;Classification code 10006204;Term: Carcinoma ... | Trade Name: YONDELIS 0,25 mg polvo para concentrado para solución para perfusión INN or Proposed INN: TRABECTEDINA Other descriptive name: TRABECTEDINA Trade Name: YONDELIS 1 mg polvo para concentrado para solución para perfusión INN or Proposed INN: TRABECTEDINA Other descriptive name: TRABECTEDINA Trade Name: YONDELIS0,25 mg polvo para concentrado para solución para perfusión INN or Proposed INN: ... | PharmaMar S.A. Sociedad Unipersonal | NULL | Not Recruiting | Female: yes Male: no | 100 | Phase 2 | Belgium;Spain | ||
8 | EUCTR2010-022968-13-BE (EUCTR) | 16/03/2011 | 04/01/2011 | Study of the medicinal product Trabectedin in Patients with AdvancedBreast Carcinoma. | Multicenter, Open-Label, Phase II Study of Trabectedin (Yondelis®) in Patients with Hormonal Receptors Positive, HER2 Negative, Advanced Breast Carcinoma, Overexpressing or Underexpressing Xeroderma Pigmentosum G Gene (XPG) Multicenter, Open-Label, Phase II Study of Trabectedin (Yondelis®) in Patients with Hormonal Recepto ... | Advanced Breast Carcinoma MedDRA version: 14.0;Level: LLT;Classification code 10006204;Term: Breast carcinoma;System Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps);Therapeutic area: Diseases [C] - Cancer [C04] Advanced Breast Carcinoma MedDRA version: 14.0;Level: LLT;Classification code 10006204;Term: Breast ... | Trade Name: Yondelis 0.25 mg powder for concentrate for solution for infusion. INN or Proposed INN: trabectedine Trade Name: Yondelis 1 mg powder for concentrate for solution for infusion. INN or Proposed INN: trabectedine Trade Name: Yondelis0.25 mg powder for concentrate for solution for infusion. INN or Proposed INN: tr ... | Pharma Mar, S.A. Sociedad Unipersonal | NULL | Not Recruiting | Female: yes Male: yes | 100 | Phase 2 | Spain;Belgium | ||
9 | NCT00002811 (ClinicalTrials.gov) | July 1996 | 1/11/1999 | T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With ... | A RANDOMIZED, DOUBLE BLIND, MULTI-CENTER CLINICAL STUDY TO TEST THE SAFETY AND EFFICACY OF T4N5 LIPOSOME LOTION ON PATIENTS WITH XERODERMA PIGMENTOSUM IN THE PROTECTION AGAINST ACTINIC KERATOSES A RANDOMIZED, DOUBLE BLIND, MULTI-CENTER CLINICAL STUDY TO TEST THE SAFETY AND EFFICACY OF T4N5 LIPO ... | Precancerous Condition | Drug: liposomal T4N5 lotion | Applied Genetics | NULL | Active, not recruiting | 2 Years | 60 Years | Both | 30 | Phase 3 | United States;Germany;United Kingdom |
10 | NCT00025012 (ClinicalTrials.gov) | June 1991 | 11/10/2001 | Isotretinoin in Preventing Skin Cancer | Use Of Isotretinion For Prevention Of Skin Cancer In Patients With Xeroderma Pigmentosum Or Nevoid Basal Cell Carcinoma Syndrome Use Of Isotretinion For Prevention Of Skin Cancer In Patients With Xeroderma PigmentosumOr Nevoid Ba ... | Melanoma (Skin);Non-melanomatous Skin Cancer | Drug: isotretinoin | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | NULL | Completed | 2 Years | N/A | Both | N/A | United States |